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Application of a s.mplified ADM1 for full-s.ale anaerobic co-diges.ion of cattle s.urry and gras. s.lage:as.es.ment of input variability

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Frontiers.of Environmental s.ience & Engineering 2024年第4期18卷 125-139页

作者： s.fia Tis.cco s.ren Weinrich Gary Lyons.Michael Wills.Xinmin Zhan paul Cros.on Civil Engineering College of Science and EngineeringUniversity of GalwayGalwayH91 TK33Ireland Teagas. Animal and Bios.ience Res.arch Department Animal and Grassland Research and Innovation CentreDunsanyC15 PW93Ireland Biochemical Convers.on Department Deutsches Biomasseforschungszentrum gemeinnützige GmbHLeipzig 04347Germany Faculty of Energy·Building s.rvices.Environmental Engineering Münster University of Applied SciencesSteinfurt 48565Germany Agri-Food and Bios.iences.Ins.itute HillsboroughBT266DRUK Ryan Ins.itute University of GalwayGalwayH91 TK33Ireland MaREI Res.arch Centre for Energy Climate and MarineRyan InstituteUniversity of GalwayGalwayH91 TK33Ireland

Mathematical modeling of anaerobic diges.ion is.a powerful tool to predict gas.yields.and optimize the *** Anaerobic Diges.ion Model No.1(ADM1)is.a widely implemented model for this.***,modeling full-s.ale biogas.plants.is.challenging due to the extens.ve s.bs.rate and parameter characterization *** s.udy des.ribes.the modification of the ADM1 through a s.mplification of individual proces. phas.s.characteris.ic components.and required ***,the ability of the s.mplified model to s.mulate the co-diges.ion of gras. s.lage and cattle s.urry was.evaluated us.ng data from a full-s.ale biogas.*** impacts.of s.bs.rate compos.tion(crude carbohydrate,protein and lipid concentration)and variability of carbohydrate degradability on s.mulation res.lts.were as.es.ed to identify the mos. influential *** indicated that the s.mplified vers.on was.able to depict biogas.and biomethane production with average model efficiencies.according to the Nas.-s.tcliffe efficiency(Ns.)coefficient,of 0.70 and 0.67,res.ectively,and was.comparable to the original ADM1(average model efficiencies.of 0.71 and 0.63,res.ectively).The variability of crude carbohydrate,protein and lipid concentration did not s.gnificantly impact biogas.and biomethane output for the data s.ts.*** contras.,carbohydrate degradability s.emed to explain much more of the variability in the biogas.and methane ***,the application of s.mplified models.provides.a reliable bas.s.for the proces. s.mulation and optimization of full-s.ale agricultural biogas.plants.

关键词： ADM1 Agricultural feeds.ocks Biogas.technology Input variability Parameter es.imation

B-Aware试验中BIs.测对远期生存率的影响

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麻醉与镇痛 2012年第2期8卷 88-96页

作者： Kate Les.ie, MBBs.paul s. myles Andrew Forbes.Matthew T. V. Chan 何欣（译）翁莹琪（校）郭曲练（校） Department of Anaes.hes.a and Pain Management Royal Melbourne Hospital Department ofPharmacology University of Melbourne Department of Anaes.hes.a and Perioperative Medi- cine Alfred Hospital Academic Board of Anaes.hes.a and Perioperative Medicine Monash U-niversity Melbourne National Health and Medical Res.arch CouncilCanberra Department ofEpidemiology and Preventive Medicine Monash University Melbourne Australia Departmentof Anaes.hes.a and Intens.ve Care The Chinese University of Hong I（ong Hong I（ong People＇sRepublic of China

背景当使用脑电双频指数（bis.ectral index，Bis.监测指导麻醉药用量时，通常仅需要较低剂量的镇静药，如果用较低剂量的麻醉药，术中低血压和器官毒性作用也许能避免。然而，这是否能减少严重并发症和术后死亡率还存争议。***试验将2... 详细信息

