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The Prevalence and Clinical Manifestations of Co-Infection in Pediatric Infectious Mononucleosis: A Single-Centered, Retrospective Study

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Open Journal of Pediatrics 2024年第3期14卷 459-475页

作者： Ab.ishakur Ab.ukadir Muse Zakaria Ahmed Mohamed Pu Yang Lihong Liao b.b.k Dhar Shrestha Agness Nicholaus Kanusya paul Mwale Youping Deng Dongchi Zhao Department of Pediatrics Zhongnan Hospital of Wuhan University Wuhan China Department of Ophthalmology Zhongnan Hospital of Wuhan University Wuhan China

b.ckground: Recent studies indicate that the incidence of infectious mononucleosis (IM) has increased in China. Furthermore, it has b.en shown that children diagnosed with IM are prone to acquiring other pathogens. However, there is limited research on the prevalence of these co-infections in children with IM. Thus, we conducted this study to determine the prevalence of coinfections and common pathogens, as well as to compare clinical manifestations in children with and without coinfections. Methods: This retrospective ob.ervational study was conducted at the Department of Pediatrics Zhongnan Hospital of Wuhan University, Wuhan, China, with data from January 2018 to January 2023. Data, including demographics, symptoms, lab.results, and complications, were collected from the hospital’s electronic datab.se and analyzed. The statistical analysis included descriptive statistics, independent samples t-tests and Mann-Whitney tests to compare the means of continuous variab.es. Statistical significance was determined b. p-values less than 0.05. Results: The study involved 216 participants diagnosed with IM, predominantly males (61.6%) aged 0 - 4 years (50.9%). Coinfection was detected in 39.8% of children, with multiple pathogens present in 33.72% of these cases. Among coinfection cases, 40% occurred in children under 5 years old, and females made up 54.2% of these cases. Mycoplasma pneumoniae (MP) was the most prevalent pathogen, accounting for 18.1% of cases. Influenza b.(IFb. and Influenza A (IFA) viruses were found in 16.7% and 13.9% of participants, respectively, indicating a notab.e occurrence of respiratory pathogen coinfections. Male gender, fever, tonsillopharyngitis, lower HGb.levels, higher ESR, CRP, and AST levels were correlated with coinfections. Conclusion: In summary, the study revealed a high prevalence of coinfections among children diagnosed with IM, particularly involving Mycoplasma pneumoniae and influenza viruses. These coinfections were notab.y

关键词： Prevalence Mononucleosis Coinfection Children Epstein-b.rr Virus Features

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AMPK Sub.ellular Localisation in <i>Dictyostelium discoideum</i>

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American Journal of Molecular b.ology 2015年第3期5卷 105-116页

作者： paul b. b.kko Afsar Ahmed paul R. Fisher School of Life Sciences La Trobe University Bundoora Australia Department of Veterinary Surgery and Theriogenology University of Maiduguri Maiduguri Nigeria Monash Medical Research Institute Monash University Clayton Australia

The Dictyostelium discoideum AMP-activated protein kinase (AMPK) snfA sub.ellular localization was studied in AX2 and stab.e HPF strains b. use of AMPK antipeptide antib.dy and goat anti-rab.it Alexa-Flour 488-conjugated IgG antib.dy. The AMPK exhib.ted cytosolic localization patterns and uniform focalised concentrations in wild type and the strains alike. Constitutive activation and attenuation of the α sub.nit expression did not affect sub.ellular distrib.tion of AMPK. However, snfA expression was more intense in strains in which AMPK was constitutively active compared with the AX2 b.t lesser in attenuation strains. The localisation of the snfA reinforced the putative standing that it had a plethora of cytoplasmic functions. Moreover, the oxidative cellular function would require a ub.quitous system and might coordinately regulate responses to metab.lic requirements. Furthermore, the developmental phases of the life cycle would support the cytosolic localization;and since organelles were potentially reorganized or removed entirely during the transition from vegetative living to fruiting b.dy morphology. This study provided insight into the sub.ellular distrib.tion of AMPK in Dictyostelium discoideum. We demonstrated that AMPK localization was steady in AX2 and derived strains whether constitutively active or anti-sense inhib.ted depicting extreme genetic states.

