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The Presence of Antisperm Antibodies in Semen of Subfertile Men—Positive ASA in Subfertile Men

Open Journal of Obstetrics and Gynecology 2021年第2期11卷 88-101页

作者： Kim Kamphorst Joyce Faber paul jan quirien van der linden Deventer Ziekenhuis Department of Gynaecology Obstetrics and Reproductive Medicine Deventer The Netherlands

Background: In more than 50% of male subfertility, the aetiology remains unknown. Antisperm antibodies (ASA) might be involved, however the exact role of ASA in unexplained male subfertility is not clear, yet. Objective: The aim of this study was to examine 1) the prevalence of ASA in subfertile men, 2) the possible causes of the presence of ASA, and 3) the influence of ASA on sperm parameters and fertilization including assisted reproductive technologies (ART) and pregnancy outcomes. Study Design, Size, Duration: In this retrospective single center study, all men with semen analyses between January 2003 and December 2017 were included as well as all subfertile couples getting treatment if at least one sperm analysis showed a spermMar test ≥50%. Methods: Collected parameters were: intoxications, medication and professions that could have an adverse effect on fertility, sperm parameters, the type and amount of ART, mode of conception, pregnancy rates and outcomes. Results: 3098 semen analyses were performed. In total, 233 ASA positive men were observed, including 175 subfertile couples with an ASA positive man in the additional analyses. The prevalence of ASA in the subfertile population was 8.2%. The presence of ASA was significantly associated with the presence of oligoasthenoteratozoospermia (OAT), asthen

关键词： Retrospective Antisperm Antibodies Infertility IgG IgA

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Postmenopausal Bleeding and Changing Bleeding Patterns after Parental Use of Corticosteroids: A Prospective Cohort Study

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Open Journal of Obstetrics and Gynecology 2017年第3期7卷 326-333页

作者： Henny Anna Rie Klomp Johannes Maria Gulielmus Cobben paul jan quirien van der linden Department of Obstetrics and Gynecology Deventer Ziekenhuis Deventer The Netherlands Department of Anesthesiology Deventer Ziekenhuis Deventer The Netherlands

Objective: To study whether there is a relation between the application of corticosteroids and occurrence of postmenopausal bleeding. Also we want to determine whether corticosteroids can cause an irregularity in a previously regular menstruation cycle. Design and Setting: Prospective cohort study in the department of anesthesiology. Patients: 209 women who received a single dosage of corticosteroids as treatment for pain. Interventions: None, observational cohort study;all women received standard care. Main outcome measures: Postmenopausal blood loss or disruption of menstruation cycle. Result: Postmenopausal blood loss or disruption of menstruation cycle were both more common 6 weeks after administration of corticosteroids, but were sometimes also reported 2 weeks after administration of corticosteroids. Conclusion: After administration of corticosteroids in a postmenopausal woman an episode of menstruation like bleeding can be expected. This is probably due to a transient drop of androstenedione. In premenopausal women a transient change in menstruation cycle can be observed.

关键词： Postmenopausal Bleeding Corticosteroids Bleeding Patterns

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