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Effect of calcination temperature on steam reforming activity of Ni-based pyrochlore catalysts

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journal of Rare Earths 2020年第7期38卷 711-718,I0002页

作者： Daniel j.Haynes Dushyant Shekhawat David Berry Amitava Roy j.mes j.Spivey National Energy Technology Laboratory U.S.Department of Energy3610 Collins Ferry RdMorgantownWV26507 USA Louisiana State University Cain Department of Chemical Engineering3307 Patrick Taylor HallBaton RougeLA70803USA

This work served as the second part of a study evaluating the effect of calcination temperature(700-1000℃) on Ni-based lanthanum zirconate pyrochlore catalysts for methane steam reforming.A previous study(Haynes et ***.2017(43) 16744) provided a thorough characterization of the material properties for the catalysts used here,and this study focuses on the evaluation of catalytic *** activity was assessed by two different experimental studies:the effect of reaction temperature using a temperature programmed surface reaction(TPSR),and the effect of reaction *** results demonstrate a complex interaction between the Ni particles and surface LaOx species under the methane steam reforming ***,the material calcined at the lowest temperature(700℃) possesses the highest activity and selectivity,which is attributed to smaller and more welldispersed Ni particles on the surface,and,more importantly,a lesser degree La enrichment at the *** catalysts were deactivated by steam to NiO under all conditions tested,but at certain low reaction pressure(p=0.23 MPa) conditions the materials calcined at 700-900℃ are able to completely recover equilibrium activity in-situ that is then robust and stable under both low and high reaction pressures(p=1.8 MPa) suggesting the formation of a synergistic relationship between Ni and La for syngas ***,exposure of a fresh material to high reaction pressures leads to a rapid and irreversible loss in both CH4 conversion and syngas selectivity whether in the fresh(no pretreatment),or pretreated(steam,H2 or Ar only at 800℃) form for any *** mechanism for deactivation appears to be due to the presence of LaOx species that become mobile,possibly by the formation of La-OH,and covers the active Ni particles and inhibits sites responsible for the CH4 decomposition.

关键词： Nickel Pyrochlore Methane Steam reforming Catalyst Lanthanum enrichment

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除草剂抗性机制

中国农药 2018年第9期14卷 9-12页

作者： Christopher Preston patrick j Tranel 杨田甜(编译) 不详济南天昱农业科技有限公司

除草剂抗性机制一般分为靶标位点和非靶标位点两类。但是每一类中,还有不同的抗性机制。本文以澳大利亚杂草抗性为基础,综述了杂草抗性机制。1靶标位点抗性机制靶标位点机制涉及与除草剂结合的蛋白发生变化,导致对杂草体内生化途径抑制... 详细信息

除草剂抗性机制一般分为靶标位点和非靶标位点两类。但是每一类中,还有不同的抗性机制。本文以澳大利亚杂草抗性为基础,综述了杂草抗性机制。1靶标位点抗性机制靶标位点机制涉及与除草剂结合的蛋白发生变化,导致对杂草体内生化途径抑制的缺失。

关键词：抗性机制除草剂杂草抗性澳大利亚发生变化靶标

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胸腺恶性肿瘤预后的标准评估方法

中国肺癌杂志 2014年第2期17卷 122-129页

作者：付浩中国胸腺瘤协作组全体成员 j.mes Huang Frank C.Detterbeck Zuoheng Wang patrick j.Loehrer 北京大学肿瘤医院 Division of Thoracic Surgery Department of SurgeryYale University School of Medicine Department of Biostatistics School of Epidemiology and Public Health Yale University Thoracic Service Memorial Sloan-Kettering Cancer Center Division of Medical Oncology Department of Internal Medicine Indiana Universitychool of Medicine

胸腺恶性肿瘤相对少见，发病率约2.5-3.2/100万[1,2]，病例也分散在各个医疗中心。现有文献几乎都是单中心的回顾性研究，为获得足够的病例，研究时间往往跨度几十年，报道结果的方式和使用的定义也各不相同，不同的研究结果很难比较。... 详细信息

