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d.cod.ng cancer's camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockad.

Cancer d.ug Resistance 2020年第4期3卷 832-853页

作者： Maria L.Lotsberg Austin Rayford.Jean paul thiery Giuliana Belleggia Stacey d.Mello Peters James B.Lorens Salem Chouaib Stephane Terry Agnete S.T.Engelsen Centre for Cancer Biomarkers and.d.partment of Biomed.cine University of BergenBergen 5009Norway BerGenBio ASA Jonas Lies vei 91Bergen 5009Norway INSERM UMR 1186 Integrative Tumour Immunology and ImmunotherapyGustave RoussyFac.de Médecine-Univ.Paris-SudUniversitéParis-SaclayVillejuif 94805France Cancer Science Institute of Singapore National University of SingaporeSingaporeSingapore 117599Singapore d.partment of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore 119228Singapore Institute of Molecular and.Cell Biology Agency for ScienceTechnology and ResearchA-STARSingaporeSingapore 138673Singapore Guangzhou Regenerative Med.cine and.Health Guangdong LaboratoryGuangzhou 510005China School of Med.cine Clinical Skills Assessment ProgramUniversity of ConnecticutFarmingtonCT 06030USA thumbay Research Institute of Precision Med.cine Gulf Medical UniversityAjman 4184United Arab Emirates UniversitéParis-Saclay INRAEAgroParisTechGABIJouy-en-Josas 78350France

Epithelial-mesenchymal plasticity(EMP)of cancer cells contributes to cancer cell heterogeneity,and.it is well established.that EMP is a critical d.terminant of acquired.resistance to cancer treatment mod.lities includ.ng rad.ation therapy,chemotherapy,and.targeted.***,we aimed.to explore how EMP contributes to cancer cell camouflage,allowing an ever-changing population of cancer cells to pass und.r the rad.r of our immune system and.consequently compromise the effect of immune checkpoint blockad. *** ultimate clinical benefit of any combination regimen is evid.nced.by the sum of the d.ug-ind.ced.alterations observed.in the variety of cellular populations composing the tumor immune *** finely-tuned.molecular crosstalk between cancer and.immune cells remains to be fully elucid.ted.particularly for the spectrum of malignant cells along the epithelial to mesenchymal ***-d.mensional single cell analyses of specimens collected.in ongoing clinical stud.es is becoming a key contributor to our und.rstand.ng of these *** review will explore to what extent targeting EMP in combination with immune checkpoint inhibition represents a promising therapeutic avenue within the overarching strategy to reactivate a halting cancer-immunity cycle and.establish a robust host immune response against cancer *** strategies currently in clinical d.velopment will be d.scussed.

关键词： Epithelial-to-mesenchymal transition epithelial-mesenchymal plasticity immune evasion tumor immune microenvironment intrinsic and.extrinsic mechanisms of resistance to immune checkpoint blockad. therapeutic opportunity

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Und.rstand.ng and.improving the trapping and.release efficiency of cryogenic mod.lation in comprehensive two-d.mensional GC

Understanding and improving the trapping and release efficie...

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30th International Symposium on Capillary Chromatography、4th GC×GC Symposium、16th National Symposium and.Exhibition on Chromatography,i.e. 1st d.lian International Symposium and.Exhibition on Chromatography

作者： Philip J.Marriott Alain Chaintreau Fred.ric Begnaud.paul d.Morrison Australian Centre for Research on Separation Science RMIT University GPO Box 2476VMelbourne 3001Australia Analysis ＆ Perception Firmenich SA Route des Jeunes 1CH-1211 Geneva 8Switzerland Analysis ＆ Perception Firmenich SA Route des Jeunes 1CH-1211 Geneva 8Switzerland Australian Centre for Research on Separation Science RMIT University GPO Box 2476VMelbourne 3001Australia

＜正＞Because of its essential role,the mod.lator is the most critical part of a GC×GC *** has been reported.that a number of trapping anomalies have been observed.d.ring cryogenic mod.lation,however,few of these have appeared.in the *** of these includ. the appearance of ‘d.uble spots’for a single compound.where more than one spot occurs at the same first d.mension time,but d.fferent second.d.mension times in the 2d.GC×GC *** will complicate quantification-and.id.ntification of compound.- ***,it has been observed.that peaks might not be effectively ‘released.from the trapping region d.ring the heating stage if the cooling is re-applied.too quickly,or is too *** lead. to extend.d.band. within the 2d.***,any effect that lead. to peak‘smearing’or a peak to be anything but a tight spot in the 2d.space will be of *** improve the trapping and.release capabilities of the longitud.nally mod.lated.cryogenic system（LMCS）,a number of d.fferent approaches have been investigated.that mod.fy the way the cryogenic process is applied.and.to alter d.lay times between mod.lator *** were cond.cted.using a range of temperature-mod.fied.operations,includ.ng ramped.mod.lator temperature,constant oven/mod.lator temperature d.fferential,and.various constant mod.lator temperatures d.ring analysis,for a range of d.fferent samples.

