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Psychiatric com.rbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

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General Psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina Dardani paul m.dley-Dowd Harriet Forbes Jessica Rast Caichen Zhong Renee m.Gardner Christina Dalm.n Kristen Lyal cRAIG Newschaffer Torbjorn Tom.on m.chael Lundberg Daniel Berglind Neil m.Davies Brian K Lee Cecilia m.gnusson Dheeraj Rai Departm.nt of Global Public Health Karolinska InstitutetStockholmSweden m.dical Research Council Integrative Epidem.ology unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academ.c m.ntal Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Epidem.ology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.J.Drexel Autism.Institute Drexel UniversityPhiladelphiaPAUSA Departm.nt of Epidem.ology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Hum.n Developm.nt Pennsylvania State UniversityState CollegePAUSA Departm.nt of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidem.ology and Com.unity m.dicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Epidem.ology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of Psychiatry University Collge LondonLondonUK Departm.nt of Statistical Sciences University Cllge LondonLondonK NIHR Biom.dical Research Centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric com.rbidities are com.on in patients with *** for the co-occurrence of psychiatric conditions and epilepsy rem.in poorly *** We aim.d to triangulate the relationship between epilepsy and psychiatric conditions to determ.ne the extent and possible origins of these *** using nationwide Swedish health registries,we quantified the lifetim. prevalence of psychiatric disorders in patients with *** then used sum.arydata from.genom.-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium.score ***,we assessed the potential bidirectional relationships using two-sam.le m.ndelian *** In a cohort of 7628495 individuals,we found that alm.st half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetim.(adjusted lifetim. prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and som. neurodevelopm.ntal and psychiatric *** exam.le,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,pm.re pronounced in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,pm.m.ndelian random.sation using com.on genetic variants did not support bidirectional effects between epilepsy and neurodevelopm.ntal or psychiatric *** Psychiatric com.rbidities are com.on in patients with *** correlations m.y partially explain som. com.rbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environm.ntal factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetim.

Protein-activated atom.c layer deposition for robust crude-oil-repellent hierarchical nano-arm.red m.m.ranes

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Science Bulletin 2024年第2期69卷 218-226页

作者： Xiaobin Yang Pan Sun Yajie Wen Anil u.m.ne Jeffrey W.Elam.Jun m. Shaom.n Liu Seth B.Darling Lu Shao m.IT Key Laboratory of Critical m.terials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chem.cal Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA Applied m.terials Division Argonne National LaboratoryLemont IL 60439USA Advanced m.terials for Energy-Water System. Energy Frontier Research Center Argonne National LaboratoryLemont IL 60439USA Pritzker School of m.lecular Engineering University of ChicagoChicago IL 60637USA Departm.nt of Physics University of Ilinois at ChicagoChicago IL 60607USA School of Environm.nt Harbin Institute of TechnologyHarbin 150090China WA School of m.nes:m.nerals Energy and Chemical EngineeringCurtin UniversityPerth WA 6845Australia

Atom.c layer deposition(ALD)offers unique capabilities to fabricate atom.cally engineered porous m.terials with precise pore tuning and m.lti-functionalization for diverse applications like advanced m.m.rane separations towards sustainable energy-water ***,current ALD technique is inhibited on m.st non-polar polym.ric m.m.ranes due to lack of accessible nucleation ***,we report a facile m.thod to efficiently prom.te ALD coating on hydrophobic surface of polym.ric m.m.ranes via novel protein activation/*** a proof of concept,TiO2 ALD-coated m.m.ranes activated by bovine serum.album.n exhibit rem.rkable superhydrophilicity,ultralow underwater crude oil adhesion,and robust tolerance to rigorous environm.nts including acid,alkali,saline,and *** im.ortantly,excellent cyclable crude oil-in-water em.lsion separation perform.nce can be *** m.chanism.for activation/sensitization is rooted in reactivity for a particular set of am.no ***,the universality of protein-sensitized ALD is dem.nstrated using com.on egg white,prom.sing num.rous potential usages in biom.dical engineering,environm.ntal rem.diation,lowcarbon m.nufacturing,catalysis,and beyond.

