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Gastroesophageal reflux disease and morbid obesity: To sleeve or not to sleeve?

World Journal of Gastroenterology 2017年第13期23卷 2269-2275页

作者： Fabrizio rebecchi Marco E Allaix Marco G patti Francisco Schlottmann Mario Morino Department of Surgical Sciences University of Torino Center for Esophageal Diseases and Swallowing University of North Carolina

Laparoscopic sleeve gastrectomy(LSG) has reached wide popularity during the last 15 years, due to the limited morbidity and mortality rates, and the very good weight loss results and effects on comorbid conditions. However, there are concerns regarding the effects of LSG on gastroesophageal reflux disease(GErD). The interpretation of the current evidence is challenged by the fact that the LSG technique is not standardized, and most studies investigate the presence of GErD by assessing symptoms and the use of acid reducing medications only. A few studies objectively investigated gastroesophageal function and the reflux profile by esophageal manometry and 24-h p H monitoring, reporting postoperative normalization of esophageal acid exposure in up to 85% of patients with preoperative GErD, and occurrence of de novo GErD in about 5% of cases. There is increasing evidence showing the key role of the surgical technique on the incidence of postoperative GErD. Main technical issues are a relative narrowing of the mid portion of the gastric sleeve, a redundant upper part of the sleeve(both depending on the angle under which the sleeve is stapled), and the presence of a hiatal hernia. Concomitant hiatal hernia repair is recommended. To date, either medical therapy with proton pump inhibitors or conversion of LSG to laparoscopic rouxen-Y gastric bypass are the available options for the management of GErD after LSG. recently, new minimally invasive approaches have been proposed in patients with GErD and hypotensive LES: the LINX? reflux Management System procedure and the Stretta? procedure. Large studies are needed to assess the safety and long-term efficacy of these new approaches. In conclusion, the recent publication of p H monitoring data and the new insights in the association between sleeve morphology and GErD control have led to a wider acceptance of LSG as bariatric procedure also in obese patients with GErD, as recently stated in the 5^(th) International Consensus Con

关键词： Sleeve gastrectomy Gastroesophageal reflux Morbid obesity Ambulatory p H monitoring Esophageal manometry

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The role of latitudinal, genetic and temperature variation in the induction of diapause of Papilio glaucus （Lepidoptera： Papilionidae）

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Insect Science 2018年第2期25卷 328-336页

作者： Sean F. ryan patti Valella Gabrielle Thivierge Matthew L. Aardema J. Mark Scriber Department of Biological Sciences University of Notre Dame Notre Dame Indiana USA USDA-ArS Center for Medical Agricultural and Veterinary Entomology 1600/1700 Southwest 23rd Drive Gainesville Florida USA Department of Entomology Michigan State University East Lansing Michigan USA Life Science Department Long Beach City College Long Beach California USA Sackler Institute for Comparative Genomics American Museum of Natural History New York New York USA McGuire Centerfor Lepidoptera and Diversity University of Florida Gainesville Florida US

A key adaptation in insects for dealing with variable environmental conditions is the ability to diapause. The tiger swallowtail butterflies, Papilio glaucus and P. canadensis are ideal species to explore the genetic causes and population genetic consequences of diapause because divergence in this trait is believed to be a salient factor in maintaining a hybrid zone between these species. Yet little is known about the factors that influence diapause induction in this system. Here we explored how spatial （latitudinal）, environmental （temperature） and genetic （hybridization） factors affect diapause induction in this system. Specifically, a series of growth chamber experiments using wild caught individuals from across the eastern United States were performed to：（1） evaluate how critical photoperiod varies with latitude, （2） isolate the stage in which induction occurs, （3） test whether changes in temperature affected rates of diapause induction, and （4） explore how the incidence of diapause is affected in hybrid offspring. We find that induction occurs in the larval stage, is not sensitive to a relatively broad range of temperatures, appears to have a complex genetic basis （i.e., is not simply a dominant trait following a Mendelian inheritance pattern） and that the critical photoperiod increases by 0.4 h with each increasing degree in latitude. This work deepens our understanding of how spatial, environmental and genetic variation influences a key seasonal adaptation （diapause induction） in a well-developed ecological model system and will make possible future studies that explore how climatic variation affects the population dynamics and genetics of this system.

