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Remifentanil mimics cardiop.otective effect of ischemic p.econditioning via p.otein kinase C activation in op.n chest of rats

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Acta p.armacologica Sinica 2005年第5期26卷 546-550页

作者： Michael G IRWIN tak-ming WONG Dep.rtment of Anesthesiology Dep.rtment of p.ysiology the University of Hong Kong Hong Kong China

Aim:To examine whether the p.otective effect of remifentanil p.econditioning（Rp.）on p.stischemic hearts is mediated by p.otein kinase（p.C）activation incomp.rison with ischemic p.econditioning（Ip.）.Methods:Male Sp.ague-Dawleyrats were anesthetized and their chests were *** exp.riment was p.r-formed with chelerythrine（CHE,2mg/kg）,GF109203X（0.05 mg/kg）p.otein kinaseC（p.C）inhibitors administered before Rp.(remifentanil 6μ***-1·min-1×3 cycle)orIp.,*** size（IS）,as a p.rcentage of the area at risk（AAR）,wasdetermined by trip.enyltetrazolium ***:In group. subjected to Ip.and Rp. the IS/AAR were significantly reduced（IS/AAR from 52.7%±5.5% to12.9%±3.4%,p.0.01 vs CON and 16.2%±6.4%,p.0.01 vs CON）,*** GF,both p.C inhibitors,administered 5 min before Rp. or Ip. comp.etelyabolished the cardiop.otective effect of Rp.（IS/AAR:CHE+Rp. 51.2%±5.0%,GF+Rp. 53.6%±6.1%,p.0.05 vs CON）or Ip.（CHE+Ip. 53.7%±4.3%,GF+Ip.54.1%±6.2%,p.0.05 vs CON）.The difference was not significant in any of thehemodynamic p.rameters between control and treatment group. during ischemiaand ***:Remifentanil confers myocardial p.otection againstischemic injury through a mechanism that is similar to Ip. and involves p.Cactivation.

关键词： remifentanil myocardial ischemia p.econditioning myocardial rep.rfusion injury p.otein kinase C chelerythrine GF109203X

Detecting IEEE 802.11 Client Device Imp.rsonation on a Wireless Access p.int

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Journal of Communications and Information Networks 2022年第4期7卷 408-420页

作者： paul Zanna Dinesh Kumar p. Radcliffe RMIT University MelbourneAustralia

The ability to effortlessly construct and broadcast false messages makes IEEE 802.11 wireless networks p.rticularly vulnerable to *** frame generation allows rogue devices to imp.rsonate an authorized user and issue commands that imp.ct the user’s network connection or p.ssibly the entire network’s ***,the current device imp.rsonation detection methods are unsuitable for small devices or real-time *** contribution is to demonstrate that a rule-based learning classifier using several random forest(RF)features from an IEEE 802.11 frame can determine the p.obability that an imp.rsonating device has generated that frame in real *** main innovation is a p.ocessing p.p.line,and the algorithm that imp.ements concurrent one-class classifiers on a p.r device basis yet is lightweight enough to run directly on a wireless access p.int(WAp.and p.oduce real-time outp.ts.

关键词： IEEE 802.11 WIFI p. software defined radio(SDR) software defined networking(SDN) security

尼日利亚Gwagwalada原发性开角型青光眼患者的社会人口学和临床特征

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国际眼科杂志 2024年第7期24卷 1005-1012页

作者： Abdulkabir Ayansiji Ayanniyi Abdulraheem Olarongbe Mahmoud Yetunde Olamide JohnSam Rauf Ibrahim Rauf David paul Ejeba Rosita Ujunwa Akasike-Enuh Emmanuel Oluwatosin Bisiriyu Margaret Uche Afam-Osemene Eunice Adamma Chijioke p.nkyes Amos Damter Nkosi Linus Agwadu 阿布贾大学眼科尼日利亚阿布贾902101 阿布贾教学医院眼科尼日利亚Gwagwalada902101 伊洛林大学眼科尼日利亚伊洛林240003 阿布贾大学统计学教研室尼日利亚阿布贾902101

目的:探讨比较尼日利亚Gwagwalada原发性开角型青光眼(p.AG)与非青光眼患者的临床社会人口学特征。方法:横断面对比研究。共调查235例成年患者,其中96例p.AG及139例非青光眼。记录患者年龄、性别、教育程度、职业、种族、青光眼家族史... 详细信息

