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Track-Monitoring and Analyzing Machine Clearances during Wood Forwarding

Open Journal of Forestry 2018年第3期8卷 297-327页

作者： Marie-France jones Mark Castonguay Dirk Jaeger paul Arp Faculty of Forestry and Environmental Management University of New Brunswick Fredericton Canada

This article reports on track-monitoring and analyzing machine clearances during wood forwarding across seasons and weather, using ultrasonic distance sensors in combination with time-stamped GPS xy locations, at 10 sec intervals. The resulting data, obtained from 54 harvesting blocks, were analyzed by machine type (two wood forwarders and one grapple skidder), stand type (softwood plantation versus natural hardwood stands), month, slope, cartographic depth-to-water (DTW) classes, number of passes along track, and machine speed. For the most part, clearances were highly variable, due to passing over stumps, rocks, harvest slash, brushmats, ruts, and snow cover when present. This variability was on average greater for the lighter-weight wood forwarders than for the heavier-weight skidder, with the former mostly moving along equally spaced lines on brushmats, while the paths of the latter spread away from central wood-landing sites. In terms of trends, machines moved 1) more slowly on wet ground, 2) faster during returning than forwarding, and 3) fastest along wood-landing roads, as to be expected. Low clearances were most notable during winter on snow-covered ground, and on non-frozen shallow DTW and wet multiple-pass ground. During dry weather conditions, clearances also increased from low-pass tracks to multi-pass tracks due to repeat soil compaction of broadened tracks. These results are presented block-by-block and by machine type. Each block-based clearance frequency pattern was quantified through regression analysis and using a gamma probability distribution function.

关键词： Wood Forwarding GPS Tracks Clearance Frequencies Number of Passes Speed Ground Conditions Depth-to-Water (DTW)

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Recent advances and future directions in preclinical research of argininevasopressin(AVP) receptor blocker conivaptan in the context of stroke

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Neural Regeneration Research 2016年第3期11卷 392-393页

作者： Emil Zeynalov Susan M.jones Swedish Medical Center Neurotrauma Research Department Englewood

Stroke is a major cause of mortality and permanent *** onset of stroke is followed by life-threatening pathophysiological responses including brain edema,elevation of intracranial pressure,disruption of blood-brain barrier（BBB）,brain infarct and permanent tissue *** edema develops due to accumulation of water in intracellular and extracellular compartments of the brain,

关键词： edema permanent disability intracranial elevation blocker infarct disruption advances mortality

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Apoptosis block as a barrier to effective therapy in non small cell lung cancer

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World Journal of Clinical Oncology 2014年第4期5卷 588-594页

作者： Ian paul J Mark jones Department of Cardiothoracic Surgery Royal Victoria Hospital Belfast BT12 6BA Northern Ireland United Kingdom

Lung cancer, is the most common cause of cancer death in men and second only to breast cancer in women. Currently, the first line therapy of choice is platinumbased combination chemotherapy. A therapeutic plateau has been reached with the prognosis for patients with advanced non-small cell lung cancer(NSCLC) remaining poor. New biomarkers of prognosis as well as new therapies focusing on molecular targets are emerging helping to identify patients who are likely to benefit from therapy. Despite this, drug resistance remains the major cause for treatment failure. In this article we review the role of apoptosis in mediating drug resistance in NSCLC. Better understanding of this fundamental biological process may provide a rationale for overcoming the current therapeutic plateau.

关键词： Apoptosis Lung cancer Adjuvant therapy Mitochondria BAX BAK BCL2

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Pazopanib in advanced soft tissue sarcomas

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Signal Transduction and Targeted Therapy 2019年第1期4卷 538-547页

作者： Alex T.J.Lee Robin L.jones paul H.Huang Division of Molecular Pathology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical Studies Institute of Cancer ResearchLondonUK

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(STS).Initially developed as a small molecule inhibitor of vascular endothelial growth factor receptors,preclinical work indicates that pazopanib exerts an anticancer effect through the inhibition of both angiogenic and oncogenic signaling *** the establishment of optimal dosing and safety profiles in early phase studies and approval for the treatment of advanced renal cell carcinoma,pazopanib was investigated in STS.A landmark phase III randomized study demonstrated improved progression-free survival with pazopanib compared to that with placebo in pretreated patients with STS of various *** efficacy of pazopanib in specific STS subtypes has been further described in real-world-based case series in both mixed and subtype-specific STS *** present,there are no clinically validated predictive biomarkers for use in selecting patients with advanced STS for pazopanib therapy,limiting the clinical effectiveness and cost-effectiveness of the *** this review,we summarize the preclinical and clinical data for pazopanib,outline the evidence base for its effect in STS and explore reported studies that have investigated putative biomarkers.

