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Sensitivity of Coupled Cha.tic Dyna.ica. System to Pa.a.eters in the Context of Da.a.a.simila.ion

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Journa. of Ma.hema.ics a.d System Science 2013年第12期3卷 641-654页

作者： Sergei Solda.enko david Smith Peter Steinle Chris Tingwell The Center for a.stra.ia. Clima.e a.d Wea.her Resea.ch 700 Collins Street Melbourne 3008 Australia

In this pa.er, a.numerica. modeling tool is described which ca. be used to explore va.ious a.pects of four dimensiona. va.ia.iona. da.a.a.simila.ion a.d pa.a.eter estima.ion a.ising in geophysica., environmenta., biologica. a.d engineering sciences. a.ma.or component of this tool is a.coupled cha.tic dyna.ica. system obta.ned by coupling two versions of the well-known Lorenz （1963） model with different time sca.es which differ by a.certa.n time-sca.e fa.tor. a.ta.gent linea. model a.d its a.joint a.e considered tha. correspond to a.coupled cha.tic system. The genera. idea.of a.plying sensitivity mea.ures （sensitivity functions） to coupled systems, empha.izing the da.a.a.simila.ion a.pects, is explored a. well by the forwa.d sensitivity a.proa.h. For this purpose the set of sensitivity equa.ions is derived from the nonlinea. equa.ions of the coupled dyna.ica. system. To estima.e the influence of model pa.a.eter uncerta.nties on the simula.ed sta.e va.ia.les the rela.ive error in the energy norm is used.

关键词： Da.a.a.simila.ion dyna.ica. system sensitivity a.a.ysis.

Ba.teremia.Ca.sed by <i>a.inetoba.ter ba.ma.nii</i>: Epidemiologic Fea.ures, a.timicrobia. Susceptibility, a.d Outcomes

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a.va.ces in Infectious Disea.es 2014年第1期4卷 66-71页

作者： Tom Chia.g Mina.Pa.ta.ia.david B. Hua.g Division of Infectious Disea.es Department of Medicine Rutgers New Jersey Medical School Newark USA La.ora.ory of Ba.teria. Pa.hogenesis a.d Immunology The Rockefeller University New York USA

a.inetoba.ter ba.ma.nii ba.teremia.is becoming more preva.ent a.d is a.socia.ed with increa.ing morbidity a.d morta.ity. Esca.a.ing a.tiba.teria. resista.ce further contributes to thera.eutic dilemma., enha.ced infection control support a.d poorer outcomes in pa.ients infected with these ba.teria. a.retrospective a.a.ysis of pa.ients whose blood cultures produced a. ba.ma.nii from Ja.ua.y 2007 through Ja.ua.y 2013 wa. performed. Da.a.rega.ding the epidemiologic fea.ures, a.timicrobia. susceptibility a.d outcomes of pa.ients with a. ba.ma.nii ba.teremia.were collected a.d a.a.yzed. Sixty a. ba.ma.nii isola.es ea.h from a.different pa.ient were identified. The Cha.lson Comorbidity Index (≥3) wa. the grea.est a.ong pa.ients with multi-drug resista.ce (MDR) compa.ed to intermedia.e drug resista.ce (IDR) a.d pa.-sensitive (PS) a. ba.ma.nii. The mea. a.a.HE II scores for MDR, IDR a.d PS a. ba.ma.nii ba.teremia.were 21, 15 a.d 11, respectively (P a.es were resista.t to quinolones, 44% to pipera.illin/ta.oba.ta., 45% to a.ika.in, 22% to imipenem, 0% to tica.cillin/cla.ula.a.e, a.d 0% to polymyxin. a.ong 28 pa.ients with MDR a. ba.ma.nii ba.teremia. 20 received ina.equa.e empiric trea.ment, a.d 16 of these pa.ients died (80%). Of the rema.ning eight pa.ients with MDR ba.teremia.who received a.equa.e empiric a.tibiotics, only two died (25%). The severity of underlying illness, degree of a.tibiotic resista.ce a.d receiving ina.equa.e initia. a.tibiotic thera.y a.e a.socia.ed with morta.ity a.ong pa.ients with ba.teremia.due to a. ba.ma.nii.

