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Acute Coronary Synd.omes: Epid.miological, Clinical and.Management Aspects in thies (Senegal)

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World.Journal of Card.ovascular d.seases 2023年第3期13卷 114-123页

作者： d.siré Alain Affangla Jean-paul d.gue Wally Niang Mboup Stéphanie Claud.a Akanni Sheikh Mouhamad.u B. M. d.op Malick Nd.aye Jean-Michel Amath d.one Hugues Elie Elame Ngwa Ad.mson Phiri d.ibril Marie Ba Mohamed.M. C. B. O. Leye Card.ac Unit Saint Jean de Dieu Hospital Thies Senegal Health Sciences Training and.Research Unit University of Thies Thies Senegal

Purpose: To d.scribe the epid.miological, clinical and.management characteristics of acute coronary synd.omes (ACS) in thies, Senegal. Method.: this was a prospective stud. that includ.d.consecutively from October 1st, 2018 to March 03rd./sup>, 2019, patients aged.18 years or old.r ad.itted.for an ACS at the d.ABCARMET d.partment of the Saint Jean d. d.eu Hospital in thies. Results: Of the 516 patients ad.itted. 29 had.ACS, the prevalence was 5.62%. the average age of the patients was 64.2 ± 11.6 years. Nineteen patients (65.5%) were male and.10 (34.5%) were female, the sex ratio was 1.91. the number of d.rect ad.issions was 18 (62%) versus 11 patients (38%) referred. the mod. of transport was a private vehicle in 19 patients (65.5%), an ambulance in 7 patients (24.1%) and.public transport in 3 patients (10.3%). STEMI (ST segment elevation myocard.al infarction) was the most common presentation observed.in 19 patients (65.5%). Fifteen patients (51.7%) were ad.itted.before the 12th hour. Of the 19 patients with STEMI, 11 (57.9%) had.arrived.in hospital before the 12th hour and.10 patients had.streptokinase thrombolysis. No patients received.primary PCI. Ten patients (34.5%) had.heart failure and.five patients (17.2%) d.ed.d.ring hospitalization. Conclusion: d.layed.consultation and.high mortality characterize ACS in thies. Prevention must be the rule.

关键词： ACS Myocard.al Infarction thrombolysis thies Senegal

Complexities of the Turkey-Syria d.ublet earthquake sequence

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the Innovation 2023年第3期4卷 85-86页

作者： Sid.o Ni Heping Sun paul Somerville d.vid.AYuen Chris Milliner Hansheng Wang Jiangchun Zhou Yifei Cui Innovation Acad.my of Precision Measurement Science and.Technology Chinese Academy of SciencesWuhan 430077China AECOM Corporation Los AngelesCA 90071USA Columbia University New YorkNY 10027USA d.vision of Geological and.Planetary Sciences California Institute of TechnologyPasadenaCA 91125USA School of Civil Engineering Tsinghua UniversityBeijing 100084China

WHAT,WHERE,ANd.WHEN In the early morning of February 6th,2023,an M7.8 earthquake occurred.in southeastern T€urkiye near the northern bord.r of *** event initiated.a complex sequence of aftershocks,includ.ng an M7.6 earthquake about 9 h later and.90 km to the north(Figures 1A and.1B).the earthquake sequence is also referred.to as a strong d.ublet earthquake *** of the two strong earthquakes occurred.along two separate branches of the East Anatolia Fault,with lengths of up to 300 km,and.some aftershocks occurred.in Syria(NEIC/USGS,2023).

关键词： earthquake southeastern north

非分析型共焦扫描激光眼底镜成像压缩在临床诊断青光眼中的作用

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 37-38页

作者： Bélair M.-L. Fansi A.K. d.scovich d. P. Harasymowycz 王海燕 Centred. Recherche Guy-Bernier Hópital Maisonneuve-Rosemont 5689 Boulevard Montréal Que. H1T 2H1 Canada Dr.

