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Non-celiac gluten sensitivity: All wheat attack is not celiac

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World Journal of Gastroenterology 2017年第40期23卷 7201-7210页

作者： Samuel O Igbinedion Junaid Ansari Anush Vasikaran Felicity N Gavins paul jordan Moheb Boktor Jonathan S Alexander Department of Internal Medicine Louisiana State University Health Sciences Center Department of Molecular and Cellular Physiology Louisiana State University School of Medicine Department of Gastroenterology and Hepatology Louisiana State University Health Sciences Center

Currently,1% of the United States population holds a diagnosis for celiac disease(CD),however,a more recently recognized and possibly related condition,"non-celiac gluten sensitivity"(NCGS)has been suggested to affect up to 6%of the United States *** reliable clinical tests for CD exist,diagnosing individuals affected by NCGS is still complicated by the lack of reliable biomarkers and reliance upon a broad set of intestinal and extra intestinal symptoms possibly provoked by *** has been proposed to exhibit an innate immune response activated by gluten and several other wheat *** present,an enormous food industry has developed to supply gluten-free products(GFP)with GFP sales in 2014 approaching$1 billion,with estimations projecting sales to reach$2 billion in the year *** enormous demand for GFP also reflects a popular misconception among consumers that gluten avoidance is part of a healthy lifestyle *** of NCGS and other gluten related disorders(e.g.,irritable bowel syndrome)call for a review of current distinctive diagnostic criteria that distinguish each,and identification of biomarkers selective or specific for *** aim of this paper is to review our current understanding of NCGS,highlighting the remaining challenges and questions which may improve its diagnosis and treatment.

关键词： Non-celiac gluten sensitivity Celiac disease Gluten Wheat Gluten related disorder Gluten free diet

Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence

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Nano Research 2013年第2期6卷 113-120页

作者： Bo Zhang jordan Price Guosong Hong Scott M. Tabakman Hailiang Wang Justin A. Jarrell Ju Feng paul J. Utz Hongjie Dai Department of Chemistry Stanford University Stanford California USA Department of Medicine Division of Immunology and Rheumatology Stanford University School of Medicine Stanford California USA Institute for Immunity Transplantation and Infection Stanford University School of Medicine Stanford California USA

Protein microarrays based on fluorescence detection have been widely utilized for high-throughput functional proteomic analysis. However, a drawback of such assays has been low sensitivity and narrow dynamic range, limiting their capabilities, especially for detecting low abundance biological molecules such as cytokines in human samples. Here, we present fluorescence-enhancing microarrays on plasmonic gold films for multiplexed cytokine detection with up to three orders of magnitude higher sensitivity than on conventional nitrocellulose and glass substrates. Cytokine detection on the gold plasmonic substrate is about one to two orders of magnitude more sensitive than enzyme-linked immunosorbent assay （ELISA） and can be multiplexed. A panel of six cytokines （Vascular endothelial growth factor （VEGF）, Interleukin 1β （IL-1β）, Interleukin 4 （IL-4）, Interleukin 6 （IL-6）, Interferon γ （IFN-γ）, and Tumor necrosis factor （TNF）） were detected in the culture media of cancer cells. This work establishes a new method of high throughput multiplexed cytokine detection with higher sensitivity and dynamic range than ELISA.

关键词： microarray cytokine plasmonic multiplex near infrared fluorescence

Longitudinal monitoring for the emergence of epidermal growth factor C797S resistance mutations in non-small cell lung cancer using blood-based droplet digital PCR

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Cancer Drug Resistance 2019年第3期2卷 912-916页

作者： Mark Bowling Hyder Arastu Victoria Edwards Leisa Jackson Scott Thurston jordan Reese Hestia Mellert Gary Pestano paul Walker East Carolina University Mail Stop 628Internal Medicine-Hematology/OncologyGreenvilleNC 27834USA Biodesix Inc.2970 Wilderness PlaceBoulderCO 80301USA.

Validation of assays for the C797S mutation as a biomarker for osimertinib resistance is promising in guiding treatment decision-making for multidrug resistant non-small cell lung cancer. A newly developed droplet digital PCR (ddPCR) assay was used to retrospectively evaluate the emergence of the C797S mutation in six remnant plasma samples in this case report. It was found that the detected emergence of C797S clearly correlated with clinical signs of treatment resistance. Had these data been available to aid treatment selection in real time, there would have been hope for recaptured disease response and control instead of treatment cessation. The results of this study show that highly sensitive ddPCR methods can be used for the monitoring of emergent epidermal growth factor somatic variant mutations in circulation.

