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Interaction of Diet/Lifes.yle Intervention and TCF7L2 Genotype on Glycemic Control and Adipos.ty among Overweight or Obes. Adults.Big Data from s.ven Randomized Controlled Trials.Worldwide

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Health Data s.ience 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi s.n Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros.Liana C.Del Gobbo Jordi s.las.s.lvadó Miguel A.Martínez-González Jan Polak Markku Laaks. Arne As.rup Dominique Langin Jorg Hager Gabby Hul Torben Hans.n Oluf Peders.n Jean-Michel Oppert Wim H.M.s.ris.Peter Arner Monts.rrat Cofán s.jatha Rajaram Jaakko Tuomilehto Jaana Linds.röm Vanes.a D.de Mello Alena s.ancacova Matti Uus.tupa Mathilde s.ends.rup Thorkild I.A.s.rens.n Chris.opher D.Gardner Joan s.baté Dolores.Corella J.Alfredo Martinez Lu Qi Department of Epidemiology&Bios.atis.ics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular Cardiovas.ular s.iences.Minis.ry of Education China Global Health Ins.itute Peking Univers.ty China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIBER Fis.opatologia de la Obes.dad y Nutrición(CIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain s.anford Prevention Res.arch Center Stanford UniversityStanford CAUSA Human Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain Univers.ty of Navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the s.udy of Obes.ty and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medicine University of Eastern FinlandKuopioFinland Univers.ty of Copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Ins.itut National de la s.ntéet de la Recherche Médicale(Ins.rm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance Nes.léIns.itute of Health s.iences LausanneSwitzerland Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands s.ction of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark s.rbonne Univers.té Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** s.ronges. locus.which as.ociated with type 2 diabetes.T2D)by the common variant rs.903146 is.the trans.ription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifes.yle interventions.and the genetic effect of TCF7L2 rs.903146 on glycemic traits.body weight,or wais. circumference in overweight or obes. adults.in s.veral randomized controlled trials.RCTs..*** October 2016 to May 2018,a large collaborative analys.s.was.performed by pooling individualparticipant data from 7 *** RCTs.reported changes.in glycemic control and adipos.ty of the variant rs.903146 after dietary/lifes.yle-related interventions.in overweight or obes. *** treatment interaction models.which us.d the genetic effect encoded by the allele dos. and common covariates.were applicable to individual participant data in all *** the joint analys.s.a total of 7 eligible RCTs.were included(n=4,114).Importantly,we obs.rved a s.gnificant effect modification of diet/lifes.yle-related interventions.on the TCF7L2 variant rs.903146 and changes.in fas.ing *** with the control group,diet/lifes.yle interventions.were related to lower fas.ing glucos. by-3.06(95%CI,-5.77 to-0.36)mg/dL(tes. for heterogeneity and overall effect:I^(2)=45:1%,ps. ***,regardles. of genetic ris.,diet/lifes.yle interventions.were as.ociated with lower wais. ***,there was.no s.gnificant change for diet/lifes.yle interventions.in other glycemic control and adipos.ty traits.per one copy of TCF7L2 ris. *** findings.s.gges. that carrying the TCF7L2 T ris. allele may have a modes.ly greater benefit for s.ecific diet/lifes.yle interventions.to improve the control of fas.ing glucos. in overweight or obes. adults.

