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Association between donor corneal endothelial cell counts and infectious agent reactivity:an eye bank database analysis

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Annals of Eye Science 2019年第1期4卷 19-22页

作者： Bella J.Wolf Ji Won kwon Gabriel M.Rand Jimmy k.Lee patrick.k.gore Moonseong Heo Roy S.Chuck Department of Ophthalmology and Visual ciences Montefiore Medical CenterAlbert Einstein College of MedicineNew YorkNYUSA Department of Ophthalmology Myongji HospitalSeonam University College of MedicineGoyangKorea Lions Eye Institute for Transplant&Research TampaFloridaUSA Saving Sight Eye Bank Kansas CityMissouriUSA Department of Epidemiology and Population Health at Einstein Montefiore Medical CenterAlbert Einstein College of MedicineBronxNew YorkUSA

Background:To evaluate the association between corneal central endothelial cell count(CECC)with reactivity for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),human T-lymphotropic virus-1(HTLV1),and syphilis from an eye bank ***:Eye bank data included 19,159 donors and 38,318 corneas screened for HBV,HCV,HIV,HTLV1,and syphilis from July 2007-May *** and binary mixed effects models were used to determine the adjusted marginal effect a positive viral screening test had on CECC and morphology,*** models were adjusted for age,race,gender,lens status,and death to *** with missing data were excluded from the *** significance was defined as P values<***:A total of 18,097 donors and 35,136 corneas were included in the final *** CECC for eyes with negative viral screening was 2,597±436 while the average CECC for eyes screening positive for syphilis,HBV,HCV,HIV,and HTLV1 were 2,638±392(P=0.073),2,569±419(P=0.815),2,603±363(P=0.207),2,615±360(P=0.733),and 2,625±436(P=0.362)***:The presence of HBV,HCV,HIV,HTLV1,and syphilis display no association with a statistically significant difference in CECC when compared to normal non-diseased donors.

关键词： Eye bank endothelial cell count infectious reactivity hepatitis B virus(HBV) syphilis

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