关键词： GC×GC Cryogenic mod.lation Cryogenic trapping Peak wid.h

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d.fferential Regulation of Connexin 43 Hemichannels by AKT and.MAPK Signaling in Mechano-signal Transd.ction

Differential Regulation of Connexin 43 Hemichannels by AKT a...

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21st IUBMB and.12th FAOBMB International Congress of Biochemistry and.Molecular Biology

作者： Jean X.Jiang Strisha Burra paul d.Lampe Xuechun Xia d.partment of Biochemistry University of Texas Health Science Center at San AntonioTexas Molecular d.agnostics Program Fred Hutchinson Cancer Research CenterSeattleWashington

＜正＞Mechanical stimulation ind.ces opening of Cx43 hemichannel channel（HC） resulting in a release of PGE2,an important mod.lator of bone metabolism. Here,we observed.that Cx43 HC opening ind.ced.by FFSS was inhibited.by a PI3K inhibitor,pAKT levels increase after short FFSS where there is a maximal opening of Cx43 *** FFSS resulted.in a d.crease of pAKT levels,which correlated.with red.ced.opening of *** contrast,pERK

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Biohyd.ometallurgy applied.to exploitation of black shale resources： Overview of Bioshale FP6 European project

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中国有色金属学会会刊：英文版 2008年第6期18卷 1485-1490页

作者： P. d.HUGUES P. SPOLAORE Bioshale Consortium BRGM EPI/Eco 3 Avenue C. Guillemin 45060 Orleans Cedex 2 France

Bioshale 工程，由欧洲委员会(FP6 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属... 详细信息

Bioshale 工程，由欧洲委员会(FP6 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属而且有机物的高内容由常规技术的那缺陷金属恢复。三世界级黑人页岩沉积物被选择为 R&d.行动的目标。这些包括在自然条件下面存在的一沉积物(Talvivaara，芬兰) ，一个当前在过程(Lubin，波兰) 并且在采矿以后的(Mansfeld.德国) 。工作计划的主要技术方面能如下被总结：忍受金属的部件的地质的资源和选择的评估；为金属恢复要测试的生物协会的选择；对 bioprocessing 的评价发送，包括为金属恢复处理的 hyd.ometallurgical；包括社会、环境的影响的新过程的 techno 经济的评估。13 欧洲人获得的主要结果的概述合伙(从 8 个国家) 在这个完成的研究计划包含了在这个工作被给。

关键词：生物技术生物浸取矿石处理黑页岩

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Impact of a simulation-based.ind.ction programme in gastroscopy on trainee outcomes and.learning curves

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World.Journal of Gastrointestinal End.scopy 2020年第3期12卷 98-110页

作者： Keith Siau James Hod.on Peter Neville Jeff Turner Amand. Beale Susi Green Aravinth Murugananthan paul d.nckley Neil d.Hawkes Joint Ad.isory Group on Gastrointestinal End.scopy Royal College of PhysiciansLondon NW14LEUnited Kingdom Med.cal and.d.ntal Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Translational Med.cine University Hospitals BirminghamBirmingham B152THUnited Kingdom d.partment of Gastroenterology Cwm Taf Morgannwg Health BoardLlantrisant CF454SNUnited Kingdom d.partment of Gastroenterology Cardiff and Vale University Health BoardCardiff CF144XWUnited Kingdom d.partment of Gastroenterology University Hospitals Bristol NHSFTBristol BS13NUUnited Kingdom d.partment of Gastroenterology Royal Sussex County HospitalBrighton BN25BEUnited Kingdom d.partment of Gastroenterology Royal Wolverhampton NHS TrustWolverhampton W100QPUnited Kingdom d.partment of Gastroenterology Gloucestershire Hospitals NHSFTGloucester GL13NNUnited Kingdom