关键词： TCF7L2 weight finding

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Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickins.n, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Wes.erberg, Henrik Adis.u, Hibret Baker, Candice N. Bower, Lynette Brown, James.M. Caddle, L. Brianna Chiani, Frances.o Clary, Dave Cleak, James.Daly, Mark J. Denegre, James.M. Doe, Brendan Dolan, Mary E. Edie, s.rah M. Fuchs. Helmut Gailus.Durner, Valerie Galli, Antonella Gambadoro, Ales.ia Gallegos. Juan Guo, s.iying Horner, Neil R. Hs., Chih-Wei Johns.n, s.ra J. Kalaga, s.wmya Keith, Lance C. Lanoue, Louis. Laws.n, Thomas.N. Lek, Monkol Mark, Manuel Ars.hall, s.s.n M. Mas.n, Jeremy McElwee, Melis.a L. Newbigging, s.s.n Nutter, Lauryl M. J. Peters.n, Kevin A. Ramirez-s.lis. Ramiro Rowland, Douglas.J. Ryder, Edward s.mocha, Kaitlin E. s.avitt, John R. s.lloum, Mohammed s.oke-Kovacs. Zs.mbor Tamura, Mas.ru Trainor, Amanda G. Tudos., Ilinca Wakana, s.igeharu Warren, Jonathan Wendling, Olivia Wes., David B. Wong, Leeyean Yos.iki, Ats.s.i MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, paul Bradley, Allan s.arnes. William C. Jus.ice, Monica J. Parkins.n, Helen E. Moore, Mark Wells. s.ra Braun, Robert E. s.ens.n, Karen L. de Angelis. Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, s.eve D. M. Adams. David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, s.ephen A. Dept Mol Phys.ol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt s.nai Hos. Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res.Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hos. s.ck Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trus. s.nger Ins. Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Ins. European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hos. s.ck Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jacks.n Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res.Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Mas.achus.tts.Gen Hos. Analyt & Translat Genet Unit Boston MA 02114 USA Broad Ins. MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res.Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mous. Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ s.ras.ourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ s.ras.ourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens.Hos. Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res.DZD D-85764 Neuherberg Germany Francis.Crick Ins. Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput dis.overy of novel developmental phenotypes.。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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CEPC Technical Des.gn Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos.Adorno de Freitas.Kons.antin Afanaciev s.akeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmanns.ofer Fabio Alves.Weiming An Rui An Daniele Paolo Anderle s.efan Antus.h Yas.o Arai Andrej Arbuzov Abdes.lam Arhrib Mus.afa As.ry s.a Bai Yu Bai Yang Bai Vipul Bairathi Cs.ba Balazs.Philip Bambade Yong Ban Tripamo Bandyopadhyay s.ou-s.an Bao Des.ond P.Barber Ays. Bat Varvara Batozs.aya s.bas. Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas.Biekotter Michela Biglietti s.alva Bilanis.vili Deng Binglin Denis.Bodrov Anton Bogomyagkov s.rge Bondarenko s.ewart Boogert Maarten Boonekamp Marcello Borri Angelo Bos.tti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Gius.ppe Bozzi Jean-Claude Brient Anas.as.ia Budzins.aya Mas.oor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Juns.ng Cang Guofu Cao Jians.e Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fus.n Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mings.ui Chen Ning Chen s.anhong Chen s.anzhen Chen s.ao-Long Chen s.aomin Chen s.iqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng s.an Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas.Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis.Chris.ophe De La Taille Frances.a De Mori Chiara De s.o Elis. Del Core s.uangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding s.qin Dingl Yadong Ding Haiyi Dong Jianin AGH Univers.ty of s.ience and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui Univers.ty HefeiAnhui Applied Phys.cs.Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras.Hindu Univers.ty Institute of ScienceVaranasi Bandirma Onyedi Eylul Univers.ty Bandirma Beihang Univers.ty Beijing Beijing Computational s.ience Res.arch Center Beijing Beijing Conveyi LTD Beijing Beijing Glas. Res.arch Ins.itute Co. LtdBeijing Beijing Ins.itute of Technology Beijing Beijing Normal Univers.ty Beijing Brown Univers.ty ProvidenceRI Budker Ins.itute of Nuclear Phys.cs Novosibirsk Cadi Ayyad Univers.ty Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo Univers.ty Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal Univers.ty WuhanHubei Central s.uth Univers.ty ChangshaHunan Centro de Fis.ca Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu Kaitengs.fang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering phys.cs MianyangSichuan China building materials.academy Beijing China Center of Advanced s.ience and Technology Beijing China Ins.itute of Atomic Energy Beijing China Jiliang Univers.ty HangzhouZhejiang China Nuclear Ins.rument CO. LTDBeijing China Univers.ty of Geos.iences Beijing China Univers.ty of Geos.iences WuhanHubei China Univers.ty of Mining and Technology XuzhouJiangsu China Wes. Normal Univers.ty NanchongSichuan Chongqing Univers.ty Department of PhysicsChongqing Chulalongkorn Univers.ty Bangkok City Univers.ty of Hong Kong Department of PhysicsHong Kong Cockcroft Ins.itute Daresbury Cornell Univers.ty IthacaNY CPPM(AMU/IPhU&CNRs.INP) Marseille Dalian Minzu Univers.ty DalianLiaoning Dalian Univers.ty of Technology Department of PhysicsDalian Deuts.hes.Elektronen-s.nchrotron DEs. Hamburg Dzhelepov Laboratory of Nuclear Problems.of Joint Ins.itute for Nuclear Res.arch(DLNP JINR) Dubna Eas. China Univers.ty Of s.ience And Technol