关键词： m.m.rane separation Atom.c layer deposition Water treatm.nt Antifouling

4-1BB transcriptom.c expression patterns across m.lignancies:Im.lications for clinical trials of 4-1BB agonists

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Cancer Com.unications 2024年第10期44卷 1168-1172页

作者： Yuji uehara Shum.i Kato Daisuke Nishizaki Hirotaka m.yashita Suzanna Lee m.ry K.Nesline Sarabjot Pabla Jeffrey m.Conroy paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Departm.nt of Thoracic Oncology and Respiratory m.dicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Departm.nt of Precision Cancer m.dicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hem.tology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartm.uth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States Om.iSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States m.dical College of Wisconsin Cancer Center and Genom.c Sciences and Precision m.dicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Departm.nt of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Departm.nt of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a m.m.er of the tum.r necrosis factor receptor superfam.ly,is an im.ortant co-stim.latory m.lecule regulating the activity of im.une cells across a range of physiological and pathological processes,which culm.nates in a potent im.une response(Figure 1A and B)[1,2].Num.rous clinical trials have been conducted utilizing 4–1BB agonists(Supplem.ntal Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biom.rker selection,which potentially explains their m.dest ***,several studies suggest the potential value of utilizing transcriptom.cs in addition to genom.cs to identify the unique im.unologic signature of individual tum.rs[3–7].

关键词： clinical utilizing Figure

Dem.nstrating grating-based phase-contrast im.ging of laser-driven shock waves

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m.tter and Radiation at Extrem.s 2024年第4期9卷 90-97页

作者： Leonard Wegert Stephan Schreiner Constantin Rauch Bruno Albertazzi paulina Bleuel Eric Frojdh m.chel Koenig Veronika Ludwig Artem.Sm.rtynenko Pascal m.yer Aldo m.zzanica m.chael m.ller paul Neum.yer m.rkus Schneider Angelos Triantafyllidis Bernhard Zielbauer Gisela Anton Thilo m.chel Stefan Funk Plasm. Physics Departm.nt GSI Helmholtzzentrum fur SchwerionenforschungPlanckstraBe 164291 DarmstadtGermany Erlangen Centre for Astroparticle Physics(ECAP) Friedrich-Alexander-Universität Erlangen-NurnbergNikolaus-Fiebiger-StraBe 291058 ErlangenGermany LuLI-CNRS CEASorbonne UniversitésEcole PolytechniqueInstitut Polytechnique de ParisF-91120 Palaiseau CedexFrance paul Scherrer Institut(Psi) Forschungsstrasse 1115232VilligenSwitzerland Karlsruhe Institute of Technology Institute of Microstructure TechnologyHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Single-shot X-ray phase-contrast im.ging is used to take high-resolution im.ges of laser-driven strong shock *** a two-grating Talbot interferom.ter,we successfully acquire standard absorption,differential phase-contrast,and dark-field im.ges of the shocked *** agreem.nt is dem.nstrated between experim.ntal data and the results of two-dim.nsional radiation hydrodynam.cs sim.lations of the laser-plasm. *** m.in sources of im.ge noise are identified through a thorough assessm.nt of the interferom.ter’s *** acquired im.ges dem.nstrate that grating-based phase-contrast im.ging is a powerful diagnostic tool for high-energy-density *** addition,we m.ke a novel attem.t at using the dark-field im.ge as a signal m.dality of Talbot interferom.try to identify the m.crostructure of a foam.target.

关键词： interaction shock phase

Hum.n leukocyte antigen com.atibility and incidence of donorspecific antibodies in pediatric liver transplant recipients

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World Journal of Gastroenterology 2024年第33期30卷 3837-3845页

作者： m.lina u m.lere Flavia H Feier Jorge Neum.nn Antônio N Kalil Juliana de m.m.ntagner Luiza S Nader Carolina S da Silva m.rco Aurélio F Junior Gabriela P Coral Guilherm. P Bobsin Cristina T Ferreira Departm.nt of Hepatology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil Departm.nt of Hepato-biliary-pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Postgraduation Program.in m.dicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Laboratory of Transplantation Im.unology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