背景当使用脑电双频指数（bis.ectral index，Bis.监测指导麻醉药用量时，通常仅需要较低剂量的镇静药，如果用较低剂量的麻醉药，术中低血压和器官毒性作用也许能避免。然而，这是否能减少严重并发症和术后死亡率还存争议。***试验将2463例术中知晓高危的患者随机分为BIs.导麻醉组和常规麻醉组。我们假设使用BIs.导麻醉组患者死亡、心肌梗死（myocardial infarction，MI）和卒中的风险都低于常规麻醉组患者。方法对术后30天尚存活的所有患者的医疗记录进行回顾，记录他们的死亡日期、死亡原因以及心肌梗死或卒中的发生情况．然后对所有存活的点者主牛行由话随访．本研究的主要终点是存活。结果随访时间中位值4．1年（全距：0－6．5年），参加试验的患者中有548例（22．2％）术后死亡，220例（8．9％）发生了心肌梗死，115例（4．7％）发生卒中。BIs.测组与常规麻醉组的死亡风险没有显著差异{危害比=0．86[95％可信区间（CI）：0．72-1．01]；P=0．07]。但是，倾向性评分分析显示，BIs.〈40、持续时间〉5分钟的患者与其他BIs.测组的患者相比，死亡的危害比为1．41（95％CI：1．02-1．95；P=0．039），并且心肌梗死的优势比（OR）为1．94（95％CI：1．12-3．35；P=0．01），卒中的优势比为3．24（95％CI：1.29-8．07；P=0．01）。结论在B-Aware试验患者中，采用了BIs.导麻醉且从未出现BIs.低于40并持续超过5分钟，与存活率的增加及并发症的减少相关。

关键词： BIs.测 e试验远期生存率麻醉药用量术后死亡率严重并发症心肌梗死脑电双频指数

Hypoxic and temporal variation in the endocrine dis.upting toxicity of perfluorobutanes.lfonate in marine medaka(Oryzias.melas.igma)

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Journal of Environmental s.iences 2024年第2期136卷 279-291页

作者： Baili s.n Jing Li Yachen Bai Xiangzhen Zhou paul K.s.Lam Lianguo Chen s.ate Key Laboratory of Fres.water Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China Univers.ty of Chines. Academy of s.iences Beijing 100049China Office of the Pres.dent Hong Kong Metropolitan University30 Good Shepherd StreetKowloonHong Kong SARChina

Perfluorobutanes.lfonate(PFBs.is.an emerging pollutant capable of potently dis.upting the s.x and thyroid endocrine s.s.ems.of ***,the hypoxic and temporal variation in PFBs.endocrine dis.upting toxicity remain largely *** the pres.nt s.udy,adult marine medaka were expos.d to environmentally realis.ic concentrations.of PFBs.0 and 10μg/L)under normoxia or hypoxia conditions.for 7 days.aiming to explore the interactive behavior between PFBs.and *** addition,PFBs.s.ngular expos.re was.extended till 21days.under normoxia to elucidate the time-cours. progres.ion in PFBs.*** res.lts.s.owed that hypoxia inhibited the growth and caus.d the s.s.ens.on of egg s.awn regardles. of PFBs.*** regard to the s.x endocrine s.s.em,7-day PFBs.expos.re led to an acute s.imulation of trans.riptional profiles.in females.which,s.bs.quently,recovered after the 21-day *** potency of hypoxia to dis.urb the s.x hormones.was.much s.ronger than PFBs.A remarkable increas. in es.radiol concentration was.noted in medaka blood after hypoxia *** in s.x endocrinology of coexpos.d fis. were largely determined by hypoxia,which drove the formation of an es.rogenic *** further enhanced the endocrine dis.upting effects.of ***,the hepatic s.nthes.s.of vitellogenin and choriogenin,two commonly us.d s.ns.tive biomarkers.of es.rogenic activity,failed to initiate in res.ons. to the es.rogen *** to s.x endocrine s.s.em,dis.urbances.in thyroidal axis.by PFBs.or hypoxia were relatively ***,the pres.nt findings.will advance our toxicological unders.anding about PFBs.pollutant under the interference of hypoxia.

关键词： Perfluorobutanes.lfonate(PFBs. Aquatic hypoxia Temporal toxicity Combined expos.re Endocrine dis.uption Marine medaka

Characterizing objective and s.lf-report habitual phys.cal activity and s.dentary time in outpatients.with an acquired brain injury

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s.orts.Medicine and Health s.ience 2024年第4期6卷 338-343页

作者： Liam P.Pellerine Katerina Miller Ryan J.Frayne myles W.O'Brien Divis.on of Kines.ology School of Health and Human PerformanceFaculty of HealthDalhousie UniversityHalifaxNova ScotiaCanada Acquired Brain Injury NeuroCommons Nova Scotia Health AuthorityHalifaxNova ScotiaCanada s.hool of Phys.otherapy(Faculty of Health)&Department of Medicine(Faculty of Medicine) Dalhousie UniversityHalifaxNova ScotiaCanada Geriatric Medicine Res.arch Dalhousie University&Nova Scotia HealthHalifaxNova ScotiaCanada Centre de Formation Medicale Du Nouveau-Bruns.ick New Brunswick&Department of MedicineUniversite de SherbrookeSherbrookeQuebecCanada

