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Life Lives on the Edge of Contradiction

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Psychology Research 2021年第5期11卷 191-198页

作者： paul a.wagner University of Houston HoustonUSA

Advice giving covers a wide range of social engagements between friends,authorities to subordinates,professionals of many kinds and especially *** generally come from fields such as psychology and psychiatry wherein many focus on research sciences and others focus on use of therapeutics to somehow make people better in some *** the latter group,coming to grips with what counts as better is problematic since it is not always clear even to the advisee what he or she would count as *** the more scientifically-minded the notion of better is often eschewed as nothing more than distracting baggage when it comes to truly understanding *** paper shows first that understanding human nature is likely a *** will never fully come within the grasp of the human sciences any more than the fist can grab ***,scientific approaches are invaluable in the quest for tying action and goals ***,while the sciences may eliminate the need for reference to some faux qualia,the phenomenology of human experience cannot be ignored *** a result,advisory planning must navigate between the tough-minded and soft-minded while avoiding contradiction.

关键词： tough-minded soft-minded qualia phenomenology pragmatist problem-solving

Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

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Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Hadley Osman paul Ashwood Department of Medical Microbiology and Immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

During pregnancy,maternal immune activation(MIA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(ASD)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 children are diagnosed with ASD by the age of 8 years,with ASD rates continuing to increase in prevalence in USA(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of ASD is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(MAA),a form of MIA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition driven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus

Emerging insights into the function of very long chain fatty acids at cerebellar synapses

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Neural Regeneration Research 2025年第6期20卷 1709-1710页

作者： Martin-paul Agbaga Mohiuddin Ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

Integrating water use systems and soil and water conservation measures into a hydrological model of an Iranian Wadi system

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Journal of Arid Land 2020年第4期12卷 545-560页

作者： Nariman MAHMOODI Jens KIESEL paul D wagner Nicola FOHRER Department of Hydrology and Water Resources Management Institute for Natural Resource ConservationKiel UniversityKiel 24118Germany Department of Ecosystem Research Leibniz-Institute of Freshwater Ecology and Inland Fisheries(IGB)Berlin 12489Germany

Water resources are precious in arid and semi-arid areas such as the Wadis of Iran. To sustainably manage these limited water resources, the residents of the Iranian Wadis have been traditionally using several water use systems(WUSs) which affect natural hydrological processes. In this study, WUSs and soil and water conservation measures(SWCMs) were integrated in a hydrological model of the Halilrood Basin in Iran. The Soil and Water Assessment Tool(SWAT) model was used to simulate the hydrological processes between 1993 and 2009 at daily time scale. To assess the importance of WUSs and SWCMs, we compared a model setup without WUSs and SWCMs(Default model) with a model setup with WUSs and SWCMs(WUS-SWCM model). When compared to the observed daily stream flow, the number of acceptable calibration runs as defined by the performance thresholds(Nash-Sutcliffe efficiency(NSE)≥0.68, –25%≤percent bias(PBIAS)≤25% and ratio of standard deviation(RSR)≤0.56) is 177 for the Default model and 1945 for the WUS-SWCM model. Also, the average Kling–Gupta efficiency(KGE) of acceptable calibration runs for the WUS-SWCM model is higher in both calibration and validation periods. When WUSs and SWCMs are implemented, surface runoff(between 30% and 99%) and water yield(between 0 and 18%) decreased in all sub-basins. Moreover, SWCMs lead to a higher contribution of groundwater flow to the channel and compensate for the extracted water by WUSs from the shallow aquifer. In summary, implementing WUSs and SWCMs in the SWAT model enhances model plausibility significantly.

关键词： SWAT model stream flow Wadis multi-metric framework water use systems soil and water conservation measures Halilrood Basin

Protein Disulfide Isomerase 2 of Chlamydomonas reinhardtii Is Involved in Circadian Rhythm Regulation

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Molecular Plant 2013年第5期6卷 1503-1517页

作者： Anna Filonova paul Haemsch Christin Gebauer Wolfram Weisheit Volker wagner Institute of General Botany and Plant Physiology Friedrich-Schiller-Universitat Jena 07743 Jena Germany

Protein disulfide isomerases （PDIs） are known to play important roles in the folding of nascent proteins and in the formation of disulfide bonds. Recently, we identified a PDI from Chlamydomonas reinhardtii （CrPDI2） by a mass spectrometry approach that is specifically enriched by heparin affinity chromatography in samples taken during the night phase. Here, we show that the recombinant CrPDI2 is a redox-active protein. It is reduced by thioredoxin reductase and catalyzes itself the reduction of insulin chains and the oxidative refolding of scrambled RNase A. By immunoblots, we confirm a high-amplitude change in abundance of the heparin-bound CrPDI2 during subjective night. Interestingly, we find that CrPDI2 is present in protein complexes of different sizes at both day and night. Among three identified interac- tion partners, one （a 2-cys peroxiredoxin） is present only during the night phase. To study a potential function of CrPDI2 within the circadian system, we have overexpressed its gene. Two transgenic lines were used to measure the rhythm of phototaxis~ In the transgenic strains, a change in the acrophase was observed. This indicates that CrPDI2 is involved in the circadian signaling pathway and, together with the night phase-specific interaction of CrPDI2 and a peroxiredoxin, these findings suggest a close coupling of redox processes and the circadian clock in C. reinhardtii.

