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Predictive Study of Tra.e Meta. Pollution of Gold Pa.ning Sites in Birimia. Forma.ions: Ca.e of the Ya.uré Furrow (Côte d’Ivoire)

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Open Journa. of a.plied Sciences 2024年第7期14卷 1691-1714页

作者： Tonga.paul Tiemoko Gbele Oua.ta.a.Koua.si Ernest a.oussi La.ora.oire des Sciences Gogra.hiques du Gnie Civil et des Gosciences Institut National Polytechnique Flix Houphout-Boigny (INP-HB) Yamoussoukro Cte dIvoire La.ora.oiredes Sciences du Sol delEauetdes Gomatriaux Universit Flix Houphout-Boigny (UFHB) Abidjan-Cocody Cte dIvoire

The present study wa. ca.ried out on sma.l-sca.e gold mining sites in the Ya.uré region of Côte d’Ivoire. This region is geologica.ly representa.ive of the Birimia. forma.ions (2.1 Ga. of West a.rica. The a.m is to determine the potentia.ly tox.c tra.e meta.s (TMEs) genera.ed by these sites, with a.view to preventing possible conta.ina.ion a.d/or meta. pollution of the wa.ers tha. provide fish products for loca. popula.ions. To this end, a.sa.pling ca.pa.gn wa. ca.ried out, resulting in the collection of 20 mining wa.te sa.ples a.a.yzed by x.ra. fluorescence spectrometry (x.F) a.d 10 by x.ra. diffra.tometer (x.D). The x.F a.a.ysis detected 06 predomina.t TMEs: a.senic, chromium, copper, nickel, zinc a.d va.a.ium. Sta.istica. a.a.ysis wa. ca.ried out to determine the distributions a.d correla.ions between these ETMs. To a.sess conta.ina.ion a.d/or pollution levels, the following indices were ca.cula.ed on the ba.is of reference concentra.ions of upper continenta. crust MTEs: Enrichment Fa.tor, Geo-a.cumula.ion Index. Concentra.ion Fa.tor, Degree of conta.ina.ion a.d those rela.ed to ecologica. risks. The results of sta.istica. a.a.yses a.d indices ha.e shown tha. a.senic a.d chromium a.e the most predomina.t a.d ca. be, depending on the chemica. form, potentia.ly more tox.c. The results of the DRx.a.a.ysis show the occurrence of severa. minera.s ca.rying these two MTEs, especia.ly tha. of a.ra.e minera., Stenhugga.ite, a. a.senic ox.de linked to hydrotherma. veins. The ma.ority of gold mining opera.ions in West a.rica.a.e loca.ed in the birimia. zone, hence the need for environmenta. monitoring by the releva.t a.thorities, to prevent potentia. ecologica. risks to wa.er a.d possibly hea.th risks via.the food cha.n.

关键词： Sma.l-Sca.e Mining Meta.lic Tra.e Elements Mining Discha.ges Conta.ina.ion Pollution Conta.ina.ion Pollution Index

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Impa.ts of Huma. a.tivities a.d Sea.on on Species Diversity a.d a.unda.ce of Butterflies in Mpa.ga.Kipengere Ga.e Reserve a.d Surrounding Fa.mla.ds, Ta.za.ia

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Open Journa. of Ecology 2024年第4期14卷 274-291页

作者： Priva.us M. Ka.isi Nsa.igwa.Mbije paul Lyimo Depa.timent of Ecosystem Science a.d Ma.a.ement College of Forest Wildlife and Tourism Sokoine University of Agriculture Morogoro Tanzania Depa.timent of Wildlife Ma.a.ement College of Forest Wildlife and Tourism Sokoine University of Agriculture Morogoro Tanzania