关键词： Epidermal growth factor non-small cell lung cancer C797S drug resistance

Effect of Hepatitis C Treatment on Renal Function in Liver Transplant Patients

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 391-395页

作者： Mohamed Shoreibah John Romano Ornar T.Sims Yuqi Guo DeAnn Jones Krishna Venkata Vishnu Kommineni jordan Orr paul Fitzmorris Omar I.Massoud Division of Gastroenterology&Hepatology School of MedicineUniversity of Alabama at BirminghamBirminghamALUSA Department of Internal Medicine School of MedicineUniversity of Alabama at BirminghamBirminghamALUSA Department of Social Work College of Arts and SciencesUniversity of Alabama at BirminghamBirminghamALUSA Department of Health Behavior School of Public HealthUniversity of Alabama at BirminghamBirminghamALUSA Center for AIDS Research School of MedicineUniversity of Alabama at BirminghamBirminghamALUSA School of Social Work University of AlabamaTuscaloosaALUSA Department of Pharmacology University of Alabama at BirminghamBirminghamALUSA Division of Gastroenterology and Hepatology Department of MedicineVanderbilt UniversityNashvilleTNUSA

Background andAims:Hepatitis C Virus(HCV)is uniformly recurrent after liver transplant(LT)and recurrence is associated with an increased risk of *** medications increase the risk of chronic kidney disease,and the presence of chronic kidney disease presents a challenge for HCV treatment in LT *** aim of this study was to assess changes in glomerular filtration rates(GFRs)of LT recipients receiving HCV ***:This is a retrospective study of LT patients who received HCV treatment between 2015 and 2016(n=60).The outcomes of interest were differences in serum creatinine levels and in GFR,measured at treatment initiation and at 24 weeks after *** average age of the patients was 59 years-old,and 17%were cirrhotic and 67%were *** patients received sofosbuvir/ledipasvir without ***:All patients achieved sustained virologic response at 12 weeks after treatment(SVR12).At baseline,55%of patients had GFR60 mL/min per 1.73 *** those patients,GFR did not change in 81%,and 19%had worsened *** the entire cohort,65%of patients had improved or stable GFR and 35%had worsened *** average change in serum creatinine between baseline and 24 weeks was 0.10(p=0.18).Conclusions:This study showed improved or unchanged GFR in 65%and worsened GFR in 35%of LT recipients who achieved *** of GFR was more frequently encountered in those with impaired renal function at *** should be used when treating HCV in LT recipients,especially those with baseline status of renal impairment.

关键词： Hepatitis C Renal function Direct-acting antivirals Liver transplant Treatment

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1629-1647页

作者： Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel paul M.jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger Tran Hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Faculty of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City 700000Viet Nam Michael Popp Institute and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Department of Pharmaceutical/Medicinal Chemistry Institute of PharmacyFriedrich Schiller University JenaJena 07743Germany Institute of Pharmacy Department of Pharmaceutical and Medicinal ChemistryParacelsus Medical University SalzburgSalzburgSalzburg 5020Austria Department of Pharmacy School of MedicineUniversity of Naples FedericoⅡNaples'80131Italy Institute of Transfusion Medicine University Hospital JenaJena 07747Germany

Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory *** mediators orchestrate both the initiation and resolution of *** from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are *** from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase *** identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 *** production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 *** shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell *** summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles.

关键词： Lipoxygenase Inflammation Resolution Natural product Lipidomics Lipid mediator

Vibration induced flow in hoppers:DEM 2D polygon model

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Particuology 2008年第6期6卷 455-466页

作者： Feras Y. Fraige paul A. Langston Andrew J. Matchett John Dodds Faculty of Mining and Environmental Engineering Al-Hussein Bin Talal University Jordan Chemical and Environmental Engineering Nottingham University University Park Chemical Engineering University of Teesside Centre RAPSODEE Ecole Des Mines

A two-dimensional discrete element model （DEM） simulation of cohesive polygonal particles has been developed to assess the benefit of point source vibration to induce flow in wedge-shaped hoppers. The particle-particle interaction model used is based on a multi-contact principle. The first part of the study investigated particle discharge under gravity without vibration to determine the critical orifice size （Bc） to just sustain flow as a function of particle shape. It is shown that polygonal-shaped particles need a larger orifice than circular particles. It is also shown that Bc decreases as the number of particle vertices increases. Addition of circular particles promotes flow of polygons in a linear manner. The second part of the study showed that vibration could enhance flow, effectively reducing Bc. The model demonstrated the importance of vibrator location （height）, consistent with previous continuum model results, and vibration amplitude in enhancing flow.

关键词： Bulk solids Vibration DEM Hoppers Materials handling Polygon

Shallow water equations for power law and Bingham fluids Dedicated to the NSFC-CNRS Chinese-French summer institute on fluid mechanics in 2010

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Science China Mathematics 2012年第2期55卷 277-283页

作者： FERNANDEZ-NIETO Enrique D. NOBLE Pascal VILA Jean-paul Departamento de Matemdtica Aplicada I Universidad de Sevilla 41012 Sevilla Spain Universite de Lyon Universitd Lyon1 Institut Camille Jordan UMR CNRS 520843 blvd du 11 novembre 1918 F-69622 ViUeurbanne Cedex France Institut de Mathdmatiques de Toulouse UMR CNRS 5219 INSA de Toulouse 135 avenue de Rangueil 31077 Toulouse Cedex 4 France

In this note, we provide a consistant thin layer theory for power law and Bingham incompressible fluids flowing down an inclined plane under the effect of gravity. The derivation of such equations is based on formal asymptotic expansions of solutions of Cauchy momentum equations in the shallow water scaling and in the neighbourhood of steady solutions so that we can close the average equations on the fluid height h and the total discharge rate q.

