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The controlling factors of high suspended sediment concentration in the intertidal flat off the Huanghe River Estuary

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Acta Oceanologica Sinica 2020年第10期39卷 96-106页

作者： Bowen Li Yonggang jia j.paul Liu jianfeng Su Xiaolei Liu Mingzheng Wen Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao 266100China Laboratory for Marine Geology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Department of Marine Earth and Atmospheric SciencesNorth Carolina State UniversityRaleighNC 27695USA State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Tianjin Center China Geological SurveyTianjin 300170China

The Huanghe River(Yellow River)is known by its high suspended sediment concentration(SSC)in its river mouth tidal ***,the factors controlling the high SSC over there are not well ***,we conducted 7-d hydrodynamic observations(water depth,wave height,and current velocity)and SSC measurements on the tidal flat off the Huanghe River *** data shows that in most of time,under the calm sea condition,the SSC ranges 0.1–3.5 g/L,and sediment discharge from the river is the main ***,when hydrodynamics are enhanced in a tidal cycle and large-scale erosion occurs on the seafloor,resuspended sediment becomes the main source,and the SSC in the water column reaches 17.3 g/*** find the suspended sediment flux is mainly controlled by the tidal current and Stokes drift,while the wave-induced shear stress could also affect the variation of suspended sediment *** the observation period,when sea under calm-rippled conditions,the current-induced resuspended sediment concentration(RSC)was greater than the wave-induced *** contrast,in smooth-wavelet sea conditions,the wave-induced RSC was greater than the current-induced RSC,for instance,a single wave event was found to cause 11.8 cm seabed erosion within 6 *** study reveals different controlling factors for the high SSC near a river-influenced tidal flat,and helps us get a better understanding of a delta's depositional and erosional mechanisms.

关键词： Huanghe River(Yellow River) sediment re-suspension sediment transport wave current in-situ observation

Biological fate and interaction with cytochromes P450 of the nanocarrier material,D-α-tocopheryl polyethylene glycol 1000 succinate

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3156-3166页

作者： Tianming Ren Runzhi Li Liqiang Zhao j.paul Fawcett Dong Sun jingkai Gu Research Center for Drug Metabolism School of Life SciencesJilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China Beijing Institute of Drug Metabolism Beijing 102209China

D-a-Tocopheryl polyethylene glycol 1000 succinate(TPGS,also known as vitamin E-TPGS)is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with polyethylene glycol(PEG)*** is approved by the US Food and Drug Administration(FDA)and has found wide application in nanocarrier drug delivery systems(NDDS).Fully characterizing the in vivo fate and pharmacokinetic behavior of TPGS is important to promote the further development of TPGS-based ***,to date,a bioassay for the simultaneous quantitation of TPGS and its metabolite,PEG1000,has not been *** the present study,we developed such an innovative bioassay and used it to investigate the pharmacokinetics,tissue distribution and excretion of TPGS and PEG1000 in rat after oral and intravenous *** addition,we evaluated the interaction of TPGS with cytochromes P450(CYP450s)in human liver *** results show that TPGS is poorly absorbed after oral administration with very low bioavailability and that,after intravenous administration,TPGS and PEG1000 are mainly distributed to the spleen,liver,lung and kidney before both being slowly eliminated in urine and feces as *** vitro studies show the inhibition of human CYP450 enzymes by TPGS is limited to a weak inhibition of ***,our results provide a clear picture of the in vivo fate of TPGS which will be useful in evaluating the safety of TPGS-based NDDS in clinical use and in promoting their further development.

关键词： TPGS LC-MS/MS Nanocarrier materials Pharmacokinetics Tissue distribution Metabolism Excretion Cytochrome P450

Electric-field driven stability control of skyrmions in an ultrathin transition-metal film

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npj Computational Materials 2022年第1期8卷 992-1000页

作者： Souvik paul Stefan Heinze Peter Grünberg Institut and Institute for Advanced Simulation Forschungszentrum Jülich and JARA52425JülichGermany Institute of Theoretical Physics and Astrophysics Christian-Albrechts-Universität zu KielLeibnizstrasse 1524098KielGermany