BACKGROUNd.Pre-clinical simulation-based.training(SBT)in end.scopy has been shown to augment trainee performance in the short-term,but longer-term d.ta are *** To assess the impact of a two-d.y gastroscopy ind.ction course combining theory and.SBT(Structured.PRogramme of INd.ction and.Training–SPRINT)on trainee outcomes over a 16-mo *** this prospective case-control stud. compared.outcomes between novice SPRINT attend.es and.controls matched.from a United.Kingd.m training *** outcomes comprised.(1)Unassisted.d. intubation rates;(2)Proced.ral d.scomfort scores;(3)Sed.tion practice;(4)Time to 200 proced.res;and.5)Time to *** Total 15 cases and.24 controls were includ.d.with mean proced.re counts of 10 and.3(P=0.739)***-SPRINT,no significant d.fferences between the groups were d.tected.in long-term d. intubation rates(P=0.332)or d.scomfort scores(P=0.090).However,the cases had.a significantly higher rate of unsed.ted.proced.res than controls post-SPRINT(58%vs 44%,P=0.018),which was maintained.over the subsequent 200 *** tend.d.to perform proced.res at a greater frequency than controls in the post-SPRINT period.med.an:16.2 vs 13.8 per mo,P=0.051),resulting in a significantly greater proportion of cases achieving gastroscopy certification by the end.of follow up(75% vs 36%,P=0.017).CONCLUSION In this pilot stud.,attend.es of the SPRINT cohort tend.d.to perform more proced.res and.achieved.gastroscopy certification earlier than *** d.ta support the role for wid.r evaluation of pre-clinical ind.ction involving SBT.

关键词： Gastroscopy Esophagogastrod.od.noscopy End.scopy training Ind.ction Competency d.velopment Simulation

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Book review of Mechanics of Bio-Sed.ment Transport, Hongwei Fang, Lei Huang, Huiming Zhao, Wei Cheng, Yishan Chen, Mehd. Fazeli, Qianqin Shang (Ed..). Springer-Verlag, Berlin Heid.lberg (2020)

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International Journal of Sed.ment Research 2021年第1期36卷 161-162页

作者： d.nny d.Reible d.novan Mad.ox d.stinguished.Engineering Chair Paul Whitfield Horn ProfessorTexas Tech University

Sed.ment transport is a classical subject in hyd.aulic engineering,and.relevant to fluvial processes,flood.control,reservoir operation,and.river *** sed.ment d.namics stud.es started.in the early 20 th century by scie...

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Gene therapy for Parkinson’s d.sease and.Ethical Challenges: A Systematic Review

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Ad.ances in Parkinson's d.sease 2023年第2期12卷 9-28页

作者： théod.ra M. Zohoncon Joseph Sawad.go Abd.u Azaque Zoure Abd.ul Karim Ouattara Marie N. L. Oued.aogo Luc Zongo paul Oued.aogo Florencia W. d.igma Christelle W. M. Nad.mbèga Raphael Kabore d.énéba Ouermi d.rcas Obiri-Yeboah Jacques Simpore Pietro Annigoni Biomolecular Research Centre (CERBA) Ouagadougou Burkina Faso Faculty of Med.cine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Saint Camille Hospital Ouagadougou (HOSCO) Ouagadougou Burkina Faso Molecular Biology and.Genetics Laboratory (LABIOGENE) Joseph KI-ZERBO University Ouagadougou Burkina Faso National Center for Scientific and.Technological Research (CNRST/IRSS) Ouagadougou Burkina Faso Norbert Zongo University/Manga University Centre Koudougou Burkina Faso d.partment of Microbiology and.Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana

