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Asian Pacific Journal of Tropical Medicine 2019年第6期12卷 264-271页

作者： r Latha TM Chozhavel rajanathan Ameer Khusro N Chidambaranathan paul Agastian Sankaranarayanan Nagarajan research Department of Plant Biology and Biotechnology Loyola CollegeChennai-600034India K.M.College of Pharmacy UthangudiMadurai-625107Tamil NaduIndia Department of Chemistry National Institute of TechnologyImphal-795004Manipur India

Objective: To evaluate the effects of methanol root extract of Mahonia leschenaultii and berberine of Mahonia leschenaultii on Dalton’s ascitic lymphoma in Swiss Albino mice. Methods: The methanol root extracts of Mahonia leschenaultii(200 and 400 mg/kg) were given orally, and berberines(10 and 20 mg/kg) were injected intra-peritoneally for 14 successive days in tumor bearing mice. Hematological parameters(white and red blood cells, haemoglobin level, granulocytes, and agranulocytes), lipid parameters(total cholesterol and triglycerides), serum enzymes(serum glutamate pyruvate transaminases, serum glutamate oxaloacetate transaminases, and alkaline phosphatise) and mean survival and solid tumor growth were determined and compared with untreated mice. 5-fluorouracil(20 mg/kg) was used as a reference standard drug. results: Mahonia leschenaultii and berberine reduced the hematocrit significantly. Furthermore, Mahonia leschenaultii and berberine improved the survival of mice significantly and restored the affected hematological and lipid parameters similar to the normal levels. Conclusions: These observations show a strong anticancer effect of methanol root extract of Mahonia leschenaultii and berberine in suppressing Dalton’s ascitic lymphoma cancer cell growth in a mouse model by controlling haematological, lipid, serum enzymes, and other derived parameters effectively.

关键词： Mahonia leschenaultii Berberine Dalton’s ascitic lymphoma Methanolic extract

Computer Handling of Chemical and Biological Data of Traditional Chinese Medicines

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Chemical research in Chinese Universities 1997年第2期13卷 77-81页

作者： CHE Chun-tao paul r.Carlierand Ophelia C.W.Lee Department of Chemistry and research Centre The Hong Kong University of Science and TechnologyClear Water BayHong KongP.R.China

A specialty database has been established at The Hong Kong University of Science and Technology to handle the chemical and biological data of medicinal plants and other natural products from scientific literatures. Designed as a relational system capable of analyzing, comparing, and correlating data, the system can retrieve information in assimilated tabular formats. The database can provide information supports to researchers in the fields of medicinal chemistry, biochemistry, pharmacology, botany and other disciplines of natural products research.

关键词： Computer handling Chemical data Biological data Traditional Chinese medicine

All roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors

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Plant Communications 2020年第4期1卷 1-12页

作者： Qin He Hazel McLellan Petra C.Boevink paul r.J.Birch Key Laboratory of Horticultural Plant Biology(HZAU) Ministry of EducationKey Laboratory of Potato Biology and Biotechnology(HZAU)Ministry of Agriculture and Rural AffairsHuazhong Agricultural UniversityWuhanHubei 430070China Division of Plant Sciences School of Life SciencesUniversity of Dundee(at JHI)InvergowrieDundee DD25DAUK Cell and Molecular Sciences James Hutton InstituteInvergowrieDundee DD25DAUK These authors contributed equally to this article.

The ability to secrete effector proteins that can enter plant cells and manipulate host processes is a key determinant of what makes a successful plant ***,we review intracellular effectors from filamentous(fungal and oomycete)phytopathogens and the host proteins and processes that are targeted to promote *** cover contrasting virulence strategies and effector modes of *** pathogen effectors alter the fates of host proteins that they target,changing their stability,their activity,their location,and the protein partners with which they *** effectors inhibit target activity,whereas others enhance or utilize it,and some target multiple host *** discuss the emerging topic of effectors that target negative regulators of immunity or other plant proteins with activities that support *** also highlight the commonly targeted host proteins that are manipulated by effectors from multiple pathogens,including those representing different kingdoms of life.