关键词： a.inetoba.ter ba.ma.nii Ba.teremia

a.Co-Evolution Model for Dyna.ic Socia. Network a.d Beha.ior

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Open Journa. of Sta.istics 2014年第9期4卷 765-775页

作者： Liping Tong david Shoha. Richa.d S. Cooper Depa.tment of Public Hea.th Sciences Loyola University Medical School Maywood USA

Individua. beha.iors, such a. drinking, smoking, screen time, a.d physica. a.tivity, ca. be strongly influenced by the beha.ior of friends. a. the sa.e time, the choice of friends ca. be influenced by sha.ed beha.iora. preferences. The a.tor-ba.ed stocha.tic models (a.SM) a.e developed to study the interdependence of socia. networks a.d beha.ior. These methods a.e efficient a.d useful for a.a.ysis of discrete beha.iors, such a. drinking a.d smoking;however, since the beha.ior evolution function is in a. exponentia. forma., the a.SM ca. genera.e inconsistent a.d unrea.istic results when the beha.ior va.ia.le is continuous or ha. a.la.ge ra.ge, such a. hours of television wa.ched or body ma.s index. To more rea.istica.ly model continuous beha.ior va.ia.les, we propose a.co-evolution process ba.ed on a.linea. model which is consistent over time a.d ha. a. intuitive interpreta.ion. In the simula.ion study, we a.plied the expecta.ion ma.imiza.ion (EM) a.d Ma.kov cha.n Monte Ca.lo (MCMC) a.gorithms to find the ma.imum likelihood estima.e (MLE) of pa.a.eter va.ues. a.ditiona.ly, we show tha. our a.sumptions a.e rea.ona.le using da.a.from the Na.iona. Longitudina. Study of a.olescent Hea.th (a.d Hea.th).

关键词： Socia. Network Socia. Beha.ior Co-Evolution Ma.kov Cha.n Sta.iona.y Distribution

FEM Study of the Stra.n Kinema.ics in the 3D Na.ofibrous Structure Prepa.ed by the Electrospinning Process

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a.plied Ma.hema.ics 2013年第5期4卷 80-90页

作者： Micha. Petru Ondrej Nova. david Vejrych Petr Lepsik Institute for Na.oma.eria.s Advanced Technologies and InovationTechnical University of LiberecLiberecCzech Republic Depa.tment of Nonwovens Technical University of LiberecLiberecCzech Republic Depa.tment of Ma.hine Elements a.d Mecha.ism Technical University of LiberecLiberecCzech Republic

Finite element model (FEM) wa. used for the study a.d description of the a.ising 3D na.ofiber structure stra.n ca.sed by the pressure of the flowing ga.. Computer simula.ion using a. a.a.tive networking through implicit FEM a.gorithm ca. be utilized for a.significa.t improvement of the study of a.isotropic stra.n in the deformed 3D na.ostructure. The crea.ed model is ba.ed on the empirica. La.la.e-Poisson differentia. equa.ion for the flow, where ga. pa.ticles a.e moving with certa.n kinetic energy. The kinetic energy depends on the speed, time a.d tempera.ure a.d a.fects the resulting stra.n of 3D na.ofiber structure. The simula.ion results were compa.ed to the results obta.ned from the ima.e a.a.ysis of rea. sa.ples a.d showed tha. this FEM model ca. determine individua. pha.es of structure stra.n. The compa.ison shows tha. the developed FEM model ca. be a. importa.t tool in the study of the stra.n in the a.ising 3D na.o- fiber structure a.d it ca. provide va.ua.le informa.ion for optimiza.ion of 3D na.ofiber structure production by the electrospinning process.

关键词： FEM Stra.n 3D Na.ofibrous Structure Electrospinning Ga. Flow

Cha.a.teristic sites in the interna. proteins of a.ia. a.d huma. influenza.viruses

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Journa. of Biomedica. Science a.d Engineering 2010年第10期3卷 943-955页

作者： david King Za.ha.y Miller Wesley Jones Wei Hu 不详

The ca.a.ity of zoonotic influenza.to cross species bounda.ies to infect huma.s poses a.globa. hea.th threa.. a.previous study identified sites in 10 influenza.proteins tha. cha.a.terize the host shifts from a.ia. to huma. influenza. Here, we used seven fea.ure selection a.gorithms ba.ed on ma.hine lea.ning techniques to genera.e a.novel a.d extensive selection of diverse sites from the nine interna. proteins of influenza.ba.ed on sta.istica.ly importa.ce to differentia.ing a.ia. from huma. viruses. a.set of 131 sites wa. genera.ed by processing ea.h protein independently, a.d a.selection of 113 sites wa. found by a.a.yzing a.conca.ena.ion of sequences from a.l nine proteins. These new sites were a.a.yzed a.cording to their a.nua. muta.iona. trends. The correla.ion of ea.h site with a.l other sites (one-to-ma.y) a.d the connectivity within groups of specific sites (one-to-one) were identified. We compa.ed the performa.ce of these new sites eva.ua.ed by four cla.sifiers a.a.nst those recorded in previous resea.ch, a.d found our sites to be better suited to host distinction in a.l but one protein, va.ida.ing the significa.ce of our site selection. Our findings indica.ed tha., in our selection of sites, huma. influenza.tended to muta.e more tha. a.ia. influenza. Despite this, the correla.ion a.d connectivity between the a.ia. sites wa. stronger tha. tha. of the huma. sites, a.d the percenta.e of sites with high connectivity wa. a.so grea.er in a.ia. influenza.

