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R绘图系统

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作者： (新西兰)保罗·莫雷尔(paul Murrell)

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不同大小钛颗粒对骨髓间充质干细胞粘附能力的影响

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中国综合临床 2006年第6期22卷 521-523页

作者：吴江陈槐卿李良 K-L paul SUNG 尹光福四川大学华西医学中心生物医学工程研究室 Departments of Bioengineering and Orthopaedics University of CaliforniaSan DiegoLa JollaCA92093USA 四川大学材料科学与工程学院

目的研究磨屑钛颗粒对骨髓间充质干细胞(BMSCs)粘附能力影响的可能细胞分子机制。方法选用经体外传代纯化培养后的大鼠骨髓间充质干细胞(rBMSCs),与不同直径大小的钛颗粒悬液共孵育,再采用精准的流室系统对钛颗粒负荷的rBMSCs施加一定... 详细信息

目的研究磨屑钛颗粒对骨髓间充质干细胞(BMSCs)粘附能力影响的可能细胞分子机制。方法选用经体外传代纯化培养后的大鼠骨髓间充质干细胞(rBMSCs),与不同直径大小的钛颗粒悬液共孵育,再采用精准的流室系统对钛颗粒负荷的rBMSCs施加一定的流体剪切应力(FSS)后立刻固定细胞,经免疫荧光抗体染色,结合流式细胞术定量分析rBMSCs表面粘附分子表达的变化情况。同时设置相应的未经钛颗粒孵育的rBMSCs细胞为对照组细胞。结果剪切应力可明显上调rBMSCs表面粘附分子的表达。不同直径大小的钛颗粒可不同程度地抑制rBMSCs的粘附能力,颗粒越小,抑制作用越明显。结论磨屑颗粒所引起的BMSCs细胞流变学异常是人工关节无菌性松动发生的可能机制。

关键词：人工关节无菌性松动钛颗粒骨髓间充质干细胞流体剪切应力

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犟妹子

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作者： (德)保尔·海泽(paul Heyes)

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Mental health and quality of life burden in Buruli ulcer disease patients in Ghana

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Infectious Diseases of Poverty 2021年第4期10卷 93-94页

作者： Yaw Ampem Amoako Nancy Ackam John-paul Omuojine Michael Ntiamoah Oppong Abena Gyawu Owusu-Ansah Harriet Boateng Mohammed Kabiru Abass George Amofa Elizabeth Ofori Portia Boakye Okyere Michael Frimpong Freddie Bailey David Hurst Molyneux Richard Odame Phillips Kumasi Centre for Collaborative Research in Tropical Medicine Kwame Nkrumah University of Science and TechnologyKumasiGhana 不详

Background Buruli ulcer disease(BUD)is a necrotic skin neglected tropical disease(NTD)that has both a mental and physical health impact on affected *** there is increasing evidence suggesting a strong association between neglected tropical diseases(NTDs)and mental illness,there is a relative lack of information on BUD’s impact on the mental health and quality of life(QoL)of affected individuals in *** study is to assess the impact of BUD on mental health and quality of life of patients with active and past BUD infection,and their *** We conducted a case control study in 3 BUD endemic districts in Ghana between August and November ***-to-face structured questionnaire-based interviews were conducted on BUD patients with active and past infection,as well as caregivers of BUD patients using WHO Quality of Life scale,WHO Disability Assessment Schedule,Self-Reporting Questionnaire,Buruli Ulcer Functional Limitation Score and Hospital Anxiety and Depression Scale data *** statistics were used to summarize the characteristics of the study *** groups were compared using student t test and chi-square(χ2)or Fisher’s exact *** quality of life scores are reported with their respective 95%confidence *** was analysed using STATA statistical *** Our results show that BUD patients with active and past infection,along with their caregivers,face significant levels of distress and mental health sequelae compared to ***(P=0.003)was more common in participants with active(27%)and past BU infection(17%),compared to controls(0%).Anxiety was found in 42%(11/26)and 20%(6/29)of participants with active and past BUD infection compared to 14%(5/36)of *** of life was also significantly diminished in active BUD infection,compared to *** the physical health domain,mean QoL scores were 54±11.1 and 56±11.0(95%CI:49.5‒58.5 and 52.2‒59.7)respectively for p

