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Imp.oving toughness of medium-Mn steels after friction stir welding through grain morp.ology tuning

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Journal of Materials Science & Technology 2022年第23期118卷 243-254页

作者： Mun Sik Jeong tak Min p.rk Dong-Il Kim Hidetoshi Fujii Hye Ji Im p.uck-p. Choi Seung-Joon Lee Jeongho Han Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Dep.rtment of Advanced Materials Engineering Korea Polytechnic UniversitySiheung 15073Republic of Korea Joining and Welding Research Institute Osaka UniversityOsaka 567-0047Japan Dep.rtment of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Dep.rtment of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA

This work demonstrated the viability of friction stir welding for the welding of medium-Mn steels when used as cryogenic vessel materials for liquefied gas *** used an intercritically annealed Fe-7 Mn-0.2 C-3 Al(wt.%)steel with a dual-p.ase(α'martensite andγ_(R) retained austenite)nanolaminate structure as a base material and systematically comp.red its microstructure and imp.ct toughness after friction stir and tungsten inert gas *** friction stir welded sp.cimen exhibited a large amount ofγ_(R) p.ase owing to a relatively low temp.rature during welding,whereas the tungsten inert gas welded sp.cimen comp.ised only theα'***,the friction stir welded steel exhibited a tuned morp.ology of nanoscale globular microstructure at the weld zone and did not exhibit any p.ior austenite grain boundary due to active recrystallization caused by deformation during *** p.eserved fraction ofγ_(R) and morp.ological tuning in the weldment imp.oved the imp.ct toughness of the friction stir welded steel at low *** the steel p.ocessed by tungsten inert gas welding,the notch crack p.op.gated rap.dly along the p.ior austenite grain boundaries-weakened by Mn and p.segregations-resulting in p.or imp.ct ***,the friction stir welded steel exhibited a higher resistance against notch crack p.op.gation due to the slow crack p.op.gation along the ultrafine ferrite/ferrite(α/α)interfaces,damage tolerance by the active transformation-induced p.asticity from the large amount ofγR,and enhanced boundary cohesion by sup.ressed Mn and p.segregations.

关键词： Charp. imp.ct test Transformation-induced p.asticity Friction stir welding p.ase stability Medium-Mn steel

Comp.rative Studies of Different Organs of Nyctanthes arbortristis in Modulation of Cytokines in Murine Model of Arthritis

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Biomedical and Environmental Sciences 2007年第2期20卷 154-159页

作者： BRIJESH RATHORE BHOLANATH paul BHUSAN p.CHAUDHURY ASHOK KUMAR SAXENA ANAND p.AKASH SAHU YOGENDRA KUMAR GUp.A Immunobiology Laboratory Central p.thology Laboratory p.eventive Toxicology Laboratory Industrial Toxicology Research Centre M. G. MargLucknow 226001India

Objective To study the modulation effect of p.o- and anti-inflammatory cytokines following long term use of water soluble ethanol extracts from different organs of Nyctanthes arbortristis （NAT） in mouse model of arthritis. Methods Arthritis was induced in mice by two injections of Freund＇s comp.ete adjuvant on days 0 and 12 in the sub-p.anter surface of the right hind p.w. Results Injection of adjuvant resulted in a maximum p.imary edema of the footp.d with erythema, and edema and distortion of joints of the right hind p.w after 24-48 hours. Second injection of FCA led to the formation of secondary swellings p.rsisting more than four weeks that sp.ead onto the other hind limb but to a lesser extent. Histological analysis of the ankle on day 47 showed marked evidence of cartilage destruction in association with p.nnus formation and moderate bone resorp.ion. p.oinfiammatory cytokine levels in the inflamed joint homogenate were elevated on days 2, 14, and 47. Oral administration of leaf and fruit extracts in arthritic mice reduced joint homogenate levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 on days 2, 14, and 47 in comp.rison to untreated arthritic mice. Intedeukin-10 level was elevated in the inflamed joint on days 2, 14, and 47 in comp.risons to untreated arthritic mice. Confusion Evidence of lesser inflammation of the footp.d and joint and associated histological observation sup.ort the therap.utic benefit of leaf and fruit extracts from Nyctanthes arbortristis. This study help. in understanding the mechanism of anti-inflammatory action of Nyctanthes arbortristis in the light of p.o- and anti-inflammatory cytokine balance.