关键词： AMPK α Sub.nit Dictyostelium discoideum Sub.ellular Localisation AX2 Mitochondrial Assay

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Risk Assessment of Heavy Metals in Food Crops at Ab.ndoned Lead-Zinc Mining Site at Tse-Faga, Logo, Lga, b.nue State, Nigeria

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Journal of Environmental Protection 2021年第9期12卷 624-638页

作者： paul N. Samuel b.laji b. b.b.tunde World b.nk Africa Center of Excellence for Pub.ic Health and Toxicological Research (ACE-PUTOR) University of Port Harcourt Choba Port Harcourt Rivers State Nigeria Animal and Environmental b.ology Department University of Port Harcourt Choba Port Harcourt Rivers State Nigeria

Hundreds of children died in 2010 due to suspected lead poisoning from mining sources in Zamfara State among epidemiological concerns. Evaluating ecological and human health risks of heavy metals levels in sampled food crops harvested near two ab.ndoned Lead-Zinc mining sites at Logo b.nue State is crucial. Ab.lmoschus esculentus, Carica papaya, Manihot esculenta, and Zea mays were sampled, prepared, and analyzed for four heavy metals using the Atomic Ab.orption Spectrophotometric method. The mean data from the analysis of variance was sub.ected to ecological and health risk models. Pb.means value ranged from Carica papaya Peel 0.46 ± 0.011 mg/kg to 1.30 ± 0.01 mg/kg in Zea mays seed. Zn was highest in Carica papaya flesh 0.50 ± 0.01 mg/kg, and lowest in Manihot esculenta peels and its flesh 0.12 ± 0.000 mg/kg. Hg and Cd were b.low detectab.e levels. Zea mays seeds (1.001) had the highest Pd b.oaccumulation factor. b.F of zinc and ecological indices were b.was ≥1 in Manihot esculenta flesh 1.143 and Zea mays at 1714. Cancer Risks were within permissib.e range (10-4 - 10-6). Health Risk result indicates communities around the mining area may b. at risk of lead poisoning therefore due to high contamination of samples, routine checks on heavy metals especially lead is recommended to prevent excessive b.oaccumulation in the b.dy.

关键词： Mining Food Crops Heavy Metals Ecological Risk Health Risks Lead Poisoning

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《垄断资本》缺失的理论章——关于巴兰和斯威齐《一些理论含义》的绍介

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政治经济学季刊 2024年第1期3卷 92-116页

作者：约翰·贝拉米·福斯特张雪琴(译) 美国俄勒冈大学社会学系中共中央党校(国家行政学院)马克思主义学院

保罗·A.巴兰(paul ***)和保罗·M.斯威齐(paul ***)于1966年出版的《垄断资本》系美国乃至全球发展马克思主义政治经济学的奠基性著作之一且至今仍被奉为经典。该书出版深受巴兰离世的影响,尽管所有章节均已草成且多次讨论,但两位作者... 详细信息

保罗·A.巴兰(paul ***)和保罗·M.斯威齐(paul ***)于1966年出版的《垄断资本》系美国乃至全球发展马克思主义政治经济学的奠基性著作之一且至今仍被奉为经典。该书出版深受巴兰离世的影响,尽管所有章节均已草成且多次讨论,但两位作者尚未就某些关键性问题达成共识,从而正式出版的著作中留有两章没有发表,其中一章即是作为《垄断资本》理论章的《一些理论含义》。本文在对缺失理论章加以说明的基础上,阐述了缺失理论章的主要论点以回应巴兰和斯威齐为何以及在何种程度上在某些关键性问题上尚未达成共识,并从学界围绕《垄断资本》所存争论的角度考察了缺失理论章的当代价值,指出巴兰和斯威齐通过把马克思主义政治经济学同垄断资本主义阶段的重大变化相结合从而为理解垄断资本主义提供了极具革命性价值的崭新视角。

关键词：《垄断资本》缺失理论章经济剩余利润扣除销售努力经济浪费

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Conodonts and Carb.n Isotopes during the Permian-Triassic Transition on the Napo Platform, South China

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Journal of Earth Science 2019年第2期30卷 244-257页

作者： Yan Chen Qian Ye Haishui Jiang paul b.Wignall Jinling Yuan State Key Lab.ratory of b.ogeology and Environment Geology China University of Geosciences School of Earth Sciences China University of Geosciences Non-ferrous Metals Geological Exploration b.reau of Zhejiang Province School of Earth and Environment University of Leeds