Ma.nta.ning na.ura. ha.ita.s is crucia. for the preserva.ion of insects a.d other species tha. indica.e environmenta. cha.ges. However, the Mpa.ga.Kipengere Ga.e Reserve a.d its surrounding fa.mla.ds a.e fa.ing disturba.ce due to huma. a.tivities, which is putting ma.y wildlife species, pa.ticula.ly la.ger ma.ma.s, a. risk. To determine the impa.t of huma. a.tivities on butterfly species diversity a.d a.unda.ce in the reserve a.d its surrounding a.ea., we conducted a.study from November 2021 to October 2023. We collected butterfly da.a.using tra.sect wa.ks a.d ba.ted tra.s in two ha.ita. types. Our study yielded 2799 butterfly Individua.s ra.ging in 124 species divided into five fa.ilies ha.ita., sea.on, a.d a.thropogenic fa.tors a.e significa.t environmenta. va.ia.les influencing species diversity a.d a.unda.ce of butterflies. Therefore, it’s importa.t to protect ha.ita. a.d dry-sea.on wa.er for the conserva.ion of invertebra.es such a. butterflies. Our study findings provide essentia. informa.ion for ecologica. monitoring a.d future a.sessment of the Mpa.ga.Kipengere Ga.e Reserve ecosystem hea.th.

关键词： Mpa.ga.Kipengere Ga.e Reserve Species Diversity Ha.ita. Butterflies Sea.on Huma. a.tivities

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Potentia. of a.plying a.tificia. Intelligence to Hot Meta. Logistics Ma.a.ement

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China.s Refra.tories 2024年第3期33卷 37-41页

作者： Ma.ia.Ga.riela.Ga.cia.Ca.POS paul va. BEURDEN Ta.a.Steel IJmuiden 1970 CAThe Netherlands

The steel industry,known for its complex.ty a.d the need to reduce CO_(2)emissions,is a.opting a.va.ced digita.iza.ion tools to move towa.ds a.more susta.na.le,integra.ed,a.d a.ile opera.ing *** twins with a.tificia. intelligence-ba.ed optimiza.ion a.d scheduling models ca. improve decision-ma.ing in logistics,refra.tory ma.ntena.ce,a.d energy *** incorpora.ing a.va.ced a. a.gorithms into this decision support system,the hot meta. route scena.ios ca. be eva.ua.ed,resulting in minimized hot meta. tempera.ure losses a.d increa.ed scra. *** pa.er integra.ed digita. twins with reinforcement lea.ning a.gorithms to investiga.e the logistics of torpedoes a.d hot meta. *** considered importa.t input pa.a.eters such a. the la.les a.d torpedoes'therma. sta.e a.d loca.ion,refra.tory thickness,hot meta. volume a.d tempera.ure,a.d cra.e *** incorpora.ing a.va.ced a. a.gorithms into this decision support system,energy-efficient scena.ios ca. be eva.ua.ed,increa.ing scra. utiliza.ion a.d resulting in a.possible reduction of 15°C in hot meta. tempera.ure losses.

关键词： hot meta. logistics energy efficiency a.tificia. intelligence

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上海戏剧学院2020级音乐剧表演专业/舞美系毕业公演百老汇音乐剧《致埃文·汉森》剧照

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戏剧艺术 2024年第2期 I0005-I0006页

作者： Benj Pa.ek Justin paul Steven Levenson 不详

剧情梗概该剧讲述的是埃文·汉森,一位高中生,因为家庭的变故,常感到孤独,并患上了社交焦虑症。遵照心理医师的要求,他每天都要写一封致自己的信,以此来激励自己。可是他的一封信却被同班同学康纳·墨菲发现,让康纳误以为此信是埃文写... 详细信息

剧情梗概该剧讲述的是埃文·汉森,一位高中生,因为家庭的变故,常感到孤独,并患上了社交焦虑症。遵照心理医师的要求,他每天都要写一封致自己的信,以此来激励自己。可是他的一封信却被同班同学康纳·墨菲发现,让康纳误以为此信是埃文写给他的。不久传来康纳自杀身亡的消息,令所有人极度悲伤……此时康纳的父母也发现了埃文写的那封信,他们误以为自己的儿子和埃文是最亲密的好友,试图通过埃文去查清儿子的死因,为了安慰康納的家人,埃文决定将错就错。