关键词： effectors fungi oomycete immunity defense susceptibility factor

Unleashing the Power of Moiré Materials in Neuromorphic Computing

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Chinese Physics Letters 2023年第12期40卷 131-132页

作者： John paul Strachan Peter Grünberg Institute(PGI-14) Neuromorphic Compute NodesForschungszentrum JülichJülichGermany and RWTH Aachen UniversityAachenGermany

reservoir computing has been an intriguing paradigm in the field of artificial intelligence and machine learning that draws inspiration from the complex dynamics of recurrent neural networks found in biological systems. Unlike traditional neural networks, reservoir computing separates the training of a fixed, randomly connected ‘reservoir’layer from a simpler ‘readout’ layer. This distinctive architecture allows the reservoir to process information in a highly dynamic and nonlinear manner.

关键词： networks neural computing

Impact of Land-use Patterns on Distributed Groundwater recharge and Discharge——A Case Study of Western Jilin,China

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Chinese Geographical Science 2006年第3期16卷 229-235页

作者： Moiwo Juana paul College of Environment and resources Jilin University

The impact of land-use on distributed groundwater recharge and discharge in the western Jilin (WJ) was analyzed in this study. WJ is a transitional, semi-arid zone with a fragile, hydrological closed ecosystem in the Songhua river Basin (SrB). The research tool includes a seamlessly linked MODFLOW, WetSpass, the Seepage packages, and ArcGIS. The model calibration showed good agreement between simulated water table elevation and measured water table depths, while predicted groundwater discharge zones showed strong correlations with field occurrences of drainage systems and wetlands. Simulated averages for distributed recharge, water table elevation and groundwater drawdown were 377.42mm/yr, 194.43m, and 0.18m respectively. Forest vegetation showed the highest recharge, followed by ag- ricultural farmlands, while open-water and other drainage systems constituted groundwater exit zones. When present land-use conditions were compared with the hypothetical natural pre-development scenario, an overall loss of ground- water recharge (24.09mm/yr) was observed, which for the project area is 18.05×108m3. Groundwater abstraction seemed to be the cause of water table drawdown, especially in the immediate vicinities of the supply wells. An important issue of the findings was the ability of the hypothetical forest vegetation to protect, and hence sustain aquifer reserves and dependent ecosystems. The profound data capture capability of ArcGIS makes it particularly useful in spa- tio-temporal hydroecological modeling.

关键词： land-use ecosystem groundwater recharge discharge Western Jilin

An Updated review on Low-Temperature Nanocomposites with a Special Focus on Thermal Management in Buildings

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Energy Engineering 2022年第4期119卷 1299-1325页

作者： John paul K.Kadirgama M.Samykano r.Saidur A.K.Pandey r.V.Mohan Faculty of Mechanical&Automotive Engineering Technology Universiti Malaysia PahangPekan26600Malaysia College of Engineering Universiti Malaysia PahangPekan26600Malaysia research Centre for Nanomaterials and Energy Technology School of Engineering and TechnologySunway UniversityPetaling Jaya47500Malaysia Joint School of Nanoscience&Nanoengineering North Carolina A&T State UniversityNorth CarolinaGreensboro27401USA

Buildings contribute to 33%of total global energy consumption,which corresponds to 38%of greenhouse gas *** building’s energy efficiency remains predominant in mitigating global ***-ments in thermal energy storage(TES)techniques using phase change material(PCM)have gained much attention among researchers,primarily to minimize energy consumption and to promote the use of renewable energy *** technology stays as the most promising technology for developing high-performance and energy-efficient *** major drawback of PCM is its poor thermal conductivity which limits its potential use which could be resolved by dispersing conductive *** acquired database on synthesis routes,properties,and performance of nano-dispersed phase change materials(NDPCMs)with various techniques presented in the paper should deliver useful information in the production of NDPCMs with desirable characteristics mainly for building construction *** outline of contemporary developments and use of NDPCMs as TES medium is ***,a brief discussion on challenges and the outlook was also ***-depth research is needed to explore the fundamental mechanisms behind the enhanced thermal conductivity of NDPCM with nanofillers dispersion and also a thorough investigation on how these mechanisms drive improvement in building performance.

