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Comparative Studies of Different Organs of Nyctanthes arbortristis in Modulation of Cytokines in Murine Model of Arthritis

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Biomedical and Environmental Sciences 2007年第2期20卷 154-159页

作者： BRIJESH RATHORE bholanath paul BHUSAN P CHAUDHURY ASHOK KUMAR SAXENA ANAND PRAKASH SAHU YOGENDRA KUMAR GUPTA Immunobiology Laboratory Central Pathology Laboratory Preventive Toxicology Laboratory Industrial Toxicology Research Centre M. G. MargLucknow 226001India

Objective To study the modulation effect of pro- and anti-inflammatory cytokines following long term use of water soluble ethanol extracts from different organs of Nyctanthes arbortristis （NAT） in mouse model of arthritis. Methods Arthritis was induced in mice by two injections of Freund＇s complete adjuvant on days 0 and 12 in the sub-planter surface of the right hind paw. Results Injection of adjuvant resulted in a maximum primary edema of the footpad with erythema, and edema and distortion of joints of the right hind paw after 24-48 hours. Second injection of FCA led to the formation of secondary swellings persisting more than four weeks that spread onto the other hind limb but to a lesser extent. Histological analysis of the ankle on day 47 showed marked evidence of cartilage destruction in association with pannus formation and moderate bone resorption. Proinfiammatory cytokine levels in the inflamed joint homogenate were elevated on days 2, 14, and 47. Oral administration of leaf and fruit extracts in arthritic mice reduced joint homogenate levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 on days 2, 14, and 47 in comparison to untreated arthritic mice. Intedeukin-10 level was elevated in the inflamed joint on days 2, 14, and 47 in comparisons to untreated arthritic mice. Confusion Evidence of lesser inflammation of the footpad and joint and associated histological observation support the therapeutic benefit of leaf and fruit extracts from Nyctanthes arbortristis. This study helps in understanding the mechanism of anti-inflammatory action of Nyctanthes arbortristis in the light of pro- and anti-inflammatory cytokine balance.

关键词： Nyctanthes arbortristis Arthritis TNF-α IL- 1β IL-6 IL-10

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COMPARATIVE STUDIES OF DIFFERENT ORGANS OF N. arbor tristis IN MODULATION OF LIPID PEROXIDE LEVELS, ANTI-OXIDANT CONTENT, CYTOKINES AND EFFECT ON HEPATIC AND RENAL MARKER ENZYMES IN EXPERIMENTAL RHEUMATOID ARTHRITIS

COMPARATIVE STUDIES OF DIFFERENT ORGANS OF N. arbor tristis ...

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The International Meeting of the Society for Free Radical Research(SFRR)-Asia & the Third International Symposium on Natural Antioxidants-Molecular Mechanisms and Health Effects(ISNA)

作者： Mahdi Abbas Ali Rathore Brijesh Das Siddarth K. paul bholanath Department of Biochemistry King George’s Medical University Lucknow 226003 INDIA Department of Medicine Immunobiology Laboratory Industrial Toxicology Research Centre M. G. Marg Lucknow 226001

Introduction: Rheumatoid arthritis is a disease characterised by joint pain followed by bone and joint destruction. Overabundance of pro-inflammatory cytokines and inadequate anti-inflammatory cytokines has been reported in rheumatoid arthritis. Abnormal liver function tests have also been reported in rheumatoid arthritis. The DMARD’s treated patients, as well as NSAID’s treated patients have shown increased risk of acute liver injury. Elevated activities of ALT and AST are more frequent in patients receiving salicylate and methotrexate. Reactive oxygen species, such as super oxide radical, hydroxyl radical etc. contribute significantly to tissue injury in rheumatoid arthritis. Rheumatoid arthritis patients are reported to bear low levels of anti-oxidants, which indicates reduced anti-oxidant potential, thus impairing anti-oxidant balance. Although leaves of NAT have been extensively studied for their anti-inflammatory property, however, little is known about the other parts of the plant. In the present study, we studied different parts of NAT for their anti-inflammatory, hepatoprotective and anti-oxidant properties.

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