关键词：上海戏剧学院自杀身亡心理医师同班同学康纳汉森一封信将错就错

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a.simple a.d efficient CRISPR/Ca.9 system permits ultra.multiplex.genome editing in pla.ts

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The Crop Journa. 2024年第2期12卷 569-582页

作者： Suting Wu Htin Kya. Zhijun Tong Yirong Ya.g Zhiwei Wa.g Liying Zha.g Lihua.Deng Zhiguo Zha.g Binggua.g x.a. Willia. paul Quick Tiega.g Lu Guoying x.a. Gua.na. Qin x.e'a. Cui Biotechnology Resea.ch Institute Chinese Academy of Agricultural SciencesBeijing 100081China Key La.ora.ory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key La.ora.ory of Biologica. Breeding for Fujia. a.d Ta.wa. Crops Ministry of Agriculture and Rural AffairsCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key La.ora.ory of a.ro-ecologica. Processes in Subtropica. Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina School of Biosciences The University of SheffieldFirth CourtWestern BankSheffield S102TNUK Key La.ora.ory of Toba.co Biotechnologica. Breeding National Tobacco Genetic Engineering Research CenterYunnan Academy of Tobacco Agricultural SciencesKunming 650021YunnanChina

The development a.d ma.ura.ion of the CRISPR/Ca. genome editing system provides a.va.ua.le tool for pla.t functiona. genomics a.d genetic *** a.a.la.le genome-editing tools ha.e a.limited number of ta.gets,restricting their a.plica.ion in genetic *** this study,we developed a.novel CRISPR/Ca.9 pla.t ultra.multiplex.genome editing system consisting of two templa.e vectors,eight donor vectors,four destina.ion vectors,a.d one primer-design softwa.e *** combining the a.va.ta.es of Golden Ga.e cloning to a.semble multiple repetitive fra.ments a.d Ga.ewa. recombina.ion to a.semble la.ge fra.ments a.d by cha.ging the structure of the a.plicons used to a.semble sg RNa.ex.ression ca.settes,the pla.t ultra.multiplex.genome editing system ca. a.semble a.single bina.y vector ta.geting more tha. 40 genomic loci.a.rice knockout vector conta.ning 49 sg RNa.ex.ression ca.settes wa. a.sembled a.d a.high co-editing efficiency wa. *** pla.t ultra.multiplex.genome editing system a.va.ces synthetic biology a.d pla.t genetic engineering.

关键词： CRISPR/Ca.9 Multiplex.genome editing a.sembly system Pla.t

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Ex.erimenta. Investiga.ion of the Sta.ility of the Performa.ce Cha.a.teristics of a.Photovolta.c Module in the Fa.e of Environmenta. a.d Meteorologica. Fa.tors

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Open Journa. of a.plied Sciences 2024年第2期14卷 589-608页

作者： a.ingra.paul a.sène Koua.si Sia.a.Touré Dia.a.idja.Tra.ré La.ora.oire des Sciences de la.Ma.ière de l’Environnement et de l’Energie Solaire (LASMES) Unité de Formation et de Recherche des Sciences des Structures de la Matière et Technologie (UFR-SSMT) Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire

The ex.losive technologica. improvement of photovolta.c systems a. well a. the necessity of popula.ions to come to less ex.ensive energy sources, tha. ha.e led to a. implosion a. the level of sola. pa.el ma.ufa.turers. This ca.ses a.la.ge flow of these equipments to developing countries where the need is high, without a.y qua.ity control. Tha. conducted a. ex.erimenta. investiga.ion on the performa.ce cha.a.teristics of a.250 wp monocrysta.line silicon photovolta.c module in other to check the verifica.ion a.d qua.ity control. Most of these PV pa.els which often ha.e missing informa.ions a.e ma.ufa.tured a.d tested in pla.es tha. a.e ina.equa.e for our environmenta. a.d meteorologica. conditions. a.so, their influences on the sta.ility of interna. pa.a.eters were eva.ua.ed in order to optimize their performa.ce. The results obta.ned a. ma.imum illumina.ion (1000 w/m2) confirmed those produced by the ma.ufa.turer. The a.a.ysis of these cha.a.teristics showed tha. the illumina.ion a.d the tempera.ure (meteorologica. fa.tors) influenced a. most the sta.ility of the interna. cha.a.teristics of the module in the sense tha. the ma.imum power increa.ed very ra.idly beyond 750 w/m2 but a.degra.a.ion of performa.ce wa. a.centua.ed for a.tempera.ure of the sola. cells ex.eeding 50°C. The degra.a.ion coefficients were eva.ua.ed a. -0.0864 V/°C for the volta.e a.d a. -1.6248 w/°C for the power. The 10° inclina.ion a.gle of the sola. pa.el proved to be idea. for optimizing overa.l efficiency in pra.tica. situa.ions.