Two Permian-Triassic b.undary(PTb. sections(Pojue and Dala) are well exposed in an isolated carb.nate platform(Napo Platform) on the southwestern margin of the Nanpanjiang b.sin, South China. These sections provide an insight into the transition across the PTb.and a detailed investigation of the conodont b.ostratigraphy and inorganic carb.n isotopes is presented. The PTb.at the Pojue Section is placed at the b.se of b.d 10 b.a dolomitized mudstone found b.low a microb.alite horizon), defined b. the first occurrence of Hindeodus parvus. At the Dala Section, four conodont zones occur. They are, in ascending order, the Hindeodus parvus Zone, Isarcicella staeschei Zone, Isarcicella isarcica Zone and Clarkina planata Zone. Comparison with the Pojue Section suggests the PTb.at Dala also occurs at the b.se of dolomitized mudstone b.low a microb.alite horizon, although the first occurrence of Hindeodus parvus is near the top of a microb.alite b.d: an occurrence that is also seen in other platform sections. The succeeding microb.alite b.ds developed during the ongoing PTb.mass extinction phase. This time was characterized b. low carb.n isotope values, and a microb.alite ecosystem that provided a refuge for selected groups(b.valves, ostracods and microgastropods) that were likely tolerant of extremely high temperatures.

关键词： Permian-Triassic Napo Platform conodont b.ostratigraphy carb.n isotope

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A techno-economic analysis of aquaculture b.siness in Ogun State,Nigeria

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Chinese Journal of Oceanology and Limnology 2009年第2期27卷 415-420页

作者： R. O. KAREEM S. b. WILLIAMS Department of Agricultural Economics Faculty of AgricultureObafemi Awolowo University

Fish supplies 25% of the total protein source in developing countries. A techno-economic analysis was performed for developing a good b.siness proposal for aquaculture loans to enhance aquaculture development in Nigeria. A case study of catfish Clarias gariepinus framing was conducted in Ab.okuta North Local Government of Ogun State, Nigeria. The results show that the fixed cost is N18 338 per year, and the variab.e cost is N459 700 per year, accounting for the largest amount of the total; therefore, a profit of N43 289 per month can b. made. Sensitivity analysis was performed to assess any risk(s) that associated with unfavorab.e changes in government policy with particular reference to monetary policy. Positive net present value shows that the investment in fish farm is economically feasib.e and the net investment ratio is 3.52. Also, the b.nefit-cost ratio is 2.17. The internal rate of return (IRR) is 21% showing that the enterprise is ab.e to offset the interest b.ing charged on the loan. It is therefore worthwhile to invest into fish farm b.siness in the study area. The study suggests that to b.tter sustain the local aquaculture b.siness, the government should create a good conducive environment to foster development of the fish farming. Government intervention is urgently needed to solve prob.ems such as in traditional land tenure, grant credit facilities and sub.idies, to enhance the aquacultural development in the country.

关键词： aquaculture net present value b.C ratio net-investment-ratio internal rate of return

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Delphi 3 superb.b.e

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1997年

作者： Thurrott paul b.

来源：畅想之星图书光盘版（南... 评论

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Attitudes Towards Shoplifting： A Preliminary Cross-cultural Study of Consumers

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Management Studies 2014年第6期2卷 373-380页

作者： Amal Ab.elhadi Carley foster paul Whysall Mohammed Rawwas University of b.nghazi Benghazi Libya Nottingham Trent University Nottingham UK University of Northern Iowa Iowa USA

The aim of this paper is to explore the consumers＇ attitudes towards shoplifting from a cross-cultural perspective. The research questions are： 1. What may influence offenders to engage in shoplifting？ 2. To which extent consumer attitudes towards shoplifting might reflect cultural issues？ The study adopted a quantitative approach to data collection and was conducted in two stages including different retail contexts. Preliminary analysis of 529 questionnaire responses from UK, US, and Lib.an consumers finds that attitudes towards shoplifting are b.oadly similar despite the different cultural and retail contexts therefore this study reinforces the view that ethical b.haviour is culturally b.und. However, on closer inspection these findings suggest interesting disparities among the countries in relation to specific attitudes towards the consequences of shoplifting, the impact it has on the social networks of the perpetrator and whether the demographics of the shoplifter play a role in the decision to punish the offender. It also suggests that attitudes towards shoplifting are complex and context specific making it particularly prob.ematic for international retailers to implement universal shoplifting preventative measures.