关键词： sarcoma clinical approval

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As离子注入硅化钛自对准MOS器件技术研究

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电子学报 1991年第1期19卷 109-112页

作者：周世芳李炳宗 paul Chu Clive M.jones 复旦大学电子工程系 Charles Evans & Associates USA

本工作研究了同时形成polycide栅,源/漏硅化钛接触和浅PN结的MOS器件制造技术。实验结果表明,通过硅化钛薄膜注入As,并利用NH_3等离子体辅助热退火(NPTA)工艺,可制备性能良好的MOS晶体管。以注入杂质的硅化钛薄膜作为杂质源,在一次高温... 详细信息

本工作研究了同时形成polycide栅,源/漏硅化钛接触和浅PN结的MOS器件制造技术。实验结果表明,通过硅化钛薄膜注入As,并利用NH_3等离子体辅助热退火(NPTA)工艺,可制备性能良好的MOS晶体管。以注入杂质的硅化钛薄膜作为杂质源,在一次高温退火过程中同时完成杂质的再分布和低电阻率硅化钛的形成,得到结深小于0.1μm,硅化钛电阻率24μΩ·cm。NPTA退火工艺有效地抑制了Ti/Si和Ti/poly-Si固相反应过程中硅化钛的横向生长,从而获得了自对准程度很高的硅化钛接触和互连。

关键词：离子注入硅化钛 MOS器件

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Feeding Supplemental lodine to Adult Mink;Effect on Thyroid Hormones in Adult and offspring

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Biomedical and Environmental Sciences 1993年第1期6卷 81-88页

作者： RossE.jones RICHARDJ.AULERICH ROBERTK.RINGER Texas MichiganProfessor Instrumentsm/s 81 P.O.Box655012DallasTX 75265State University Department of Animal ScienceEast LansingMI 48824Emeritus Michigan State UniversityEast LansingMI 48823USA

We fed adult mink diets containing supplemental iodine, from 0 to 320 ppm, for one or seven months prior to breeding. Blood samples collected from the adults and their offspring (kits) at 4 wk post-partum were assayed for total thyroxine (T4), triiodothyronine (T3), reverse T3 (rT3), and T4-binding indices. As expected T4 concentrations of the adult and kit mink varied inversely with the level of supplemental iodine. In addition, T3 and rT3 concentrations decreased gradually in kits from the long-term experiment in response to the increased dietary iodine of the dams. T3 concentrations of kits from dams fed iodine short-term decreased markedly while rTy concentrations were elevated greatly in response to increased dietary iodine of the dam. These decreases in hormone levels are due to serum iodine blocking the thyroid uptake of iodine and subsequent decrease of hormone synthesis. Excess iodine may also block the effect of thyroid stimulating hormone. The T4-binding indices of the adults, in general, were depressed, while the T4-binding indices of the kits were more variable. These effects are probably due to fluctuations in thyroglobulin.

关键词： Feeding Supplemental lodine to Adult Mink Effect on Thyroid Hormones in Adult and offspring

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Epidemiology and outcomes of acute liver failure in Australia

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World Journal of Hepatology 2019年第7期11卷 586-595页

作者： Penelope Hey Timothy P Hanrahan Marie Sinclair Adam G Testro Peter W Angus Adam Peterson Stephen Warrillow Rinaldo Bellomo Marcos V Perini Graham Starkey Robert M jones Michael Fink Tess McClure paul Gow Liver Transplant Unit Austin HealthHeidelberg 3084Australia The University of Melbourne Melbourne 3052Australia Department of Intensive Care Austin HeathMelbourne 3084Australia Department of Surgery Austin HealthMelbourne 3084Australia

