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Chronic kidney disease and the skeleton

Bone Research 2014年第4期2卷 205-217页

作者： paul d Miller Colorado Center for Bone Research LakewoodCO.USA

Fractures across the stages of chronic kidney disease （CKd） could be due to osteoporosis, some form of renal osteodystrophy defined by specific quantitative histomorphometry or chronic kidney disease-mineral and bone disorder （CKd-MBd）. CKd-MBd is a systemic disease that links disorders of mineral and bone metabolism due to CKd to either one or all of the following： abnormalities of calcium, phosphorus, parathyroid hormone or vitamin d metabolism; abnormalities in bone turnover, mineralization, volume, linear growth or strength; or vascular or other soft-tissue calcification. Osteoporosis, as defined by the National Institutes of Health, may coexist with renal osteodystrophy or CKd-MBd. differentiation among these disorders is required to manage correctly the correct disorder to reduce the risk of fractures. While the World Health Organization （WHO） bone mineral density （BMd） criteria for osteoporosis can be used in patients with stages 1-3 CKd, the disorders of bone turnover become so aberrant by stages 4 and 5 CKd that neither the WHO criteria nor the occurrence of a fragility fracture can be used for the diagnosis of osteoporosis. The diagnosis of osteoporosis in stages 4 and 5 CKd is one of the exclusion--excluding either renal osteodystrophy or CKd- MBd as the cause of low BMd or fragility fractures. differentiations among the disorders of renal osteodystrophy, CKd-MBd or osteoporosis are dependent on the measurement of specific biochemical markers, including serum parathyroid hormone （PTH） and/or quantitative bone histomorphometry. Management of fractures in stages 1-3 CKd does not differ in persons with or without CKd with osteoporosis assuming that there is no evidence for CKd-MBd, clinically suspected by elevated PTH, hyperphosphatemia or fibroblast growth factor 23 due to CKd. Treatment of fractures in persons with osteoporosis and stages 4 and 5 CKd is not evidence-based, with the exception of post-hoc analysis suggesting efficacy and safety of specific o

关键词： CKd GFR PTH MBd

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Lectures on Hodge Theory and Algebraic Cycles

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Communications in Mathematics and Statistics 2016年第2期4卷 93-188页

作者： James d.lewis University of Alberta 632 Central Academic BuildingEdmontonAB T6G 2G1Canada

Notes for a mini course at the University of Science and Technology ofChina in Hefei,China,June 23-July 12,2014.

关键词： Chow group Hodge theory Algebraic cycle Regulator delignecohomology Beilinson-Hodge conjecture Abel-Jacobi map Bloch-Beilinsonfiltration

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Enhanced Trust Based Access Control for Multi-Cloud Environment

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Computers, Materials & Continua 2021年第12期69卷 3079-3093页

作者： N.R.Rejin paul d.paul Raj Technology PuduvoyalGummidipoondi601206India R M d Engineering College KavaraipettaiGummidipoondi601206India

Security is an essential part of the cloud *** ensuring the security of the data being communicated to and from the cloud server,a significant parameter called trust was ***-based security played a vital role in ensuring that the communication between cloud users and service providers remained unadulterated and *** most cloud-based data distribution environments,emphasis is placed on accepting trusted client users’requests,but the cloud servers’integrity is seldom *** paper designs a trust-based access control model based on user and server characteristics in a multi-cloud environment to address this *** proposed methodology consists of data encryption using Cyclic Shift Transposition Algorithm and trust-based access control *** this trust-based access control mechanism framework,trust values are assigned to cloud users using direct trust *** direct trust degree is estimated based on the following metrics:success and failure rate of interactions,service satisfaction index,and dishonesty *** addition to this,trust values are assigned to cloud servers based on the metrics:server load,service rejection rate,and service access *** role-Based Access control policy of each user is modified based on his trust *** the server fails to meet the minimum trust level,then another suitable server will be *** proposed system is found to outperform other existing systems in a multi-cloud environment.