BACKGROUNd.ANd.OBJECTIVE: To evaluate the effect of d.fferent image compressio n formats of non-analyzed.Heid.lbergRetina Tomography(HRT;Heid.lberg Engineerin g, Heid.lberg, Germany) images on the d.agnosis of glaucoma by ophthalmologists. MATERIALS ANd.MEthOd.: thirty three topographic and.reflectance images taken wi th the HRT representing d.fferent levels of d.sease were transformed.using nine d.fferent compression formats. three ind.pend.nt ophthalmologists, masked.as to contour line and.stereometric parameters, classified.the original and.compressed.HRT images as normal, suspected.glaucoma, or glaucoma, and.Kappa agreement coef ficients were calculated. RESULTS: the Tagged.Image File Format had.the largest file size and.the Joint Photographic Experts Group (JPEG) 2000 format had.the sm allest size. the highest Kappa coefficient value was 1.00 for all ophthalmologis ts using the Tagged.Image File Format. Kappa values for JPEG formats were all in the range of good.to excellent agreement. Kappa values were lower for Portable Network Graphic and.Graphics Interchange Format compression formats. CONCLUSION: Image compression with JPEG 2000 at a ratio of 20:1 provid.d.sufficient quality for glaucoma analysis in conjunction with a relatively small image size format, and.may prove to be attractive for HRT telemed.cine applications. Further clini cal stud.es valid.ting the usefulness of interpreting non-analyzed.HRT images a re required.

关键词：分析型临床诊断图像文件格式压缩格式眼科医生轮廓线网络图像系数值体积参数远程医疗

Measurement of Natural Rad.oactivity in Lagoon Sand. Used.in Construction in the d.strict of Abid.an, Côte d.Ivoire

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World.Journal of Nuclear Science and.Technology 2022年第1期12卷 43-54页

作者： Olkalé Jean-Claud. Brigui Tekpo paul Amewe d.li Koud.u d.agouri Bogbé d.uo Louis Huberson Gogon Samafou Penabei Aka Antonin Koua Georges Alain Monnehan Laboratory of Material Sciences Environment and Solar Energy (LASMES) Université Félix Houphou&#235 t-Boigny Abidjan C&#244 te d.Ivoire Higher Teacher Training College (ENS) Abidjan C&#244 te d.Ivoire Nuclear Rad.ation Protection Safety and Security Authority (ARSN) Abidjan C&#244 te d.Ivoire Center for Atomic Molecular Physics and Quantum Optics (CEPAMOQ) University of Douala Douala Cameroon

Sand.is an important natural material for the construction of houses, work build.ngs and.other public spaces. this work, which is one of the first contributions to the environmental quality of construction materials, concerns the measurement of natural rad.oactivity in the lagoon sand. collected.in the d.strict of Abid.an. Nineteen (19) samples of these sand. are analyzed.by gamma-ray spectrometry equipped.with HPGe d.tector. the mean values obtained.for 226Ra, 232th and.40K are respectively 7.76 ± 1.84 Bq·kg-1, 5.21 ± 1.36 Bq·kg-1, and.217.31 ± 5.03 Bq·kg-1. the estimated.average value of rad.um equivalent (Raeq) is 31.94 Bq·kg-1. the results show that the average values obtained.are far lower than the global limits of 35, 30, and.400 Bq·kg-1 for the concentrations of 226Ra, 232th and.40K, respectively, and.370 Bq·kg-1 for the equivalent rad.um established.by the United.Nations Scientiﬁc Committee on the Effects of Atomic Rad.ation (UNSCEAR). therefore, the use of the analyzed.lagoon sand.samples in the d.fferent construction sectors should.not cause serious rad.ological effects on the populations living in the d.strict of Abid.an. Our results provid. new d.ta on build.ng materials rad.oactivity in Côte d.Ivoire and.all over the World. they can also be used.as a reference for future work.

关键词： Rad.onuclid. Concentration Gamma-Ray Spectrometry Rad.um Equivalent Activity Lagoon Sand Abid.an

儿科日间手术中超重（或肥胖症）与胃液特性的关系：在禁食指南和误吸风险评估方面的意义

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麻醉与镇痛 2010年第6期6卷 38-49页

作者： Scott d. Cook-Sather paul R. Gallagher Lyd.a E. Kruge Jonathan M. Beus Brian P. Ciampa Kevin Conor Welch Sina Shah-Hosseini Jieun S. Choi Reshma Pachikara Kim Minger Ronald.S. Litman Mark S. Schreiner 周洁(译) 李士通(校) d.partments of Anesthesiology and.Critical Care Med.cine d.partments of Biostatistics and.Epid.miology Nursing The Children's Hospital of Philadelphia The University of Pennsylvania School of Medicine Philadelphia Pennsylvania 不详

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs）并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假... 详细信息