关键词： shallow water equations asymptotic analysis non-Newtonian fluids

Experimental Investigation of the Small-scale Fixed Multi-chamber OWC Device

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Chinese Journal of Mechanical Engineering 2021年第5期34卷 408-421页

作者： Mohammad Shalby Ahmed Elhanafi paul Walker David G.Dorrell Ahmad Salah Mohamed R.Gomaa Mohamed Behiri Mechanical Engineering Department Faculty of EngineeringAl-Hussein Bin Talal UniversityMa’an 71111Jordan National Centre for Maritime Engineering and Hydrodynamics Australian Maritime CollegeUniversity of TasmaniaLauncestonTAS 7250Australia School of Mechanical and Mechatronic Systems University of Technology SydneySydneyNSW 2007Australia School of Electrical and Information Engineering University of the WitwatersrandDurban 2000South Africa Electrical Engineering Department Faculty of EngineeringAl Hussein Bin Talal UniversityMa’an 71111Jordan Mechanical Engineering Department Benha Faculty of EngineeringBenha UniversityBenha 13518Egypt 不详

Sea wave energy generators or converters(WECs)have the potential to become a viable technology for clean,renewable energy *** the WEC technologies,the oscillating water columns(OWCs)are the most common WEC devices *** have been studied and developed over many ***-chamber oscillating water columns(MC-OWC)have the potential to have a higher energy conversion when extracting energy in mixed sea states than single-chamber *** the work reported in this paper,physical experiments are carried under regular wave conditions to test the wave power extraction of a fixed MC-OWC small-scale *** Power Take-Off(PTO)of the device is simulated using orifice *** flow characteristics through these orifices are pre-calibrated such that the extracted power can be obtained only using the pressure *** condition effects on the damping of the PTO of the device power extraction are *** test results illustrate that the PTO system damping is critical and affects device performance.

关键词： cean wave energy Energy conversion Oscillating water column Multi-chamber OWC

Gastric cancer in women: A regional health-center seven year retrospective study

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World Journal of Gastroenterology 2015年第25期21卷 7805-7813页

作者： Kunal Suryawala Demiana Soliman Monica Mutyala Shaheen Nageeb Moheb Boktor Abhishek Seth Avinash Aravantagi Ankur Sheth James Morris paul jordan Kenneth Manas Urska Cvek Marjan Trutschl Felix Becker Jonathan Alexander Department of Gastroenterology and Hepatology Louisiana State University Health Sciences Center Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center Department of Computer Science LSU Shreveport and Center for Molecular and Tumor Virology Louisiana State University Health Sciences Center Department of General and Visceral Surgery University Hospital Muenster

AIM: To investigate whether regional geography influences ethnic and gender trends for the development of gastric cancer(GC).METHODS: This retrospective analysis of the INVISION patient database at Louisiana State University Health Sciences Center-Shreveport(LSUHSC-S), a southern United States regional hospital, was performed from 2005-2011. Using the international statistical classification of diseases 9(ICD-9), inpatient, day surgery outpatient, and emergency outpatient diagnosis codes entered into medical records were used to identify GC patients. For each study year, the patients were evaluated for age, ethnicity, and gender, and each patient was counted only once throughout the study. Subsequent patient encounters were counted as visits and separated by inpatient and clinic visits. Complex or severe disease may require more frequent and intensive clinical management; therefore, we evaluated annual clinic visits as "surrogate markers" of disease severity. Finally, we studied the primary diagnosis for Helicobacter pylori(H. pylori) infection(ICD-9 code 41.86) as an additional factor that might increase the risk of ***: A total of 285 patients were diagnosed with GC at LSUHSC-S between 2005 and 2011. African Americans(181 patients, 89 males and 92 females, 63.5% of total patients) had significantly higher frequencies of GC diagnosis compared with non-Hispanic whites(104 patients, 54 males and 50 females, 36.5% of total patients), at a ratio of 1.74(P = 0.002). Within each ethnic group, men and women were diagnosed at approximately equal annual rates. Our findings differed significantly from United States national trends, which found that African American females and white females had lower risks for GC than their corresponding male counterparts. The United States national trend between 2005 and 2011 showed that African Americans males had a higher incidence of GC, with an annual mean(per 100000) of 16.31 ± 0.76 compared with white males(9 ± 0.1, P < 0.001),

关键词： Gender Helicobacter pylori Ethnicity Riskfactors Health disparities