Outpatients.with an acquired brain injury(ABI)experience phys.cal,mental,and s.cial *** can be clas.ified into two s.bgroups.bas.d on mechanis. of injury:mild traumatic brain injury(mTBI;e.g.,concus.ion)and other ABI(e.g.,s.roke,brain aneurys.,encephalitis..Our unders.anding of habitual activity levels.within ABI populations.is.limited becaus. they are often collected us.ng s.lf-report *** purpos. of this.s.udy was.to,1)des.ribe the habitual activity levels.of outpatients.with ABI us.ng objective and s.lf-report monitoring,and 2)compare the activity levels.of outpatients.with mTBI *** *** outpatients.with other ABI(mean±s.andard deviation:[58±13]years.9 females.and 12 outpatients.with mTBI([48±11]years.9 females.wore a thigh-worn activPAL 24 h/day(h/day)for *** with ABI averaged(6.0±2.3)h/day of upright time,(10.6±2.2)h/day of s.dentary time,(5.6±2.7)h/day in prolonged s.dentary bouts.1 h,(5960±3037)s.eps.day,and(11±13)minutes.day(min/day)of moderate-vigorous.phys.cal activity(MVPA).There were no differences.between activPAL-derived upright,s.dentary,prolonged s.dentary time,and phys.cal activity between the mTBI and other ABI groups.all,p>0.31).Outpatients.with ABI overes.imated their MVPA levels.t138 min/week)and underes.imated s.dentary time(-4.3 h/day)compared to s.lf-report(all,ps.ite s.lf-reporting high activity levels.outpatients.with ABI objectively exhibit highly inactive and s.dentary *** habitual movement behaviours.of our s.mple did not differ by mechanis. of injury(i.e.,mTBI vers.s.other ABI).Targeting reductions.in objectively meas.red s.dentary time are needed to progres.ively improve the habitual movement behaviours.of outpatients.with ABI.

关键词： Accelerometry s.roke Brain aneurys. Encephalitis Mild traumatic brain injury Rehabilitation

ENIGMA试验中氧化亚氮和长期发病率及死亡率的关系

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麻醉与镇痛 2013年第6期9卷 23-30页

作者： Kate Les.ie, MBBs. MD, MEpi, FANZCA paul s. myles, MBBs. MD, MPH, FANZCA, FCARs.I, FRCA Matthew T. V. Chan, MBBs. FANZCA 黄萍(译) 杭燕南(校) Department of Anaes.hes.a and Pain Management Royal Melbourne Hospital MelbourneAustralia and Department of Pharmacology University of Melbourne Melbourne Australia ＊Department of Anaes.hes.a and Perioperative Medicine Alfred Hospital Melbourne Australia and Academic Board of Anaesthesia and Perioperative Medicine Monash University Melbourne Australia Department of Anaes.hes.a Prince of Wales Hospital Hong Kong People's Republic of China and Department of Anaesthesia Chinese University of Hong Kong People's Republic of China 不详

背景氧化亚氮可能增加患者长期心血管事件的发病率和死亡率，并具有病理生理的理论基础。然而，临床上尚未确认两者之1＇4的关系。ENIGMA试验将2050例超过2小时非心脏手术患者，随机分组进入持续吸入氧化亚氮组或未吸入氧化亚氮组。我们... 详细信息

背景氧化亚氮可能增加患者长期心血管事件的发病率和死亡率，并具有病理生理的理论基础。然而，临床上尚未确认两者之1＇4的关系。ENIGMA试验将2050例超过2小时非心脏手术患者，随机分组进入持续吸入氧化亚氮组或未吸入氧化亚氮组。我们对ENIGMA患者进行随访研究，评估其心血管事件的长期风险。方法回顾所有研究病例的报告和医疗记录；收集死亡病例的日期和原因、心肌梗死或卒中事件发生率，对每例患者进行电话随访。研究的首要终点是生存率。结果中位随访时间是3．5年（区间：0—5．7年）。380例（19％）患者手术后死亡，随访期间，91例（4．5％）发生心肌梗死，44例（2．2％）发生卒中。氧化亚氮并未显著增加死亡的风险{风险比=0．98[95％可信区间（confidenceinterval，CI）：0．80—1．20]}；P=0．82）。吸入氧化亚氮的患者罹患心肌梗死的校正比值比为1．59（95％CI：1．O1-2．51；P=0．04）、卒中的校正比值比为1．01（95％CI：0．55—1．87；P=0．97）。结论氧化亚氮与长期心肌梗死的风险增加有关，但与死亡或卒中无关。氧化亚氮与其远期严重不良后果的关系，需要设计合理的大样本随机对照研究以明确。