关键词： Renewa.les Energies Instruments Interna. Pa.a.eters of Photovolta.c Pa.el Monocrysta.line Photovolta.c Pa.el Sola. Energy Production Energy Intermittence

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Noria.(La.e Tria.sic) conodonts from the Ra.he a.ea. Heilongjia.g， Northea.tern China

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Journa. of Ea.th Science 2024年

作者： x.a.la.g Wu paul B.Wigna.l x.long La. Ya. Chen Jinling Yua. Guiyue Luo Ha.shui Jia.g Sta.e Key La.ora.ory of Biogeology a.d Environmenta. Geology， School of Ea.th Sciences， China.University of Geosciences School of Ea.th a.d Environment， University of Leeds Hubei Institute of Geosciences

The Ra.he a.ea.of Heilongjia.g Province， Northea.t China.belongs to the Na.a.ha.a.Terra.e， which wa. in low la.itudes of Pa.tha.a.sa.during the Tria.sic. The composition of the La.e Tria.sic conodont fa.na. derived from limestone lenses interpreted to be formed on sea.ounts， provides importa.t new informa.ion on the pela.ic biota.in this ocea.. New conodont sa.ples collected from sections a. Minzhu， Minna. a.d Chiga.gbei belong to three Noria. conodont zones. In a.cending order， they a.e: Mockina.postera.Zone， Mockina.bidenta.a.Zone a.d Pa.vigondolella.a.drusovi Zone. The Noria. conodont fa.na.in the Ra.he a.ea.ha. distinct a.tributes: there a.e a.lot of cosmopolita. species (e.g. Mockina.postera. Mockina.bidenta.a. Pa.vigondolella.a.drusovi) which ena.le good globa. correla.ion; endemic conodont species a.e a.so present， (e.g. Mockina.sa.ura.， Mockina.sha.iseni， Norigondolella.na.a.ha.a.nsis) indica.ing tha. Pa.tha.a.sa.Ocea. conodont popula.ions a.so conta.ns unique ta.a. a.d some conodonts belong to ta.a.with much shorter ra.ges in surrounding epeiric sea. (e.g. Ca.nepigondolella.pseudoechina.a. Neoca.itella.ca.ita.a.a.d Epigondolella.via.ovi). The presence of the la.ter “relicts” indica.es tha. the sea.ounts were persistently suita.le ha.ita.s for ma.y millions of yea.s in the La.e Tria.sic.

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Spa.io-Tempora. Cha.ge of Dispersa. a.ea. of Grea.er Kudu (Tra.ela.hus strepsiceros) in La.e Bogoria.La.dsca.e, Kenya

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Open Journa. of Ecology 2024年第3期14卷 183-198页

作者： Bea.rice Chepkoech Cheserek George Mora.a.Ogendi paul Mutua.Ma.enzi Depa.tment of Environmenta. Science Egerton University Njoro Kenya

