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新奥尔良的文化瑰宝认识路易斯安那州长沼岸边的迷人城市

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空中英语教室（高级版．彭蒙惠英语） 2024年第2期 12-14,40,41页

作者： patti Nickell 不详

新奥尔良是美国最具文化意义的都市,其文化在长沼、河流、湖泊和墨西哥湾环绕的湿热沼泽中孕育而生、蓬勃生长。受到西班牙、法国、加勒比非裔和英国等地的文化熏陶,新奥尔良创造出自己的美食与音乐,对生命抱持热情,因而衍生出这句新奥... 详细信息

新奥尔良是美国最具文化意义的都市,其文化在长沼、河流、湖泊和墨西哥湾环绕的湿热沼泽中孕育而生、蓬勃生长。受到西班牙、法国、加勒比非裔和英国等地的文化熏陶,新奥尔良创造出自己的美食与音乐,对生命抱持热情,因而衍生出这句新奥尔良的名言——“尽情享受欢乐时光吧。”

关键词：新奥尔良文化熏陶路易斯安那州加勒比文化瑰宝墨西哥湾西班牙

Minimally invasive esophagectomy

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World Journal of Gastroenterology 2010年第30期16卷 3811-3815页

作者： Fernando A Herbella Marco G patti Department of Surgery University of Chicago Pritzker School of MedicineChicagoIL 60637United States

Esophageal resection is associated with a high morbidity and mortality rate. Minimally invasive esophagectomy (MIE) might theoretically decrease this rate. We reviewed the current literature on MIE, with a focus on the available techniques, outcomes and comparison with open surgery. This review shows that the available literature on MIE is still crowded with heterogeneous studies with different techniques. There are no controlled and randomized trials, and the few retrospective comparative cohort studies are limited by small numbers of patients and biased by historical controls of open surgery. Based on the available literature, there is no evidence that MIE brings clear benef its compared to conventional esophagectomy. Increasing experience and the report of larger series might change this scenario.

关键词： Esophageal resection Transhiatal esophagectomy Transthoracic esophagectomy Esophageal cancer Minimally invasive esophagectomy Laparoscopy Thoracoscopy

Gastroesophageal reflux disease:From pathophysiology to treatment

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World Journal of Gastroenterology 2010年第30期16卷 3745-3749页

作者： Fernando A Herbella Marco G patti Department of Surgery University of Chicago Pritzker School of MedicineChicagoIL 60637United States

This review focuses on the pathophysiology of gastroesophageal reflux disease (GErD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett’s esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GErD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GErD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GErD.

关键词： Gastroesophageal reflux disease Pathophysiology Acid reflux Non-acid reflux Esophageal manometry Ambulatory pH Barrett’s esophagus Esophageal adenocarcinoma

Splenic lymphangiomatosis showing rapid growth during lactation:A case report

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World Journal of Gastroenterology 2010年第9期16卷 1155-1157页

作者： rosalia patti Emilio Iannitto Gaetano Di Vita General Surgery Unit Department of Surgical and Oncological SciencesUniversity of Palermo Haematological Division University of Palermo

Splenic lymphangiomatosis is a very rare condition that,from 1990 to date,has been described only nine *** the present report,we describe the first case of splenic lymphangiomatosis with rapid growth during lactation in a 35-year-old *** also underline the difficultly in making an accurate preoperative diagnosis,despite more modern imaging *** splenectomy was considered to be the treatment needed,both to make a definitive diagnosis and to exclude the presence of malignancy.

关键词： Lymphangiomatosis Spleen Lactation

Gastroesophageal reflux disease:From heartburn to cancer

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World Journal of Gastroenterology 2010年第30期16卷 3743-3744页

作者： Marco G patti Irving Waxman Department of Surgery University of ChicagoPritzker School of MedicineChicagoIL 60637United States Center for Endoscopic research and Therapeutics (CErT) University of Chicago Pritzker School of MedicineChicagoIL 60637United States

About 10%-15% of patients with gastroesophageal reflux disease develop Barrett’s esophagus. This is considered a premalignant condition because it can progress from metaplasia to high-grade dysplasia, and eventually to adenocarcinoma. recently, major advances have been made in the endoscopic treatment of Barrett’s esophagus, therefore limiting the role of surgery in the treatment of this disease.