关键词： adaptation critical photoperiod development diapauses facultative hybridization

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Vegetated treatment area (VTAs) efficiencies for E. coli and nutrient removal on small-scale swine operations

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International Soil and Water Conservation research 2018年第2期6卷 153-164页

作者： r.Daren Harmel rehanon Pampell Terry Gentry Doug r.Smith Chad Hajda Kevin Wagner patti K.Smith rick L.Haney Kori D.Higgs USDA-ArS 2150Centre Ave.Bldg.DSuite340Fort CollinsCO80526USA Texas A&M AgriLife research 720E.Blackland RoadTempleTX76502USA Soil and Crop Sciences Dept. Texas A&M UniversityCollege StationTX77843USA USDA-ArS 808E.Blackland RoadTempleTX76502USA Oklahoma State University 139Ag HallStillwaterOK74078USA Biological and Agricultural Engineering Dept. Texas A&M UniversityCollege StationTX77843USA

As small-scale animal feeding operations work to manage their byproducts and avoid regulation, they need practical, cost-effective methods to reduce environmental impact. One such option is using vege-tative treatment areas (VTAs) with perennial grasses to treat runoff;however, research is limited on VTA effectiveness as a waste management alternative for smaller operations. This study evaluated the effi-ciencies of VTAs in reducing bacteria and nutrient runoff from small-scale swine operations in three counties in Central Texas. Based on 4 yr of runoff data, the Bell and Brazos VTAs significantly reduced loads and concentrations of E. coli and nutrients (except NO3-N) and had treatment efficiencies of 73–94%. Most notably, the Bell VTA reduced loads of E. coli, NH4-N, PO4-P, total N, and total P similar to that of the background (control). In spite of significant reductions, runoff from the Brazos VTA had higher concentrations and loads than the control site, especially following installation of concrete pens and increased pen washing, which produced standing water and increased E. coli and nutrient influx. The robertson VTA produced fewer significant reductions and had lower treatment efficiencies (29–69%);however, E. coli and nutrient concentrations and loads leaving this VTA were much lower than observed at the Bell and Brazos County sites due to alternative solids management and enclosed pens. Based on these results and previous research, VTAs can be practical, effective waste management alternatives for reducing nutrient and bacteria losses from small-scale animal operations, but only if properly designed and managed.

关键词： Bacteria Nutrients Swine manure Waste management Water quality

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Deletion of Glutl in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxidation

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Bone research 2021年第4期9卷 507-520页

作者： Cuicui Wang Jun Ying Xiangfeng Niu Xiaofei Li Gary J.patti Jie Shen regis J.O’Keefe Department of Orthopaedic Surgery School of MedicineWashington UniversitySt.LouisMOUSA Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhouChina Zhejiang Chinese Medical University HangzhouChina Department of Chemistry Genetics and MedicineWashington UniversitySt.LouisMOUSA

Glucose metabolism is fundamental for the functions of all tissues,including *** the emerging evidence related to glucose metabolism in the regulation of prenatal cartilage development,little is known about the role of glucose metabolism and its biochemical basis in postnatal cartilage growth and *** show here that genetic deletion of the glucose transporter Glutl in postnatal cartilage impairs cell proliferation and matrix production in growth plate(GPs)but paradoxically increases cartilage remnants in the metaphysis,resulting in shortening of long *** the other hand,articular cartilage(AC)with Glutl deficiency presents diminished cellularity and loss of proteoglycans,which ultimately progress to cartilage ***,predisposition to Glutl deficiency severely exacerbates injury-induced *** of the disparities in glucose metabolism between GP and AC chondrocytes under normal conditions,both types of chondrocytes demonstrate metabolic plasticity to enhance glutamine utilization and oxidation in the absence of glucose ***,uncontrolled glutamine flux causes collagen overmodification,thus affecting extracellular matrix remodeling in both cartilage *** results uncover the pivotal and distinct roles of Glutl-mediated glucose metabolism in two of the postnatal cartilage compartments and link some cartilage abnormalities to altered glucose/glutamine metabolism.