To realize future spintronic applications with magnetic skyrmions—topologically nontrivial swirling spin structures—it is essential to achieve efficient writing and deleting capabilities of these ***-field assisted nucleation and annihilation is a promising route,however,the understanding of the underlying microscopic mechanisms is still ***,we show how the stability of individual magnetic skyrmions in an ultrathin transition-metal film can be controlled via external electric *** demonstrate based on density functional theory that it is important to consider the changes of all interactions with electric field,i.e.,the pair-wise exchange,the Dzyaloshinskii–Moriya interaction,the magnetocrystalline anisotropy energy,and the higher-order exchange *** energy barriers for electric-field assisted skyrmion writing and deleting obtained via atomistic spin simulations vary by up to a factor of three more than the variations of the interactions calculated from *** surprising effect originates from the electric-field dependent size of metastable skyrmions at a fixed magnetic *** large changes in lifetimes allow the possibility of electric-field assisted thermally activated writing and deleting of skyrmions.

关键词： field stability film

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

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Cellular & Molecular Immunology 2010年第5期7卷 361-374页

作者： C Edward Rose jr joanne A Lannigan paul Kim james j Lee Shu Man Fu Sun-sang j Sung Division of Pulmonary and Critical Care Department of MedicineUniversity of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology University of Virginia School of MedicineCharlottesvilleVAUSA Center for Immunity Inflammationand Regenerative Medicine and Division of NephrologyDepartment of MedicineUniversity of Virginia School of MedicineCharlottesvilleVAUSA Division of Pulmonary Medicine Department of Biochemistry and Molecular BiologyMayo Clinic ArizonaScottsdaleAZUSA

Eosinophils play important roles in asthma and lung *** models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these ***,little is known about tissue eosinophils in *** addition,little data on eosinophil chemokine production during allergic airway inflammation are *** this study,the properties and functions of homeostatic and activated eosinophils were *** from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell ***,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine *** intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal *** eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c *** were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed *** production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation.

关键词： allergy chemokines eosinophils lung mouse

Surface texture evaluation of additively manufactured metallic cellular scaffolds for acetabular implants using *** computed tomography

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Bio-Design and Manufacturing 2019年第2期2卷 55-64页

作者： Shan Lou Luca Pagani Wenhan Zeng Muhammad U.Ghori Xiangqian jiang paul j.Scott EPSRC Future Metrology Hub University of HuddersfieldQueensgateHuddersfield HD1 3DHUK Department of Pharmacy University of HuddersfieldQueensgateHuddersfield HD1 3DHUK

The surface topography of acetabular implants plays a key role in providing cell attachment and *** measurement and characterisation of the surface texture of the cellular scaffold layer on the acetabular cup are very difficult due to the 3D nature of scaffold *** is proposed to use X-ray computed tomography(XCT)to measure the surface texture of an electron beam melting-produced titanium acetabular *** surface texture of its cellular scaffold is evaluated using the newly developed 3D surface texture parameters,which allows surface characterisation on 3D triangular mesh *** commonly used height parameters,*** arithmetical mean height Sa,the root mean square height Sq,the skewness Ssk and the kurtosis Sku,are calculated from surface patches extracted from the XCT scanned triangular mesh *** addition,the surface peak density and pit density,which are more related to cell communication and proliferation,are estimated based on the 3D watershed *** Wolf pruning with an empirical threshold 12μm is used to control the over-segmentation.

关键词： Additive manufacturing Cellular scaffold Surface texture X-ray computed tomography

A simple catalyst for aqueous phase Suzuki reactions based on palladium nanoparticles immobilized on an ionic polymer

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Science China Chemistry 2016年第4期59卷 482-486页

作者： Saeideh Ghazali-Esfahani Emilia Paunescu Mojtaba Bagherzadeh Zhaofu Fei Gabor Laurenczy paul j.Dyson Institut des Sciences et Ingénierie Chimiques Ecole Polytechnique Fédérale de LausanneLausanne CH-I O15Switzerland Chemistry Department Sharif University of TechnologyTehran 11155-3615lran

Palladium nanoparticles immobilized on a cross-linked imidazolium-containing polymer were evaluated as a catalyst for Suzuki carbon-carbon cross-coupling reactions using water as the solvent. The nanocatalysts show good catalytic activities for aryl iodides and aryl bromides and moderate activity with aryl chloride substrates. Coupling of sterically hindered substrates could also be achieved in reasonable yields. The heterogeneous catalyst is stable, can be stored without precautions to exclude air or moisture, and can be easily recycled and reused.