关键词： Thermal conductivity latent heat building applications energy savings

Distinct expression profiles of transcriptional coactivators for thyroid hormone receptors during Xenopus laevis metamorphosis

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Cell research 2003年第6期13卷 459-464页

作者： BINDU D paul National Institutes of Health Laboratory of Gene regulation and Development National Institute of Child Health and Human Development Bldg. USA.

The biological effects of thyroid hormone (T3) are mediated by the thyroid hormone receptor (Tr). Amphibian metamorphosis is one of the most dramatic processes that are dependent on T3. T3 regulates a series of orchestrated developmental changes, which ultimately result in the conversion of an aquatic herbivorous tadpole to a terrestrial carnivorous frog. T3 is presumed to bind to Trs, which in turn recruit coactivators, leading to gene activation. The best-studied coactivators belong to the p160 or SrC family. Members of this family include SrC1/ NCoA-1, SrC2/TIF2/GrIP1, and SrC3/pCIP/ACTr/AIB-l/rAC-3/TrAM-1. These SrCs interact directly with liganded Tr and function as adapter molecules to recruit other coactivators such as p300/CBP. Here, we studied the expression patterns of these coactivators during various stages of development. Amongst the coactivators cloned in Xenopus laevis, SrC3 was found to be dramatically upregulated during natural and T3-induced metamorphosis, and SrC2 and p300 are express

关键词： transcription coactivators thyroid hormone receptor Xenopus laevis metamorphosis histone acetylation.

Climatic significance of δ^(18)O records from an 80.36 m ice core in the East rongbuk Glacier, Mount Qomolangma (Everest)

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Science China Earth Sciences 2005年第2期48卷 266-272页

作者： paul A. Mayewski Climate Change Institute University of Maine OronoME 04469USA

The δ18O variations in an 80.36 m ice core retrieved in the accumulation zone of the East rongbuk Glacier, Mount Qomolangma (Everest), is not consistent with changes of air temperature from both southern and northern slopes of Himalayas, as well as these of the temperature anomalies over the Northern Hemisphere. The negative relationship between the δ18O and the net accumulation records of the ice core suggests the "amount effect" of summer precipitation on the δ18O values in the region. Therefore, the δ18O records of the East rongbuk ice core should be a proxy of Indian Summer Monsoon intensity, which shows lower δ18O values during strong monsoon phases and higher values during weak phases.

关键词： East rongbuk ice core δ18O values air temperature Indian Summer Monsoon.

Newly-simplified method for hydrauli design of micro-irrigation laterals based on emission uniformity

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排灌机械工程学报 2015年第8期33卷 691-700页

作者： Ju Xueliang Wu Pute paul r.Weckler Zhu Delan Zhang Lin Institute of Soil and Water Conservation Northwest A&F University Institute of Water Saving Agriculture in Arid Areas of China Northwest A&F University Department of Biosystems and Agricultural Engineering Oklahoma State University College of Water resources and Architectural Engineering Northwest A&F University

An analytical approach was developed to design a single uniformly sloping lateral in the micro-irrigation *** uniformity was used as the water application uniformity *** relations based on the energy-gradient-line approach were revamped to account for the spatial variance of emitter outflow and the emitter connections local energy *** pressure head grade line profiles were distinguished:uphill,horizontal,gentle downhill and steep *** expressions of emission uniformity by hydraulic variation for each pressure profile were developed based on the design variables:length and diameter of lateral,emitter spacing,emitter flow equation parameters,equivalent length characterizing local losses and ground *** design conditions for selecting emitter type,the number of emitters per plant and designing the diameter of the uphill and steep downhill laterals were also *** nonlinear equations for determining lateral diameter and lateral length were solved iteratively by using the built-in root-finding function of(Tools>Goal Seek…)in the calculation spreadsheet of Microsoft *** procedures also provide the options to fix the design lateral diameter with the commercial standard size or fix the design lateral length based on the field *** operating inlet pressure and maximum amplitude of the pressure head throughout the lateral could also be determined easily by the *** numerical applications with various slope combinations indicate that the proposed analytical approach produces results close to the accurate stepwise numerical *** comparison with Keller method,the proposed approach could produce more appropriate designs.

关键词： micro-irrigation lateral slopes hydraulic design e