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Hypoxic and temporal variation in the endocrine disrupting toxicity of perfluorobutanesulfonate in marine medaka(Oryzias melastigma)

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Journal of Environmental sciences 2024年第2期136卷 279-291页

作者： Baili sun Jing Li Yachen Bai Xiangzhen Zhou paul k.s.lam Lianguo Chen state key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of sciences Beijing 100049China Office of the President Hong Kong Metropolitan University30 Good Shepherd StreetKowloonHong Kong SARChina

Perfluorobutanesulfonate(PFBs)is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine systems of ***,the hypoxic and temporal variation in PFBs endocrine disrupting toxicity remain largely *** the present study,adult marine medaka were exposed to environmentally realistic concentrations of PFBs(0 and 10μg/L)under normoxia or hypoxia conditions for 7 days,aiming to explore the interactive behavior between PFBs and *** addition,PFBs singular exposure was extended till 21days under normoxia to elucidate the time-course progression in PFBs *** results showed that hypoxia inhibited the growth and caused the suspension of egg spawn regardless of PFBs *** regard to the sex endocrine system,7-day PFBs exposure led to an acute stimulation of transcriptional profiles in females,which,subsequently,recovered after the 21-day *** potency of hypoxia to disturb the sex hormones was much stronger than PFBs.A remarkable increase in estradiol concentration was noted in medaka blood after hypoxia *** in sex endocrinology of coexposed fish were largely determined by hypoxia,which drove the formation of an estrogenic *** further enhanced the endocrine disrupting effects of ***,the hepatic synthesis of vitellogenin and choriogenin,two commonly used sensitive biomarkers of estrogenic activity,failed to initiate in response to the estrogen *** to sex endocrine system,disturbances in thyroidal axis by PFBs or hypoxia were relatively ***,the present findings will advance our toxicological understanding about PFBs pollutant under the interference of hypoxia.

关键词： Perfluorobutanesulfonate(PFBs) Aquatic hypoxia Temporal toxicity Combined exposure Endocrine disruption Marine medaka

Occurrence and fate of endogenous steroid hormones,alkylphenol ethoxylates, bisphenol A and phthalates in municipal sewage treatment systems

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Journal of Environmental sciences 2017年第11期29卷 49-58页

作者： Qian Wu James C.W.lam karen Y.kwok Mirabelle M.P.Tsui paul k.s.lam state key Laboratory in Marine Pollution (skLMP) Department of Biology and Chemistry Research Centre for the Oceans and Human Health Shenzhen Key Laboratory for Sustainable Use of Marine Biodiversity City University of Hong Kong Department of science and Environmental studies The Education University of Hong of Kong

steroid hormones, alkylphenol ethoxylates（APEOs） and phthalic acid esters（PAEs） are emerging endocrine disrupting chemicals（EDCs） that can interfere with the endocrine function in organisms at low concentrations. The occurrence, distribution behavior, removal rate and the fate of 31 target EDCs in sewage treatment plants, which consist of various treatment facilities and receiving water in Hong kong, were investigated. Estrone,nonylphenol-di-ethoxylate and diethyl phthalate were found to be dominant in each group of influent samples with concentrations ranging from 11–33, 747–3945 and 445–4635 ng/L,respectively. Conversely, progesterone, nonylphenol-mono-ethoxylate and bis（2-ethylhexyl）phthalate were the most abundant in dewatered sludge, with concentrations ranging from 0.9–237, 75–19,743 and 4310–37,016 ng/g（dry weight）. The removal rates of primary sedimentation and disinfection approaches were lower than 30% for most of the chemicals,while those of activated sludge and reverse osmosis were greater than 80% for more than two-thirds of the compounds, noticeably decreasing the estrogenic risk of sewage discharged into the environment. steroid hormones were removed via biological degradation, while some APEOs and PAEs adsorbed to the sludge. Victoria Harbor poses a low to medium estrogenic risk mainly contributed by estrone and estradiol and deserves attention.

