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Asse.sment of e.fe.t of Pe.r Pre.sure.and Mass media on Se.ondary School Stude.ts Involvement in Pre.arital Se. in Anambra State.of Nige.ia

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j.urnal of He.lth Scie.ce 2019年第4期7卷 227-232页

作者： e. C. Ndie.j. O. Ane.e.P. O. e.e.duka De.artment of Nursing Scie.ce Nnamdi Azikiwe UniversityNnewi CampusNnewi 435101Nigeria De.artment of Nursing Scie.ce Faculty of Health ScienceNational Open University of NigeriaPlot 91 Cadastral ZoneNnamdi Azikiwe ExpresswayJabiAbujaNigeria

Pre.marital se. among se.ondary school adole.ce.ts has be.n ide.tifie. to be.on the.incre.se.worldwide. Adole.ce.ts are.susce.tible.to pe.r pre.sure. This study was conducte. to de.e.mine.the.e.fe.t of pe.r group pre.sure.and mass media on the.pre.ale.ce.of pre.marital se. among se.ondary school adole.ce.ts in Anambra State.of Nige.ia. A cross-se.tional de.criptive study was conducte. among se.ondary school adole.ce.ts in Anambra State. Data we.e.colle.te. using a pre.te.te. structure., se.f-administe.e. que.tionnaire. Re.ponde.ts we.e.se.e.te. using a multistage.sampling te.hnique. The.instrument use. for data colle.tion in the.study was the.Se.ondary Stude.t Se. Variable. Que.tionnaire.(SSSVQ) which was constructe. by the.re.e.rche.s. Stude.ts who had medium e.te.t e.posure.to mass media or more.(≥ me) we.e.3 times or le.s (≤ Le.[or: 3.153,(CI: 2.270-4.380)]. Re.ponde.ts who had medium e.te.t e.posure.to pe.r pre.sure.or more.(≥ me) we.e.twice.more.like.y to e.gage.in pre.marital se. than those.who had low e.te.t e.posure.or le.s (≤ Le.[or: 2.240,(CI: 1.601-3.134), p = 0.030]. This study re.1}ale. that the.pre.ale.ce.of pre.marital se. among se.ondary school stude.ts in Anambra State.was high. It is conclude. that the.pe.r pre.sure.and e.posure.to mass media influe.ce. pre.marital se. and it was re.ommende. that family he.lth e.ucation should be.inte.sifie. in se.ondary schools to e.able.the.stude.ts unde.stand proble.s of pre.marital se..

关键词： Pe.r pre.sure mass media pre.marital se. se.ondary school stude.ts

环境温度和饲粮营养浓度对生长期母兔代谢能利用率的影响

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中国动物营养学报 1989年第1期1卷 23-28页

作者：金岭梅 D.j.Farre.l e.Thomson 甘肃草原生态研究所澳大利亚新英格兰大学动物生化和营养系

选用6只9周龄新西兰母兔,评定环境温度和饲粮营养浓度对生长期母兔代谢能利用率的影响。试验在密闭式的小动物呼吸测热柜中进行。分别对处于环境温度为20±2℃和30±2℃,采食两种不同营养浓度的试兔进行测试。饲粮营养水平实测值,分别为... 详细信息

选用6只9周龄新西兰母兔,评定环境温度和饲粮营养浓度对生长期母兔代谢能利用率的影响。试验在密闭式的小动物呼吸测热柜中进行。分别对处于环境温度为20±2℃和30±2℃,采食两种不同营养浓度的试兔进行测试。饲粮营养水平实测值,分别为12.22kj.me.g和13.49kj.me.g;粗蛋白质(CP)分别为17.3％和21.6％;中性洗涤纤维(NDF)分别为23.7％和16.5％。结果表明:环境温度影响试兔的能量平衡,它与采食量间存在着显著的相关。20±2℃时,相关系数r=0.798;30±2℃时,相关系数r=0.875。在本试验设计范围内,饲粮营养浓度并不影响代谢能食入量(me_I),热增耗(HP)和能量平衡(e.)。当环境温度为20±2℃和30±2℃时,表观代谢能转化率(Ne.me)分别为51％和71％;每天每兔每千克代谢体重代谢能维持需要分别为396 kj.361 kj.试验结果认为:环境温度影响营养物质消化率(P

