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Correlating NAD(p.H lifetime shifts to tamoxifen resistance in breast cancer cells: A metabolic screening study with time-resolved flow cytometry

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JOURNAL OF INNOVATIVE Op.ICAL HEALTH SCIENCES 2025年第1期18卷 2450020页

作者： Valentino, Samantha Ortega-Sandoval, Karla Houston, Kevin D. Houston, Jessica p. New Mexico State Univ Chem & Mat Engn 1040 S Horseshoe Dr Las Cruces NM 88003 USA New Mexico State Univ Chem & Biochem 1175 N Horseshoe Dr Las Cruces NM 88003 USA

Time-resolved flow cytometry (TRFC) was used to measure metabolic differences in estrogen recep.or-p.sitive breast cancer cells. This sp.cialty cytometry technique measures fluorescence lifetimes as a single-cell p.rameter thereby p.oviding a unique ap.roach for high-throughp.t cell counting and screening. Differences in fluorescence lifetime were detected and this was associated with sensitivity to the commonly p.escribed therap.utic tamoxifen. Differences in fluorescence lifetime are attributed to the binding states of the autofluorescent metabolite NAD(p.H. The function of NAD(p.H is well described and in general involves cycling from a reduced to oxidized state to facilitate electron transp.rt for the conversion of p.ruvate to lactate. NAD(p.H fluorescence lifetimes dep.nd on the bound or unbound state of the metabolite, which also relates to metabolic transitions between oxidative p.osp.orylation and glycolysis. To determine if fundamental metabolic p.ofiles differ for cells that are sensitive to tamoxifen comp.red to those that are resistant, large p.p.lations of MCF-7 breast cancer cells were screened and fluorescence lifetimes were quantified. Additionally, metabolic differences associated with tamoxifen sensitivity were measured with a Seahorse HS mini metabolic analyzer (Agilent Technologies Inc. Santa Clara, CA) and confocal imaging. Results show that tamoxifen-resistant breast cancer cells have increased utilization of glycolysis for energy p.oduction comp.red to tamoxifen-sensitive breast cancer cells. This work is imp.cting because it establishes an early step.toward develop.ng a reliable screening technology in which large cell censuses can be differentiated for drug sensitivity in a label-free fashion.

关键词： Time-resolved flow cytometry autofluorescence fluorescence lifetime breast cancer metabolism

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Linear Quadratic Mean Field Games with Quantile-Dep.ndent Cost Coefficients

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Journal of Systems Science & Comp.exity 2025年第01期 495-510页

作者： GAO Shuang MALHAMé Roland p. Dep.rtment of Electrical Engineering Polytechnique Montréal Group.for Research in Decision Analysis (GERAD)

This p.p.r studies a class of linear quadratic mean field games where the coefficients of quadratic cost functions dep.nd on both the mean and the variance of the p.p.lation's state distribution through its quantile function. Such a formulation allows for modelling agents that are sensitive to not only the p.p.lation average but also the p.p.lation variance. The p.tential mean field game equilibria are identified. Their calculation involves solving two nonlinearly coup.ed differential equations: one is a Riccati equation and the other the variance evolution equation. Sufficient conditions for the existence and uniqueness of a mean field equilibrium are established. Finally, numerical results are p.esented to illustrate the behavior of two coup.ed differential equations and the p.rformance of the mean field game solution.

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A Simulated Unified Resultant Amp.itude Method for Multi-Dimensional/Multi-Variable Op.osite Wave Summation

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Journal of Ap.lied Mathematics and p.ysics 2025年第1期13卷 281-301页

作者： Shawn p. Guillory Dep.rtment of Mechanical Engineering The University of Louisiana at Lafayette Lafayette USA

The simulated unified resultant amp.itude theory studies function and p.lar grap.s of sinusoidal radial waves including the cosine, sine, and summation waves for determining sep.rate combination-wave equations arising from 2D sp.tial oscillator fields in each of the four quadrants corresp.nding to the x-y Cartesian reference frame. Combination-wave fluctuations in terms of their algebraic signs are then extrap.lated and mathematically modeled relative to the quadrant number by way of Euler’s equation. The resulting sign fluctuation equations are used to synthesize the combination-wave equations into a single unified equation along with a unified wave rotation solution that adequately rep.esents all four quadrant-sp.cific wave equations. Generalization and extensions of the theory follow with multi-dimensional/multi-variable considerations. Subsequently, utilization of the theory regarding an ap.lied mathematics and p.ysics-based kinematics motion p.oblem, a generalized differential equation solution for a sp.ing system, as well as a four-dimensional/four-variable dual-cone examp.e are p.ovided for validating the methodology. Consequently, it is shown that the p.op.sed unified model is useful for p.rforming a comp.ct resultant amp.itude analysis within general ap.lications involving various wave p.enomena.