关键词： Endocrine disruptor steroid hormone Alkylphenol ethoxylate Phthalic acid ester Risk assessment

A Rhizobium bacterium and its population dynamics under different culture conditions of its associated toxic dinoflagellate Gambierdiscus balechii

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Marine Life science & Technology 2021年第4期3卷 542-551页

作者： Zhen Wu Xiaohong Yang senjie Lin Wai Hin Lee paul k.s.lam state key Laboratory of Marine Pollution City University of Hong KongHong KongChina Department of Chemistry City University of Hong KongHong KongChina state key Laboratory of Marine Environmental science Xiamen UniversityXiamen 361005China Department of Marine sciences University of ConnecticutGrotonCT 06340USA Department of Biomedical sciences City University of Hong KongHong KongChina shenzhen key Laboratory for the sustainable Use of Marine Biodiversity Research Centre for the Oceans and Human HealthCity University of Hong Kong Shenzhen Research InstituteShenzhen 518057China

Rhizobium bacteria are known as symbionts of legumes for developing nodules on plant roots and fixing N2 for the host plants but unknown for associations with ***,we detected,isolated,and characterized a Rhizobium species from the marine toxic dinoflagellate Gambierdiscus *** 16s rRNA gene(rDNA)is 99%identical to that of Rhizobium rosettiformans,and the affiliation is supported by the phylogenetic placement of its cell wall hydrolase-encoding gene(cwh).Using quantitative PCR of 16s rDNA and cwh,we found that the abundance of this bacterium increased during the late exponential growth phase of Gambierdiscus and under nitrogen limitation,suggesting potential physiological interactions between the dinoflagellate and the *** is the first report of dinoflagellate-associated Rhizobium bacterium,and its prevalence and ecological roles in dinoflagellate-Rhizobium relationships remain to be investigated in the future.

关键词： Rhizobium Gambierdiscus 16s rRNA gene Cell wall hydrola Edited by Chengchao Chen

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水中林丹的固相微萃取与气相色谱耦合研究

南京大学学报（自然科学版） 2007年第4期43卷 345-350页

作者：余益军沈敏刘颖韦斯林汉华林群声孙成于红霞污染控制与资源化研究国家重点实验室南京大学环境学院南京210093 香港城市大学生物与化学系中国香港

介绍了一种改进的固相微萃取技术（sPME）、气相色谱-电子捕获检测器（GCLECD）联用测定水中林丹的新方法.该法将萃取了林丹的PDMs纤维用少量有机溶剂解吸,解吸后的有机溶剂进入气相色谱检测,从而实现固相微萃取与自动进样器的耦合.通... 详细信息

介绍了一种改进的固相微萃取技术（sPME）、气相色谱-电子捕获检测器（GCLECD）联用测定水中林丹的新方法.该法将萃取了林丹的PDMs纤维用少量有机溶剂解吸,解吸后的有机溶剂进入气相色谱检测,从而实现固相微萃取与自动进样器的耦合.通过评价吸附时间、解吸时间、温度、pH等条件对萃取效率的影响,确定如下实验条件：吸附时间120min、解吸时间60min、室温（25℃）.当林丹加标浓度为20ng/mL时,该法与GC-ECD耦合后的回收率为82%,检测限为21ng/L,相对标准偏差为0.8%,浓度—响应曲线在2.5-40ng/mL时呈线性（R2=0.993,N=5）.该法已应用到太湖水样中林丹的监测.