胸腺恶性肿瘤相对少见，发病率约2.5-3.2/100万[1,2]，病例也分散在各个医疗中心。现有文献几乎都是单中心的回顾性研究，为获得足够的病例，研究时间往往跨度几十年，报道结果的方式和使用的定义也各不相同，不同的研究结果很难比较。加之胸腺恶性肿瘤的进展、复发模式及致死原因等都具有其一定的特殊性，如何报道其结局显得十分重要。由于胸腺恶性肿瘤患者数量相对有限，从现有的经验中收集信息较为困难，而且存在过度描述和错误结论的风险。因此，专业胸腺肿瘤学术组织（International Thymic Malignacy Interest Group, ITMIG）对临床试验结果的报告制定了一套标准，已被该组织承担的合作项目采用。该标准的广泛应用将增强不同研究结果的可比性。只有采用统一的定义和规范的结果报告，胸腺肿瘤研究才能取得重要进展。2010年以前由外科医生、肿瘤内科医生和统计学家组成的小组共同回顾已有文献使用的评估方法形成初步的建议，再经过一个扩展小组审查，并最终将提炼的建议分发给所有ITMIG成员进行进一步讨论。最后在2010年5月6日的纽约年会上得到ITMIG的认可并被采用。本文就ITMIG标准作一综述。

关键词：胸腺肿瘤恶性肿瘤评估方法肿瘤预后标准学术组织医疗中心致死原因

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古埃及人的五项神奇发明

新东方英语（中学版） 2016年第1期 68-71页

作者： jonathan Atteberry patrick j.Kiger 赵青奇

提到古埃及,你首先联想到的是什么呢?岿然屹立的金字塔,蜿蜒流淌的尼罗河,美丽聪颖的埃及艳后,还是神秘莫测的木乃伊?其实,古埃及文明远不止如此。在长达数千年的历史长河里,古埃及人还发明了各种实用的物品,其中有不少为我们沿用至今... 详细信息

提到古埃及,你首先联想到的是什么呢?岿然屹立的金字塔,蜿蜒流淌的尼罗河,美丽聪颖的埃及艳后,还是神秘莫测的木乃伊?其实,古埃及文明远不止如此。在长达数千年的历史长河里,古埃及人还发明了各种实用的物品,其中有不少为我们沿用至今。让我们一起来长长知识,看看智慧非凡的古埃及人都有哪些神奇的发明吧!

关键词：蜿蜒流淌埃及艳后利比亚沙漠吉萨自由女神像 teeth applying 眼线笔 appearance 埃及人

French Spine Surgery Society guidelines for management of spinal surgeries during COVID-19 pandemic

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World journal of Clinical Cases 2020年第10期8卷 1756-1762页

作者： Solène Prost Yann Philippe Charles jérome Allain jean-Luc Barat Henri d'Astorg Manuel Delhaye Chistophe Eap Fahed Zairi Pierre Guigui Brice Ilharreborde jean Meyblum jean-Charles Le Huec Nicolas Lonjon Guillaume Lot Olivier Hamel Guillaume Riouallon Stéphane Litrico patrick Tropiano Benjamin Blondel Aix-Marseille Université APHMCNRSISMCHU TimoneUnitéde Chirurgie RachidienneMarseille 13005France Service de Chirurgie du Rachis Hopitaux Universitaires de StrasbourgStrasbourg 67200France Institut Parisien du dos Paris 75005France Service de Neurochirurgie Hopital privéClairval-Ramsay santéMarseille 13009France Unitéde Chirurgie du Rachis Centre Orthopédique SantyLyon 69008France Centre Francilien du dos Versailles 78000France CHU Reims Hopital Maison BlancheNeurochirurgieReims 51100France Hopital PrivéLe Bois Ramsay Santé Lille 59000France Hopital Européen Georges-Pompidou HEGP Paris 75015France Service de Chirurgie Orthopédique Pédiatrique CHU Robert DebréAPHPUniversitéde ParisParis 75019France Service de Chirurgie Orthopédique Groupe Hospitalier Paris Saint-JosephParis 75014France Polyclinique Bordeaux Nord Aquitaine Bordeaux 33300France Service de Neurochirurgie Hopital Gui de ChauliacMontpellier 34090France Hopital-Fondation Rothschild Service de NeurochirurgieParis 75019France Clinique Des Cèdres Service de Neurochirurgie Chateau D’AlliezCornebarrieu 31700France Hopital Paris Saint-joseph Paris 75014France Unitéde Chirurgie Rachidienne Hopital Pasteur 2CHU de NiceNice 06001France