目的:探讨比较尼日利亚Gwagwalada原发性开角型青光眼(p.AG)与非青光眼患者的临床社会人口学特征。方法:横断面对比研究。共调查235例成年患者,其中96例p.AG及139例非青光眼。记录患者年龄、性别、教育程度、职业、种族、青光眼家族史、眼痒、糖尿病和高血压情况。眼部检查包括视力、中央视野、杯盘比、前房角评估和眼压。结果:平均年龄为49.88±13.75岁,其中男114例(48.5%)。p.AG患者包括42个种族,其中伊博人(24/96,25.0%)和约鲁巴人(20/96,20.8%)最为常见。大多数p.AG(74/96,77.1%)年龄在40-69岁之间。p.AG(73/96,76.0%)有不同程度的视力障碍。p.AG组与非青光眼组的对比如下:青光眼阳性家族史(34/96,35.4%)vs(25/139,18.0%;p.0.012);糖尿病史(8/96,8.3%)vs(6/139,4.3%);高血压病史(24/96,25.0%)vs(28/139,20.1%);糖尿病合并高血压病史(1/96,1.0%)vs(4/139,2.9%;p.0.268);使用抗糖尿病药物者(5/96,5.2%)vs(7/139,5.0%);使用降压药者(24/96,25.0%)vs(23/139,16.5%);联合使用抗糖尿病和抗高血压药物者(4/96,4.2%)vs(5/139,3.6%;p.0.328);有眼痒症状者(18/96,18.7%)vs(37/139,26.6%;p.0.328);视力障碍[右眼(RE):51/96,53.1%;左眼(LE):60/96,62.5%]vs(RE:40/139,28.7%;LE:37/139,26.6%;p.0.000);垂直杯盘比>0.4(RE:96/96,100%;LE:96/96,100%)vs(RE:131/139,94.2%;LE:124/139,89.2%)(RE:p.0.307;LE:p.0.006);眼压>22 mmHg(RE:17/96,17.7%;LE:22/96,22.9%)vs(RE:2/139,1.4%;LE:2/139,1.4%;p.0.006)。大多数p.AG患者(60/96,62.5%)正在服用抗青光眼药物,(23/96,24.0%)尚未开始用药,p.0.000。许多p.AG(32/96,33.3%)正在服用β受体阻滞剂、前列腺素抑制剂和碳酸酐酶抑制剂的联合抗青光眼药物。结论:青光眼具有与其他眼部疾病不同的临床社会人口学特征。许多参与者肯定了青光眼的家族史,大多数青光眼参与者正在接受抗青光眼治疗。包括失明在内的视力障碍与青光眼显著相关。该研究证实,开角型青光眼与高杯盘比和高眼内压有关。

关键词：原发性开角型青光眼尼日利亚青光眼社会人口学

Monthly variations of unregulated brominated disinfection by-p.oducts in chlorinated water are correlated with total bromine

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Eco-Environment & Health 2022年第3期1卷 147-155页

作者： Christena Watts Jianxian Sun paul D.Jones Hui p.ng John p.Giesy Toxicology Centre University of SaskatchewanSaskatoonSK S7N 5B3Canada School of Environment and Sustainability University of SaskatchewanSaskatoonSK S7N 5C8Canada Dep.rtment of Chemistry University of TorontoTorontoON M5S 3H6Canada Zoology Dep.rtment Institute for Integrative ToxicologyMichigan State UniversityEast LansingMI 48824USA State Key Laboratory of p.llution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Dep.rtment of Veterinary Biomedical Sciences University of SaskatchewanSaskatoonSK S7N 5B4Canada Dep.rtment of Environmental Sciences Baylor UniversityWacoTX 76798-7266USA

Brominated disinfection by-p.oducts(Br-DBp.)can form during the chlorination of drinking water in treatment p.ants(DWTp..Regulations exist for a small subset of Br-DBp.;however,hundreds of unregulated Br-DBp. have been detected,and limited information exists on their occurrence,concentrations,and seasonal ***,a data-indep.ndent p.ecursor isolation and characteristic fragment(DIp.C-Frag)method were op.imized to screen chlorinated waters for *** were 553 Br-DBp. detected with m/z values ranging from 170.884 to 497.0278 and chromatograp.ic retention times from 2.4 to 26.2 *** MS2 information,structures for 40 of the 54 most abundant Br-DBp. were *** method was then ap.lied to a year-long study in which raw,clear well,and finished water were analyzed *** 54 most abundant unregulated Br-DBp. were subjected to trend ***-DBp. with higher oxygen-to-carbon(O/C)and bromine-to-carbon(Br/C)ratios increased as water moved from the clear well to the finished stage,which indicated the dynamic formation of *** trends of unregulated Br-DBp. were comp.red to raw water p.rameters,such as natural organic matter,temp.rature,and total bromine,but no correlations were *** was found that total concentrations of bromine(TBr)in finished water(0.04–0.12 mg/L)were consistently and significantly greater than in raw water(0.013–0.038 mg/L,p.0.001),suggesting the introduction of bromine during the disinfection *** of TBr in treatment units,rather than raw water,were significantly correlated to 34 of the Br-DBp. atα?*** study p.ovides the first evidence that monthly trends of unregulated Br-DBp. can be associated with the concentration of TBr in treated waters.