关键词： Mental health Depression Anxiety Quality of life Buruli ulcer disease Neglected tropical disease

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大地蓝得像一只橙子

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作者： (法)保罗·艾吕雅(paul Eluard)

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Social apoptosis in honey bee superorganisms

Social apoptosis in honey bee superorganisms

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二十一世纪第二届全国蜂业科技与蜂产业发展大会

作者：蔺哲广 paul Page Ninat Buawangpong Huoqing Zheng Fuliang Hu Peter Neumann Panuwan Chantawannakul Vincent Dietemann College of Animal Sciences Zhejiang University Institute of Bee Health Vetsuisse FacultyUniversity of Bern Social Insect Research Group Department of Zoology and EntomologyUniversity of Pretoria

蜜蜂作为一种典型的真社会性昆虫可以被视作超级生物体,蜂群内世代层叠、协同合作的个体组成了一个功能上类似于多细胞生物的有机体,这种协作配合可通过社会性免疫机制限制群体内致病原的传播。然而,当蜂群面对一种新兴的疾病时,已有的... 详细信息

蜜蜂作为一种典型的真社会性昆虫可以被视作超级生物体,蜂群内世代层叠、协同合作的个体组成了一个功能上类似于多细胞生物的有机体,这种协作配合可通过社会性免疫机制限制群体内致病原的传播。然而,当蜂群面对一种新兴的疾病时,已有的社会性免疫便突显出不足,如蜜蜂的体外寄生虫狄斯瓦螨Varroa destructor,从其原始寄主东方蜜蜂Apis cerana迁移至西方蜜蜂Apis mellifera,目前已成为全球养蜂业的最大威胁。本研究首次揭示了发育中的东方蜜蜂工蜂幼虫较西方蜜蜂更为脆弱、敏感的生理特性致使其在被狄斯瓦螨寄生后更易死亡,从而有效限制了瓦螨的繁殖与传播。这种通过牺牲部分患病个体以避免疾病在群体中传播,从而保全整体健康的现象很可能是群居生物抵抗疾病的一种基本防御策略。社会性昆虫跨世代（transgenerational）群体免疫的新机制——类细胞凋亡免疫的提出,增进了当前对社会性昆虫生物学的了解,提升了对狄斯瓦螨与其原始寄主间互作关系的认识,且具有颇高的蜂群抗病育种的应用价值。

关键词：真社会性昆虫社会性免疫东方蜜蜂西方蜜蜂狄斯瓦螨

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Staphylococcal thoracic aortitis complicated by aortic dissection

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World Journal of Emergency Medicine 2013年第2期4卷 154-156页

作者： paul Chun Yih Lim Jean Mui Hua Lee Yeow Leng Chua Stanley Chia1 National Heart Centre Singapore Mistri Wing168752Singapore Department of Emergency Medicine Singapore General Hospital169608Singapore

BACKGROUND:The diagnosis of aortitis is often delayed as symptoms are largely *** report a case of Staphylococcal thoracic aortitis in a 73-year-old Chinese woman complicated by aortic ***:The patient presented with pyrexia of unknown origin,and a contrast enhanced computed tomography aortogram revealed a large thrombus at the anterior aspect of the ascending aorta with two large ulcerations as a result of a chronic type A aortic dissection.A hemiarch replacement with a 28 mm Gleweave Vascutek graft was performed with resuspension of aortic valve *** thrombus cultures were positive for coagulase negative Staphylococcus aureaus,and histology showed chronic dissection of the ***:The patient was treated with intravenous cefazolin for a 6-week duration and made good ***:This case highlights Staphylococcal infective aortitis complicated by dissection presenting as fever of unknown *** diagnosis is essential as progression to catastrophic rupture may occur.