关键词： Chlamydomonas reinhardtii protein disulfide isomerase 2 circadian clock.

National Cancer Institute’s early detection research network:a model organization for biomarker research

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Journal of the National Cancer Center 2023年第2期3卷 93-99页

作者： paul D.wagner Sudhir Srivastava Cancer Biomarkers Research Group Division of Cancer PreventionNational Cancer InstituteBethesdaUSA

For many cancers a primary cause of poor survival is that they are detected at a late stage when therapies are less *** screening methods exist to detect some types of cancer at an early stage,there are currently no effective methods to screen for most types of *** have the potential to improve detection of early-stage cancers,risk stratification,and prediction of which pre-cancerous lesions are likely to progress and to make screening tests less *** thousands of research articles on biomarkers for early detection are published every year,few of these biomarkers have been validated and shown to be clinically *** reflects both the inherent difficulty in detecting early-stage cancers and a disconnect between the process of discovering biomarkers and their use in the *** overcome this limitation the US National Cancer Institute created the Early Detection Research *** is a highly collaborative program that brings together biomarker discoverers,assay developers,and *** provides an infrastructure that is essential for developing and validating biomarkers and imaging methods for early cancer detection and has successfully completed several multicenter validation studies.

关键词： Biomarkers Early detection Validation Collaboration Data sharing

Identifying the most important spatially distributed variables for explaining land use patterns in a rural lowland catchment in Germany

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Journal of Geographical Sciences 2019年第11期29卷 1788-1806页

作者： Chaogui LEI paul D.wagner Nicola FOHRER Institute for Natural Resource Conservation Kiel University

Land use patterns arise from interactive processes between the physical environment and anthropogenic activities. While land use patterns and the associated explanatory variables have often been analyzed on the large scale, this study aims to determine the most important variables for explaining land use patterns in the 50 km2 catchment of the Kielstau, Germany, which is dominated by agricultural land use. A set of spatially distributed variables including topography, soil properties, socioeconomic variables, and landscape indices are exploited to set up logistic regression models for the land use map of 2017 with detailed agricultural classes. Spatial validation indicates a reasonable performance as the relative operating characteristic (ROC) ranges between 0.73 and 0.97 for all land use classes except for corn (ROC = 0.68). The robustness of the models in time is confirmed by the temporal validation for which the ROC values are on the same level (maximum deviation 0.1). Non-agricultural land use is generally better explained than agricultural land use. The most important variables are the share of drained area, distance to protected areas, population density, and patch fractal dimension. These variables can either be linked to agriculture or the river course of the Kielstau.

关键词： land use pattern logistic regression model rural lowland catchment Germany

Tunable filter Raman spectroscopy of purified semiconducting and metallic carbon nanotubes

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Nano Research 2016年第9期9卷 2715-2728页

作者： paul Finnie Security and Disruptive Technologies Portfolio National Research Council Canada1200 Montreal RoadOttawaOntarioK1A 0R6Canada

Tunable filter Raman spectroscopy is used to efficiently produce Raman excitation maps of unpurified and type-purified single walled carbon nanotubes (SWCNTs). Maps with fine excitation resolution (1 nm) are created over a wide wavelength range (727 to 980 nm), extending from metallic to semiconducting resonances. At a given wavelength, the wide bandwidth (>3,000 cm–1) allows the comparison of the G band with the radial breathing mode (RBM), and shows the 2D band and other less prominent bands. Materials examined included unsorted powders, aqueous sorted semiconductors, aqueous sorted metals, and polyfluorene sorted semiconductors in toluene. The Raman excitation profiles of the G band are broad, relative to the RBM bands. The maps offer evidence of minority species contamination, except in the case of the polyfluorene sorted semiconductors. Tunable Raman spectroscopy data help validate the simpler fixed wavelength Raman spectroscopy approaches to purity assessment. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

关键词： single walled carbon nanotube (SWCNT) tunable Raman spectroscop purity metallicity

Gas Quenching Small Components

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材料热处理学报 2004年第5期25卷 494-497页

作者： paul Stratton BOC Sheffield UK

Gas quenching is an environmentally friendly and effective way of quenching components. However it has not been possible to apply it to small components because of the difficulties of jigging. A method of gas quenching such small components is described in which they are levitated in a confined gas stream. The method is suitable for quenching low alloy steel components that weigh between 1 and lOg.

关键词：气体流淬火悬浮低合金钢热处理