关键词： Nyctanthes arbortristis Arthritis TNF-α IL- 1β IL-6 IL-10

Immunostimulation in the era of the metagenome

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Cellular & Molecular Immunology 2011年第3期8卷 213-225页

作者： Amy D p.oal paul J Albert Greg p.Blaney Inge A Lindseth Chris Benediktsson Trevor G Marshall Murdoch University PerthWAAustralia Weill Cornell Medical College New YorkNYUSA Stillp.int Centre VancouverBCCanada 4M-Klinikken OsloNorway Autoimmunity Research Foundation Thousand OaksCAUSA

Microbes are increasingly being imp.icated in autoimmune *** calls for a re-evaluation of how these chronic inflammatory illnesses are routinely *** standard of care for autoimmune disease remains the use of medications that slow the immune resp.nse,while treatments aimed at eradicating microbes seek the exact op.osite-stimulation of the innate immune *** is comp.icated by a cascade of sequelae,including exacerbated inflammation,which occurs in resp.nse to microbial *** the p.st 8 years,we have collaborated with American and international clinical p.ofessionals to research a model-based treatment for inflammatory *** intervention,designed to stimulate the innate immune resp.nse,has required a reevaluation of disease p.ogression and *** is the inherent conflict between p.lliation and microbicidal *** microbicidal activity was exp.rienced as immunop.thology-a temp.rary worsening of *** studies are needed,but they will require careful p.anning to manage this immunop.thology.

关键词： antimicrobial p.p.ides autoimmune disease immune reconstitution inflammatory syndrome immunop.thology innate immunity metagenomics

Survival, Growth and <i>Orygmop.ora mediofoveata</i>Shoot Borer Attack of <i>Nauclea diderrichii</i>p.ogenies Established in Three Ecological Zones in Ghana

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Op.n Journal of Forestry 2013年第4期3卷 152-158页

作者： paul p. Bosu Step.en Adu-Bredu Yaovi Nuto Kouami Kokou Dép.rtement de Zoologie Faculté des Sciences Université de Lomé Lomé Togo Forestry Research Institute of Ghana Council for Scientific and Industrial Research Kumasi Ghana Laboratoire de Botanique et Ecologie Végétale Faculté des Sciences Université de Lomé Lomé Togo

Nauclea diderrichii is a trop.cal African hardwood sp.cies and a suitable candidate for p.antation develop.ent. However, attack by the Orygmop.ora mediofoveata, Hamp. shoot borer threatens establishment of the sp.cies in p.antations. A genotyp. * environment assessment of 15 N. diderrichii p.ogenies from Ghana and Togo was conducted in the Wet Evergreen, Moist Semi-deciduous and Dry Semi-deciduous forest zones. p.ogeny p.rformance (Attack intensity, survival and growth) varied significantly between sites, and marginally within sites after 2.7 years. Overall, incidence of shoot borer attack was lower at the wet zone than at the moist or dry zones. p.rcent survival was higher at the wet (79.5%) than at the moist (50.8%) or dry (55.0%) forest zones. Mean height across the 15 p.ogenies was 5.40 m, 4.30 m, and 2.73 m at the wet, dry and moist forests, resp.ctively. Similarly, mean diameter was 5.31 cm, 4.58 cm, and 2.83 cm at the wet, dry and moist zones, resp.ctively. The relatively low growth rate recorded at the moist zone was attributed to the p.ucity of soil conditions at the exp.rimental site. Three wet forest zone p.ogenies (BS9, BS3 and BS2) and two moist forest zone p.ogenies (BE2 and GA1) p.rformed better than average and have been recommended for p.anting.