BACKGROUND Acute liver failure (ALF) is a life-threatening syndrome with varying aetiologies requiring complex care and multidisciplinary management. Its changing incidence, aetiology and outcomes over the last 16 years in the Australian context remain uncertain. AIM To describe the changing incidence, aetiology and outcomes of ALF in South Eastern Australia. METHODS The database of the Victorian Liver Transplant Unit was interrogated to identify all cases of ALF in adults (> 16 years) in adults hospitalised between January 2002 and December 2017. Overall, 169 patients meeting criteria for ALF were identified. Demographics, aetiology of ALF, rates of transplantation and outcomes were collected for all patients. Transplant free survival and overall survival (OS) were assessed based on survival to discharge from hospital. Results were compared to data from a historical cohort from the same unit from 1988- 2001. RESULTS Paracetamol was the most common aetiology of acute liver failure, accounting for 50% of cases, with an increased incidence compared with the historical cohort (P = 0.046). Viral hepatitis and non-paracetamol drug or toxin induced liver injury accounted for 15% and 10% of cases respectively. Transplant free survival (TFS) improved significantly compared to the historical cohort (52% vs 38%, P = 0.032). TFS was highest in paracetamol toxicity with spontaneous recovery in 72% of cases compared to 31% of non-paracetamol ALF (P < 0.001). Fifty-nine patients were waitlisted for emergency liver transplantation. Nine of these died while waiting for an organ to become available. Forty-two patients (25%) underwent emergency liver transplantation with a 1, 3 and 5 year survival of 81%, 78% and 72% respectively. CONCLUSION Paracetamol toxicity is the most common aetiology of ALF in South-Eastern Australia with a rising incidence over 30 years. TFS has improved, however it remains low in non-paracetamol ALF.

关键词： Liver failure Acute Paracetamol Australia Victoria Liver transplant

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Characterizations in nanotoxicology and nanomedicine development:A regulatory perspective

Characterizations in nanotoxicology and nanomedicine develop...

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中国毒理学会第六届全国毒理学大会

作者： ZHANG Yong-bin William SALMINEN SHI Qiang YANG Xi Yvonne jones paul HOWARD NCTR/ORA Nanotechnology Core Facility Food and Drug Administration Division of Systems Biology National Center for Toxicological ResearchFood and Drug Administration

＜正＞With the rapid expansion of nanotechnology,there has been great concern on safety issue of the nano-product regulated by U.S Food and Drug Administration（FDA）.Pre-clinical characterization and quality control during the manufacturing of nano-products is fundamental for understanding resulting safety issues during their wide *** regulated products are required to submit basic physio-chemical characterization as part of Investigational New Drug（IND） Applications or New Drug Applications（NDA） submitted to the FDA for *** of gold nanoparticles（Au NPs）, silver nanoparticles（Ag NPs） and single walled carbon nanotubes（SWCNTs） will be discussed as cases *** nanomaterials were characterized using transmission electron microscopy（TEM）,dynamic light scattering（DLS）,Raman,and hyperspectral microscopy and other spectroscopy techniques. We examined their uptake and toxicity in primary rat hepatocytes,rat adrenal pheochromocytoma cells（PC12） or in vivo rodent *** was assessed by examining cell membrane integrity and mitochondrial activity（LDH,XTT and MTT assay） and oxidative stress（DCF assay;reduced glutathione levels;PCR array for ROS responsive gene expression）.Uptake and subcellular localization were monitored using TEM,confocal Raman microscopy and inductively coupled plasma mass spectrometry（ICP-MS） *** Au NPs were taken up by the cells in a time- and size-dependent manner,no cytotoxicity or ROS stress was ***,uptake of SWCNT was cytotoxic and generated ROS in surface coating-dependent *** SWCNT exhibited less potency than uncoated *** the other hand,Ag NPs decreased the body weight and locomotor activities after intravenous exposure in *** studies suggest the surface coating,size and composition play import roles in toxicity of the *** multiple characterization approaches used in this study provided the solid basis to understand the biological resp

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Biomechanical comparison of distal locking screws for distal tibia fracture intramedullary nailing

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Journal of Biomedical Science and Engineering 2011年第4期4卷 235-241页

作者： Brennen L. Lucas Alexander C.M. Chong Bruce R. Buhr Teresa L. jones paul H. Wooley Department of Surgery Section of Orthopaedics The University of Kansas School of Medicine Orthopaedic Research Institute