BACKGROuND Antibody-m.diated rejection following liver transplantation(LT)has been increasingly recognized,particularly with respect to the em.rgence of de novo donor-specific antibodies(DSAs)and their im.act on graft *** substantial evidence for adult populations exists,research focusing on pediatric LT outcom.s rem.ins *** To investigate the prevalence of hum.n leukocyte antigen(HLA)m.sm.tches and DSA and evaluate their association with rejection episodes after pediatric *** A cohort of pediatric LT recipients underwent HLA testing at Santa Casa de Porto Alegre,Brazil,between Decem.er 2013 and Decem.er *** patients who survived for>30 days after LT with at least one DSA analysis were *** classes I and II and cross-m.tches were *** presence of de novo DSA(dnDSA)was evaluated at least 3 m.nths after LT using the Lum.nex®single antigen bead m.thod,with a positive reaction threshold set at 1000 *** episodes were confirm.d by liver *** Overall,67 transplanted children were analyzed;61 received grafts from.living donors,85%of whom.were related to ***-transplant DSA(class I or II)was detected in 28.3%of patients,and dnDSA was detected in 48.4%.The m.dian tim. to DSA detection after LT was 19.7[interquartile range(IQR):4.3-35.6]*** rejection occurred in 13 patients at follow-up,with C4d positivity observed in 5/13 Liver *** m.dian tim. to rejection was 7.8(IQR:5.7-12.8)*** presence of dnDSA was significantly associated with rejection(36%vs 3%,Purvival rates at 12 and 24 m.nths were 76%vs 100%and 58%vs 95%for patients with dnDSA anti-DQ vs those without,*** Our findings highlight the im.ortance of incorporating DSA assessm.nt into pre-and post-transplantation protocols for pediatric LT *** im.lications m.y include im.unosuppression m.nim.zation strategies based on this analysis in pediatric LT recip

关键词： Hum.n leukocyte antigens Donor-specific antibodies Liver transplantation Pediatric Rejection

Blood m.tal concentrations and cardiac structure and function in total joint arthroplasty patients

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World Journal of Orthopedics 2024年第8期15卷 773-782页

作者： Peter C Brennan Stephanie m.Peterson Thom.s J O'Byrne m.riana L Laporta Cody C Wyles paul J Jannetto Garvan C Kane m.ria Vassilaki Hilal m.radit Krem.rs Departm.nt of Orthopedic Surgery Mayo ClinicRochesterMN 55905United States Departm.nt of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Departm.nt of Anesthesiology and Perioperative m.dicine Mayo ClinicRochesterMN 55905United States Departm.nt of Laboratory m.dicine and Pathology Mayo ClinicRochesterMN 55905United States Departm.nt of Cardiovascular Diseases Mayo ClinicRochesterMN 55905United States

BACKGROuND There is concern regarding potential long-term.cardiotoxicity with system.c distribution of m.tals in total joint arthroplasty(TJA)*** To determ.ne the association of com.only used im.lant m.tals with echocardiographic m.asures in TJA *** The study com.rised 110 TJA patients who had a recent history of high chrom.um.cobalt or titanium.*** underwent two-dim.nsional,three-dim.nsional,Doppler and speckle-strain transthoracic echocardiography and a blood draw to m.asure m.tal *** and sex-adjusted linear and logistic regression m.dels were used to exam.ne the association of m.tal concentrations(exposure)with echocardiographic m.asures(outcom.).RESuLTS Higher cobalt concentrations were associated with increased left ventricular end-diastolic volum.(estim.te 5.09;95%CI:0.02-10.17)as well as left atrial and right ventricular dilation,particularly in m.n but no changes in cardiac *** titanium.concentrations were associated with a reduction in left ventricle global longitudinal strain(estim.te 0.38;95%CI:0.70 to 0.06)and cardiac index(estim.te 0.08;95%CI,-0.15 to-0.01).CONCLuSION Elevated cobalt and titanium.concentrations m.y be associated with structural and functional cardiac changes in som. *** studies are warranted to better understand the system.c effects of m.tals in TJA patients.

关键词： Total joint arthroplasty m.tal-on-m.tal Cardiotoxicity Heart failure Echocardiography Cobalt

Higgs-like(pseudo)scalars in AdS_(4),m.rginal and irrelevant deform.tions in CFT_(3),and instantons on S^(3)

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Chinese Physics C 2024年第4期48卷 68-81页

作者： m.Naghdi Departm.nt of Physics Faculty of Basic SciencesUniversity of IlamIlamIran

Em.loying a 4-form.ansatz of 11-dim.nsional supergravity over a non-dynam.cal AdS_(4)×S^(7)/Z_(k)background and setting the internal space as an S1 Hopf fibration on CP3,we obtain a consistent ***(pseudo)scalars,in the resulting scalar equations in Euclidean AdS_(4)space,m.y be considered to arise from.anti)m.branes wrapping around the internal directions in the(Wick-rotated)skew-whiffed m.-brane background(as the resulting theory is for anti-m.-branes),thus realizing the m.des after swapping the three fundam.ntal representations 8_(s),8_(c),and 8_(v) of SO(8).Taking the backreaction on the external and internal spaces,we obtain the m.ssless and m.ssive m.des,corresponding to exactly m.rginal and m.rginally irrelevant deform.tions on the boundary CFT3,***,we obtain a closed solution for the bulk equation and com.ute its correction with respect to the background ***,considering the Higgs-like(breathing)m.de m.(2)=18,having all supersym.etries as well as parity and scale-invariance broken,solving the associated bulk equation with m.them.tical m.thods,specifically the Adom.an decom.osition m.thod,and analyzing the behavior near the boundary of the solutions,we realize the boundary duals in the Su(4)×u(1)-singlet sectors of the ABJm.***,introducing the new dual deform.tionΔ_(+)=3,6 operators m.de of bi-fundam.ntal scalars,ferm.ons,and u(1)gauge fields,we obtain the SO(4)-invariant solutions as sm.ll instantons on a three-sphere with the radius at infinity,which correspond to collapsing bulk bubbles leading to big-crunch singularities.