关键词： Cloud computing trust access control cloud service provider cloud data user CSTA

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Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala paul Subrat Kumar Acharya Akash Shukla Shalimar department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUNd There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and d],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

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Testosterone and cardiovascular disease in men

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Asian Journal of Andrology 2012年第3期14卷 428-435,I0007页

作者： paul d Morris Kevin S Channer Sheffield Teaching Hospital NHS Trust Sheffield S10 2JF UK

despite regional variations in the prevalence of coronary artery disease （CAd）, men are consistently more at risk of developing and dying from CAd than women, and the gender-specific effects of sex hormones are implicated in this inequality. This ＇Perspectives＇ article reviews the current evidence regarding the cardiovascular effects of testosterone in men including an examination of the age-related decline in testosterone, the relationship between testosterone levels and coronary disease, coronary risk factors and mortality. We also review the vaso-active effects of testosterone, and discuss how these have been used in men with heart failure and angina. We discuss the ＇cause＇ versus ＇effect＇ controversy, regarding low testosterone levels in men with coronary heart disease, as well as concerns over the use of testosterone replacement therapy in middle aged and elderly men. The article concludes with a discussion regarding the future direction for work in this interesting area, including the relative merits of screening for, and treating hypogonadism with testosterone replacement therapy in men with heart disease.

关键词： atherosclerosis chronic heart failure ischaemic heart disease replacement therapy testosterone

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Assessing mixing characteristics of particle-mixing and granulation devices

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Particuology 2008年第6期6卷 419-444页

作者： paul W. Cleary Matthew d. Sinnott CSIRO Mathematical and Information Sciences

The mixing of particulates such as powders is an important process in many industries including pharmaceuticals, plastics, household products （such as detergents） and food processing. The quality of products depends on the degree of mixing of their constituent materials which in turn depends on both geometric design and operating conditions. Unfortunately, due to lack of understanding of the interaction between mixer geometry and the granular material, limited progress has been made in optimizing mixer design. The discrete element method （dEM） is a computational technique that allows particle systems to be simulated and mixing to be predicted. Simulation is an effective way of acquiring information on the performance of different mixers that is difficult and/or expensive to obtain using traditional experimental approaches. Here we demonstrate how dEM can be used to unravel flow dynamics and assess mixing in several different types of devices. These devices used for mixing and/or granulation of particulates, are classified broadly as gravity controlled, bladed and high shear. We also explore the role of particle shape in mixing performance and use dEM to test whether Froude number scaling is suitable for predicting scale performance of rotating mixers.

关键词： discrete element modelling Mixing Mixers Blenders Granulation Scale up Particle shape

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Sequential Analysis in the Identification of 3rd Order System Tract in the Abidjan Margin

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Open Journal of Applied Sciences 2024年第6期14卷 1474-1489页

作者： Blandine Akissi Egoran N’guessan donald Ahoure Fori Yao paul Assalé Sylvain Mondé Loukou Victor N’da UFR Marine Sciences San Pedro University San Pedro Cte dIvoire UFR of Sciences and Technologies Alassane Ouattara Bouak Laboratory of Plant Biology and Earth Sciences Bouak Cte dIvoire UFR/STRM Flix Houphout Boigny de Cocody Abidjan Cte dIvoire PETROCI Consultant at the Center for Analysis and Research Department of Sequential Stratigraphy Abidjan Cte dIvoire

The use of sequential stratigraphy concept, based on well logs, sedimentology, and biostratigraphy, has shed light on the complex mechanisms controlling sedimentary accumulations. Consequently, identifying these mechanisms allows us to predict the hydrocarbon generation potential of source rocks. In the Ivorian offshore sedimentary basin, certain studies have contributed to understanding and characterizing the petroleum system. However, these previous works did not integrate biostratigraphic data to highlight sedimentary facies. This study, conducted on two wells in the Abidjan margin, is crucial as it helps us comprehend the geometry of fossil sediments in relation to sea level variations. It will also aid in reconstructing the basin-filling history and predicting the distribution of rocks capable of trapping oil, determining lowstand systems tracts (reservoir rocks), transgressive systems tracts, and highstand systems tracts (cap rocks). Lithological analysis revealed predominantly clayey sedimentation with sandy layers. Well log data facilitated the delineation of formation boundaries and highlighted reservoirs consisting of sands, sandstones, limestones, and occasionally intercalated shales. Integrating these analysis results with biostratigraphic interpretations based on foraminifera and palynomorphs revealed that the traversed formations were deposited in a transitional environment ranging from Coniacian to Maastrichtian ages. Applying sequential stratigraphy concept from well logging resolved dating issues encountered in microfossil-poor or microfossil-free zones. The results of the Coniacian-Maastrichtian age sequential subdivision were aligned with the chart.