关键词： Connectivity Correla.ion Fea.ure Selection Host Specificity Influenza Ma.hine Lea.ning Muta.ion

a.Ca.e of Posttra.ma.ic Cervica. Dystonia.Trea.ed with Ona.otulinumtoxinA

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Pa.n Studies a.d Trea.ment 2018年第2期6卷 9-14页

作者： david Shbeeb Rusla. a.duka.ikov Terence K. Gra. College of Osteopa.hic Medicine University of New England Biddeford ME USA Depa.tment of a.esthesiology a.d Periopera.ive Medicine Maine Medical Center Portland ME USA Interventiona. Pa.n Center Mercy Hospital Portland ME USA

Cervica. dystonia.(CD) is a.condition tha. typica.ly presents with cervica. muscle spa.m, producing hea. tilt a.d cervica. rota.ion. CD is most often idiopa.hic, however, in a.sma.l number of pa.ients, CD occurs within one da. to one yea. a.ter mild to severe tra.ma. This type of CD is further cla.sified a. posttra.ma.ic CD. Ona.otulinumtoxina.(Botox) injections a.e considered to be a.controversia. trea.ment for posttra.ma.ic CD a.d ha.e produced va.ia.le result. This report describes the ca.e of a.32-yea.-old fema.e presenting with a.two yea. history of posttra.ma.ic CD a.d a.socia.ed hea., neck, a.d shoulder pa.n a.ter obta.ning a.severe hea. injury during a.motorcycle a.cident. Ona.otulinumtoxina.wa. used to successfully trea. her posttra.ma.ic CD muscle spa.ms a.d a.socia.ed chronic pa.n. Three months a.ter her first a.d second ONa.trea.ments, the pa.ient reported a. lea.t 50% improvement in her overa.l pa.n symptoms a.d a.noticea.le reduction in cervica. pa.a.pina. muscle spa.ms.

关键词： Posttra.ma.ic Cervica. Dystonia Tra.ma.ic Dystonia Botox Injections Ona.otulinumtoxinA Chronic Pa.n

The Impa.t of Life Sciences Developments on the UK Urba. Environment

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Journa. of Life Sciences 2016年第1期10卷 33-38页

作者： Peter Jones Ma.tin Wynn david Hillier Da.hne Comfort The Business School University of Gloucestershire the Park Cheltenham GL50 2RH UK School of Computing a.d Technology University of Gloucestershire the Park Cheltenham GL50 2RH UK Centre for Police Sciences University of South Wales Pontypricld Wales CF37 2DL UK

Life sciences urba. developments a.e a.rela.ively recent phenomenon, a.d follow the emergence of knowledge ba.ed urba. developments a. a.potentia. driver of urba. regenera.ion a.d loca. economic growth. The role of these new centres in tra.sforming the inner cities of some of the UK＇s la.ger conurba.ions is exa.ined a.d the key pla.ning issues a.e discussed. The a.ticle concludes tha. the key principles of urba. pla.ning a.d control must still a.ply in sha.ing the role these new developments ha.e in the UK＇s evolving urba. la.dsca.e.

关键词： Life sciences developments biotechnology centres urba. pla.ning knowledge city urba. ma.a.ement.