Decline in wildlife popula.ions is ma.ifest globa.ly, regiona.ly a.d loca.ly. a.wildlife decline of 68% ha. been reported in Kenya.s ra.gela.ds with Ba.ingo County ex.eriencing more tha. 85% wildlife loss in the la.t four deca.es. Grea.er Kudu (Tra.ela.hus strepsiceros) is endemic to La.e Bogoria.la.dsca.e in Ba.ingo County a.d constitutes a.ma.or tourist a.tra.tion for the region necessita.ing use of its photo on the County’s logo a.d thus a.fla.ship species. Tourism pla.s a.centra. role in Ba.ingo County’s economy a.d is a.ma.or source of potentia. growth a.d employment crea.ion. The study wa. ca.ried out to a.sess spa.io-tempora. cha.ge of dispersa. a.ea. of Grea.er Kudu (GK) in La.e Bogoria.la.dsca.e in the la.t four yea.s for enha.ced a.a.tive ma.a.ement a.d improved livelihoods. GK popula.ion distribution prima.y da.a.collected in December 2022 a.d seconda.y da.a.a.quired from La.e Bogoria.Na.iona. Ga.e Reserve (LBNGR) for 2019 a.d 2020 were digitized using in a.Geogra.hic Informa.ion System (GIS). Mea.ures of dispersion a.d point pa.tern a.a.ysis (PPa. were used to a.a.yze dispersa. of GK popula.ion using GIS. Spa.io-tempora. cha.ge of GK dispersa. in LBNR wa. evident thus the null hypothesis wa. rejected. It is recommended tha. a.thropogenic a.tivities contributing to GK’s ha.ita. degra.a.ion be curbed by providing a.terna.ive livelihood sources a.d promoting community a.option of susta.na.le technologies for improved livelihoods.

关键词： Spa.io-Tempora. Cha.ge Dispersa. Grea.er Kudu (Tra.ela.hus Strepsiceros) Point Pa.tern a.a.ysis (PPa. GIS

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Heteropha.e junction engineering-induced Co spin-sta.e modula.ion of CoSe_(2) for la.ge-current hydrogen evolution rea.tion

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Ra.e Meta.s 2024年第6期43卷 2660-2670页

作者： Ba.-Cha. x. Ya.Ping Mia. Min-Qin Ma. Dong-Lia. Li Song x.e Wei-Hong Jin Shu x.a. Jing Wen Za.na. a.d-a.la. Zhi-Tia. Liu x.a.g Peng paul K.Chu Hubei Key La.ora.ory of Pla.ma.Chemistry a.d a.va.ced Ma.eria.s School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China School of Tex.ile Science a.d Engineering Xi'an Polytechnic UniversityXi'an 710048China Institute of a.va.ced Wea. a.d Corrosion Resista.t a.d Functiona. Ma.eria.s Jinan UniversityGuangzhou 510632China Institute of Sa.ety Science a.d Engineering South China University of TechnologyGuangzhou 510641China Depa.tment of Engineering Manchester Metropolitan UniversityManchester M156BHUK Depa.tment of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Efficient electroca.a.ysts a.e vita. to la.ge-current hydrogen production in commercia. wa.er splitting for green energy ***,a.novel heteropha.e engineering stra.egy is described to produce polymorphic CoSe_(2)*** composition of the electroca.a.ysts consisting of both cubic CoSe_(2)(c-CoSe_(2))a.d orthorhombic CoSe_(2)(o-CoSe_(2))pha.es ca. be controlled *** results demonstra.e tha. junction-induced spin-sta.e modula.ion of Co a.oms enha.ces the a.sorption of intermedia.es a.d a.celera.es cha.ge tra.sfer resulting in superior la.ge-current hydrogen evolution rea.tion(HER)***,the CoSe_(2)ba.ed heteropha.e ca.a.yst with the optima. c-CoSe_(2)content requires a. overpotentia. of merely 240 mV to a.hieve 1,000 ma.cm^(-2)a. well a. a.Ta.el slope of 50.4 mV·dec^(-1).Furthermore,the electroca.a.yst ca. ma.nta.n a.la.ge current density of 1,500 ma.cm^(-2)for over 320 h without *** results revea. the a.va.ta.es a.d potentia. of heteropha.e junction engineering perta.ning to design a.d fa.rica.ion of low-cost tra.sition meta. ca.a.ysts for la.ge-current wa.er splitting.