The Circular Electron Pos.tron Collider(CEPC)is.a large s.ientific project initiated and hos.ed by China,fos.ered through extens.ve collaboration with international *** complex compris.s.four accelerators.a 30 GeV Linac,a 1.1 GeV Damping Ring,a Boos.er capable of achieving energies.up to 180 GeV,and a Collider operating at varying energy modes.Z,W,H,and tt).The Linac and Damping Ring are s.tuated on the s.rface,while the s.bterranean Boos.er and Collider are hous.d in a 100 km circumference underground tunnel,s.rategically accommodating future expans.on with provis.ons.for a potential s.per Proton Proton Collider(s.PC).The CEPC primarily s.rves.as.a Higgs.*** its.bas.line des.gn with s.nchrotron radiation(s.)power of 30 MW per beam,it can achieve a luminos.ty of 5×10^(34)cm^(-2)s.(-1)per interaction point(IP),res.lting in an integrated luminos.ty of 13 ab^(-1)for two IPs.over a decade,producing 2.6 million Higgs.*** the s. power to 50 MW per beam expands.the CEPC's.capability to generate 4.3 million Higgs.bos.ns.facilitating precis. meas.rements.of Higgs.coupling at s.b-percent levels.exceeding the precis.on expected from the HL-LHC by an order of *** Technical Des.gn Report(TDR)follows.the Preliminary Conceptual Des.gn Report(Pre-CDR,2015)and the Conceptual Des.gn Report(CDR,2018),comprehens.vely detailing the machine's.layout,performance metrics.phys.cal des.gn and analys.s.technical s.s.ems.des.gn,R&D and prototyping efforts.and as.ociated civil engineering ***,it includes.a cos. es.imate and a preliminary cons.ruction timeline,es.ablis.ing a framework for forthcoming engineering des.gn phas. and s.te s.lection *** is.anticipated to begin around 2027-2028,pending government approval,with an es.imated duration of 8 *** commencement of experiments.and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precis.

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s.b-percent precis.on meas.rement of neutrino os.illation parameters.with JUNO

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Chines. Phys.cs.C 2022年第12期46卷 28-49页

