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A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by autodisplay-based screening

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Journal of Pharmaceutical Analysis 2024年第7期14卷 1091-1094页

作者： Alexander Dombovski Ruben Steigerwald Nadine Ritter paul disse Gunnar Goerges Jana Osthues Isabel Aymanns Carina Dilkaute Julian Schreiber Martina Düfer Guiscard Seebohm Bernhard Wünsch Joachim Jose University of Münster Institute of Pharmaceutical and Medicinal ChemistryPharmacampus48149MünsterGermany University of Münster GRK 2515Chemical Biology of Ion Channels(Chembion)48149MünsterGermany University of Münster Institute for Genetics of Heart Diseases(IfGH)Department of Cardiovascular MedicineUniversity Hospital Münster48149MünsterGermany

Autodisplay of N-methyl-D-aspartate(NMDA)receptor[1]ligand binding domains(LBDs)was done by inserting the coding sequence for each LBD[2]into a plasmid for maximized autotransporter-mediated expression(pMATE)between the coding sequences of signal peptide and translocator domain[3](Figs.1A and S1).Surface display and functionality of LBDs was confirmed by protease accessibility and radioligand binding(Figs.S2 and S3).This is discussed in more detail in the Sections S1.1S1.5 in the Supplementary *** with surface displayed LBDs were applied for a flow cytometry-based binding assay to evaluate fluorescent TCN-201 derivatives[4](Figs.1B,S4,and S5).More detailed information about the structural prerequisites of TCN-201 derivatives for interacting with the modulatory binding site and synthesis of fluorescent derivatives is given in the Sections S1.6 and S1.7 in the Supplementary data.

关键词： compound synthesis sequences

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Enhancing Fire Safety in Commercial Vehicles: Assessing the Efficacy and Advantages of Exploding Fire Extinguishing Balls

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Journal of Transportation Technologies 2024年第4期14卷 521-548页

作者： paul W. Ford Occupational Health and Safety Capitol Technology University Laurel MD USA

Fire incidents in commercial vehicles pose significant risks to passengers, drivers, and cargo. Traditional fire extinguishing systems, while effective, may have limitations in terms of response time, coverage, and human intervention [1]. This study investigates the efficacy of a novel fire suppression technology—the Exploding Fire Extinguishing Ball (EFEB) —as an alternative and complementary fire safety solution for commercial vehicles. The research employs a multidisciplinary approach, encompassing engineering, materials science, fire safety, and human factors analysis. A systematic literature review establishes a comprehensive understanding of existing fire suppression technologies, including EFEBs. Subsequently, this study analyzes the unique features of EFEBs, such as automatic activation, as well as manual activation upon exposure to fire, and their potential to provide rapid, localized, and autonomous fire suppression. The study presents original experimental investigations to assess the performance and effectiveness of EFEBs in various fire scenarios representative of commercial vehicles. Experiments include controlled fires in confined spaces and dynamic simulations to emulate real-world fire incidents. Data on activation times, extinguishing capability, and coverage area are collected and analyzed to compare the efficacy of EFEBs with traditional fire extinguishing methods. Furthermore, this research shows the practical aspects of implementing EFEBs in commercial vehicles. A feasibility study examines the integration challenges, cost-benefit analysis, and potential regulatory implications. The study also addresses the impact of EFEBs on vehicle weight, stability, and overall safety. Human factors and user acceptance are crucial elements in adopting new safety technologies. Therefore, this research utilizes an experimental design to assess the performance and effectiveness of EFEBs in various fire scenarios representative of commercial vehicles. This disse

关键词： Exploding Fire Extinguishing Balls Commercial Vehicles Fire Suppression Fire Safety Technology Human Factors Usability Feasibility Study

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