关键词： metabolism cartilage chondrocytes

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Honolulu： The Heart of Hawaii

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空中英语教室（高级版．彭蒙惠英语） 2009年第8期 30-33页

作者： patti Nickell

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CSF biomarkers in multiple sclerosis:beyond neuroinflammation

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Neuroimmunology and Neuroinflammation 2021年第1期8卷 14-41页

作者： Simona Toscano Francesco patti Department"GF Ingrassia" Section of NeurosciencesMultiple Sclerosis CenterUniversity of CataniaCatania 95123Italy

For many years,quantifiable biomarkers in neurological diseases have represented a hot *** multiple sclerosis(MS),cerebrospinal fluid biomarkers have played a diagnostic role since the introduction of Poser's criteria in 1983,with IgG oligoclonal bands playing a supporting role in an epoch prior to magnetic resonance imaging and a complementary one after the introduction of McDonald criteria in ***,that supporting role has turned into a main one in substituting for dissemination in time and defining the diagnosis of MS in patients with a first clinical event,according to the 2017 revised McDonald *** kappa free light chains,N-CAM,chitinase 3-like protein 1 and IgM oligoclonal bands,not yet implemented in clinical practice,could similarly gain importance in the near ***,the increasing knowledge of molecular mechanisms leading to chronic inflammation has enhanced interest in looking for biomarkers of disease activity,better defining the MS phenotype and patients with highly active ***,myelin proteins,intermediate filaments,metalloproteinases and other molecules involved in the inflammatory cascade,are currently under ***,it has long been known that axonal loss occurs from the early phases,leading to a progressive neurological *** established criteria to assess treatment failure and transition to progressive forms are still lacking,both treatment response and prognostic biomarkers would be useful to predict MS course,and neurofilaments seem to have this *** purpose of this review article was to illustrate biomarkers that have been already validated or require further validation after proving to be useful in exploratory studies and potentially could prove useful in clinical practice in the coming years.

关键词： Multiple sclerosis biomarkers cerebrospinal fluid neurofilaments oligoclonal bands disease activity

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Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis(DISH)

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Bone research 2020年第2期8卷 209-218页

作者： Dale E.Fournier patti K.Kiser ryan J.Beach S.Jeffrey Dixon Cheryle A.Séguin Health and rehabilitation Sciences(Physical Therapy) Faculty of Health SciencesThe University of Western OntarioLondonON N6A 5B9Canada Bone and Joint Institute The University of Western OntarioLondonON N6G 2V4Canada Department of Laboratory Medicine and Pathology Schulich School of Medicine&DentistryThe University of Western OntarioLondonON N6A 5C1Canada Department of Physiology and Pharmacology Schulich School of Medicine&DentistryThe University of Western OntarioLondonON N6A 5C1Canada

Diffuse idiopathic skeletal hyperostosis(DISH) is a prevalent noninflammatory spondyloarthropathy characterized by ectopic mineral formation along the anterolateral aspect of the vertebral column, yet little is known about its underlying pathogenesis. Our objective was to evaluate the histopathological features and composition of ectopic mineral within spinal tissues affected by DISH in humans. Thoracic spine segments from six embalmed cadaveric donors(one female and five males;median age 82 years)meeting the radiographic diagnostic criteria for DISH were evaluated using radiological, histological, and physical analyses. Overall,the histological features of ectopic mineralization at individual motion segments were heterogeneous, including regions of heterotopic ossification and dystrophic calcification. Heterotopic ossifications were characterized by woven and lamellar bone,multifocal areas of metaplastic cartilage, and bony bridges along the anterior aspect of the intervertebral disc space. Dystrophic calcifications were characterized by an amorphous appearance, a high content of calcium and phosphorus, an X-ray diffraction pattern matching that of hydroxyapatite, and radiodensities exceeding that of cortical bone. Dystrophic calcifications were found within the anterior longitudinal ligament and annulus fibrosus in motion segments both meeting and not meeting the radiographic criteria for DISH. In summary, our findings indicate that in DISH, ectopic mineral forms along the anterior aspect of the spine by both heterotopic ossification and dystrophic calcification of fibrocartilaginous tissues. Although both types of ectopic mineralization are captured by current radiographic criteria for DISH, dystrophic calcification may reflect a distinct disease process or an early stage in the pathogenesis of DISH.

