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Abnormally activated wingless/integrated signaling modulates tumor-associated macrophage polarization and potentially promotes hepatocarcinoma cell growth

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World Journal of Gastroenterology 2024年第41期30卷 4490-4495页

作者： Wei-Lu Wang paul kwong hang tam Yan Chen School of Pharmacy Faculty of MedicineMacao University of Science and TechnologyMacao 999078China

In this article,we comment on the article by Huang et *** urgent development of new therapeutic strategies targeting macrophage polarization is critical in the fight against liver ***-associated macrophages(tams),primarily of the M2 subtype,are instrumental in cellular communication within the tumor microenvironment and are influenced by various signaling pathways,including the wingless/integrated(Wnt)*** of the Wnt signaling pathway is pivotal in promoting M2 tams polarization,which in turn can exacerbate hepatocarcinoma cell proliferation and *** manuscript emphasizes the burgeoning significance of the Wnt signaling pathway and M2 tams polarization in the pathogenesis and progression of liver cancer,highlighting the potential therapeutic benefits of inhibiting the Wnt ***,we point out areas in Huang et al’s study that require further research,providing guidance and new directions for similar studies.

关键词： Liver cancer Hepatocarcinoma cell Wingless/integrated signaling pathway M2 tumor-associated macrophages Polarization

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Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype

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World Journal of Gastroenterology 2015年第7期21卷 2040-2046页

作者： William Wai-Chun Cheng Clara Sze-Man Tang Hong-Sheng Gui Man-Ting So Vincent Chi-hang Lui paul kwong-hang tam Maria-Mercè Garcia-Barcelo Department of Surgery Li Ka Shing Faculty of Medicine the University of Hong Kong Department of Psychiatry Li Ka Shing Faculty of Medicine the University of Hong Kong Center for Genomic Sciences of the Li Ka Shing Faculty of Medicine the University of Hong Kong Centre for Reproduction Development and Growth Li Ka Shing Faculty of Medicine the University of Hong Kong

AIM:To investigate the role of IKBKAP(inhibitor of kappa light polypeptide gene enhancer in B-cells,kinase complexassociated protein)in the development of enteric nervous system(ENS)and Hirschsprung disease(HSCR).METHODS:In this study,we injected a morpholino that blocked the translation of ikbkap protein to 1-cell stage zebrafish *** phenotype in the ENS was analysed by antibody staining of the pan-neuronal marker Hu C/D followed by enteric neuron *** mean numbers of enteric neurons were compared between the morphant and the *** also studied the expressions of ret and phox2bb,which are involved in ENS development,in the ikbkap morpholino injected embryos by quantitative reverse transcriptase polymerase chain reaction and compared them with the ***:We observed aganglionosis(χ2,P<0.01)and a reduced number of enteric neurons(38.8±9.9 vs50.2±17.3,P<0.05)in the zebrafish embryos injected with ikbkap translation-blocking morpholino(morphant)when compared with the control *** of the morpholino was confirmed by similar results obtained using a second non-overlapping morpholino that blocked the translation of *** further studied the morphant by analysing the expression levels of genes involved in ENS development such as ret,phox2bb and sox10,and found that phox2bb,the ortholog of human PHOX2B,was significantly down-regulated(0.51±0.15 vs 1.00±0,P<0.05).Although we also observed a reduction in theexpression of ret,the difference was not ***:Loss of IKBKAP contributed to HSCR as demonstrated by functional analysis in zebrafish embryos.

关键词： Hirschsprung disease Enteric nervous system IKBKAP

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