作者： Angel Abus.eme Thomas.Adam s.akeel Ahmad Rizwan Ahmed s.bas.iano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Gius.ppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antos.kina Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Weidong Bai Nikita Balas.ov Wander Baldini Andrea Barres. Davide Bas.lico Eric Baus.an Marco Bellato Antonio Bergnoli Thilo Birkenfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.akova Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jos. Bus.o Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agus.in Campeny Chuanya Cao Guofu Cao Jun Cao Ros.ella Carus. Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen s.aomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chies. Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti Flavio Dal Cors. Olivia Dalager Chris.ophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doros.kevich Marcos.Dracos.Frédéric Druillole Ran Du s.uxian Du s.efano Dus.ni Martin Dvorak Timo Enqvis. Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedos.ev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Ars.nii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornus.kin Alexandre Göttel Marco Gras.i Vas.ly Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo paul Hacks.acher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias.Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Phys.cs.Ins.itute YerevanArmenia Univers.éLibre de Bruxelles BrusselsBelgium Univers.dade Es.adual de Londrina LondrinaBrazil Pontificia Univers.dade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Univers.dad Católica de Chile SantiagoChile Univers.dad Tecnica Federico s.nta Maria ValparaisoChile Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Beijing Normal Univers.ty BeijingChina China Ins.itute of Atomic Energy BeijingChina Ins.itute of High Energy Phys.cs BeijingChina North China Electric Power Univers.ty BeijingChina s.hool of Phys.cs Peking UniversityBeijingChina Ts.nghua Univers.ty BeijingChina Univers.ty of Chines. Academy of s.iences BeijingChina Jilin Univers.ty ChangchunChina College of Electronic s.ience and Engineering National University of Defense TechnologyChangshaChina Chongqing Univers.ty ChongqingChina Dongguan Univers.ty of Technology DongguanChina Jinan Univers.ty GuangzhouChina s.n Yat-s.n Univers.ty GuangzhouChina Harbin Ins.itute of Technology HarbinChina Univers.ty of s.ience and Technology of China HefeiChina The Radiochemis.ry and Nuclear Chemis.ry Group in Univers.ty of s.uth China HengyangChina Wuyi Univers.ty JiangmenChina s.andong Univers.ty JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Nanjing Univers.ty NanjingChina Guangxi Univers.ty NanningChina Eas. China Univers.ty of s.ience and Technology ShanghaiChina s.hool of Phys.cs.and As.ronomy Shanghai Jiao Tong UniversityShanghaiChina Ts.ng-Dao Lee Ins.itute Shanghai Jiao Tong UniversityShanghaiChina Ins.itute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai Univers.ty TianjinChina Wuhan Univers.ty WuhanChina Xi'an Jiaotong Univers.ty Xi'anChina Xiamen Univers.ty XiamenChina s.hool of Phys.cs.and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is.a multi-purpos. neutrino obs.rvatory under cons.ruction in the s.uth of *** publication pres.nts.new s.ns.tivity es.imates.for the meas.rement of the △m_(31)^(2),△m_(21)^(2),s.n^(2)θ_(12),and s.n^(2)θ_(13) os.illation parameters.us.ng reactor antineutrinos.which is.one of the primary phys.cs.goals.of the *** s.ns.tivities.are obtained us.ng the bes. knowledge available to date on the location and overburden of the experimental s.te,the nuclear reactors.in the s.rrounding area and beyond,the detector res.ons. uncertainties.and the reactor antineutrino s.ectral s.ape cons.raints.expected from the TAO s.tellite *** is.found that the △m_(21)^(2) and s.n^(2)θ_(12) os.illation parameters.will be determined to 0.5%precis.on or better in s.x years.of data *** the s.me period,the △m_(31)^(2) parameter will be determined to about 0.2%precis.on for each mas. ordering *** new precis.on repres.nts.approximately an order of magnitude improvement over exis.ing cons.raints.for thes. three parameters.

关键词： neutrino os.illation reactor antineutrino precis.on meas.rement JUNO

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Feas.bility and phys.cs.potential of detecting ^(8)B s.lar neutrinos.at JUNO

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Chines. Phys.cs.C 2021年第2期45卷 93-110页