关键词： Gastroesophageal reflux disease Barrett’s esophagus Esophageal adenocarcinoma Laparoscopic fundoplication radiofrequency ablation Esophageal endoscopic mucosal resection Minimally invasive esophagectomy

Granular cell tumor of stomach: A case report and review of literature

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World Journal of Gastroenterology 2006年第21期12卷 3442-3445页

作者： rosalia patti Piero Luigi Almasio Gaetano Di Vita Department of Surgical and Oncological Science Division of General Surgery University of PalermoPalermoItaly Chair in Gastroenterology University of Palermo PalermoItaly

Granular cell tumor （GCT） was described for the first time by Abrikosoff in 1926. It is a relatively rare neoplasm that may occur at many sites, but most commonly in the skin or soft tissues. The occurrence of GCT in the gastrointestinal tract is rare, accounting approximately for 8% of all tumors, among which the most common site is the esophagus, whereas gastric localization is very rare. Gastric GCTs can be solitary or, more frequently, associated with other gastrointestinal localization. Although GCTs are usually clinically and histologically benign, some malignant cases have been reported. Histologically, these tumors consist of polygonal and fusiform cells disposed in compact ＂nests＂ and immunohistochemical staining for S-100 protein supports the proposed derivation from Schwann cells. A correct preoperative diagnosis of this tumor can only be made in 50% of all patients and it is always based on endoscopic biopsy. Laparoscopic or conventional wedge resection represents the treatment of choice. In this study, the authors reported a case of a 49-year-old woman with a solitary granular cell tumor of the stomach with infiltrative pattern, successfully treated with surgical resection. A review of literature is also presented with emphasis on diagnostic criteria concerning the malignant form.

关键词： Granular cell tumor Stomach Benign Surgical resection

Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson’s disease: a post-mortem observational study

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Translational Neurodegeneration 2022年第1期11卷 737-746页

作者： risa Isonaka patti Sullivan David S.Goldstein Autonomic Medicine Section Clinical Neurosciences ProgramDivision of Intramural ResearchNational Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMD 20892USA

Background: Parkinson’s disease (PD) is characterized by intra-neuronal deposition of the protein α-synuclein (α-syn) and by deficiencies of the catecholamines dopamine and norepinephrine (NE) in the brain and heart. Accumulation of α-syn in sympathetic noradrenergic nerves may provide a useful PD biomarker;however, whether α-syn buildup is pathophysiological has been unclear. If it were, one would expect associations of intra-neuronal α-syn deposition with catecholaminergic denervation and with decreased NE contents in the same samples. Methods: We assayed immunoreactive α-syn and tyrosine hydroxylase (TH, a marker of catecholaminergic innerva-tion) concurrently with catecholamines in coded post-mortem scalp skin, submandibular gland (SMG), and apical left ventricular myocardial tissue samples from 14 patients with autopsy-proven PD and 12 age-matched control subjects who did not have a neurodegenerative disease. results: The PD group had increased α-syn in sympathetic noradrenergically innervated arrector pili muscles (5.7 times control, P rol, P = 0.0011), and myocardium (11 times control, P = 0.0011). Myocar-dial TH in the PD group was decreased by 65% compared to the control group (P = 0.0008), whereas the groups did not differ in TH in either arrector pili muscles or SMG. Similarly, myocardial NE was decreased by 92% in the PD group (P roups did not differ in NE in either scalp skin or SMG. Conclusions: PD entails increased α-syn in skin, SMG, and myocardial tissues. In skin and SMG, augmented α-syn deposition in sympathetic nerves does not seem to be pathogenic. The pathophysiological significance of intra-neuronal α-syn deposition appears to be organ-selective and prominent in the heart.