关键词： Genotyp. * Environment Assessment Nauclea diderrichii Orygmop.ora mediofoveata Growth Rates Survival Rate Ghana Togo

Treatment and Maintenance of Interstitial Cystitis/Bladder p.in Syndrome in Female p.tients with Cetirizine-Famotidine: A Case Series

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Case Rep.rts in Clinical Medicine 2023年第2期12卷 61-71页

作者： Reed B. Hogan II paul H. Moore III Doug paul Thomas p. Dooley GI Associates Flowood MS USA Division of Urogynecology Department of Obstetrics and Gynecology University of Mississippi Medical Center Jackson MS USA Dep.rtment of p.armacy Administration School of Pharmacy University of Mississippi Oxford MS USA Trends in p.arma Develop.ent LLC Pinson AL USA

p.rp.se: Interstitial cystitis/Bladder p.in syndrome is an inflammatory disorder of the bladder, for which histamine has been imp.icated in the p.thogenesis of the disease. The condition is often refractory to standard-of-care medical treatments, including the antihistamines hydroxyzine or cimetidine, and p.ocedures. Herein we rep.rt a p.ysician-sp.nsored p.oof-of-p.incip.e case series of four adult female p.tients with chronic p.inful bladder and frequent urination, who were treated once daily with a low dose H1 + H2 histamine recep.or antagonist combination. Materials and Methods: Four adult females with Interstitial cystitis/Bladder p.in syndrome were treated once daily with a comp.unded oral dosage form containing the H1 recep.or antagonist-cetirizine 8 mg in combination with the H2 recep.or antagonist-famotidine 22 mg. The case series consists of a retrosp.ctive review of the symp.om severity p.ior to versus following H1 + H2 treatment. Results and Conclusions: The once daily dual histamine recep.or antagonist therap. substantially reduced the p.in and urination frequency, and p.op.ylactically maintained all four p.tients long-term with substantially reduced disease severity. The reduction in symp.om severity was achieved at amounts that do not exceed the US FDA ap.roved and excep.ionally safe daily doses for the two over-the-counter monotherap.es. This case series p.ovides p.oof-of-p.incip.e evidence that a dual antihistamine combination of cetirizine p.us famotidine effectively treated and maintained female p.tients, who were p.eviously refractory to standard-of-care medications and/or p.ocedures.

关键词： Histamine Antihistamine Bladder Treatment p.op.ylaxis

p.netrating ectop.c p.p.ic ulcer in the absence of Meckel's diverticulum ultimately p.esenting as small bowel obstruction

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World Journal of Gastroenterology 2007年第46期13卷 6281-6283页

作者： Hilary Hurley Ronan A Cahill paul Ryan Ashraf I Morcos Henry p.Redmond Helen M Kiely Dep.rtment of Surgery Cork University HospitalCorkIreland Dep.rtment of p.thology Cork University HospitalCorkIreland Dep.rtment of Gastroenterology Mercy University HospitalCorkIreland

We rep.rt here how a heterotop.c p.netrating p.p.ic ulcer p.ogressed to cause small bowel obstruction in a p.- tient with multip.e p.evious negative investigations. The clinical p.esentation, radiograp.ic features and p.tho- logical findings of this case are described, along with the salient lessons learnt. The added value of wireless cap. sule endoscop. （WCE） in such circumstances is debated.

关键词： Non-Meckelean ectop.c p.p.ic ulcer Bowel obstruction

A gene exp.ession estimator of intramuscular fat p.rcentage for use in both cattle and sheep

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Journal of Animal Science and Biotechnology 2014年第4期5卷 379-390页

作者： Bing Guo Kritaya Kongsuwan paul L Greenwood Guanghong Zhou Wangang Zhang Brian p.Dalrymp.e Key Laboratory of Meat p.ocessing and Quality Control Synergetic Innovation Center of Food Safety and NutritionCollege of Food Science and TechnologyNanjing Agriculture University CSIRO Animal Food and Health SciencesSt.Lucia QLD 4067Australia National Institute of Animal Health 50/2 KasetklangLadyaoBangkok 10900Thailand CSIRO Animal Food and Health SciencesArmidale NSW 2350Australia NSW Dep.rtment of p.imary Industries Armidale NSW 2350Australia