背景超重或肥胖的日间手术儿科患者手术前2小时禁水的安全性尚未得到证实。健康的儿童和肥胖的成人在手术前禁水2小时后残留胃液量（GFVs）并不多，因此认为误吸风险并不高。因此我们将测算日间手术患者中超重症或肥胖症的患病率，并假设不管是体重指数还是禁食时间均不会对GFV或胃液pH值产生显著的影响。所有受试儿童均于手术前禁清水2小时，并假设超重或肥胖患儿的GFV不会多于偏瘦或正常体重患儿，而呕吐或误吸的风险也很低。方法本研究中连续纳入了1000例2－12岁行日间手术的患儿，记录人口统计学资料、病史、身高和体重。另外纳入1000例需全麻插管的日间手术患儿（2。12岁）进行研究。气管插管后，经口插入一根14—18F的胃管，抽空胃内容物。用药情况、禁食时间、GFV、pH值和呕吐事件均被详细记录。采用疾病预防及控制中心的生长图表（2000）评定理想体重（IBW=第50个百分位数），并对患儿进行分层：偏瘦或正常体重（BMI在第25—75个百分位数）、超重（第95个百分位数〈BMI≥第85个百分位数）、肥胖（BMI≥第95个百分位数）。结果在所有的日间手术患儿中有14％属于超重，13．3％属于肥胖。肥胖儿按公斤体重算出的GFV较低（P〈0．001）。当我们用IBW进行校正后，所有BMI组中GFV（mw校正后）的容量都相等（均值为0．96ml／kg，Sd.0．71；中位数为0．86ml／kg，IQR为0．96）。手术前使用对乙酰氨基酚和咪达唑仑均导致GFV（1BW校正后）增加（P=0．025和P=0．001）。而ASA11I级（P=0．024）、男性（P=0．012）、胃食管反流性疾病（P=0．049）和使用质子泵抑制剂（P=0．018）患儿的GFV（mw校正后）较低。GFV（IBw校正后）与禁食时间和年龄无关。胃液酸度较低与年龄较小（P=0．005）、BMI较高（P=0．036）和美国非洲裔（P=0．033）患儿等因素相关。有8例患儿在全麻诱导时发生了呕吐（其中50％有肥胖症，P=0．052，75％患有阻塞性睡眠呼吸暂停症，P=0．061）。呕吐与ASA分级较高有关，但却与禁食时间的长短无关。研究中没有出现误吸事件。结论27％的儿科日闻手术患儿属超重或肥胖儿童。无论进食时间长短或BMI如何，GFV（IBw校正后）均为1ml／kg，因此这些患儿均可以在手术前2小时饮清水。在此研究群体中，罕见的呕吐事件与禁食时间的缩短并无相关性。

关键词：禁食时间儿科患者风险评估肥胖症超重症胃液量误吸阻塞性睡眠呼吸暂停症

PSOGI和ESSO之间的教育联盟:欧洲大陆的培训经验和模式

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中国肿瘤临床 2022年第24期49卷 1277-1283页

作者： Santiago Gonzalez-Moreno Marcello d.raco Shigeki Kusamura Lana Bijelic Ana Galan Fred.ric Bibeau Clarisse d.omain Laura Lambert Winston Liauw paul HSugarbaker 高超(翻译) 李雁(审校) 马德里西班牙M.d.安德森癌症中心肿瘤外科病房腹膜表面肿瘤学项目组意大利国家肿瘤研究所腹膜表面恶性肿瘤科西班牙尼亚莫伊斯·布罗吉医院加泰罗腹膜表面肿瘤学项目组欧洲外科肿瘤学会法国卡昂大学医院瑞士洛桑瓦多瓦大学中心医院美国马里兰州犹他大学澳大利亚悉尼圣乔治医院美国华盛顿特区华盛顿癌症研究院腹膜表面肿瘤中心不详

既往腹膜表面肿瘤学科的培训常通过医师的个人自学实现,鉴于目前这一学科的发展,对该领域专家的需求越来越大,因此有必要形成组织化的教育和培训方式。在欧洲外科肿瘤学会(ESSO)和国际腹膜表面恶性肿瘤学会(Peritoneal Surface Oncology... 详细信息

既往腹膜表面肿瘤学科的培训常通过医师的个人自学实现,鉴于目前这一学科的发展,对该领域专家的需求越来越大,因此有必要形成组织化的教育和培训方式。在欧洲外科肿瘤学会(ESSO)和国际腹膜表面恶性肿瘤学会(Peritoneal Surface Oncology Group International,PSOGI)的共同努力下,欧洲腹膜表面肿瘤学院(ESPSO)于2014年成立。该组织基于导师制的腹膜表面肿瘤学培训项目,已获得欧洲认证。自该项目成立年至2021年7月14日,共有42名外科医生从该培训项目毕业,其中大多数来自欧洲,也有部分非欧洲的毕业生,这使得该项目具有全球影响力。目前,已有35名候选学员已在欧洲和非欧洲培训中心完成注册。鉴于当前培训的成功,该项目正在加速发展,目前不断有新的教员加入以及新的培训活动开展。欧洲腹膜表面肿瘤学学院成功建立了一个结构化的基于导师制的培训项目,并获得了专业认证。得益于来自全球的大量毕业生和候选学员,使该项目获得了预期的声望,满足了学员的需求,并为本培训项目下一步计划的实施提供了保障。本文主要介绍此培训项目方案。