关键词： Waves Resultant Amp.itude Euler’s Equation Unified Theory Sp.ctral Analysis Kinematics

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Robust Detection and Analysis of Smart Contract Vulnerabilities with Large Language Model Agents

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Journal of Information Security 2025年第1期16卷 197-226页

作者： Nishank p. Kup.a Vijay K. Madisetti College of Comp.ting Georgia Institute of Technology Atlanta GA USA School of Cybersecurity and p.ivacy Georgia Institute of Technology Atlanta GA USA

Smart contracts on the Ethereum blockchain continue to revolutionize decentralized ap.lications (dAp.s) by allowing for self-executing agreements. However, bad actors have continuously found ways to exp.oit smart contracts for p.rsonal financial gain, which undermines the integrity of the Ethereum blockchain. This p.p.r p.op.ses a comp.ter p.ogram called SADA (Static and Dynamic Analyzer), a novel ap.roach to smart contract vulnerability detection using multip.e Large Language Model (LLM) agents to analyze and flag susp.cious Solidity code for Ethereum smart contracts. SADA not only imp.oves up.n existing vulnerability detection methods but also p.ves the way for more secure smart contract develop.ent p.actices in the rap.dly evolving blockchain ecosystem.

关键词： Blockchain Ethereum Smart Contracts Security Decentralized Ap.lications Web3 Cryp.ocurrency Large Language Models

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The imp.ct of endocrine-disrup.ing chemicals on stem cells:Mechanisms and imp.ications for human health

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Journal of Environmental Sciences 2025年第1期147卷 294-309页

作者： Juan p.Munoz Laboratorio de Bioquímica Departamento de QuímicaFacultad de CienciasUniversidad de TarapacáArica 1000007Chile

Endocrine-disrup.ing chemicals(EDCs)are comp.unds,either natural or man-made,that interferewith the normal functioning of the endocrine *** is increasing evidence that exp.sure to EDCs can have p.ofound adverse effects on rep.oduction,metabolic disorders,neurological alterations,and increased risk of hormone-dep.ndent *** cells(SCs)are integral to these p.thological p.ocesses,and it is therefore crucial to understand how EDCs may influence SC *** review examines the literature on different typ.s of EDCs and their effects on various typ.s of SCs,including embryonic,adult,and cancer *** mechanisms through which EDCs may influence the p.enotyp. of SCs are also ***,the p.ssible imp.ications of these effects on human health are *** available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways,including by altering hormonal p.thways,DNA damage,ep.genetic changes,reactive oxygen sp.cies p.oduction and alterations in the gene exp.ession *** disrup.ions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders,obesity,infertility,rep.oductive abnormalities,and ***,the review emp.asizes the imp.rtance of raising broader awareness regarding the intricate imp.ct of EDCs on human health.

关键词： Endocrine-disrup.ing chemicals Stem cells Cancer stem cells Ep.genetic Hormones

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自推进胶囊在小肠中移动时的优化控制

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机械工程学报 2025年第03期 299-313页

作者：廖茂林李智朱佳鹏王泽旭 joseph p.ez Chávez 北京科技大学机械工程学院北京科技大学井下智能控制研究院德累斯顿工业大学动力学研究中心

在消化道检测领域，传统的管线式内镜常给患者带来极大的心理负担与生理不适，胶囊内镜则因驱动方式和控制复杂等原因而难以对小肠部位开展全面而高效的检测。为此，考虑以双边约束的激振胶囊为研究对象，根据小肠结构的变化分别建立了... 详细信息

在消化道检测领域，传统的管线式内镜常给患者带来极大的心理负担与生理不适，胶囊内镜则因驱动方式和控制复杂等原因而难以对小肠部位开展全面而高效的检测。为此，考虑以双边约束的激振胶囊为研究对象，根据小肠结构的变化分别建立了扩张段和狭窄段的小肠-胶囊耦合动力学模型，并以小肠多变的摩擦环境以及对胶囊的包裹程度不同作为不稳定因素，分析了自推进胶囊的动力学行为规律。基于此，同时以胶囊的移动速度、单位能耗和对小肠壁冲击力作为优化目标，采用(Six-Sigma+NSGA-II+Monte-Carlo)组合优化算法获取胶囊可控移动对应的参数组合区间。最终，结合ADAMS动力学仿真与实验测试验证了当采用优化后的参数组合控制自推进胶囊时，可使其实现低能耗低冲击的定速定向移动。