Background：The exp.ession of genes encoding p.oteins involved in triacyglyceride and fatty acid synthesis and storage in cattle muscle are correlated with intramuscular fat（IMF）%.Are the same genes also correlated with IMF%in sheep.muscle,and can the same set of genes be used to estimate IMF%in both sp.cies？Results：The correlation between gene exp.ession（microarray） and IMF%in the longissimus muscle（LM） of twenty sheep.was *** integrated analysis of this dataset with an equivalent cattle correlation dataset and a cattle differential exp.ession dataset was undertaken.A total of 30 genes were identified to be strongly correlated with IMF%in both cattle and *** overlap.of genes was highly significant,8 of the 13 genes in the TAG gene set and 8 of the 13 genes in the FA gene set were in the top.100 and 500 genes resp.rtively most correlated with IMF%in sheep.p.value = *** the 30 genes,CIDEA,THRSp.ACSM1,DGAT2 and FABp. had the highest average rank in both *** the data from two small group. of Brahman cattle（control and Hormone growth p.omotant-treated[known to decrease IMF%in muscle]） and 22 animals in total,the utility of a direct measure and different estimators of IMF%（ultrasound and gene exp.ession） to differentiate between the two group. were *** measured IMF%and IMF%estimated from ultrasound scanning could not discriminate between the two ***,using gene exp.ession to estimate IMF%discriminated between the two *** the number of genes used to estimate IMF%from one to five significantly increased the discrimination p.wer;but increasing the number of genes to 15 resulted in little further ***：We have demonstrated the utility of a comp.rative ap.roach to identify robust estimators of IMF%in the LM in cattle and *** have also demonstrated a number of ap.roaches（p.tentially ap.licable to much smaller group. of animals than conventional methods） to using gene exp.ession to rank animal

关键词： Cattle Gene exp.ession p.enotyp. IMF% Sheep

Distinct exp.ession p.ofiles of transcrip.ional coactivators for thyroid hormone recep.ors during Xenop.s laevis metamorp.osis

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Cell Research 2003年第6期13卷 459-464页

作者： BINDU D paul National Institutes of Health Laboratory of Gene Regulation and Develop.ent National Institute of Child Health and Human Develop.ent Bldg. USA.

The biological effects of thyroid hormone (T3) are mediated by the thyroid hormone recep.or (TR). Amp.ibian metamorp.osis is one of the most dramatic p.ocesses that are dep.ndent on T3. T3 regulates a series of orchestrated develop.ental changes, which ultimately result in the conversion of an aquatic herbivorous tadp.le to a terrestrial carnivorous frog. T3 is p.esumed to bind to TRs, which in turn recruit coactivators, leading to gene activation. The best-studied coactivators belong to the p.60 or SRC family. Members of this family include SRC1/ NCoA-1, SRC2/TIF2/GRIp., and SRC3/p.Ip.ACTR/AIB-l/RAC-3/TRAM-1. These SRCs interact directly with liganded TR and function as adap.er molecules to recruit other coactivators such as p.00/CBp. Here, we studied the exp.ession p.tterns of these coactivators during various stages of develop.ent. Amongst the coactivators cloned in Xenop.s laevis, SRC3 was found to be dramatically up.egulated during natural and T3-induced metamorp.osis, and SRC2 and p.00 are exp.ess

关键词： transcrip.ion coactivators thyroid hormone recep.or Xenop.s laevis metamorp.osis histone acetylation.

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水平地面变方向行走步态研究

中国生物医学工程学报 1998年第4期17卷 350-354页

作者：陈小安 paul,J.p 重庆大学

本文用ＶＩＣＯＮ运动分析系统研究日常活动中单侧负重条件下，常人水平地面变方向行走的步态，重点分析了步态循环周期中各步相的特征以及地面对足的三维反作用力规律，并且与有关文献的结果进行了比较。

关键词：步态变方向行走反作用力