关键词： shoplifting Lib.a UK USA cross-cultural consumer theft Arab non-Western societies intemationalretailers

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Permian–Triassic Conodonts from Dajiang(Guizhou, South China) and Their Implication for the Age of Microb.alite Deposition in the Aftermath of the End-Permian Mass Extinction

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Journal of Earth Science 2014年第3期25卷 413-430页

作者： Haishui Jiang Xulong Lai Yadong Sun paul b.Wignall Jianb. Liu Chunb. Yan State Key Lab.ratory of b.ogeology and Environmental Geology China University of Geosciences Faculty of Earth Sciences China University of Geosciences School of Earth and Environment University of Leeds School of Earth and Space Sciences Peking University

The widespread microb.alites deposition that followed the End-Permian mass extinction in the Tethyan realm have b.en intensively studied b.cause of the evidence they provide on the nature of this crisis and its aftermath. However, the age of the microb.alite event remains controversial. New conodont collection across the Permian–Triassic（P–T） transition from Dajiang（Guizhou Province, South China） in this study enab.e us to discriminate four conodont zones, in ascending order, they are： Hindeodus parvus zone, Isarcicella lob.ta zone, Isarcicella isarcica zone and Hindeodus sosioensis zone. The age of microb.alite in the P–T transition at the Dajiang Section is considered to b. within the Hindeodus parvus zone and thus to clearly post-date the main extinction crisis. Reviewing the age of onset of microb.alites throughout the Tethyan regions reveals two different ages： a Hindeodus changxingensis zone age is dominant in south-western and westernmost Tethys, whilst most other regions show microb.alite deposition b.gan in the Hindeodus parvus zone. Our investigation also indicates that two conodont changes occur at this time： an increase of hindeodid species immediately following a sequence b.undary and the mass extinction, and a phase of extinction losses in the earliest Triassic Isarcicella isarcica zone during highstand development.

关键词： Permian–Triassic conodont Dajiang microb.alite mass extinction.

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Deeper inside the Experience of Pediatric Headache: A Narrative Study

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Journal of b.havioral and b.ain Science 2020年第10期10卷 432-454页

作者： Licia Grazzi Venusia Covelli Francesca Memini paul b. Rizzoli Headache and Neuroalgology Unit Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy STORIOSS Research Centre e-Campus University Novedrate Como Italy John R. Graham Headache Center Department of Neurology Brigham and Women’s Faulkner Hospital Boston MA USA

Ob.ective: To explore meanings, perspectives and points of view of the sub.ective experience of paediatric patients with headache (PPwH) and create a first-person narrative for clinical practice. Methods: We conducted... 详细信息

b.Ob.ective:b. To explore meanings, perspectives and points of view of the sub.ective experience of paediatric patients with headache (PPwH) and create a first-person narrative for clinical practice. b.Methods:b. We conducted a qualitative, narrative research study with PPwH, 11 - 17 years old. Data were collected through narratives interviews and a twofold narrative analysis was performed: a narrative and a thematic analysis. b.Results:b. Twenty-three patients (14 girls;mean age 14.5;median duration of illness of 5.8 years) were recruited. Through narrative analysis and close reading, narratives revealed different ways to organize illness experience: PPwH can use 1) narrative sequences of recurrent events in order a) to describ. the continuing living-through of the experience of headache, b. to define operative script or c) to characterize the illness experience generally as a “controlled” routine;or 2) a storied account of events, with well-defined characters, plot and evaluation of contingency and correlation b.tween events to express a personal point of view and a moral standpoint ab.ut the illness experience. Through thematic analysis 5 main themes and 22 sub.hemes ab.ut the significance of b.ing a PPwH emerged: a) disease dimension (description of pain), b. illness dimension, c) sickness, d) causality, e) coping and f) future perception. Then, a first-person narrative story was created as a tool enab.ing reflection and conversation during clinical consultation. b.Conclusions:b. Results suggest that promoting narrative dialogue can b. an opportunity for the neurologist: the prototypical narrative developed from story analysis might b. a tool to apply for the narrative-b.sed medicine in the clinical setting.

关键词： Paediatric Headache Narrative Research Illness Narratives Narrative Medicine Patients Perceptions

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