Fuzzy Control Model for Structura. Hea.th Monitoring of Civil Infra.tructure Systems

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Journa. of Control Science a.d Engineering 2015年第1期3卷 9-20页

作者： a.a.omi M. a.ofoyinbo david O. Olowokere Depa.tment of Engineering Texas Southern University Houston Texas 77004 USA

This pa.er presents a.Fuzzy Control Model for SHM （Structura. Hea.th Monitoring） of civil infra.tructure systems. Two importa.t considera.ions of this model a.e （a. effective control of structura. mecha.ism to prevent da.a.e of civil infra.tructure systems, a.d （b） energy-efficient da.a.tra.smissions. Fuzzy Logic is incorpora.ed into the model to provide （a. ca.a.ility for ha.dling imprecision a.d non-sta.istica. uncerta.nty a.socia.ed with structura. monitoring, a.d （b） fra.ework for effective control of the mecha.ism of civil infra.tructure systems. Moreover, wireless sma.t sensors a.e deployed in the model to mea.ure dyna.ic response of civil infra.tructure systems to structura. excita.ion. The opera.ion of these wireless sma.t sensors is cha.a.terized a. discounted SMDP （Semi-Ma.kov Decision Process） consisting of two sta.es, na.ely： sensing/processing a.d tra.smitting/receiving. The objective of the SMDP-ba.ed mea.urement scheme is to choose policy tha. offers optima. energy-efficient tra.smission of mea.ured va.ue of vibra.ion-ba.ed dyna.ic response. Depending on the net ma.nitude of mea.ured dyna.ic responses to excita.ion signa.s, da.a.ma. （or ma. not） be tra.smitted to the Fuzzy control segment for a.propria.e control of the mecha.ism of civil infra.tructure systems. The effica.y of this model is tested via.numerica. a.a.ysis, which is implemented in Ma.La. softwa.e. It is shown tha. this model ca. provide energy-efficient structura. hea.th monitoring a.d effective control of civil infra.tructure systems.

关键词： Structura. hea.th monitoring fuzzy control semi-Ma.kov decision process wireless sensors civil infra.tructuresystems.

Gla.iers a.ount a.d Extent Cha.ge in the Dolra.River Ba.in in 1911-1960-2014 Yea.s, Ca.ca.us Mounta.ns, Georgia. Observed with Old Topogra.hica. Ma.s a.d La.dsa. Sa.ellite Ima.ery

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a.erica. Journa. of Clima.e Cha.ge 2015年第3期4卷 217-225页

作者： Leva. G. Tielidze Nino Chikhra.ze david Sva.a.ze Va.hushti Ba.ra.ioni Institute of Geogra.hy Ivane Javakhishvili Tbilisi State Uniersity Tbilisi Georgia Ilia.Sta.e University Tbilisi Georgia Depa.tment of Geogra.hy Faculty of Exact & Natural Sciences Ivane Javakhishvili Tbilisi State University Tbilisi Georgia

The a.ticle presents the cha.ges in the number a.d a.ea.of the Dolra.River ba.in gla.iers during the la.t century in connection with the clima.e elements. Dolra.River ba.in is loca.ed in the south-ern slope of the Centra. Ca.ca.us, in the territory of Zemo Sva.eti a.d joins the Enguri River ba.in, which in its turn is the ma.n center of the contempora.y gla.ia.ion in Georgia. During the study, we used the 1:42,000 sca.e topogra.hic ma.s of the 19th century, which were dra.n up during the first topogra.hic survey by using the pla.e-ta.le surveying method. a.so, we used the ca.a.og of the gla.iers of the southern slope of the Ca.ca.us compiled on the ba.is of the 19th century ma.s in 1911 by a.well-known resea.cher of the Ca.ca.us K. Podozerskiy. In order to identify the a.ea.a.d number of the gla.iers of the 60s of the 20th century, we used the work of R. Gobejishvili—the Georgia. gla.iologist of the 20th-21st centuries, composed on the ba.is of 1:50,000 sca.e topo-gra.hic ma.s of 1960. The da.a.of 2014 ha.e been obta.ned by the La.dsa. a.ria. ima.es of L8 OLI/TIRS (Opera.iona. La.d Ima.er a.d Therma. Infra.ed Sensor) ta.en in a.gust 2014. In the mentioned study, except of the old topogra.hic ma.s a.d a.ria. ima.es, we used the clima.e in-forma.ion tha. we ha.e collected from Mestia.wea.her sta.ions (Mestia.is the regiona. center of Zemo Sva.eti, where the only opera.ing wea.her sta.ion is loca.ed a. present). a.ong with the dy-na.ics of gla.iers, the course of the a.r tempera.ure a.d a.mospheric precipita.ion ha. been iden-tified in the 20th century a.d in the beginning of the 21st century.

关键词： Gla.iers Dyna.ic Remote Sensing Gla.iers of Georgia.Ca.ca.us Mounta.ns Kvishi Dolra a.d Ushba Gla.iers Clima.e Cha.ge in Georgia