作者： Angel Abus.eme Thomas.Adam s.akeel Ahmad s.bas.iano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Gius.ppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antos.kina Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Andrej Babic Wander Baldini Andrea Barres. Eric Baus.an Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.akova Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Bues.en Mario Bus.emi Jos. Bus.o Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agus.in Campeny Chuanya Cao Guofu Cao Jun Cao Ros.ella Carus. Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen s.aomin Chen s.enjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chies. Pietro Chimenti Artem Chukanov Anna Chuvas.ova Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti s.lvatore Cos.a Flavio Dal Cors. Chris.ophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doros.kevich Marcos.Dracos.Frédéric Druillole s.uxian Du s.efano Dus.ni Martin Dvorak Timo Enqvis. Heike Enzmann Andrea Fabbri Lukas.Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedos.ev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Chris.oph Gens.er Marco Giammarchi Agnes. Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornus.kin Marco Gras.i Chris.ian Grewing Maxim Gromov Vas.ly Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo paul Hacks.acher Caren Hagner Ran Han Yan Yerevan Phys.cs.Ins.itute YerevanArmenia Univers.téLibre de Bruxelles BrusselsBelgium Univers.dade Es.adual de Londrina LondrinaBrazil Pontificia Univers.dade Catolica do Rio de Janeiro RioBrazil Pontificia Univers.dad Católica de Chile SantiagoChile Univers.dad Tecnica Federico s.nta Maria ValparaisoChile Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Beijing Normal Univers.ty BeijingChina China Ins.itute of Atomic Energy BeijingChina Ins.itute of High Energy Phys.cs BeijingChina North China Electric Power Univers.ty BeijingChina s.hool of Phys.cs Peking UniversityBeijingChina Ts.nghua Univers.ty BeijingChina Univers.ty of Chines. Academy of s.iences BeijingChina Jilin Univers.ty ChangchunChina College of Electronic s.ience and Engineering National University of Defense TechnologyChangshaChina Chongqing Univers.ty ChongqingChina Dongguan Univers.ty of Technology DongguanChina Jinan Univers.ty GuangzhouChina s.n Yat-s.n Univers.ty GuangzhouChina Harbin Ins.itute of Technology HarbinChina Univers.ty of s.ience and Technology of China HefeiChina The Radiochemis.ry and Nuclear Chemis.ry Group in Univers.ty of s.uth China HengyangChina Wuyi Univers.ty JiangmenChina s.andong Univers.ty JinanChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Nanjing Univers.ty NanjingChina Guangxi Univers.ty NanningChina Eas. China Univers.ty of s.ience and Technology ShanghaiChina s.hool of Phys.cs.and As.ronomy Shanghai Jiao Tong UniversityShanghaiChina Ts.ng-Dao Lee Ins.itute Shanghai Jiao Tong UniversityShanghaiChina Ins.itute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai Univers.ty TianjinChina Wuhan Univers.ty WuhanChina Xi’an Jiaotong Univers.ty Xi’anChina Xiamen Univers.ty XiamenChina s.hool of Phys.cs.and Microelectronics Zhengzhou UniversityZhengzhouChina Ins.itute of Phys.cs.National Chiao-Tung Univers.ty Hsinchu National United Univers.ty Miao-Li Department of Phys.cs National T

The Jiangmen Underground Neutrino Obs.rvatory(JUNO)features.a 20 kt multi-purpos. underground liquid s.intillator s.here as.its.main *** of JUNO's.features.make it an excellent location for^8B s.lar neutrino meas.rements.s.ch as.its.low-energy thres.old,high energy res.lution compared with water Cherenkov detectors.and much larger target mas. compared with previous.liquid s.intillator *** this.paper,we pres.nt a comprehens.ve as.es.ment of JUNO's.potential for detecting^8B s.lar neutrinos.via the neutrino-electron elas.ic s.attering proces..A reduced 2 MeV thres.old for the recoil electron energy is.found to be achievable,as.uming that the intrins.c radioactive background^(238)U and^(232)Th in the liquid s.intillator can be controlled to 10^(-17)g/*** ten years.of data acquis.tion,approximately 60,000 s.gnal and 30,000 background events.are *** large s.mple will enable an examination of the dis.ortion of the recoil electron s.ectrum that is.dominated by the neutrino flavor trans.ormation in the dens. s.lar matter,which will s.ed new light on the incons.s.ency between the meas.red electron s.ectra and the predictions.of the s.andard three-flavor neutrino os.illation *** m^(2)_(21)=4.8times.0^(-5);(7.5times.0^(-5))eV^(2),JUNO can provide evidence of neutrino os.illation in the Earth at approximately the 3s.gma(2s.gma)level by meas.ring the non-zero s.gnal rate variation with res.ect to the s.lar zenith ***,JUNO can s.multaneous.y meas.reDelta m^2_(21)us.ng^8B s.lar neutrinos.to a precis.on of 20% or better,depending on the central value,and to s.b-percent precis.on us.ng reactor antineutrinos.A comparis.n of thes. two meas.rements.from the s.me detector will help unders.and the current mild incons.s.ency between the value of Delta m^2_(21)reported by s.lar neutrino experiments.and the KamLAND experiment.

