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Acute fractures of the pediatric foot and ankle

World Journal of Pediatrics 2015年第1期11卷 14-20页

作者： Mansur Halai Bilal Jamal paul rea Mobeen Qureshi Anand Pillai Department of Trauma and Orthopedics University Hospitials of South ManchesterManchester M239LTUK

Background:Injuries around the foot and ankle are *** is a paucity of literature,outside that of specialist orthopedic journals,that focuses on this subject in the pediatric *** sources:In this review,we outline pediatric foot and ankle fractures in an anatomically oriented manner from the current *** aim is to aid the emergency department doctor to manage these challenging injuries more efectively in the acute ***:These injuries require a detailed history and examination to aid the ***,plain radiographs are suficient,but more complex injuries require the use of magnetic resonance *** is dependent on the proximity to skeletal maturity and the degree of displacement of *** have a marked ability to remodel after fractures and therefore mainstay treatment is immobilization by a cast or *** fxation,although uncommon in this population,may be necessary with adolescents,certain unstable injuries or in cases with displaced articular *** the setting of severe foot trauma,skin compromise and compartment syndrome of the foot must be ***:The integrity of the physis,articular surface and soft tissues are all equally important in treating these injuries.

关键词： ankle foot fractures

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Novel,non-colonizing,single-strain live biotherapeutic product ADS024 protects against Clostridioides difficile infection challenge in vivo

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世界胃肠病理生理学杂志:英文版(电子版) 2023年第4期14卷 71-85页

作者： Christopher K Murphy Michelle M O’Donnell James W Hegarty Sarah Schulz Colin Hill R paul Ross Mary C rea Ronald Farquhar Laurent Chesnel Research and Development Adiso Therapeutics Inc.ConcordMA 01742United States APC Microbiome Ireland University College CorkCork T12 K8AFIreland Teagasc Food Research Centre Moorepark FermoyCork P61 C996Ireland Executive Leadership Team Adiso Therapeutics Inc.ConcordMA 01742United States

BACKGROUND The Centers for Disease Control and Prevention estimate that Clostridioides difficile(***)causes half a million infections(CDI)annually and is a major cause of total infectious disease death in the United States,causing inflammation of the colon and potentially deadly *** recently reported the isolation of ADS024,a Bacillus velezensis(***)strain,which demonstrated direct in vitro bactericidal activity against ***,with minimal collateral impact on other members of the gut *** this study,we hypothesized that in vitro activities of ADS024 will translate in vivo to protect against CDI challenge in mouse *** To investigate the in vivo efficacy of *** ADS024 in protecting against CDI challenge in mouse *** To mimic disruption of the gut microbiota,the mice were exposed to vancomycin prior to dosing with *** the mouse single-dose study,the recovery of ADS024 was assessed via microbiological analysis of intestinal and fecal samples at 4 h,8 h,and 24 h after a single oral dose of 5×108 colony-forming units(CFU)/mouse of freshly grown *** single-dose study in miniature swine included groups that had been pre-dosed with vancomycin and that had been exposed to a dose range of ADS024,and a group that was not pre-dosed with vancomycin and received a single dose of *** ADS024 colonies[assessed by quantitative polymerase chain reaction(qPCR)using ADS024-specific primers]were counted on agar *** the 28-d miniature swine study,qPCR was used to measure ADS024 levels from fecal samples after oral administration of ADS024 capsules containing 5×109 CFU for 28 consecutive days,followed by MiSeq compositional sequencing and bioinformatic analyses to measure the impact of ADS024 on *** studies were performed to determine the efficacy of ADS024 in a mouse model of CDI:Study 1 to determine the effects of fresh ADS024 culture and ADS024 spore preparations on the clinical mani

关键词： Gut Single-strain live biotherapeutic product ADS024 Clostridioides difficile Clostridioides difficile challenge model Microbiota

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Biocompatibility and internalization of molecularly imprinted nanoparticles

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Nano Research 2016年第11期9卷 3463-3477页

作者： Francesco Canfarotta Alicia Waters Robyn Sadler paul McGill Antonio Guerreiro Dmitri Papkovsky Karsten Haupt Sergey Piletsky MIP Diagnostics Ltd. University of Leicester Fielding Johnson Building University Road Leicester LE 1 7RH UK School of Biochemistry and Cell Biology University College Cork College Road Cork Ireland GSK David Jack Centre for R&D Park Road Ware Hertfordshire SG 12 0DP UK Chemistry Department University of Leicester Leicester LE1 7RH UK Compiegne University of Technology CNRS Enzyme and Cell Engineering Laboratory Rue Roger Couttolenc CS 50319 50203 Compiegne Cedex France

Molecularly imprinted polymers （MIP） are receiving increasing attention thanks to their robustness, stability, and inexpensive manufacture compared with their bio-analogues such as antibodies. The molecular imprinting process can be defined as the generation of molecular recognition sites in a synthetic polymer. The template-derived sites created within a polymeric matrix allow MIPs （often referred as plastic antibodies） to selectively recognize and bind to the target molecule. Therefore, MIPs can be used in sensors and in separation and diagnostics. Owing to their size and functional properties, MIP nanoparticles （NPs） can potentially be used in biomedicine, but comprehensive analysis of their interaction with cells and in vitro toxicological tests must be performed first. Herein, we report the synthesis of bare and core-shell imprinted NPs using an innovative solid-phase approach and the toxicological evaluation of such NPs in different cell lines （HaCaT, MEFs, HT1080, and macrophages）. We also evaluated the influence of the protein corona on particle stability, the internalization of NPs in cells, and the influence of various surface coatings. Studies on the metabolic effects of imprinted NPs on fibroblasts showed that bare MIPs do not alter cell metabolism, whereas some issues arise when specific particle coatings are used. Furthermore, in vitro cytokine release studies revealed that macrophages were not activated in the presence of the MIPs evaluated in this study. The results suggest that MIP NPs are biocompatible, paving the way for their in vivo application.