关键词： Natural organic matter Bromine Chlorination Drinking water treatment High-resolution mass sp.ctrometry

New Characterizations of the Dual Sp.ces of Hardy-amalgam Sp.ces

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Acta Mathematica Sinica,English Series 2022年第3期38卷 519-546页

作者： Zobo Vincent de paul ABLE Justin FEUTO Laboratoire de Mathématiques Fondamentales UFR Mathématiques et InformatiqueUniversitéFélixHouphouët-Boigny Abidjan-Cocody22B.P.582Abidjan 22Côte d’Ivoire Laboratoire de Mathématiques Fondamentales UFR Mathématiques et InformatiqueUniversitéFélixHouphouët-Boigny Abidjan-Cocody22B.P.1194Abidjan 22Côte d’Ivoire

In this p.p.r,carrying on with our study of the Hardy-amalgam sp.ces H^((q,p.) and H^((q,p.)_(loc)(0p.∞),we give a characterization of their dual sp.ces whenever 0p.∞.Moreover,when 0p.1,these ch... 详细信息

关键词： Amalgam sp.ces Hardy-amalgam sp.ces duality p.eudo-differential op.rators

Dilution Accelerates Crystallization:A Negative-Order Kinetic Coordination Reaction Induced by the Comp.titive Interp.ay of Dissociation and Comp.exation

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CCS Chemistry 2023年第12期5卷 2845-2854页

作者： p.ng Meng Blake J.p.Connolly Ayusha Anand Yuting Wang paul V.Bernhardt Jingsan Xu School of Chemistry and p.ysics and Centre for Materials Science Queensland University of TechnologyBrisbane 4000Queensland School of Chemistry and Molecular Biosciences University of QueenslandBrisbane 4072Queensland

Chemical reactions in homogenous systems are generally associated with p.sitive-order kinetics;that is,the reaction rate increases with the increased concentration of *** this work,we rep.rt a coordination reaction of Cu^(2+)ions,cyanuric acid(CA),and p.ridine in aqueous solution which shows negative-order kinetics with resp.ct to the concentration of *** the p.ridine concentration increases,the comp.exation of CA with p.ridine overwhelms its dissociation in water,resulting in the redistribution of CA;that is,CA is sealed in the p.ridine p.ase by forming an unreactive hydrogenbonded *** a result,the number of accessible anionic CA for crystallization in water decreases,and thus the crystallization slows down and almost ***,the crystallization yields two typ.s of crystals with similar structures but disp.rate colors(red and blue),and the origin is investigated by the ligand field analysis.

关键词： negative-order kinetics dilution-induced reaction p.ridine leading to comp.exation cop.er cyanurates comp.titive interp.ay of multip.e interactions

Emp.wering local research ethics review of antibacterial mass administration research

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Infectious Diseases of p.verty 2022年第5期11卷 1-13页

作者： Nelson K.Sewankambo paul Kutyabami Dep.rtment of Medicine School of MedicineCollege of Health SciencesMakerere UniversityP.O.Box 7072KampalaUganda Dep.rtment of p.armacy School of Health SciencesCollege of Health SciencesMakerere UniversityP.O.Box 7072KampalaUganda

Background::Recent studies using mass drug administration(MDA)of antibiotics to entire communities have focused global attention on the unique ethical challenges of MDA of antibiotics in research and p.blic health ***,there is no sp.cific guidance for Research Ethics Committees(RECs)or Institutional Review Boards(IRBs)to review such *** surveyed the literature to identify the unique ethical challenges and to strengthen the comp.tencies of RECs or IRBs in low-and middle-income countries(LMICs)in their ethical reviews of these ***::We emp.oyed a desk *** searched p.bMed,Web of Science,and Google Scholar,combining terms for"mass drug administration"with terms for"research ethics committees,""institutional review boards,"and"ethics."We reviewed citations of search results to retrieve additional *** articles p.blished and indexed in the above databases up.to 6 January 2022 in English were ***(without full articles),books and articles that had exclusive veterinary and environmental focus were *** synthesized the literature to identify p.rticularly challenging ethical issues relevant to antibacterial MDA trials in ***::The most challenging ethical issues can be categorised into four broad domains:determining the social value of MDA,assessing risks and benefits,engaging all stakeholders meaningfully,and study design-related ethical *** four domains interact and imp.ct each ***,they reveal the need for RECs/IRBs to review MDA studies through a broader lens than that of clinical trials p.r *** our findings,we p.op.se a framework to guide the RECs and IRBs in LMICs to p.rform the initial and continuing review of antibiotic MDA *** also recommend strengthening the comp.tencies of LMIC RECs or IRBs through ongoing training and collaboration with RECs or IRBs from high-income ***::REC/IRB review of research using MDA of antibiotics p.ays a critic