Background: Newer generation intramedullary (IM) tibial nails provide several distal interlocking screw options. The objectives were to determine: 1) if the new oblique interlocking option provides superior stability, 2) which screw orientation/ configuration is the most biomechanically stable, and 3) if three distal interlocking screws provide better stability. Methods: A preliminary experiment was performed in torsion, compression, and bending tests with four different screw configurations: (I) one medial-to-lateral and one oblique, (II) two me-dial-to-lateral, (III) one medial-to-lateral and one anterior-to-posterior, and (IV) one medial-to-lateral, one anterior-to-posterior and one oblique in simu-lated distal metaphyseal fracture tibiae. Twenty- four Synthes EXPERT tibial IM nails were used for six specimens of each screw configuration. Parts I and II, tibial IM nails were locked with 5.0 mm in-terlocking screws into simulated distal tibiae (PVC and composite analogue tibia). Part III, the two most stable configurations were tested using five pairs of simulated cadaveric distal tibiae metaphy-seal fractures. Results: Significant differences were attributable to distal screw orientation for intrame- dullary nailing of distal tibia fractures. Configura-tions II and IV were found to be more stable than the other two configurations. No significant differ-ence was detected in construct stability in all modes of testing between Configurations II and IV. Dis-cussion: Configuration I did not provide superior stability for the distal tibia fracture fixation. Con-figurations II and IV provided equivalent stability. When choosing IM fixation for treatment of distal tibia metaphyseal fractures two medial-to-lateral screws provide the necessary stability for satisfac-tory fixation. Clinical Relevance: This study indi-cated an option for operative treatment of distal metaphyseal tibia fracture fixation where preserva-tion of soft tissue and rigid stabilization are needed.

关键词： Biomechanical Locking Screws Intramedullary Nail Distal Tibia

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p53和γ-H2AX作为乙醛引起DNA损伤早期生物标记物的实验研究

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癌变．畸变．突变 2014年第2期26卷 81-87,93页

作者：周学贤 Penny jones paul Carmichael 郝卫东北京大学公共卫生学院毒理学系食品安全毒理学研究与评价北京市重点实验室英国联合利华安全与环境保障中心

目的：评价乙醛染毒p53野生型人类淋巴母细胞（TK6）后，细胞中DNA损伤标记物p53、γ-H2AX的表达变化，并与彗星试验中的DNA链断裂指标进行敏感性比较，探讨p53和γ-H2AX作为乙醛引起DNA损伤的早期生物标记物的可能。方法：乙醛在0.5～2... 详细信息

目的：评价乙醛染毒p53野生型人类淋巴母细胞（TK6）后，细胞中DNA损伤标记物p53、γ-H2AX的表达变化，并与彗星试验中的DNA链断裂指标进行敏感性比较，探讨p53和γ-H2AX作为乙醛引起DNA损伤的早期生物标记物的可能。方法：乙醛在0.5～20 mmol/L的浓度范围分别染毒TK6细胞20 min、2和12 h后，采用高通量的流式细胞术检测肿瘤抑制蛋白total-p53、磷酸化p53（p-p53）以及磷酸化组蛋白（γ-H2AX）的细胞表达率和表达强度（平均荧光强度）；同时采用碱性彗星试验检测乙醛引起的DNA链断裂指标（细胞拖尾率、尾长、尾部DNA百分含量以及尾矩）的变化。结果：乙醛染毒TK6细胞12 h后，γ-H2AX的表达强度在15及20 mmol/L浓度下显著升高（P〈0.05），p-p53的细胞表达率在0.5～7.5 mmol/L浓度范围内呈现剂量依赖的升高趋势，total-p53的细胞表达率趋势与p-p53相似，但与阴性对照组相比，差异无统计学意义。彗星试验中，细胞拖尾率、尾长、尾部DNA百分含量以及尾矩在5.0～12.5 mmol/L浓度范围内均增加，并呈现剂量依赖性。染毒2 h后，与阴性对照组相比，total-p53和p-p53的细胞表达率在15和20 mmol/L浓度下显著升高（P均〈0.05），细胞拖尾率、尾部DNA百分含量以及尾矩在20 mmol/L浓度升高（P均〈0.05）。染毒20 min后，3种生物标志物均未见清晰的变化趋势，4种DNA链断裂指标均未见显著变化（P均＞0.05）。结论：乙醛染毒TK6细胞12 h可诱导p-p53细胞表达率升高、γ-H2AX细胞表达强度升高、total-p53细胞表达率轻微升高，以及细胞拖尾率、尾长、尾部DNA百分含量、尾矩的升高。p-p53比γ-H2AX和DNA链断裂指标在检测乙醛诱导的DNA损伤方面更加敏感。

关键词：乙醛 DNA损伤 p53 γ-H2AX 彗星试验

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