关键词： Aneurysm Aortic diseases Endovascular stent Infected/microbiology Stapha/ococcus aureus

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Maize Carbohydrate Partitioning Defective33 Encodes an MCTP Protein and Functions in Sucrose Export from Leaves

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Molecular Plant 2019年第9期12卷 1278-1293页

作者： Thu M.Tran Tyler J.McCubbin Saadia Bihmidine Benjamin T.Julius R.Frank Baker Martin Schauflinger Clifford Weil Nathan Springer paul Chomet Ruth Wagner Jeff Woessner Karen Grote Jeanette Peevers Thomas L.Slewinski David M.Braun Division of Biological Sciences’Interdisciplinary Plant Group Missouri Maize CenterUniversity of MissouriColumbiaMO 65211USA Division of Plant Sciences University of MissouriColumbiaMO 65211USA Electron Microscopy Core Facility University of MissouriColumbiaMO 65211USA Department of Agronomy Purdue UniversityWest LafayetteIN 47907USA Department of Plant and Microbial Biology University of MinnesotaSaint PaulMN 55108USA NRGene Inc. 8910 University Center Lane\r\n S u ite 400San DiegoCA 92122USA Bayer Crop Science ChesterfieldMO 63017USA National Key Laboratory for Plant Cell Technology Agricultural Genetics InstituteHanoiVietnam

To sustain plant growth,development,and crop yield,sucrose must be transported from leaves to distant parts of the plant,such as seeds and *** identify genes that regulate sucrose accumulation and transport in maize(Zea mays),we isolated carbo/iydrafe part/f/ofi/ngf defecf/Ve33(cpd33),a recessive mutant that accumulated excess starch and soluble sugars in mature *** cpd33 mutants also exhibited chlorosis in the leaf blades,greatly diminished plant growth,and reduced ***33 encodes a protein containing multiple C2 domains and transmembrane *** localization experiments showed the CPD33 protein localized to plasmodesmata(PD),the plasma membrane,and the endoplasmic *** also found that a loss-of-function mutant of the CPD33 homolog in Arabidopsis,QUIRKY,had a similar carbohydrate hyperaccumulation *** labeled sucrose transport assays showed that sucrose export was significantly lower in cpd33 mutant leaves relative to wild-type ***,PD transport in the adaxial-abaxial direction was unaffected in cpd33 mutant ***,transmission electron microscopy revealed fewer PD at the companion cell-sieve element interface in mutant phloem tissue,providing a possible explanation for the reduced sucrose export in mutant ***,our results suggest that CPD33 functions to promote symplastic transport into sieve elements.

关键词： carbohydrate accumulation companion cells phloem, plasmodesmata sieve elements symplastictransport

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Glut3 promotes cellular O-GlcNAcylation as a distinctive tumorsupportive feature in Treg cells

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Cellular & Molecular Immunology 2024年第12期21卷 1474-1490页

作者： Amit Sharma Garima Sharma Zhen Gao Ke Li Mutong Li Menglin Wu Chan Johng Kim Yingjia Chen Anupam Gautam Hong Bae Choi Jin Kim Jung-Myun Kwak Sin Man Lam Guanghou Shui Sandip paul Yongqiang Feng Keunsoo Kang Sin-Hyeog Im Dipayan Rudra Department of Life Sciences Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea Innovation Research Center for Biofuture Technology(B-IRC) Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea ImmmunoBiome Inc Pohang37673Republic of Korea School of Life Science&Technology ShanghaiTech UniversityShanghai201210China Department of Biochemistry University of WashingtonSeattleWA98195USA Department of Immunology St.Jude Children’s Research HospitalMemphisTN38105USA Institute for Bioinformatics and Medical Informatics University of TübingenSand 14Tübingen72076Germany International Max Planck Research School“From Molecules to Organisms” Max Planck Institute for Biology TübingenMax-Planck-Ring 5Tübingen72076Germany Daehang Hospital Seoul06699Republic of Korea Department of Surgery Korea University College of MedicineSeoul02841Republic of Korea State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing100101China Lipidall Technologies Company Limited Changzhou213022Jiangsu ProvinceChina University of Chinese Academy of Sciences Beijing100101China Center for Health Science and Technology JIS Institute of Advanced Studies and ResearchJIS UniversityKolkata700091India Department of Microbiology College of Natural SciencesDankook UniversityCheonan31116Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul03722Republic of Korea