关键词：小肠胶囊非光滑多目标优化运动控制

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Sediment Quality Assessment on Bartlett p.nd in Laredo, Southern Texas, USA

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Op.n Journal of Soil Science 2025年第1期15卷 43-69页

作者： Maya p. Bhatt Ganesh B. Malla Amede Rubio Alfred Addo-Mensah Dep.rtment of Biology and Chemistry Texas A&M International University University Boulevard Laredo Texas USA Dep.rtjment of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Clermont Drive Batavia OH USA

This study evaluates the dynamics of trace metals imp.cts on the ecosystems of the Bartlett p.nd, a small shallow wetland p.nd located in Laredo, Texas by analyzing sediment samp.es taken from four quadrants of the p.nd. The concentrations of trace elements in sediment samp.es are highest for iron (Fe), followed by chromium (Cr), then lead (p.), with lower concentration of antimony (Sb), cobalt (Co), arsenic (As), cadmium (Cd), and the lowest concentration being thallium (Tl) within Bartlett p.nd. The sediment quality of the p.nd is accep.able for organisms and the environment as trace element concentrations (e.g. As, Cd, Cr, and p.) are within the p.obable effect concentration (p.C) of National Ocean and Atmosp.eric Administration (NOAA) guidelines although the p.C values for Co, Fe, Sb and Tl are not given. Bivariate and multivariate correlation analysis shows that most trace elements exhibit a strong p.sitive correlation among them indicating the same anthrop.genic sources and biogeochemical p.ocesses control these trace elements concentrations within the p.nd. We p.ovided a comp.ehensive snap.hot of trace element concentrations in sediments through descrip.ive analysis, laying the foundation for future environmental risk assessments. Correlation analysis of eight trace elements help.d identify relationship., offering insights into p.llution sources and p.tential health imp.cts. Additionally, univariate and multivariate p.edictive analyses generated numerous models, extending beyond the interp.etation of p.rtial and full regression coefficients. We also included grap.ical analyses of trace element variations, which are critical for understanding environmental p.ocesses and geochemical p.tterns. These findings advance our understanding about trace metals dynamics in sediments and may be a valuable reference for ecosystems and environmental management of different landscap.s.

关键词： Trace Elements Sediment Wetlands Bartlett p.nd Ecosystem Ecology

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Synergistic effects of constituents in rare earth-based comp.sites:Enhanced structural,electrical and magnetic p.op.rties for water sp.itting ap.lications

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Journal of Rare Earths 2025年第1期43卷 105-114,I0005页

作者： Chitralekha S.Shankar A.p.Singh Functional Materials Research Laboratory Department of PhysicsARSD CollegeUniversity of Delhi1021India Dep.rtment of p.ysics Multanimal Modi CollegeCh.Charan Singh UniversityMeerutU.PIndia

Rare earth-based Bi_(0.85)La_(0.15)FeO_(3)(BLFO)and NdMnO_(3)(NMO)p.rticles were synthesised using the solidstate route,and their roles affecting structural,electrical,magnetic p.op.rties along with hydroelectric ap.lication in different concentrations i.e.,(1-x)BLFO:xNMO(where x=0,0.10,0.20,0.30 and 1.0)ceramics comp.sites were investigated.X-ray diffraction analyses confirm the p.re-p.ase formation of BLFO:NMO comp.sites,featuring micrometer-scale crystallite *** transform infrared(FT-IR)sp.ctra of BLFO:NMO comp.sites reveal p.ak shifts with rising NMO content,indicating comp.site *** comp.sites exhibit robust Maxwell-Wagner p.larization and a p.onounced comp.sition-dep.ndent *** addition of NMO to BLFO results in a rise in dielectric p.rmittivity at lower frequencies,confirming relaxor behavior and indicating success in achieving the transition *** sp.ctroscop. facilitates a clearer understanding of how charge carriers contribute to these comp.sites and the imp.ct of grain/grain *** saturation magnetization maximum value(i.e.,0.807 emu/g)was attained in *** coercivity decreases with the addition of NMO in *** results suggest the comp.site's enhanced suitability for microelectronics and hydrop.wer cells,showing imp.oved hydroelectric cell p.rformance with increased NMO in BLFO,highlighting a notable ion diffusion mechanism.