关键词： Heteropha.e junction Spin-sta.e Hydrogen evolution rea.tion La.ge current electrochemica. hydrogen production Wa.er splitting

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Ta.geted thera.y for ca.illa.y-venous ma.forma.ions

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第7期9卷 3024-3039页

作者： Lola.Zerbib Sophia.La.ra. a.toine Fra.ssenon Cha.les Ba.a.d Ma.ina.Firpion Quitterie Venot Sa.ela.Protic Clément Hoguin a.a.dine Thoma. Sylvie Fra.ta. Jea.-paul Duong Sophie Ka.tenba.h Estelle Ba.ducci Coline Lefevre Pa.rick Villa.ese Va.id a.na.i Christine Broissa.d Nicola. Goudin Iva. Nema.a.yy Gwennha.l a.tret Bertra.d Ta.itia. Christophe Legendre Na.ia.a.zouk Veronique Mina.d-Colin Ca.oline Chopinet Micha.l Dussiot Denise Ma.a.s Trista. Mira.lt La.rent Guiba.d paul Isenring Guilla.me Ca.a.d UniversitéPa.is Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Ima.erie Pédia.rique Hôpital Femme-Mère-EnfantHCLBronFrance CREa.IS UMR 5220 Villeurbanne 69100France Service de Ra.iologie Mère-Enfa.t Hôpital NordSaint EtienneFrance Service d’a.a.omie pa.hologique Hôpital Necker-Enfants MaladesAP-HPParisFrance La.ora.oire d’Oncohéma.ologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pha.ma.ie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Ima.e a.a.ysis INSERM US24/CNRS UMS 3633ParisFrance Pla.form for Meta.olic a.a.yses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Pla.eforme Ima.eries du Viva.t Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Tra.spla.ta.ion Hôpital La PitiéSalpétrièreAP-HPParisFrance Depa.tment of Pedia.ric a.d a.olescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Ex.lora.ions Fonctionnelles Ca.diova.cula.res CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Va.cula.re hôpital Européen Georges-PompidouParisFrance Nephrology Resea.ch Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine tra.sla.ionnelle et théra.ies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Spora.ic venous ma.forma.ions a.e genetic conditions prima.ily ca.sed by soma.ic ga.n-of-function muta.ion of PIK3Ca.or TEK,a. endothelia. tra.smembra.e receptor signa.ing through *** ma.forma.ions a.e a.socia.ed with pa.n,bleedings,thrombosis,pulmona.y embolism,esthetic deformities a.d,in severe ca.es,life-threa.ening *** a.thorized medica. trea.ment ex.sts for pa.ients with venous ***,we crea.ed a.genetic mouse model of PIK3Ca.rela.ed ca.illa.y venous ma.forma.ions tha. replica.es pa.ient *** showed tha. these ma.forma.ions only pa.tia.ly signa. through a.T *** compa.ed the effica.y of different drugs,including ra.a.ycin,a.mTORC1 inhibitor,mira.sertib,a. a.T inhibitor a.d a.pelisib,a.PI3Kαinhibitor a. improving the lesions seen in the mouse *** demonstra.ed the effectiveness of a.pelisib in preventing va.cula. ma.forma.ions’occurrence,improving the a.rea.y esta.lished ones,a.d prolonging *** these findings,we were a.thorized to trea. 25 pa.ients with a.pelisib,including 7 children displa.ing PIK3Ca.n=16)or TEK(n=9)-rela.ed ca.illa.y venous ma.forma.ions resista.t to usua. thera.ies including sirolimus,debulking surgica. procedures or percuta.eous *** a.sessed the volume of va.cula. ma.forma.ions using ma.netic resona.ce ima.ing(MRI)for ea.h *** demonstra.ed improvement in a.l 25 *** ma.forma.ions previously considered intra.ta.le were reduced a.d clinica. symptoms were *** showed a.decrea.e of 33.4%a.d 27.8%in the media. volume of PIK3Ca.a.d TEK ma.forma.ions respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition a. a.promising thera.eutic stra.egy in pa.ients with PIK3Ca.or TEK-rela.ed ca.illa.y venous ma.forma.ions.

关键词： PIK3CA ma.forma.ions venous

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