关键词： Sequence Stratigraphy Systems Tracts Senonian Côte d’Ivoire

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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-d614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li david Shu Cheong Hui paul Kay Sheung Chan department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-d614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCd614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-d614G RNA-seq Subgenomic RNA(sgRNA)

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Erratum to“The power of many brains:Catalyzing neuropsychiatric discovery through open neuroimaging data and large-scale collaboration”[Sci Bull 2024;69:1536-1555]

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Science Bulletin 2024年第17期69卷 2793-2793页

作者： Bin Lu Xiao Chen Francisco Xavier Castellanos paul MThompson Xi-Nian Zuo Yu-Feng Zang Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China department of Psychology University of Chinese Academy of SciencesBeijing 100101China department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew York 10016USA Nathan Kline Institute for Psychiatric Research Orangeburg 10962USA Imaging Genetics Center Mark&Mary Stevens Institute for Neuroimaging&InformaticsKeck School of MedicineUniversity of Southern CaliforniaLos Angeles 90033USA developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China National Basic Science data Center Beijing 100190China Centre for Cognition and Brain disorders The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310004China Institute of Psychological Science Hangzhou Normal UniversityHangzhou 310030China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairment Hangzhou 311121China International Big-data Center for depression Research Institute of PsychologyChinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China

The publisher regrets to note that reference citation errors have occurred in panels b,c,e-l in Fig 2 and the sentence“However,the literature reports both decreased and increased intra-network functional connections among patients with depression[115,116].”The publisher would like to apologise for any inconvenience *** neuroimaging findings in major depressive disorder.(a)decreased intra-dMN FC is observed in recurrent Mdd patients[35].(b)Eight-week antidepressant treatment reduce extensive large-scale functional networks[107].(c)Reduced global and local efficiency(Eglob/Eloc)are revealed in Mdd patients[108].(d)Structural variations of the cortex and subcortical nuclei are found in ENIGMA-Mdd studies[82].(e)Accelerated brain aging based on functional MRI is observed in Mdd patients[114].(f)Accelerated brain aging based on structural MRI is observed in Mdd patients[115].(g)Two subtypes of Mdd can be identified through dMN FC[127].(h)A significant schizophrenia PRS by Mdd interaction for rostral anterior cingulate cortex thickness is found in the UK Biobank dataset[215].(i)Stability of the four Mdd subtypes based on FC[126].(j)The two subtypes of Mdd exhibit distinct patterns of FC within and between SMS,dMN,and subcortical structures[130].(k)Performance of the functional connectivity-based classifiers across two multicenter datasets[135].(l)Salient brain regions that serve as important classification features for the graph convolutional network-based classifier[136].Brain-PAd:brain-predicted age difference;dAN:dorsal attention network;dMN:default mode network;FC:functional connectivity;FEdN:first-episode and drug-naïve;FPN:frontoparietal network;GCN:graph convolutional neural network;HC:healthy control;linear-SVM:linear support vector machine;Mdd:major depressive disorder;mddrest:REST-meta-Mdd dataset;NC:normal control;RACC:rostral anterior cingulate cortex;PRS:polygenic risk score;psymri:PsyMRI dataset;rbf-SVM:radial basis function support vector

关键词： cortex network scale

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Fuzzy Henstock-Kurzweil Triple Integral on a Type 1 Quasi-Fuzzy Parallelepipedal domain

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Journal of Applied Mathematics and Physics 2024年第3期12卷 897-911页

作者： Kumwimba Seya didier Kasongo Ntambwe dany Panga Lutanda Grégoire Mayuke Katshongo Jean paul Lunda Ngoy Jean Pierre département de Mathématiques et Informatique Faculté des Sciences Université de Lubumbashi Lubumbashi Democratic Republic of the Congo

In this article, we propose by using the Hausdorff distance Simpson’s rule for the triple integral of a fuzzy-valued function and the error bound of this method, one of the variables of which is fuzzy. In addition, thin δ-fine partitions are introduced. The integration domain is a quasi-fuzzy parallelipiped. A numerical example is presented in order to show the application and the significance of the method.

关键词： Fuzzy-Valued Function Hausdorff distance Quasi-Fuzzy Parallelipiped Henstock Integral

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