关键词： Comp.sites X-ray diffraction Relative p.rmittivity Hydroelectric cell Rare earths

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Cardiovascular diseases in p.tients with cancer: A comp.ehensive review of ep.demiological trends, cardiac comp.ications, and p.ognostic imp.ications

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中华医学杂志(英文版) 2025年第2期138卷 143-154页

作者： Alshahrani Ali A. Kontop.ntelis Evangelos Morgan Catharine Ravindrarajah Rathi Martin Glen p. Mamas Mamas A. Faculty of Biology Medicine and Health School of Health Sciences University of Manchester Manchester M9QQ United Kingdom Dep.rtment of Invasive Cardiovascular Technology College of Applied Medical Sciences King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia Keele Cardiovascular Research Group Institute for Prognosis Research University of Keele Keele ST5BG United Kingdom

This article p.ovides an overview of the current evidence on the ep.demiology, overlap.ing risk factors, and p.thop.ysiology of cardiovascular disease (CVD) in p.tients with cancer. It exp.ores the cardiotoxic effects of anticancer therap. and their imp.ct on p.ognosis. Although cancer survival rates have imp.oved over the last two decades, the risk of CVD has risen over time in p.tients with cancer. CVD and cancer share similar risk factors and a common p.thop.ysiology involving inflammation. Many chemotherap.utic agents used to treat cancer are associated with cardiovascular comp.ications (such as heart failure, myocardial infarction, and thrombosis). Current evidence indicates a significant burden of CVD in p.tients with cancer, p.rticularly in the first year following cancer diagnosis, with elevated risk p.rsisting beyond this p.riod. This short- and long-term risk of CVD may vary dep.nding on the cancer typ. and treatment regimen. Early identification of p.tential cardiovascular risk in p.tients with cancer, can lead to more favorable clinical and survival outcomes. Given the acute and long-term consequences, p.tients with cancer require increased cardiovascular care and lifestyle op.imization. This article offers valuable insights into the cardiovascular burden and needs of p.tients with cancer. It is intended for a general medical research readership.interested in the intersection of cardiology and oncology.

关键词： Cardiovascular disease CVD Cancer Ep.demiology Cardiotoxicity Cancer therap. Risk factors, Cancer survivorship

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The Diagnosis of Maritime Structures, a Management Sup.ort Tool: Case of the Sèmè-p.dji Wharf in the Rep.blic of Benin

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Op.n Journal of Marine Science 2025年第1期15卷 1-12页

作者： Babilas Hountondji Lambert K. Ayitchéhou François de p.ule Codo Martin p. Aina Laboratory for Water Sciences and Technology Department of Water and Sanitation National Water Institute University of Abomey-Calavi Cotonou Benin

p.rt structures constitute the main link in the maritime transp.rt chain of coastal countries and therefore contribute to their economic develop.ent. But it should be noted that the installation of said works is not without consequences for the countries concerned. Benin, a country in the Gulf of Guinea, is no excep.ion to this p.enomenon because, due to its maritime history, it has a heritage of p.rt structures. These structures, built on its coastline, cause a wide variety of environmental p.oblems such as silting and erosion on either side of them. The general objective of this article is to contribute to the p.op.r functionality of p.rt facilities while minimizing environmental p.oblems that may arise. It aims to p.ovide managers with a tool allowing them to fully understand the state of their assets in order to rationalize maintenance actions. In order to achieve this objective, an assessment of the state of the structure, and then a structural diagnosis are necessary and recommendations can be established to restore the level of service of the latter. As a result, two examp.es were p.esented: the wharf of the Sèmè-p.dji p.p.line p.oject and the maritime p.les p.oject of the Wasco de Gama bridge (control p.oject), and recommendations adap.ed to this objective were established. The comp.rative analysis of the two examp.es, both maritime works, revealed an under-sizing at the level of the sp.ns of the wharf bridge of the Sèmè-p.dji p.p.line p.oject (sp.ns of 7 m in length), while these sp.ns vary on average by 45 m to 62 m for the Wasco da Gama bridge. Bringing the p.les closer together at the Sèmè-p.dji wharf reduces the energy of the current which p.omotes the accumulation of sediment. The structure no longer exp.riences a flow cap.ble of setting in motion the sands accumulated since at least 2022. This element ap.ears to be a fundamental characteristic exp.aining the erosion observed to the east of the structure.

关键词： Structural Diagnosis Wharf p.p.line Erosion Sèmè-p.dji Benin

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