关键词： DISH ossification calcification

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面向城镇住宅建筑光伏一体化的GIS开放数据协同仿真平台

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Engineering 2023年第7期26卷 198-213,I0008页

作者： Marco Massano Enrico Macii Andrea Lanzini Edoardo patti Lorenzo Bottaccioli Interuniversity Department of regional and Urban Studies and Planning Politecnico di TorinoTorino 10129Italy Department of Energy“Galileo Ferraris” Politecnico di TorinoTorino 10129Italy Department of Control and Computer Engineering Politecnico di TorinoTorino 10129Italy

The rising awareness of environmental issues and the increase of renewable energy sources(rESs)has led to a shift in energy production toward rES,such as photovoltaic(PV)systems,and toward a distributed generation(DG)model of energy production that requires systems in which energy is generated,stored,and consumed *** this work,we present a methodology that integrates geographic information system(GIS)-based PV potential assessment procedures with models for the estimation of both energy generation and consumption *** particular,we have created an innovative infrastructure that co-simulates PV integration on building rooftops together with an analysis of households’electricity *** model relies on high spatiotemporal resolution and considers both shadowing effects and real-sky conditions for solar radiation *** integrates methodologies to estimate energy demand with a high temporal resolution,accounting for realistic populations with realistic consumption *** a solution enables concrete recommendations to be drawn in order to promote an understanding of urban energy systems and the integration of rES in the context of future smart *** proposed methodology is tested and validated within the municipality of Turin,*** the whole municipality,we estimate both the electricity absorbed from the residential sector(simulating a realistic population)and the electrical energy that could be produced by installing PV systems on buildings’rooftops(considering two different scenarios,with the former using only the rooftops of residential buildings and the latter using all available rooftops).The capabilities of the platform are explored through an in-depth analysis of the obtained *** power and energy profiles are presented,emphasizing the flexibility of the resolution of the spatial and temporal *** energy indicators are presented for the self-consumption of produced energy and the avoidance of CO_(

关键词： Energy informatics Geographic information system Load estimation Open data Photovoltaic residential Urban planning Co-simulation

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Semi-supervised multi-layered clustering model for intrusion detection

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Digital Communications and Networks 2018年第4期4卷 277-286页

作者： Omar Y.Al-Jarrah Yousof A1-Hammdi patti D.Yoo Sami Muhaidat Mahmoud Al-Qutayri Department of Electrical and Computer Enooineering Khalifa Universityof Science and TechnologyAbu DhabiUnited Arab Emirates Centre for Electronic Warfare Information and Cyber (EWIC)Cranfield UniversityDefence Academy of the United KingdomShrivenhamSwindonSN68LAUnited Kingdom

A Machine Learning (ML)-based Intrusion Detection and Prevention System (IDPS)requires a large amount of labeled up-to-date training data to effectively detect intrusions and generalize well to novel ***,the labeling of data is costly and becomes infeasible when dealing with big data,such as those generated by Intemet of Things *** this effect,building an ML model that learns from non-labeled or partially labeled data is of critical *** paper proposes a Semi-supervised Mniti-Layered Clustering ((SMLC))model for the detection and prevention of network *** has the capability to learn from partially labeled data while achieving a detection performance comparable to that of supervised ML-based *** performance of SMLC is compared with that of a well-known semi-supervised model (tri-training)and of supervised ensemble ML models, namely ***,Bagging,and AdaboostM1on two benchmark network-intrusion datasets,NSL and Kyoto 2006+.Experimental resnits show that SMLC is superior to tri-training,providing a comparable detection accuracy with 20%less labeled instances of training ***,our results demonstrate that our scheme has a detection accuracy comparable to that of the supervised ensemble models.

关键词： Semi-supervised intrusion detection Machine learning Classification Ensembles Big data

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A Comparison of Linear Array and Hybrid Capture 2 for Detection of Carcinogenic HPV and Cervical Precancer and Cancer

A Comparison of Linear Array and Hybrid Capture 2 for Detect...

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24th International Papillomavirus Conference and Clinical Workshop

作者： patti Gravitt Mark Diane Philip Johns Hopkin University NCI/NIH（USA） NCI/NIH（USA） NCI/NIH（USA）

＜正＞We evaluated Linear Array（LA）,a commercialized PGMY09/11 L1 consensus primer PCr test that detects 37 human papillomavirus（HPV）genotypes by reverse line blot hybridization,for the detection of individual HPV genotypes and carcino- genic HPV and its clinical performance for detecting 2-year cumulative cervical precancer and cancer using archived speci- mens from the ASCUS and LSIL Triage Study（ALTS）LA testing was conducted on enrollment specimens from women referred

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