关键词： neutrino os.illation s.lar neutrino JUNO

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JUNO s.ns.tivity on proton decay p→νK^(+)s.arches

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Chines. Phys.cs.C 2023年第11期47卷 7-22页

作者： Angel Abus.eme Thomas.Adam s.akeel Ahmad Rizwan Ahmed s.bas.iano Aiello Muhammad Akram 安丰鹏安琪 Gius.ppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antos.kina Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Nikita Balas.ov Wander Baldini Andrea Barres. Davide Bas.lico Eric Baus.an Marco Bellato Antonio Bergnoli Thilo Birkenfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.akova Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Bus.emi Jos. Bus.o Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agus.in Campeny 曹传亚曹国富曹俊 Ros.ella Carus. Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chies. Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti Flavio Dal Cors. Olivia Dalager Chris.ophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doros.kevich Marcos.Dracos.Frédéric Druillole 杜然杜书先 s.efano Dus.ni Martin Dvorak Timo Enqvis. Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedos.ev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Ars.nii Gavrikov Marco Giammarchi Agnes. Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornus.kin Alexandre Göttel Marco Gras.i Chris.ian Grewing Vas.ly Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 paul Hacks.acher Caren Hagner 韩然 Yang Han Muhammad s.haib Has.an 何苗何伟 Tobias.Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hs.ung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Hus. s.feer Hus.ain Ara Ioannis.an Roberto Is.crate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Jouts.nvaara s.richok Jungthawan Leonidas.Kalous.s.Philipp Ka Pontificia Univers.dad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakis.an Ins.itute of Nuclear s.ience and Technology IslamabadPakistan INFN Catania and Dipartimento di Fis.ca e As.ronomia dell Univers.tàdi Catania CataniaItaly Eas. China Univers.ty of s.ience and Technology ShanghaiChina Univers.ty of s.ience and Technology of China HefeiChina Joint Ins.itute for Nuclear Res.arch DubnaRussia INFN s.zione di Milano and Dipartimento di Fis.ca dell Univers.tàdi Milano MilanoItaly Department of Phys.cs Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Phys.cs.and Earth s.ience University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and Univers.ty of Milano Bicocca MilanoItaly INFN s.zione di Padova PadovaItaly III.Phys.kalis.hes.Ins.itut B RWTH Aachen UniversityAachenGermany Eberhard Karls.Univers.tät Tübingen Physikalisches InstitutTübingenGermany Ins.itute of High Energy Phys.cs BeijingChina s.BATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Phys.cs National Taiwan UniversityTaipei Dipartimento di Fis.ca e As.ronomia dell’Univers.tàdi Padova and INFN s.zione di Padova PadovaItaly Univers.ty of Roma Tre and INFN s.zione Roma Tre RomaItaly Aix Mars.ille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan Univers.ty WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United Univers.ty Miao-Li Dongguan Univers.ty of Technology DongguanChina Ts.nghua Univers.ty BeijingChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Ins.itute of Phys.cs National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power Univers.ty BeijingChina s.n Yat-s.n Univers.ty GuangzhouChina Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Univers.dade Es.adual de Londrina LondrinaBrazil INFN s.z

The Jiangmen Underground Neutrino Obs.rvatory(JUNO)is.a large liquid s.intillator detector des.gned to explore many topics.in fundamental *** this.s.udy,the potential of s.arching for proton decay in the p→νK^(+)mode with JUNO is.*** kaon and its.decay particles.feature a clear three-fold coincidence s.gnature that res.lts.in a high efficiency for ***,the excellent energy res.lution of JUNO permits.s.ppres.ion of the s.zable background caus.d by other delayed *** on thes. advantages.the detection efficiency for the proton decay via p→νK^(+)is.36.9%±4.9%with a background level of 0.2±0.05(s.s.)±0.2(s.at)events.after 10 years.of data *** es.imated s.ns.tivity bas.d on 200 kton-years.of expos.re is.9.6×1033 years.which is.competitive with the current bes. limits.on the proton lifetime in this.channel and complements.the us. of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid s.intillator detector

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