检索结果-南通市图书馆

Gastric cancer in women: A regional health-center seven year retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第25期21卷 7805-7813页

作者： Kunal Suryawala Demiana Soliman Monica Mutyala Shaheen Nageeb Moheb Boktor Abhishek Seth Avinash Aravantagi Ankur Sheth James Morris paul jordan Kenneth Manas Urska Cvek Marjan Trutschl Felix Becker Jonathan Alexander Department of Gastroenterology and Hepatology Louisiana State University Health Sciences Center Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center Department of Computer Science LSU Shreveport and Center for Molecular and Tumor Virology Louisiana State University Health Sciences Center Department of General and Visceral Surgery University Hospital Muenster

AIM: To investigate whether regional geography influences ethnic and gender trends for the development of gastric cancer(GC).METHODS: This retrospective analysis of the INVISION patient database at Louisiana State University Health Sciences Center-Shreveport(LSUHSC-S), a southern United States regional hospital, was performed from 2005-2011. Using the international statistical classification of diseases 9(ICD-9), inpatient, day surgery outpatient, and emergency outpatient diagnosis codes entered into medical records were used to identify GC patients. For each study year, the patients were evaluated for age, ethnicity, and gender, and each patient was counted only once throughout the study. Subsequent patient encounters were counted as visits and separated by inpatient and clinic visits. Complex or severe disease may require more frequent and intensive clinical management; therefore, we evaluated annual clinic visits as "surrogate markers" of disease severity. Finally, we studied the primary diagnosis for Helicobacter pylori(H. pylori) infection(ICD-9 code 41.86) as an additional factor that might increase the risk of ***: A total of 285 patients were diagnosed with GC at LSUHSC-S between 2005 and 2011. African Americans(181 patients, 89 males and 92 females, 63.5% of total patients) had significantly higher frequencies of GC diagnosis compared with non-Hispanic whites(104 patients, 54 males and 50 females, 36.5% of total patients), at a ratio of 1.74(P = 0.002). Within each ethnic group, men and women were diagnosed at approximately equal annual rates. Our findings differed significantly from United States national trends, which found that African American females and white females had lower risks for GC than their corresponding male counterparts. The United States national trend between 2005 and 2011 showed that African Americans males had a higher incidence of GC, with an annual mean(per 100000) of 16.31 ± 0.76 compared with white males(9 ± 0.1, P < 0.001),

关键词： Gender Helicobacter pylori Ethnicity Riskfactors Health disparities

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第6期11卷 1629-1647页

作者： Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel paul M.jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger Tran Hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Faculty of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City 700000Viet Nam Michael Popp Institute and Center for Molecular Biosciences Innsbruck(CMBI) University of InnsbruckInnsbruck 6020Austria Department of Pharmaceutical/Medicinal Chemistry Institute of PharmacyFriedrich Schiller University JenaJena 07743Germany Institute of Pharmacy Department of Pharmaceutical and Medicinal ChemistryParacelsus Medical University SalzburgSalzburgSalzburg 5020Austria Department of Pharmacy School of MedicineUniversity of Naples FedericoⅡNaples'80131Italy Institute of Transfusion Medicine University Hospital JenaJena 07747Germany

Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory *** mediators orchestrate both the initiation and resolution of *** from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are *** from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase *** identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 *** production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 *** shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell *** summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles.

关键词： Lipoxygenase Inflammation Resolution Natural product Lipidomics Lipid mediator

油气公司采用根本原因分析方法提高设备的可靠性

在线全文

学校读者我要写书评

暂无评论

设备管理与维修 2007年第10期 54-56页

作者： paul Rodriguez jordan Daniel Ragazzini 王秩信

你的继续改进工作在取得初步成效后,是否仍以预定计划为中心而未取得实际进展?你们公司是否把长期存在的问题作为开展工作的动力?你们是否在不同的场所经常重复分析同样的问题?在你们公司里,对于什么是可靠性的问题,每个人是否都有不同... 详细信息

你的继续改进工作在取得初步成效后,是否仍以预定计划为中心而未取得实际进展?你们公司是否把长期存在的问题作为开展工作的动力?你们是否在不同的场所经常重复分析同样的问题?在你们公司里,对于什么是可靠性的问题,每个人是否都有不同的理解?我们公司在拉丁美洲5个国家中都有许多油田和气田,并且都遇到了困难,为了创造持久的利润,我们决定对不断改进的方法全面地进行标准化。改进的方法有:(1)把问题和机遇按轻重缓急依次排列起来;(2)分析这些问题和机遇的根本原因(RC);(3)开发和实施解决方法;(4)继续研究上述各种方法的利润。

关键词：油气公司根本原因分析RCA 可靠性计划解决问题方法PSM 改良型FMEA 不断改进CI

Gut sterilization in experimental colitis leukocyte mediated colon injury, and effects on angiogenesis/lymphangiogenesis

