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Regulation of nonsense-mediated mRNA decay in neural development and disease

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Journal of Molecular Cell Biology 2021年第4期13卷 269-281页

作者： paul Jongseo lee Suzhou Yang Yu Sun Junjie U.Guo Department of Neuroscience Yale University School of MedicineNew HavenCT 06520USA Interdepartmental Neuroscience Program Yale UniversityNew HavenCT 06520USA

Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential deleterious *** them,nonsense-mediated mRNA decay(NMD)functions not only as a quality control mechanism targeting aberrant mRNAs containing a premature termination codon but also as a posttranscriptional gene regulation mechanism tar-geting numerous physiological *** its well-characterized molecular basis,the regulatory scope and biological functions of NMD at an organismal level are incompletely *** humans,mutations in genes encoding core NMD factors cause specific developmental and neurological syndromes,suggesting a critical role of NMD in the central nervous ***,we review the accumulating biochemical and genetic evidence on the developmental regulation and physiological functions of NMD as well as an emerging role of NMD dysregulation in neurodegenerative diseases.

关键词： RNA metabolism nonsense-mediated mRNA decay neurodegeneration neurodevelopment amyotrophic lateral sclerosis frontal temporal dementia mRNA translation

Complex Inpatient Pain Management in a Critically Ill Lung Transplant Recipient: A Case Report

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Case Reports in Clinical Medicine 2019年第6期8卷 157-163页

作者： Tina Vajdi paul lee Mary Alice Vijjeswarapu Cedars-Sinai Medical Center Department of Anesthesiology Los Angeles CA USA

Thoracic surgery is known to cause severe pain that may not subside during the course of hospitalization. Early pain control is important in these patients because it improves ventilation and promotes mobility. Lung transplant recipients can experience post-operative complications that lead to extended hospital stays. This increases the time a patient is sedentary, which further deconditions patients;therefore, rehabilitation should be initiated early post-operatively. We present a unique case of a critically ill double lung transplant recipient whose rehabilitation post-operatively was hindered by severe vasopressor-induced ischemic pain. Due to debilitating pain, he was unable to regain mobility. His pain management course was challenging due to sensitivity to opioids, renal failure, and anticoagulation.

关键词： Pain Management Regional Anesthesia Lung Transplant Ischemic Pain

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高重复率紧凑型等离子体软X射线源

高电压技术 2002年第B12期28卷 32-34页

作者：张贵新罗承沐王新新 Sing lee paul lee M.H.Liu 清华大学电机工程与应用电子技术系北京100084 南洋理工大学等离子体实验室新加坡259756

我们研制了一套以微电子光刻为应用背景的紧凑型高重复率、高性能、工作气体为氖气的等离子焦点装置(NX2 )做为软 X射线源。其储能电容由四组电容器组成。每一组又包括 12个并联的 0 .6 μF电容器 ,共用一个轨道式开关。充电电压为 11.5... 详细信息

我们研制了一套以微电子光刻为应用背景的紧凑型高重复率、高性能、工作气体为氖气的等离子焦点装置(NX2 )做为软 X射线源。其储能电容由四组电容器组成。每一组又包括 12个并联的 0 .6 μF电容器 ,共用一个轨道式开关。充电电压为 11.5 k V时 ,其峰值电流可达 4 0 0 k A。该装置中采用水冷式电极与真空室设计 ,以 16 Hz重复率连续运行几分钟产生 30 0 W的软 X射线。初步的光刻实验结果表明连续放电 30 0次便可取得足够软

关键词：高重复率紧凑型等离子体软X射线源光刻等离子体焦点微电子

Evaluating the degree of oxygenation of organic aerosols during foggy and hazy days in Hong Kong using high-resolution time-of-flight aerosol mass spectrometry(HR-ToF-AMS)

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Evaluating the degree of oxygenation of organic aerosols dur...

聚焦更宽的禁带!下一代电源系统设计中的新型宽禁带技术

十一届全国气溶胶会议暨第十届海峡两岸气溶胶技术研讨会

作者： Yongjie Li Berto paul Yok Long lee Chak K.Chan Division of Environment Hong Kong University of Science and Technology Department of Chemical and Biomolecular Engineering Hong Kong University of Science and Technology