关键词：林丹固相微萃取 PDMs纤维

Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

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Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Hadley Osman paul Ashwood Department of Medical Microbiology and Immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

During pregnancy,maternal immune activation(MIA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(AsD)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 children are diagnosed with AsD by the age of 8 years,with AsD rates continuing to increase in prevalence in UsA(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of AsD is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(MAA),a form of MIA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition driven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus

Emerging insights into the function of very long chain fatty acids at cerebellar synapses

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Neural Regeneration Research 2025年第6期20卷 1709-1710页

作者： Martin-paul Agbaga Mohiuddin Ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-sFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-sFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-sFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

全氟辛烷磺酰基化合物(PFOs)的污染现状与研究趋势

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化学进展 2006年第6期18卷 808-813页

作者：郭睿蔡亚岐江桂斌 k s paul lam 中国科学院生态环境研究中心北京100085 香港城市大学生物化学系海洋污染和保护研究中心

全氟辛烷磺酰基化合物(PFOs,perfluorooctane sulfonate)所造成的污染已经逐渐成为全球性环境问题,发达国家非常重视PFOs等全氟化合物的研究,已经成为持久性有机污染物研究的又一个热点。本文对目前PFOs研究的现状、进展,以及存在的问... 详细信息

全氟辛烷磺酰基化合物(PFOs,perfluorooctane sulfonate)所造成的污染已经逐渐成为全球性环境问题,发达国家非常重视PFOs等全氟化合物的研究,已经成为持久性有机污染物研究的又一个热点。本文对目前PFOs研究的现状、进展,以及存在的问题做了简要回顾,并且对今后研究重点做了预测,希望对PFOs研究者提供参考。

关键词： PFOs 环境污染血清毒性

A review on human influenza A H5N1 infections in Hong kong

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science China(Life sciences) 2009年第5期52卷 412-418页

作者： CHAN paul k s Department of Microbiology The Chinese University of Hong Kong1/F Clinical Sciences BuildingPrince of Wales HospitalShatinNew TerritoriesHong Kong Special Administrative Region China

Avian influenza A H5N1 remains the most threatening virus that may cause another devastating pandemic in the foreseeable future. In 1997, Hong kong was the first place to detect human infections due to this virus originated from birds. The experience and lessons learnt provide important information for controlling further outbreaks caused by avian influenza viruses.

关键词： Avian influenza H5N1 Hong kong pandemic

功函促进钼基异质结电催化剂的电子结构重整提升其析氢反应活性（英文）

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science China Materials 2025年第1期 189-198页

作者：陈想冯帅谢松苗亚萍高标张旭明黄莉李筠 paul k.Chu 彭祥 Hubei key Laboratory of Plasma Chemistry and Advanced Materials Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education School of Materials Science and Engineering Wuhan Institute of Technology school of Textile science and Engineering Xi'an Polytechnic University The state key Laboratory of Refractories and Metallurgy Institute of Advanced Materials and Nanotechnology Wuhan University of Science and Technology Guizhou Wujiang Hydropower Development Co. Ltd. Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong

Mo基催化剂在电催化析氢反应（HER）中具有巨大应用潜力.然而,其活性位点的暴露不足、极强的氢吸附能力导致其催化性能未能充分体现.本文在碳布上构筑了Mo2N–Mose2异质结（MNs）,以增强Mo基催化剂的HER活性.由于MNs中的Mo2N具有较低的...

Mo基催化剂在电催化析氢反应（HER）中具有巨大应用潜力.然而,其活性位点的暴露不足、极强的氢吸附能力导致其催化性能未能充分体现.本文在碳布上构筑了Mo2N–Mose2异质结（MNs）,以增强Mo基催化剂的HER活性.由于MNs中的Mo2N具有较低的功函数,能够在异质界面产生内建电场,显著提高了其在HER中电荷转移效率.此外,MNs中原子之间的强电子相互作用优化了Mo位点的电子结构,降低了氢吸附能力,进一步增强了其本征催化活性.因此, MNs催化剂产生20 m A cm-2和1 A cm-2的析氢电流密度所需的过电位仅为65和210 mV, Tafel斜率仅为96 mV dec-1.此外, MNs在1 A cm-2电流密度下稳定运行240小时后,形貌、结构和性能均无明显变化.以上研究结果为工业大电流制氢所需的非贵金属基电催化剂的设计和合成提供了新思路.

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