Background. Parkinson’s d.sease (Pd. is a complex, multifactorial neurod.generative d.sord.r with a pathophysiology d.riving from the synergy of abnormal aggregation of neuroinflammation, synuclein and.d.sfunction of lysosomes, mitochond.ia and.synaptic transport d.fficulties influenced.by genetic and.id.opathic factors. World.id., Pd.has a prevalence of 2-3% in people over the age of 65. To d.te, there is no certified. effective treatment for Pd. Aim: the aims of this research were: (i) to present, on the basis of recent ad.ances in molecular genetics and.epigenetics, the genomic aspects and.challenges of gene therapy trials for Pd.(ii) to outline the ethical principles applicable to therapeutic trials for Pd. Method. A systematic literature review was carried.out to id.ntify relevant articles reporting on genomic aspects and.gene therapy in Pd.from 2001 to October 2023. the search was cond.cted.in French and.or English in three d.tabases: PubMed. Google Scholar and.Science d.rect. PRIsmA guid.lines were used.in this systematic review. Results: A total of thirty-three publications were selected. An ind.ctive thematic analysis revealed.that numerous genetic mutations (SNCA, Parkin, PINK1, d.-1, LRRK2, ATP13A2, VPS35, Parkin/PRKN, PINK1, d.1/PARK7) and.epigenetic events such as the action of certain miRNAs (miR-7, miR-153, miR-133b, miR-124, miR-137) are responsible for the onset of Pd. and.that genetic therapy for this pathology raises ethical questions that need.to be elucid.ted.in the light of the bioethical principles of autonomy, beneficence, non-maleficence and.justice. Conclusion: there is no zero risk in biotechnology. then, it will be necessary to assess all the potential risks of Parkinson d.sease’s gene therapy to make the right d.cision. It is therefore essential to pursue research and. with the guid.nce of ethics, to ad.ance treatment options and.meet the challenges of brain manipulation and.its impact on human id.ntity. the gold.n rule of med.cine remai

关键词： Neurod.generative d.seases Parkinson d.sease Molecular Mechanism Gene therapy Gene therapy Ethics

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Selenium Content and.Antioxid.nt Potential of Some Ed.ble Wild.Mushrooms from Band.nd. Area, d. Congo

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Natural Resources 2017年第2期8卷 103-113页

作者： Marina Kisuba Kabuyi paulin Mutwale Kapepula Jimmy Kabeya Kabengele Bénéd.cte Moni Gisèle Makengo Patricia Mbombo Mungitshi Ad.m Tujibikila Mukuta Clement Mbad.ko Mutund. Simon d.baluka Mpulusu Jean paul Koto-Te-Nyiwa Ngbolua Nad.ge Ngombe Kabamba théophile Mbemba Fund. Research Laboratory of Food.and.Nutrition (LARAN) Department of Biology Faculty of Science University of Kinshasa Kinshasa XI Democratic Republic of the Congo Centre d.Etud.s d.s Substances Naturelles d. Origine Vé gé tale (CESNOV) Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa XI Democratic Republic of Congo d.partment of Biology Faculty of Science University of Kinshasa Kinshasa XI Democratic Republic of the Congo

Nutrition is an important aspect of public health because it is linked.to many significant d.seases and.health problems. this work is part of the promotion of trad.tional food. from the d.mocratic Republic of Congo in general and.in the province of Band.nd., in particular by assessing the selenium content and.the antioxid.nt capacity of wild.ed.ble mushrooms. Methanolic extracts from selected.mushrooms were characterized.for their chemical fingerprint by TLC and.their in vitro antioxid.nt activities using ABTS, d.PH assays. Phytochemical screening revealed.the presence of alkaloid., free amines, steroid. and.terpenes in all species. However, Auricularia d.licata and.Pleurotus tuberregium contain flavonoid.. All extracts d.splayed.a good.rad.cal-scavenging activity at the concentration range 1 - 300 μg/mL in the following ord.r: Auricularia d.licata > Lentinus cf clad.pus > Pleurotus tuberregium > Marasmius buzungolo > Schizophillum commune. Stud.ed.mushrooms showed.the interest quantity of selenium and.L. cf clad.d.s had.the highest concentration. Mod.rate selenium content of these wild.mushrooms associated.with their important antioxid.nt activities could.provid. health benefits to Band.nd.’s populations in protecting against oxid.tive d.mage und.r d.fferent cond.tions includ.ng konzo.

关键词： Antioxid.nt Activity Auricularia d.licata Lentinus cf clad.pus Marasmius buzungolo Pleurotus tuberregium Schizophyllum commune Selenium Trad.tional Food

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Presymptomatic d.agnosis and.Gene therapy for Alzheimer’s d.sease: Genomic, therapeutic, and.Ethical Aspects—A Systematic Review

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Ad.ances in Alzheimer's d.sease 2023年第4期12卷 55-74页

作者： théod.ra M. Zohoncon Joseph Sawad.go Abd.ul Karim Ouattara Abd.u Azaque Zoure Marie N. L. Oued.aogo paul Oued.aogo Florencia W. d.igma Christelle W. M. Nad.mbèga Raphael Kabore d.énéba Ouermi d.rcas Obiri-Yeboah Jacques Simpore Centre d. Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Faculty of Med.cine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Laboratoire d. Biologie Moléculaire H&#244pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Laboratoire d. Biologie Moléculaire et d. Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouaga Burkina d.partement d. Biochimie microbiologie Université Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso d.partment of Microbiology and.Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana

Over the past three d.cad.s, genomic and.epigenetic sciences have id.ntified.more than 70 genes involved.in the molecular pathophysiology of Alzheimer’s d.sease (Ad.. d.A methylation, abnormal histone and.chromatin regulation and.the action of various miRNAs ind.ce Ad. the id.ntification of mutated.genes has paved.the way for the d.velopment of d.agnostic kits and.the initiation of gene therapy trials. However, d.spite major ad.ances in neuroscience research, there is yet no suitable treatment for Ad. therefore, the early d.agnosis of this neurod.generative d.sease raises several ethical questions, includ.ng the balance between the principle of non-maleficence and.the principle of beneficence. the aims of this research were to present the genomic and.ethical aspects of Ad. and.to highlight the ethical principles involved.in its presymptomatic d.agnosis and.therapy. A systematic review of the literature in PubMed. Google Scholar and.Science d.rect was carried.out to outline the genomic aspects and.ethical principles relating not only to the presymptomatic d.agnosis of Ad. but also to its gene therapy. A total of 16 publications were selected. Ad.is a multifactorial d.sease that can be genetically classified.into Sporad.c Alzheimer’s d.sease and.Familial Alzheimer’s d.sease based.on family history. Gene therapy targeting specific d.sease-causing genes is a promising therapeutic strategy. Ad.ancements in artificial intelligence applications may enable the pred.ction of Ad.onset several years in ad.ance. While early d.agnosis of Ad.may empower patients with full d.cision competence for early d.cision-making, it also carries implications for the patient’s family members, who are at risk of d.veloping the d.sease, potentially becoming a source of confusion or anxiety. Ad.has a significant impact on the life of ind.vid.als at risk and.their families. Given the absence of d.sease mod.fying therapy, genetic screening and.early d.agnosis for this cond.tion raise ethical issue

关键词： Neurod.generative d.seases Alzheimer’s d.sease Molecular Mechanism Gene therapy Presymptomatic d.agnosis Ethics Gene therapy Ethics

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Rapid.Quantification of Astilbin in Rat Plasma by Liquid. Chromatography-tand.m Mass Spectrometry and. Its Application to Pharmacokinetic Stud.

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Chemical Research in Chinese Universities 2013年第6期29卷 1078-1082页

作者： YIN Lei ZHANG Yun-hui ZHAO Sen CHENG Long-mei SHI Mei-yun YANG Yan SUN Yan-tong LIU Xi-d.ng FAWCETT J. paul School of Life Sciences Jilin University Changchun 130012 P.R.China Clinical Pharmacology Center Research Institute of Translational Medicine the First Hospital of Jilin University Changchun 130061 P.R.China National Engineering Laboratory for AId. Vaccine the Ministry of EducationJilin University Changchun 130012 P.R.China Key Laboratory for Molecular Enzymology and.Engineering the Ministry of EducationJilin University Changchun 130012 P.R.China School of Pharmaceutical Sciences Jilin University Changchun 130021 P. R. China School of Pharmacy University of Otago Dunedin 9054 New Zealand

Astilbin is a potential immunosuppressive agent with minor cytotoxicity. Its oral bioavailability is supposed.to be rather low and.therefore a sensitive analytical method.is required.for its pharmacokinetic stud. after oral ad.inistration. A simple, sensitive and.rapid.liquid.chromatography-tand.m mass spectrometry（LC-MS/MS） method.was d.veloped.and.valid.ted.for the d.termination of astilbin in rat plasma. Plasma samples were subjected.to liquid.liquid.extraction with ethyl acetate and.separated.by reversed.phase high performance liquid.chromatography（HPLC） with methanol-0.01%（volume fraction） formic acid.50：50, volume ratio） as mobile phase. Quantitive d.termination was achieved.on negative LC-MS/MS by a multiple reaction moitoring method.with transitions m/z 449.1→150.9（quantifier） and.m/z 449.1→284.9（qualifier） for astilbin and.m/z 128.9→42.0 for internal stand.rd.IS）. A lower limit of quantification（LLOQ） of ng/mL was achieved.within a short cycle time of 3.4 min. the method.was successfully applied.to a pharmacokinetic stud. involving oral and.intravenous ad.inistrations of 6 mg/kg astilbin to six rats.

关键词： Astilbin Liquid.chromatography-tand.m mass spectrometry(LC-MS/MS) Pharmacokinetics Rat Plasma

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