关键词： Synuclein Tyrosine hydroxylase Norepinephrine Immunofluorescence Parkinson Post-mortem

Impact of minimally invasive surgery on the treatment of benign esophageal disorders

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World Journal of Gastroenterology 2012年第46期18卷 6764-6770页

作者： Brian Bello Fernando A Herbella Marco E Allaix Marco G patti Department of Surgery University of Chicago Pritzker School of Medicine

Thanks to the development of minimally invasive surgery, the last 20 years have witnessed a change in the treatment algorithm of benign esophageal disorders. Today a laparoscopic operation is the treatment of choice for esophageal achalasia and for most patients with gastroesophageal reflux disease. Because the pathogenesis of achalasia is unknown, treatment is palliative and aims to improve esophageal emptying by decreasing the functional obstruction at the level of the gastro-esophageal junction. The refinement of minimally invasive techniques accompanied by large, multiple randomized control trials with long-term outcome has allowed the laparoscopic Heller myotomy and partial fundoplication to become the treatment of choice for achalasia compared to endoscopic procedures, including endoscopic botulinum toxin injection and pneumatic dilatation. Patients with suspected gastroesophageal reflux need to undergo a thorough preoperative workup. After establishing diagnosis, treatment for gastroesophageal reflux should be individualized to patient characteristics and a decision about an operation made jointly between surgeon and patient. The indications for surgery have changed in the last twenty years. In the past, surgery was often considered for patients who did not respond well to acid reducing medications. Today, the best candidate for surgery is the patient who has excellent control of symptoms with proton pump inhibitors. The minimally invasive approach to antireflux surgery has allowed surgeons to control reflux in a safe manner, with excellent long term outcomes. Like achalasia and gastroesophageal reflux, the treatment of patients with paraesophageal hernias has also seen a major evolution. The laparoscopic approach has been shown to be safe, and durable, with good relief of symptoms over the long-term. The most significant controversy with laparoscopic paraesophageal hernia repair is the optimal crural repair. This manuscript reviews the evolution of these tec

关键词： Gastroesophageal reflux disease Esophageal achalasia Hiatal hernia Laparoscopic fundoplication Laparoscopic Heller myotomy

Multidisciplinary approach for patients with esophageal cancer

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World Journal of Gastroenterology 2012年第46期18卷 6737-6746页

作者： Victoria M Villaflor Marco E Allaix Bruce Minsky Fernando A Herbella Marco G patti Department of Medicine Section Hematology/Oncology University of Chicago Medicine Department of Surgery University of Chicago Medicine radiation Oncology University of Chicago Medicine

Patients with esophageal cancer have a poor prognosis because they often have no symptoms until their disease is advanced. There are no screening recommendations for patients unless they have Barrett's esophagitis or a significant family history of this disease. Often, esophageal cancer is not diagnosed until patients present with dysphagia, odynophagia, anemia or weight loss. When symptoms occur, the stage is often stage Ⅲ or greater. Treatment of patients with very early stage disease is fairly straight forward using only local treatment with surgical resection or endoscopic mucosal resection. The treatment of patients who have locally advanced esophageal cancer is more complex and controversial. Despite multiple trials, treatment recommendations are still unclear due to conflicting data. Sadly, much of our data is difficult to interpret due to many of the trials done have included very heterogeneous groups of patients both histologically as well as anatomically. Additionally, studies have been underpowered or stopped early due to poor accrual. In the United States, concurrent chemoradiotherapy prior to surgical resection has been accepted by many as standard of care in the locally advanced patient. Patients who have metastatic disease are treated palliatively. The aim of this article is to describe the multidisciplinary approach used by an established team at a single high volume center for esophageal cancer, and to review the literature which guides our treatment recommendations.

关键词： Esophageal Cancer Multimodality therapy Multidisciplinary therapy Chemoradiotherapy Esophageal resection Esophagectomy