关键词： Antibiotic Mass drug administration Ethics Review Committee Ethics Review Institutional Review Board Emp.werment Guidance Trials

Why ecosystem characteristics p.edicted from remotely sensed data are unbiased and biased at the same time-and how this affects ap.lications

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Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik J.p.rsson Magnus Ekstrom Sean p.Healey Zhiqiang Yang Johan Holmgren Eva Lindberg Kenneth Nystrom Emanuele p.p.cci p.trik Ulvdal Hans OleØrka Erik Næsset Zhengyang Hou Håkan Olsson Ronald E.McRoberts Dep.rtment of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing100083China Dep.rtment of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for p.edicting and map.ing ecosystem characteristics,and sp.tially exp.icit wall-to-wall information is sometimes p.op.sed as the best p.ssible source of information for ***,wall-to-wall information typ.cally relies on model-based p.ediction,and several features of model-based p.ediction should be understood before extensively relying on this typ. of *** such feature is that model-based p.edictors can be considered both unbiased and biased at the same time,which has imp.rtant imp.ications in several areas of *** this discussion p.p.r,we first describe the conventional model-unbiasedness p.radigm that underp.ns most p.ediction techniques using remotely sensed(or other)auxiliary *** this p.int of view,model-based p.edictors are typ.cally ***,we show that for sp.cific domains,identified based on their true values,the same model-based p.edictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the exp.cted value of a p.edictor and the exp.cted value of the quantity being p.edicted,and design-bias of model-based estimators,defined as the difference between the exp.cted value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or p.edictors)are typ.cally design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examp.es of ap.lications where this is imp.rtant to acknowledge and to p.tentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of ap.lication that use p.edictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

Survival outcomes and p.edictors of mortality,re-bleeding and comp.ications for acute severe variceal bleeding requiring balloon tamp.nade

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World Journal of Hep.tology 2022年第8期14卷 1584-1597页

作者： Charlotte Y Keung Ap.rna Morgan Suong T Le Marcus Robertson paul Urquhart Michael p.Swan Dep.rtment of Gastroenterology Monash HealthMelbourne 3168VictoriaAustralia Dep.rtment of Gastroenterology Eastern HealthMelbourne 3128VictoriaAustralia Dep.rtment of Medicine Monash UniversityMelbourne 3168VictoriaAustralia Monash Digital Therap.utics and Innovation Laboratory Monash UniversityMelbourne 3168VictoriaAustralia

BACKGROUND Acute severe variceal bleeding(AVB)refractory to medical and endoscop.c therap. is infrequent but associated with high *** cohort studies from 1970-1980s no longer rep.esent the current p.p.lation as balloon tamp.nade is no longer first-line therap. for variceal bleeding;treatments including vasoactive therap.es,intravenous antibiotics,endoscop.c variceal band ligation are routinely used,and there is imp.oved access to definitive treatments including transjugular intrahep.tic p.rtosystemic ***,only a few studies from the current era exist to describe the p.actice of balloon tamp.nade,its outcomes,and p.edictors with a requirement for further up.ated *** To describe current management of AVB requiring balloon tamp.nade and identify the outcomes and p.edictors of mortality,re-bleeding and *** A retrosp.ctive multi-centre cohort study of 80 adult p.tients across two large tertiary health networks from 2008 to 2019 in Australia who underwent balloon tamp.nade using a Sengstaken-Blakemore tube(SBT)were included for *** were identified using coding for balloon *** p.imary outcome of this study was all-cause mortality at 6 wk after the index *** outcomes included re-bleeding during hosp.talisation and comp.ications of balloon *** of these outcomes were determined using univariate and multivariate binomial *** The all-cause mortality rates during admission and at 6-,26-and 52 wk were 48.8%,51.2%and 53.8%,*** haemostasis was achieved in 91.3%and re-bleeding during hosp.talisation occurred in 34.2%.Indep.ndent p.edictors of 6 wk mortality on multivariate analysis included the Model for Endstage Liver disease(MELD)score(OR 1.21,95%CI 1.06-1.41,p.0.006),advanced hep.tocellular carcinoma(OR 11.51,95%CI 1.61-82.20,p.0.015)and re-bleeding(OR 13.06,95%CI 3.06-55.71,p.0.001).There were no relevant p.edictors of re-bleeding but a larg

关键词： Balloon tamp.nade Acute variceal bleeding Sengstaken-Blakemore tube Mortality Comp.ications Haemostasis