Since the outbreak of coronavirus disease 2019(COVID-19)in December 2019 in China,various measures have been adopted in order to attenuate the impact of the virus on the *** regard to spine surgery,French physicians are devoted to take place in the national plan against COVID-19,the French Spine Surgery Society therefore decided to elaborate specific guidelines for management of spinal disorders during COVID-19 pandemic in order to prioritize management of patients.A three levels stratification was elaborated with Level I:Urgent surgical indications,Level II:Surgical indications associated to a potential loss of chance for the patient and Level III:Non-urgent surgical *** also report French experience in a COVID-19 cluster region illustrated by two clinical *** hope that the guidelines formulated by the French Spine Surgery Society and the experience of spine surgeons from a cluster region will be helpful in order optimizing the management of patients with urgent spinal conditions during the pandemic.

关键词： COVID-19 Spine Surgery Guidelines Organization Cluster region

A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6j mice

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Liver Research 2021年第4期5卷 239-242页

作者： Satyanarayana R Pondugula julia M Salamat Kodye L Abbott patrick C Flannery Mohammed Majrashi Mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che j Huang Yoshimi Iwaki Kristina Gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar Timothy Moore Muralikrishnan Dhanasekaran Department of Anatomy Physiology and PharmacologyCollege of Veterinary MedicineAuburn UniversityAuburnALUSA Department of Pharmacology Faculty of MedicineUniversity of JeddahJeddahSaudi Arabia Department of Drug Discovery and Development Harrison School of PharmacyAuburn UniversityAuburnALUSA Department of Pathobiology College of Veterinary MedicineAuburn UniversityAuburnALUSA Animal Biochemistry Division National Dairy Research InstituteICAR-National Dairy Research InstituteKarnalHaryanaIndia Department of Clinical Science College of Veterinary MedicineAuburn UniversityAuburnALUSA

Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast *** is not well understood whether a combination therapy with DOX and CPS can induce *** therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in ***:Male C57BL/6j mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 *** the treatment period,liver histology and various serum bio-markers of hepatotoxicity were ***:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),bilirubin,albumin,globulin,or total ***,co-administration of DOX and CPS did not result in a noticeable change in liver ***,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and ***:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice.

关键词： Cyclophosphamide(CPS) Doxorubicin(DOX) Hepatotoxicity Liver injury Muscle injury

Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography:A prospective study

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World journal of Hepatology 2021年第12期13卷 2179-2191页

作者： Alshaima Alhinai Afsheen Qayyum-Khan Xun Zhang patrick Samaha Peter Metrakos Marc Deschenes Philip Wong Peter Ghali Tian-Yan Chen Giada Sebastiani Experimental Medicine McGill UniversityMontreal H4A3J1Canada Medicine McGill University Health CentreMontreal H4A3J1Canada Departments of Pediatrics and Epidemiology McGill UniversityMontreal H4A3J1Canada Cancer Research Program The Research Institute of McGill University and The Research Institute of McGill University Health CenterMontreal H4A3J1Canada Medicine University of FloridaJacksonvilleFlorida 32218United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and nonalcoholic steatohepatitis(NASH)seem common after liver *** To investigate incidence and predictors of NAFLD and NASH by employing noninvasive testing in liver transplant recipients,namely controlled attenuation parameter(CAP)and the serum biomarker cytokeratin 18(CK-18).We also evaluated the diagnostic accuracy of CK-18 and CAP compared to liver *** We prospectively recruited consecutive adult patients who received liver transplant at the McGill University Health Centre between *** measurements of CK-18 and CAP were *** and NASH were diagnosed by CAP≥270 dB/m,and a combination of CAP≥270 dB/m with CK-18>130.5 U/L,*** and predictors of NAFLD and NASH were investigated using survival analysis and Cox proportional *** Overall,40 liver transplant recipients(mean age 57 years;70%males)were *** a median follow-up of 16.8 mo(interquartile range 15.6-18.0),63.0%and 48.5%of patients developed NAFLD and NASH,*** multivariable analysis,after adjusting for sex and alanine aminotransferase,body mass index was an independent predictor of development of NAFLD[adjusted hazard ratio(aHR):1.21,95%confidence interval(CI):1.04-1.41;P=0.01]and NASH(aHR:1.26,95%CI:1.06-1.49;P<0.01).Compared to liver histology,CAP had a 76%accuracy to diagnose NAFLD,while the accuracy of CAP plus CK-18 to diagnose NASH was 82%.CONCLUSION NAFLD and NASH diagnosed non-invasively are frequent in liver transplant recipients within the first 18 *** follow-up and nutritional counselling should be planned in overweight patients.