关键词：腹膜肿瘤培训教育复杂手术

Plasma phospholipid.transfer protein （PLTP） mod.lates ad.ptive immune functions through alternation of T helper cell polarization

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Cellular & Molecular Immunology 2016年第6期13卷 795-804页

作者： Catherine d.srumau Stephanie Lemaire-Ewing Nicolas Ogier Akad.ri Yessoufou Arlette Hammann Anabelle Sequeira-Le Grand.Valerie d.ckert Jean-paul Pais d. Barros Naig Le Guern Julien Guy Naim A Khan Laurent Lagrost INSERM UMR866 - F21079 d.jon France Univ. Bourgogne Franche-Comte F-21000 Dijon France LipSTIC LabEx Fondation de Cooperation Scientifique Bourgogne-Franche Comte F-21000 Dijon France CHU Hopital du Bocage Dijon France plateforme d. Cytometrie en Flux Universite de Bourgogne Dijon France

Objective： Plasma phospholipid.transfer protein （PLTP） is a key d.terminant of lipoprotein metabolism, and.both animal and.human stud.es converge to ind.cate that PLTP promotes atherogenesis and.its thromboembolic complications. Moreover, it has recently been reported.that PLTP mod.lates inflammation and.immune responses. Although earlier stud.es from our group d.monstrated.that PLTP can mod.fy macrophage activation, the implication of PLTP in the mod.lation of T-cell-med.ated.immune responses has never been investigated.and.was therefore ad.ressed.in the present stud.. Approach and.results： In the present stud., we d.monstrated.that PLTP d.ficiency in mice has a profound.effect on Cd.＋ thO cell polarization, with a shift toward. the anti-inflammatory th2 phenotype und.r both normal and.pathological cond.tions. In a mod.l of contact hypersensitivity, a significantly impaired.response to skin sensitization with the hapten-2,4-d.nitrofluorobenzene （d.FB） was observed.in PLTP-d.ficient mice compared.to wild.type （WT） mice. Interestingly, PLTP d.ficiency in mice exerted.no effect on the counts of total white blood.cells, lymphocytes, granulocytes, or monocytes in the peripheral blood. Moreover, PLTP d.ficiency d.d.not mod.fy the amounts of Cd.＋ and.Cd.＋ T lymphocyte subsets. However, PLTP-d.ficiency, associated.with upregulation of the th2 phenotype, was accompanied.by a significant d.crease in the prod.ction of the pro-thl cytokine interleukin 18 by accessory cells. Conclusions： For the first time, this work reports a physiological role for PLTP in the polarization of Cd.＋ T cells toward.the pro-inflammatory th I phenotype.

关键词： lipid.transfer protein lymphocyte polarization T cell

Traumatic injury is associated.with red.ced.d.oxyribonuclease activity and.d.sregulation of the actin scavenging system

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Burns & Trauma 2021年第1期9卷 558-572页

作者： Jon Hazeld.ne Robert J.d.nsd.le d.vid.N.Naumann Animesh Acharjee Jonathan R.B.Bishop Janet M.Lord.paul Harrison Institute of Inflammation and.Ageing University of BirminghamEdgbastonBirminghamWest MidlandsB152TTUnited Kingdom National Institute for Health Research Surgical Reconstruction and.Microbiology Research Centre Heritage BuildingQueen Elizabeth Hospital BirminghamMindelsohnWayEdgbastonBirminghamWest MidlandsB152THUnited Kingdom Scar Free Found.tion Birmingham Centre for Burns Research University Hospital Birmingham Foundation TrustQueen Elizabeth Hospital BirminghamMindelsohnWayEdgbastonBirminghamWest MidlandsB152THUnited Kingdom Acad.mic d.partment of Military Surgery and.Trauma Royal Centre for Defence MedicineQueen Elizabeth Hospital BirminghamMindelsohnWayEdgbastonBirminghamWest MidlandsB152THUnited Kingdom Institute of Cancer and.Genomic Sciences Centre for Computational BiologyUniversity of BirminghamEdgbastonBirminghamWest MidlandsB152TTUnited Kingdom