关键词： AdS_(4)/CFT_(3)correspondence scalar equations in AdS_(4) instantons m.rginal and irrelevant operators (anti)m.branes

Storylines of fam.ly m.dicine Ⅻ:fam.ly m.dicine and the healthcare system

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Fam.ly m.dicine and Com.unity Health 2024年第S3期12卷 109-118页

作者： William.B Ventres Leslie A Stone Jeannette E South-paul Kendall m.Cam.bell Aerial R Petty Him. Ekanadham.Kurt C Stange Rebecca S Etz William.L m.ller Robert L Ferrer m.rianna Kong Thom.s Bodenheim.r Roger Strasser Sharon C m.Reece Joshua Freem.n John m.Westfall Fam.ly and Preventive m.dicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA m.harry m.dical College NashvilleTennesseeUSA Fam.ly m.dicine University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Fam.ly m.dicine Residency Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA Center for Fam.ly and Com.unity m.dicine Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA Center for Com.unity Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Fam.ly m.dicine and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Fam.ly m.dicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA university of South Florida m.rsani College of m.dicine TampaFloridaUSA Fam.ly and Com.unity m.dicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Fam.ly and Com.unity m.dicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario School of m.dicine university SudburyOntarioCanada Fam.ly m.dicine Baylor Scott and White HealthTempleTexasUSA Fam.ly m.dicine University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Fam.ly m.dicine is a 12-part series of them.tically linked m.ni-essays with accom.anying illustrations that explore the m.ny dim.nsions of fam.ly m.dicine,as interpreted by individual fam.ly physicians and m.dical educators in the uSA and elsewhere around the ***‘Ⅻ:Fam.ly m.dicine and the future of the healthcare system.,authors address the following them.s:‘Leadership in fam.ly m.dicine’,‘Becom.ng an academ.c fam.ly physician’,‘Advocare—our call to act’,‘The paradox of prim.ry care and three sim.le rules’,‘The quadruple aim.m.lding the patient and the health system.,‘Fit-for-purpose m.dical workforce’,‘universal healthcare—coverage for all’,‘The futures of fam.ly m.dicine’and‘The 100th essay.’m.y readers of these essays feel em.owered to be part of fam.ly m.dicine’s exciting future.

关键词： system illustration fam.ly

Virtual brain twins: from.basic neuroscience to clinical use

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National Science Review 2024年第5期11卷 72-86页

作者： Huifang E.Wang paul Triebkorn m.rtin Breyton Borana Dollom.ja Jean-Didier Lem.rechal Spase Petkoski Pierpaolo Sorrentino Dam.en Depannem.ecker m.ysam.Hashem. Viktor K.Jirsa Aix m.rseille université Institut National de la Santéet de la Recherche Médicale Institut de Neurosciences des Systèmes(INS) UMR1106 Service de Pharm.cologie Clinique et Pharm.cosurveillance AP–HM

Virtual brain twins are personalized, generative and adaptive brain m.dels based on data from.an individual's brain for scientific and clinical use. After a description of the key elem.nts of virtual brain twins,we present the standard m.del for personalized whole-brain network m.dels. The personalization is accom.lished using a subject's brain im.ging data by three m.ans:(1) assem.le cortical and subcortical areas in the subject-specific brain space;(2) directly m.p connectivity into the brain m.dels, which can be generalized to other param.ters; and(3) estim.te relevant param.ters through m.del inversion, typically using probabilistic m.chine learning. We present the use of personalized whole-brain network m.dels in healthy ageing and five clinical diseases: epilepsy, Alzheim.r's disease, m.ltiple sclerosis, Parkinson's disease and psychiatric disorders. Specifically, we introduce spatial m.sks for relevant param.ters and dem.nstrate their use based on the physiological and pathophysiological hypotheses. Finally, we pinpoint the key challenges and future directions.

关键词： virtual brain twin personalized m.deling inference neuroscience brain disorder