关键词： Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease Controlled attenuation parameter Cytokeratin 18 Overweight Accuracy

A novel non-invasive method for predicting bone mineral density and fracture risk using demographic and anthropometric measures

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Sports Medicine and Health Science 2023年第4期5卷 308-313页

作者： justin Aflatooni Steven Martin Adib Edilbi Pranav Gadangi William Singer Robert Loving Shreya Domakonda Nandini Solanki patrick C.McCulloch Bradley Lambert Orthopedic Biomechanics Research Laboratory Department of Orthopedics and Sports MedicineHouston Methodist HospitalHoustonTXUSA Sydney&j.L.Huffines Institute for Sports Medicine&Human Performance Department of Health and KinesiologyTexas A&M UniversityCollege StationTXUSA

Fractures are costly to treat and can significantly increase *** dual-energy x-ray absorptiometry(DEXA)is used to screen at risk people with low bone mineral density(BMD),not all areas have access to *** sought to create a readily accessible,inexpensive,high-throughput prediction tool for BMD that may identify people at risk of fracture for further *** and demographic data were collected from 492 volunteers(♂275,♀217;[44-20]years;Body Mass Index(BMI)=[27.6-6.0]kg/m^(2))in addition to total body bone mineral content(BMC,kg)and BMD measurements of the spine,pelvis,arms,legs and total ***-linear-regression with step-wise removal was used to develop a two-step prediction model for BMC followed by *** selection was determined by the highest adjusted R2,lowest error of estimate,and lowest level of variance inflation(α=0.05).Height(HTcm),age(years),sex^(m=1,f=0),%body fat(%fat),fat free mass(FFMkg),fat mass(FMkg),leg length(LLcm),shoulder width(SHWDTHcm),trunk length(TRNKLcm),and pelvis width(PWDTHcm)were observed to be significant predictors in the following two-step model(p<0.05).Step1:BMC(kg)=(0.0063×HT)+(-0.0024×AGE)+(0.1712×SEX^(m=1,f=0))+(0.0314×FFM)+(0.001×FM)+(0.0089×SHWDTH)+(-0.0145×TRNKL)+(-0.0278×PWDTH)-0.5073;R^(2)=0.819,***2:Total body BMD(g/cm^(2))=(-0.0028×HT)+(-0.0437×SEX^(m=1,f=0))+(0.0008×%FAT)+(0.2970×BMC)+(-0.0023×LL)+(0.0023×SHWDTH)+(-0.0025×TRNKL)+(-0.0113×PWDTH)+1.379;R^(2)=0.89,*** models were also developed to predict leg,arm,spine,and pelvis BMD(R^(2)=0.796-0.864,p<0.05).The equations developed here represent promising tools for identifying individuals with low BMD at risk of fracture who would benefit from further evaluation,especially in the resource or time restricted setting.

关键词： Bone Bone density Fracture Fracture risk Assessment Osteoporosis

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腹股沟疝

英国医学杂志中文版 2008年第3期11卷 164-167页

作者： john T jenkins patrick j O'Dwyer 陈雷(译) University Department of Surgery Western Infirmary Glasgow G11 6NT professor of gastrointestinal surgery 不详

对于没有症状的腹股沟疝，如果患者适于手术，应该进行手术修补网片修补是复发率最低的疝修补方式建议对复发和双侧的腹股沟疝采用腹腔镜修补，初发疝修补也可以采用该方法疝修补术后患者不上班的中位时间是7天，对于那些高强度劳动者... 详细信息

对于没有症状的腹股沟疝，如果患者适于手术，应该进行手术修补网片修补是复发率最低的疝修补方式建议对复发和双侧的腹股沟疝采用腹腔镜修补，初发疝修补也可以采用该方法疝修补术后患者不上班的中位时间是7天，对于那些高强度劳动者可能为14天早期并发症包括淤血。

关键词：腹股沟疝手术修补腹腔镜修补早期并发症远期并发症疝修补中位时间术后患者