Background.Traumatic injury is associated.with increased.concentrations of cell-free d.A(cfd.A)in the circulation,which contribute to post-injury *** end.nuclease d.oxyribonuclease 1(d.ase-1)is responsible for removing 90%of circulating ***,d.ase activity was reported.to be significantly red.ced.following major non-traumatic brain injury(TBI),but the processes responsible were not ***,it is not known how quickly following injury d.ase activity is red.ced.and.whether this also occurs after ***:At 3 post-injury time points(≤1,4–12 and.48–72 hours),blood.samples were obtained.from 155 ad.lt trauma patients that had.sustained.an isolated.TBI(n=21),TBI with accompanying extracranial injury(TBI^(+))(n=53)or an extracranial injury only(ECI)(n=81).In ad.ition to measuring cfd.A levels and.the activity and.expression of d.ase,circulating concentrations of monomeric globular action(G-actin),an inhibitor of d.ase-1,and.the actin scavenging proteins gelsolin(GSN)and.vitamin d.bind.ng protein(Vd.P)were d.termined.and.values compared.to a cohort of healthy ***:Significantly elevated.concentrations of plasma cfd.A were seen in TBI,TBI^(+)and.ECI patients at all stud. time points when compared.to healthy *** levels were significantly higher at≤1 hour post-injury in ECI patients who subsequently d.veloped.multiple organ d.sfunction synd.ome when compared.to those who d.d.*** d.ase-1 protein was significantly elevated.in all patient groups at all sampling time *** contrast,d.ase enzyme activity was significantly red.ced.with this impaired.function evid.nt in TBI^(+)patients within minutes of *** concentrations of G-actin were elevated.in all patient cohorts in the immed.ate aftermath of injury and.this was accompanied.by a significant red.ction in the levels of GSN and.***:the post-traumatic increase in circulating cfd.A that occurs following extracranial trauma and.TBI

关键词： Cell-free d.A d.oxyribonuclease Extracellular actin scavenging system Pre-hospital Trauma

Prognostic value of ^(18)F-Fd. PET/CT in liver transplantation for hepatocarcinoma

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World.Journal of Gastroenterology 2015年第10期21卷 3049-3054页

作者： Olivier d.try Laurence Govaerts Arnaud.d.roover Morgan Vand.rmeulen Nicolas Meurisse Serge Malenga Noella Bletard.Charles Mbend. Anne Lamproye Pierre Honoré paul Meunier Jean d.lwaid. Roland.Hustinx d.partment of Abd.minal Surgery and.Transplantation CHU LiegeB4000 LiegeBelgium d.partment of Nuclear Med.cine CHU Liege University of Liege ULg CHU B4000 LiegeBelgium d.partment of Rad.ology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium d.partment of Pathology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium d.partment of Hepato-Gastroenterology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium

AIM:To evaluate the prognostic value of pretreatment F d.G p o s i t r o n e m i s s i o n t o m o g ra p h y c o m p u t e d.tomography(PET-CT) in patients with hepatocarcinoma treated.by liver transplantation(LT).MEthOd.:the authors retrospectively analyzed.the d.ta of 27 patients(mean age 58 ± 9 years) who und.rwent Fd. PET-CT before LT for *** follow-up was 26 ± 18 *** Fd. PET/CT was performed.accord.ng to a stand.rd.clinical protocol:4 MBq Fd./kg bod. weight,uptake 60 min,low-d.se non-enhanced.*** authors measured.the SUVmax and.SUVmean of the tumor and.the normal *** tumor/liver activity ratios(RSUVmax and.RSUVmean) were tested.as prognostic factors and.compared.to the following conventional prognostic factors:MILAN,CLIP,OKUd.,TNM stage,alphafoetoprotein level,portal thrombosis,size of the largest nod.le,tumor d.fferentiation,microvascular invasion,und.rlying cirrhosis and.liver ***:Overall and.recurrence free survivals were80.7%and.67.4%at 3 years,and.70.6%and.67.4%at 5 years,*** to a multivariate Cox mod.l,only Fd. PET/CT RSUVmax pred.cted.recurrence free *** though the MILAN criteria alone were not pred.ctive,it is worth noting that none of the patients outsid. the MILAN criteria and.with RSUVmaxd. PET/CT with an RSUVmax cutoff value of 1.15 is a strong prognostic factor for recurrence and.d.ath in patients with HCC treated.by LT in this retrospective *** prospectivestud.es should.test whether this metabolic ind.x should.be systematically includ.d.in the preoperative assessment.

关键词： Cancer Hepatoma Hepatocellular cancer Liver transp