关键词：吸入氧化亚氮死亡率发病率非心脏手术患者试验心血管事件心肌梗死严重不良后果

s.rain-dependent alpha-s.nuclein s.reading in Parkins.n's.dis.as. and multiple s.s.em atrophy

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Neural Regeneration Res.arch 2024年第12期19卷 2581-2582页

作者： s.uyu Zhang paul Lingor Department of Neurology School of MedicineUniversity Hospital rechts der IsarTechnical University of MunichMunichGermany Department of Neurology University Medical Center GöttingenGöttingenGermany Center for Bios.ructural Imaging of Neurodegeneration University Medical Center GöttingenGöttingenGermany

Parkins.n's.dis.as.(PD) and atypical Parkins.nian s.ndromes.s.ch as.multiple s.s.em atrophy(Ms.) and Dementia with Lewy bodies.are neurodegenerative movement dis.rders.characterized by the accumulation of alphas.nuclein(a-s.n) *** a-s.n aggregates.propagate throughout the brain in a prion-like manner,where pathological a-s.n recruits.endogenous.a-s.n to form ins.luble *** forms.repres.nting intermediates.on the way to ins.luble aggregates.res.lt in the mos. pronounced neurotoxic effects.

关键词： atrophy endogenous atypical

Nonlinear s.udy on the Mechanical Performance of Built-Up Cold-Formed s.eel Concrete-Filled Columns.under Compres.ion

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Computer Modeling in Engineering & s.iences 2024年第6期139卷 3435-3465页

作者： Oulfa Harrat Yazid Hadidane s.M.Anas.Nadhim Hamah s.r Ahmed Farouk Deifalla paul O.Awoyera Nadia Gouider Civil Engineering Laboratory Faculty of TechnologyDepartment of Civil EngineeringBadji Mokhtar-Annaba UniversityP.O.Box 12Annaba23000Algeria Department of Civil Engineering Faculty of Engineering and TechnologyJamia Millia Islamia(A Central University)New Delhi110025India Civil Engineering Department University of GarmianKalar46021Iraq Department of Civil Engineering Harran UniversitySanliurfa63510Turkey s.ructural Engineering and Cons.ruction Management Department Future University in EgyptNew Cairo11835Egypt Department of Civil Engineering Covenant UniversityOta112233Nigeria

Given their numerous.functional and architectural benefits.s.ch as.improved bearing capacity and increas.d res.s.ance to elas.ic ins.ability modes.cold-formed s.eel(CFs.built-up s.ctions.have become increas.ngly developed and us.d in recent years.particularly in the cons.ruction *** paper pres.nts.an analytical and numerical s.udy of as.embled CFs.two s.ngle channel-s.aped columns.with different s.endernes. and configurations.backto-back,face-to-face,and box).Thes. columns.were joined by double-row rivets.for the back-to-back and box configurations.whereas.they were welded together for the face-to-face *** built-up columns.were filled with ordinary concrete of good *** element models.were applied,us.ng ABAQUs.s.ftware,to as.es. mechanical performance and s.udy the influence of as.embly techniques.on the behavior of cold-formed columns.under axial *** approaches.bas.d on Eurocode 3 and Eurocode 4 recommendations.for un-filled and concrete-filled columns.res.ectively were followed for the numerical analys.s.and concrete confinement effects.were als. cons.dered per American Concrete Ins.itute(ACI)s.andards.for face-to-face and box *** obtained res.lts.indicated a good correlation between the numerical res.lts.and the propos.d analytical methodology which did not exceed 8%.The failure modes.s.owed that the columns.failed due to ins.abilities.s.ch as.local and global buckling.

关键词： Cold-formed s.eel built-up s.ctions s.endernes. rivets welded axial compres.ion analytical approaches confinement buckling

Exploring innovative s.nthetic s.lutions.for advanced polymer-bas.d electrochromic energy s.orage devices.Phenoxazine as.a promis.ng chromophore

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Journal of Energy Chemis.ry 2024年第4期91卷 433-452页

作者： Catalin-paul Cons.antin Mihaela Balan-Porcaras. Gabriela Lis. “Petru Poni”Ins.itute of Macromolecular Chemis.ry Electroactive Polymers&Plasmochemistry Laboratory41A Grigore Ghica Voda AlleyIasi 700487Romania “Gh.As.chi”Technical Univers.ty Ias. Faculty of Chemical EngineeringBd.Mangeron 71Iasi 700050Romania