关键词： pegylation core-shell toxicology inflammatory response particle uptake metabolism

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Physics and astrophysics of strong magnetic field systems with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 74-96页

作者： Andrea Santangelo Silvia Zane Hua Feng RenXin Xu Victor Doroshenko Enrico Bozzo Ilaria Caiazzo Francesco Coti Zelati Paolo Esposito Denis González-Caniulef Jeremy Heyl Daniela Huppenkothen Gianluca Israel ZhaoSheng Li Lin Lin Roberto Mignani Nanda rea Mauro Orlandini Roberto Taverna Hao Tong Roberto Turolla Cristina Baglio Federico Bernardini Niccolo'Bucciantini Marco Feroci Felix Fürst Ersin G??ü? Can Güngör Long Ji FangJun Lu Antonios Manousakis Sandro Mereghetti Romana Mikusincova Biswajit paul Chanda Prescod-Weinstein George Younes Andrea Tiengo YuPeng Xu Anna Watts Shu Zhang Shuang-Nan Zhang Institut für Astronomie und Astrophysik Eberhard Karls Universität Key Laboratory for Particle Astrophysics Institute of High Energy Physics Mullard Space Science Laboratory University College LondonHolmbury St Mary Department of Engineering Physics and Center for Astrophysics Tsinghua University School of Physics Peking University Department of Astronomy University of Geneva Department of Physics and Astronomy University of British Columbia Universitädell’Insubria Anton Pannekoek Institute for Astronomy University of Amsterdam INAF-Osservatorio Astronomico di Brera Center for Data Science New York University INAF-Osservatorio Astronomico di Roma Department of Physics Xiangtan University Department of Astronomy Beijing Normal University INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano Janusz Gil Institute of Astronomy University of Zielona Góra Instituto de Ciencias del Espacio(ICE) CSIC-IEEC INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Bologna Department of Physics and Astronomy University of Padova School of Physics and Electronic Engineering Guangzhou University NYU Abu Dhabi Saadiyat Campus P.O. NAF Osservatorio di Arcetri Largo Enrico Fermi 5 INAF-Istituto di Astrofisica e Planetologia Spaziali INFN-Roma Tor Vergata European Space Astronomy Centre(ESA/ESAC) Science Operations Department Sabanci University Faculty of Engineering and Natural Sciences Centrum Astronomiczne im.M.Kopernika Department of Physics Sultan Qaboos University Institute of Theoretical Physics Faculty of Mathematics and PhysicsCharles University in Prague Raman Research Institute Sadashivanagar Department of Astronomy University of Washington The George Washington University Physics department 725 21st St NW Scuola Universitaria Superiore IUSS Pavia Palazzo del Broletto

In this paper we present the science potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies of strongly magnetized objects. We will focus on the physics and astrophysics of strongly magnetized objects, namely magnetars, accreting X-ray pulsars, and rotation powered pulsars. We also discuss the science potential of eXTP for QED studies. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s.

关键词： neutron stars QED magnetars accreting pulsars eXTP

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Effects of Imperfect Quality and Defective Items on Economic Production Lot Size

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厦门大学学报（自然科学版） 2002年第S1期41卷 247-页

作者： Raafat N Ibrahim paul Lochert Department of Mechanical Engineering Monash UniversityDepartment of Mechanical Engineering Monash University AustraliaAustralia

The classical EPQ model has been used for a long ti me and is widely accepted and implemented. Nevertheless, the analysis for finding an economic lot size has based on a number of unrealistic assumptions. A common unrealistic assumption in using EPQ is that all units produced are of good quali ty. The classical EPQ model shows that the optimal lot size will generate minimum ma nufacturing cost, thus producing minimum setup cost and inventory cost. However, this is only true if all products manufactured in the process are assumed to be of good quality (i.e. all products are within the specification limits). In rea lity this is not the case, therefore, it is necessary to consider the cost of im perfect quality items, because this cost can influence the economic lot size. Ma ny studies and recent papers have indicated that there is a significant relation ship between economic production lot size and process/product quality. However, their models included either the imperfect quality items (not necessarily de fective) which are to be sold at a discounted price or defective items which can be reworked or rejected. The aim of this paper is to provide a framework to integrate three different sit uations (discounted pricing/rework/reject) into a single model. 100% inspection is performed in order to distinguish the amount of good quality items, imper fect quality items and defective items in each lot. In this paper, a mathematica l model is developed, and a numerical example is presented to illustrate the sol ution procedures. It is found that the economic production lot size tends to inc rease as the average percentage of imperfect quality items and defectives (rejec ted items) increases.

关键词： EPQ lot size imperfect/defective items

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