在线全文

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2013年第1期3卷 12-24页

作者： Mihir Patel Justin Olinde Allison Tatum Chaitanya V. Ganta Walter E. Cromer Ankur R. Sheth Merilyn H. Jennings J. Michael Mathis Traci Testerman paul A. jordan Kenneth Manas Christopher P. Monceaux J. Steven Alexander Department of Cellular Biology and Anatomy LSU Health Shreveport Shreveport USA Department of Gastroenterology and Hepatology LSU Health Shreveport Shreveport USA Department of Microbiology and Immunology LSU Health Shreveport Shreveport USA Department of Molecular and Cellular Physiology LSU Health Shreveport Shreveport USA

Inappropriate responses to normal commensal bacteria trigger immune activation in both inflammatory bowel disease and experimental colitis. How gut flora contribute to the pathogenesis of inflammatory bowel disease is unclear, but may involve entrapment of leukocytes and remodeling of the vascular system. Here we evaluated how the progression and tissue remodeling in experimental colitis differ in a germ- free model of mouse colitis. Four treatment groups were used: control, antibiotic-treated (ABX), dextran sulfate colitis (DSS) and DSS pre- and co-treated with antibiotics (DSS + ABX). In days 0 - 3 of the study, germ-free mice received antibiotics (vancomycin, neomycin, and metronidazole). During the next 11 days, antibiotics were continued and DSS (3%) added to “colitis” groups. Disease activity, weight, stool form and blood were monitored daily. Mice were sacrificed and tissue samples harvested. Histopathological scores in controls (0.00) and in ABX (1.0+/–0.81) were significantly (p –0). Extents of injury, inflammation and crypt damage were all improved in DSS + ABX. The Disease Activity Index score (day 11) was significantly worse in the DSS group compared to the DSS + ABX group. Stool blood and form scores were also significantly improved among these groups. Importantly, myeloper- oxidase was significantly reduced in DSS + ABX, indicating that neutrophil infiltration was blocked. Colitis was associated with an increase in blood and lymphatic vessels;both of these events were also significantly reduced by gut sterilization. Our experiment shows that clinical and histopathological severity of colitis was significantly worse in the DSS colitis group compared to the DSS + ABX group, supporting the hypothesis that development of IBD is likely to be less severe with appropriate antibiotic treatment. In particular, gut sterilization effectively reduces leuko- cyte-dependent (PMN) injury to improve outcomes and may be an important target for therapy.

关键词： Crohn’s Disease Antibiotics Myeloperoxidase Lymphatics Angiogenesis

<i>Helicobacter</i>infection decreases basal colon inflammation, but increases disease activity in experimental IBD

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2013年第3期3卷 177-189页

作者： Christopher P. Monceaux Traci L. Testerman Moheb Boktor paul jordan Patrick Adegboyega David J. McGee Merilyn H. Jennings Courtney P. Parker Shelly Gupta Ping Yi Vijay C. Ganta Haidy Galous Kenneth Manas J. Steven Alexander Department of Gastroenterology and Hepatology LSU Health Shreveport Shreveport USA Department of Microbiology and Immunology LSU Health Shreveport Shreveport USA Department of Molecular and Cellular Physiology LSU Health Shreveport Shreveport USA Department of Pathology LSU Health Shreveport Shreveport USA

Background: Helicobacter species are best known for their roles in the pathology of gastritis;however, several Helicobacter species also colonize the intestine, and less is known about effects of Helicobacter on the development of intestinal inflammation. To evaluate contributions of Helicobacter in inflammatory bowel disease, we investigated whether and how pre-existing intestinal colonization would affect disease severity and biomarkers of inflammation in experimental IBD. Materials and Methods: Mice were infected with H. muridarum 2 weeks prior to induction of colitis mediated by 3% dextran sulfate (DSS). Disease activity index, stool blood and consistency, colon length, myeloperoxidase, histopathology, blood and lymphatic vessels, and numbers of dilated mucosal crypts were measured in control, DSS-only, H. muridarum-infected, and H. muridarum-infected + DSS mice. Results: Prior to DSS challenge, H. muridarum-infected mice showed little distal gut injury by several indices of colon inflammation with decreased blood vessel density in the submucosa, and lower lymphatic density in the mucosa and submucosa. However, after DSS colitis, H. muridarum-infected mice exhibited significantly greater disease. Weight change, stool bleeding, diarrhea, and angiogenesis were all increased in H. muridarum-infected mice in DSS colitis compared to DSS controls. Conclusions: Our data show that Helicobacter colonization of the intestine, unlike that of the stomach, lowers basal gut inflammatory scores, but increases disease activity and inflammation in an acute colitis model. Intestinal Helicobacter infection may therefore represent a significant sub-clinical factor which predisposes the gut to inflammatory injury.