关键词： catalysis biphasic catalysis polymeric ionic liquids nanoparticles aqueous phase catalysis Suzuki reaction

Genetic algorithms for computational materials discovery accelerated by machine learning

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npj Computational Materials 2019年第1期5卷 746-751页

作者： paul C.jennings Steen Lysgaard jens Strabo Hummelshøj Tejs Vegge Thomas Bligaard SUNCAT Center for Interface Science and Catalysis Department of Chemical EngineeringStanford UniversityStanfordCA 94305USA SLAC National Accelerator Laboratory 2575 Sand Hill RoadMenlo ParkCA 94025USA Department of Energy Conversion and Storage Technical University of DenmarkLyngbyDenmark Toyota Research Institute Los AltosCA 94022USA

Materials discovery is increasingly being impelled by machine learning methods that rely on pre-existing *** datasets are lacking,unbiased data generation can be achieved with genetic *** a machine learning model is trained on-the-fly as a computationally inexpensive energy predictor before analyzing how to augment convergence in genetic algorithm-based approaches by using the model as a *** leads to a machine learning accelerated genetic algorithm combining robust qualities of the genetic algorithm with rapid machine *** approach is used to search for stable,compositionally variant,geometrically similar nanoparticle alloys to illustrate its capability for accelerated materials discovery,e.g.,nanoalloy *** machine learning accelerated approach,in this case,yields a 50-fold reduction in the number of required energy calculations compared to a traditional“brute force”genetic *** makes searching through the space of all homotops and compositions of a binary alloy particle in a given structure feasible,using density functional theory calculations.

关键词： alloy alloys searching

Impact of COVID-19 on Liver Transplant Activity in the USA: Variation by Etiology and Cirrhosis Complications

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journal of Clinical and Translational Hepatology 2023年第1期11卷 130-135页

作者： Yong-Fang Kuo paul Kwo Robert j Wong Ashwani K.Singal Department of Biostatistics University of Texas Medical BranchGalvestonTXUSA Division of Gastroenterology and Hepatology Veterans Affairs Palo Alto Healthcare SystemStanford University School of MedicinePalo AltoCAUSA University of South Dakota Sanford School of MedicineVermillionSDUSA Avera Transplant Institute Sioux FallsSDUSA

Background and Aims:The COVID-19 pandemic has impacted the care of patients with liver *** examined impact of COVID-19 on liver transplant(LT)activity in the ***:LT listings in the United Network for Organ Sharing(UNOS)database(April 2018–May 2021)were analyzed to examine the impact of COVID-19 pandemic on the LT activity based on etiology:hepatitis C virus(HCV),alcohol-associated liver disease(ALD),alcoholic hepatitis(AH),and nonalcoholic steatohepatitis(NASH)complications:hepatocellular carcinoma(HCC)and acute-on-chronic liver failure(ACLF)grade 2 or 3 and Model for End-Stage Liver Disease(MELD)*** regression models assessed time trend changes on a log ***:Of 23,871 recipients(8,995 in the COVID era,April 2018–February 2020),mean age 52 years,62% men,61% Caucasian,32%ALD,15%HCC,30%ACLF grades 2–3,and mean MELD score 20.5,monthly LT changes were a decrease of 3.4%for overall LTs and 22%for HCC after September 2020,and increase of 4.5%for ALD since 11/2020 and 17%since 03/2021 for ACLF grade 2–*** MELD scores increased by 0.7 and 0.36 after june 2020 for HCV and HCC ***:The COVID-19 pandemic has impacted LT activity,with a decrease of LTs especially for HCC,and an increase of LTs for ALD and severe *** are needed to reorganize cirrhosis patients to overcome the aftereffects of COVID-19 pandemic.

关键词： COVID-19 UNOS OLT Region Public policies

Women's health and Chinese integrative medicine

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journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第3期18卷 183-185页

作者： Fan QU Fang-fang WANG Nicola ROBINSON paul j.HARDIMAN Women's Hospital School of Medicine Zhejiang University School of Health and Social Care London South Bank University Institute for Women's Health University College London Medical School

Researchers in the fields of obstetrics, gynecology, and Chinese integrative medicine （CIM） were invited to share their perspectives on the most recent studies.

关键词：女性健康中西医结合医学妇产科学