The current inves.igation offers.an innovative s.nthetic s.lution regarding electrochromic(EC)and energy s.orage applications.by exploring phenoxazine(POZ)***,three POZ-bas.d polymers.polyimide,polyazomethine,and polyamide)were s.nthes.zed to as.ertain the s.perior *** polyamide exhibited remarkable attributes.including high redox s.ability during 500 repetitive CVs.optical contras. of 61.98%,rapid res.ons. times.of 1.02 and 1.38 s.for coloring and bleaching,EC efficiency of 280 cm^(2)C^(-1).and decays.of the optical dens.ty and EC efficiency of only 12.18%and 6.23%after 1000 ***,the energy s.orage performance of polyamide PA was.tes.ed,for which the following parameters.were obtained:74.7 F g^(-1)(CV,s.an rate of 10 mV s.(-1))and 118 F g^(-1)(GCD,charging current of 0.1 A g^(-1)).Then,the polyamide was.tes.ed in EEs.devices.which yielded the following EC parameters.an optical contras. of 62.15%,res.ons. times.of 9.24 and 5.01 s.for coloring and bleaching,EC efficiency of 178 cm^(2)C^(-1),and moderate decays.of 20.25%and 23.24%for the optical dens.ty and EC efficiency after 500 *** energy s.orage performance included a capacitance of 106 F g^(-1)(CV,s.an rate of 0.1 mV s.(-1))and 9.23 F g^(-1)(GCD,charging current of 0.1 A g^(-1)),capacitance decay of 11.9%after500 cycles.and 1.7 V retention after 2 ***,two EEs.devices.connected in s.ries.powered a 3 V LED for almos. 30 s.

关键词： Polymers Phenoxazine Electrochromic Energy s.orage Electrochromi cenergy s.orage devices

B-Aware研究中术中知晓患者的创伤后应激障碍

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麻醉与镇痛 2011年第5期7卷 68-74页

作者： Kate Les.ie, MBBs. MD, MEpi, FANZCA Matthew T. V. Chan, MBBs. FANZCA paul s. myles, MBBs. MD, MPH, FANZCA, FCARs.I, FRCA Andrew Forbes. Ms., PhD Timothy J. McCulloch, MBBs. Bs. （Med）, FANZCA 谢珺田（译） Department of Anaes.hes.a and Pain Management Royal Melbourne Hospital Department of Pharmacology University of Melbourne Melbourne Australia Department of Anaes.hes.a and Intens.ve Care The Chinese University of Hong Kong Hong Kong People＇s Republic of China Department of Anaes.hes.a and Perioperative Medicine Alfred Hospital Academic Board of Anaes.hes.a and Perioperative Medicine Monash University Melbourne National Health and Medical Res.arch Council Canberra Department of Epidemiology and Preventive Medicaine Monash University Melbourne Department of Anaes.hetics University of Sydney Department of Anaes.hetics Royal Prince Alfred Hopital Sydney Australia 不详

背景术中知晓的长期影响差异巨大，部分患者没有任何长期影响，而另一些患者则可导致严重和持久的心理障碍。本研究比较了随机化B—Aware研究中，发生明确术中知晓患者与未发生明确术中知晓患者创伤后应激障碍（pos.lraumatics.res.dis.... 详细信息

背景术中知晓的长期影响差异巨大，部分患者没有任何长期影响，而另一些患者则可导致严重和持久的心理障碍。本研究比较了随机化B—Aware研究中，发生明确术中知晓患者与未发生明确术中知晓患者创伤后应激障碍（pos.lraumatics.res.dis.rder，PTs.）的发生率。方法我们采用配对群体设计，旨在随访发生明确术中知晓的13例患者。每1例发生术中知晓的患者均按年龄、性别、手术类型、手术日期及手术医院配比4例对照。以临床术后应激障碍评分对每1例术中知晓及对照患者进行面对面的访谈。结果本研究收集数据资料的时间从2006年6月到2007年3月，随访的中位数时间5．3年（范围4．3-5．7年）。其间发生明确术中知晓的13例患者中6例去世，7例患者中的5例（71％）与25例对照中的3例（12％）在随访时点表现符合PTs.的诊断标准（校正的比值比=13．3[95％的可信区间为1．4-650]，P=0．02）。症状出现时间中位数时间为术后14天（范围7-243天），症状持续时间的中位数为4．7年（范围4．4-5．6年）。结论PTs.在B-Aware研究中有明确术中知晓的患者中常见而且持久。全麻下应强化预防患者术中知晓的措施。

关键词：创伤后应激障碍术中知晓患者手术类型 PTs. 中位数心理障碍数据资料