The role of aqueous-phase chemistry in the formation of secondary organic aerosols(SOA) is still poorly constrained. Here we present observation results of the degree of oxygenation of organic aerosols(OA) based on high-resolution time-of-flight aerosol mass spectrometer(HR-To F-AMS) measurements made at a coastal site in Hong Kong from late April to the end of May, 2011 for 37 days. Two foggy periods and one hazy period were chosen for detailed analysis to compare the changes in degree of oxygenation of OA due to different processes. The Extended Aerosol Inorganic Model(E-AIM) predicted fine particle liquid water content(LWC fp) was up to 85 μg/m3 during the foggy days. Particle concentration as measured by the HR-To F-AMS was up to 60 μg/m3 during the hazy days. The degree of oxygenation of OA, as indicated by several parameters including fraction of m/z 44 in organic mass spectra(f44), oxygen to carbon elemental ratio(O:C), and carbon oxidation state was evaluated against odd oxygen(O x) concentration, LWC fp, ionic strength(IS), and in-situ p H(p H is). Results suggested that for the hazy period, the high concentration of OA(on average 11 μg/m3) and the high degree of oxygenation were mainly due to gas-phase oxidation. During the foggy periods with low photochemical activities, the degree of oxygenation of OA was almost as high as that in the hazy days and significantly higher than that during non-fog/non-haze days. However, the evolution of OA behaved quite differently in these two foggy periods. The first foggy period in late April and early May had larger LWC fp and lower O x concentration and the OA had more semi-volatile oxygenated organic aerosols(SVOOA) as resolved by positive matrix factorization(PMF). The second foggy period in mid-May had higher O x concentration and lower LWC fp, and produced more low-volatility oxygenated organic aerosols(LVOOA). Examination into the particle-phase constituents suggests that partitioning may be the dominating process

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中国集成电路 2021年第3期30卷 18-20,89页

作者： paul lee 贸泽电子

1当务之急:尽可能降低发热量根据国际能源署的数据,全球电能需求目前处于惊人的水平,预测到2020年将达到近30拍瓦。对于我们这些认为几千瓦的烤面包机就属高功率的普通人来说,这几乎是一个无法想像的数字。主要受亚洲经济体的驱动,这个... 详细信息

1当务之急:尽可能降低发热量根据国际能源署的数据,全球电能需求目前处于惊人的水平,预测到2020年将达到近30拍瓦。对于我们这些认为几千瓦的烤面包机就属高功率的普通人来说,这几乎是一个无法想像的数字。主要受亚洲经济体的驱动,这个数字一定还会增加,当然,现在有一项关注重点是通过可再生能源满足这种需求,以便缓解气候变化影响。截留太阳辐射、风能和其他绿色能源,在其转化为热量前提取电力,这样的方法应该没有净增温效应,但是化石燃料仍然是主要的能源,它们会释放出本来会被“锁定”的热量。因此,在从原矿到有用功的转换过程中,效率非常关键,较高的效率可以避免过多的能量损失到环境中,同时也节约了成本。

关键词：国际能源署可再生能源烤面包机绿色能源气候变化影响化石燃料增温效应电能需求

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采用宽带隙半导体为下一代系统供电

世界电子元器件 2021年第3期 14-16页

作者： paul lee 不详

降低能量损耗预计到2020年,全球电能需求将达到30拍瓦(petawatts)峰值[1],而在那之后还会进一步增加。电能来源可能是化石燃料或可再生能源,但无论如何,功率转换设备效率对于最大程度地降低成本和电能损耗至关重要。工业马达消耗了全球... 详细信息

降低能量损耗预计到2020年,全球电能需求将达到30拍瓦(petawatts)峰值[1],而在那之后还会进一步增加。电能来源可能是化石燃料或可再生能源,但无论如何,功率转换设备效率对于最大程度地降低成本和电能损耗至关重要。工业马达消耗了全球50%以上能源,但是数据中心也非常耗电,而电动汽车(EV)充电正在快速增大负荷。所有这些以及许多其他应用都已经促使开发"更智能"且耗电更少的创新技术,但是相关电源转换器件也须跟上步伐,其损耗需要越来越低。在本文中,我们将回顾能够实现这一目标的宽带隙半导体技术。

关键词：宽带隙半导体电能损耗能量损耗电源转换器可再生能源系统供电功率转换数据中心

内皮素-1促进猪冠状动脉再生内皮释放内皮衍生内过氧化物和血栓素A2（英文）

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Acta Pharmacologica Sinica 1999年第10期 10-16页

作者： Seung-Jung PARK,John J lee,paul M VANHOUTTE Center for Experimental Therapeutics Department of Medicine Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA Center for Experimental Therapeutics Department of Medicine Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA Center for Experimental Therapeutics Department of Medicine Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA

AIM: To determine the role of endothelium-derivedcontracting factor (EDCF) in the response toendothelin-1 in arteries with regenerated ***: Rings of porcine coronary arteries, withand without endothelium of previously deendothelializedleft anterior descending coronary arteries and native leftcircumflex coronary arteries, were suspended inconventional organ chambers for the measurement ofisometric force. RESULTS: In quiescent rings of thepreviously deendothelialized left anterior descending

关键词：冠状血管内皮素-1 吲哚美辛前列腺素内过氧化物合酶一氧化氮血栓素A2 血管内皮