关键词： Helicobacter Colon Lymphatics Crohn’s Disease Ulcerative Colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

解码民俗服装:行列舞者的着装规则(下)

长江大学学报（社会科学版） 2020年第6期43卷 21-27页

作者：劳雷尔·霍顿保罗·乔丹·史密斯程萌桑俊[译] 塞内卡南卡罗来纳州29678 西雅图华盛顿州98052 华中师范大学国家文化产业研究中心湖北武汉430079 长江大学人文与新媒体学院湖北荆州434023

民俗服装是指少数种族的、宗派的和职业化的小范围服装传统,于众多学者而言,这是一个过时的术语。民俗学者又往往对某些似乎仅反映日常穿着的服装视若无睹。在服装行为上有两种立场:一是男女舞者都穿T恤,二是男舞者逐渐开始穿短裙。这... 详细信息

民俗服装是指少数种族的、宗派的和职业化的小范围服装传统,于众多学者而言,这是一个过时的术语。民俗学者又往往对某些似乎仅反映日常穿着的服装视若无睹。在服装行为上有两种立场:一是男女舞者都穿T恤,二是男舞者逐渐开始穿短裙。这两种立场有助于打开参与者所使用的复杂的交流资源,并暗示在此相对未开发的领域进行民俗研究,可能会收获颇丰。

关键词：民俗服装行列舞者着装规则

在线全文

学校读者我要写书评

暂无评论

解码民俗服装:行列舞者的着装规则(上)

长江大学学报（社会科学版） 2020年第5期43卷 49-56页

作者：劳雷尔·霍顿保罗·乔丹·史密斯程萌(译) 桑俊(译) 塞内卡南卡罗来纳州29678 西雅图华盛顿州98052 华中师范大学国家文化产业研究中心湖北武汉430079 长江大学人文与新媒体学院湖北荆州434023

民俗服装是指少数种族的、宗派的和职业化的小范围服装传统,于众多学者而言,这是一个过时的术语。民俗学者又往往对某些似乎仅反映日常穿着的服装选择视若无睹。在服装行为上有两种立场:一是男女舞者都穿T恤,二是男舞者逐渐开始穿短裙... 详细信息

民俗服装是指少数种族的、宗派的和职业化的小范围服装传统,于众多学者而言,这是一个过时的术语。民俗学者又往往对某些似乎仅反映日常穿着的服装选择视若无睹。在服装行为上有两种立场:一是男女舞者都穿T恤,二是男舞者逐渐开始穿短裙。这两种立场有助于打开参与者所使用的复杂的交流资源,并暗示在此相对未开发的领域进行民俗研究,可能会收获颇丰。

关键词：民俗服装行列舞者着装规则

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 156-171页

作者： Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris paul jordan Kenneth Manas Felix Becker Jonathan Steven Alexander Department of Medicine Section of Gastroenterology and Hepatology Louisiana State University Health Sciences Center Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center Digestive Health Center of Louisiana Department of General and Visceral Surgery

Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using "top-down" care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed.

关键词： Inflammatory bowel diseases Pregnancy Biologics Br

Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2013年第2期6卷 113-120页

作者： Bo Zhang jordan Price Guosong Hong Scott M. Tabakman Hailiang Wang Justin A. Jarrell Ju Feng paul J. Utz Hongjie Dai Department of Chemistry Stanford University Stanford California USA Department of Medicine Division of Immunology and Rheumatology Stanford University School of Medicine Stanford California USA Institute for Immunity Transplantation and Infection Stanford University School of Medicine Stanford California USA

Protein microarrays based on fluorescence detection have been widely utilized for high-throughput functional proteomic analysis. However, a drawback of such assays has been low sensitivity and narrow dynamic range, limiting their capabilities, especially for detecting low abundance biological molecules such as cytokines in human samples. Here, we present fluorescence-enhancing microarrays on plasmonic gold films for multiplexed cytokine detection with up to three orders of magnitude higher sensitivity than on conventional nitrocellulose and glass substrates. Cytokine detection on the gold plasmonic substrate is about one to two orders of magnitude more sensitive than enzyme-linked immunosorbent assay （ELISA） and can be multiplexed. A panel of six cytokines （Vascular endothelial growth factor （VEGF）, Interleukin 1β （IL-1β）, Interleukin 4 （IL-4）, Interleukin 6 （IL-6）, Interferon γ （IFN-γ）, and Tumor necrosis factor （TNF）） were detected in the culture media of cancer cells. This work establishes a new method of high throughput multiplexed cytokine detection with higher sensitivity and dynamic range than ELISA.

关键词： microarray cytokine plasmonic multiplex near infrared fluorescence