Regulatory T cells(Tregs)establish dominant immune tolerance but obstruct tumor immune surveillance,warranting context-specific mechanistic insights into the functions of tumor-infiltrating Tregs(TIL-Tregs).We show that enhanced posttranslational O-linked N-acetylglucosamine modification(O-GlcNAcylation)of cellular factors is a molecular feature that promotes a tumor-specific gene expression signature and distinguishes TIL-Tregs from their systemic *** found that altered glucose utilization through the glucose transporter Glut3 is a major facilitator of this ***-specific deletion of Glut3 abrogates tumor immune tolerance,while steady-state immune homeostasis remains largely unaffected in ***,by employing mouse tumor models and human clinical data,we identified the NF-κB subunit c-Rel as one such factor that,through Glut3-dependent O-GlcNAcylation,functionally orchestrates gene expression in Tregs at tumor ***,these results not only identify immunometabolic alterations and molecular events contributing to fundamental aspects of Treg biology,specifically at tumor sites but also reveal tumor-specific cellular properties that can aid in the development of Treg-targeted cancer immunotherapies.

关键词： Regulatory T cells Treg Glut3 O-GlcNAcylation Treg metabolism

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海藻β-1,3葡聚糖对南美白对虾(Litopenaeus vannamei)生长性能及体成分的影响

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饲料工业 2014年第24期35卷 12-15页

作者：张志勇程宗佳柏世军姜思然 paul Horst 林黑着中粮营养健康研究院有限公司动物营养与饲料中心北京102209 美国ALGAL SCIENTIFIC公司密西根州48170 中国水产科学研究院南海水产研究所广东省渔业生态环境重点实验室广东广州510300

试验旨在观察海藻β-1,3葡聚糖对南美白对虾(Litopenaeus vannamei)生长性能、存活率及体成分的影响。选用初始体重(10.84±0.30)g的南美白对虾450尾,随机分为5个处理组,每组设3个重复,每个重复30尾虾,分别饲喂含海藻β-1,3葡聚糖为0、0... 详细信息

试验旨在观察海藻β-1,3葡聚糖对南美白对虾(Litopenaeus vannamei)生长性能、存活率及体成分的影响。选用初始体重(10.84±0.30)g的南美白对虾450尾,随机分为5个处理组,每组设3个重复,每个重复30尾虾,分别饲喂含海藻β-1,3葡聚糖为0、0.05%、0.10%、0.15%及0.20%的饲料,并命名为S-0.00%、S-0.05%、S-0.10%、S-0.15%和S-0.20%;饲养周期为60 d。结果显示,在0~32 d阶段,海藻β-1,3葡聚糖对南美白对虾的生长性能均无显著差异(P>0.05);但随着添加水平的上升,其成活率呈显著降低的趋势(P0.05);但0~60 d S-0.05%处理组的末均重、特定生长率及相对增重率均高于其它各组,且饲料系数低于其它处理组。各个处理组的对虾体成分中脂肪和灰分的含量均无显著性差异(P>0.05);但水分和蛋白含量差异明显,随着海藻β-1,3葡聚糖添加水平上升,水分呈现先下降再上升的趋势,但蛋白含量恰好相反,呈现先上升再下降的趋势。结果表明,以特定生长率及饲料系数作为评价指标,饲料中添加低水平(≤0.05%)的海藻β-1,3葡聚糖对南美白对虾有益,并可提高其体成分中蛋白含量。

关键词：海藻β-1,3葡聚糖南美白对虾生长性能体成分

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