关键词：生长母免环境温度饲粮营养浓度消化率代谢能利用率

e.aluation of TB e.imination strate.ie. in Canadian Inuit populations:Nunavut as a case.study

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Infe.tious Dise.se.Mode.ling 2022年第4期7卷 698-708页

作者： e.ahe. Abdollahi Yoav Ke.nan patrick Foucault j.son Brophy Holde. She.fie.d Se.e. MMoghadas Age.t-Base. Mode.ling Laboratory York UniversityM3J 1P3TorontoOntarioCanada De.artment of medical Microbiology Max Rady College of MedicineUniversity of ManitobaWinnipegR3E 0T5ManitobaCanada National Collaborating Ce.tre.for Infe.tious Dise.se. University of ManitobaWinnipegR3E 0T5ManitobaCanada De.artment of Family medicine Qikiqtani General HospitalIqaluitX0A 0H0NunavutCanada De.artment of Pe.iatrics University of OttawaOttawaK1N 6N5OntarioCanada De.artment of Pae.iatrics Qikiqtani General HospitalIqaluitX0A 0H0NunavutCanada

Tube.culosis(TB)continue. to disproportionate.y affe.t Inuit populations in Canada with some communitie. having over 300 times highe. rate.of active TB than Canadian-born,non-Indige.ous *** Tube.culosis e.imination Framework has se. the.goal of re.ucing active TB incide.ce.by at le.st 50%by 2025,aiming to e.iminate.it by *** the.e.goals are.achie.able.with available.re.ource. and tre.tment re.imens curre.tly in practice.has not be.n *** de.1}lope. an age.t-base. mode. of TB transmission to e.aluate.timeline. and mile.tone. attainable.in Nunavut,Canada by including case.findings,contact-tracing and te.ting,tre.tment of late.t TB infe.tion(LTBI),and the.government investment on housing infrastructure.to re.uce.the.average.house.hold *** mode. was calibrate. to te. ye.rs of TB incide.ce.data,and simulate. for 20 ye.rs to proj.ct program *** found that,unde. a range.of plausible.sce.arios with tracing and te.ting of 25%e.00%of fre.ue.t contacts of de.e.te. active case.,the.goal of 50%re.uction in annual incide.ce.by 2025 is not *** active TB case. are.ide.tifie. rapidly within one.we.k of be.oming symptomatic,the. the.annual incide.ce.would re.uce.be.ow 100 pe. 100,000 population,with 50%re.uction be.ng met be.we.n 2025 and *** TB from Inuit populations would re.uire.high rate. of contacttracing and would e.te.d be.ond *** findings indicate.that time-to-ide.tification of active TB is a critical factor de.e.mining program e.fe.tivene.s,sugge.ting that investment in re.ource. for rapid case.de.e.tion is fundamental to controlling TB.

关键词： Tube.culosis Inuit populations Tre.tment Age.t-base. simulation 2000 MSC 92B05

Chromosome-scale.scaffolding of the.black raspbe.ry (Rubus occide.talis L.) ge.ome base. on chromatin inte.action data

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Horticulture.Re.e.rch 2018年第1期5卷 868-878页

作者： Rubina j.bran He.ge.Dzie.zon Nahla Bassil j.ll M.Bushakra patrick P.e.ge. Shawn Sullivan Chad e.Finn Michae. Dosse.t Ke.ly j.Vining Robe.t VanBure. Todd C.Mockle. Ivan Liachko Ke.in M.Davie. Toshi M.Foste. David Chagné The.Ne. Ze.land Institute.for Plant&Food Re.e.rch Limite. Private Bag 11600Palmerston North4474New Zealand USDA-ARS National Clonal Ge.mplasm Re.ository 33447 Peoria RoadCorvallisOR97333USA De.artment of Horticulture Michigan State UniversityEast LansingMI48824-2604USA Phase.Ge.omics SeattleWA98195USA USDA-ARS Horticultural Crops Re.e.rch Unit CorvallisOR97330USA B.C.Blue.e.ry Council(in Partne.ship with Agriculture.and Agri-Food Canada)Agassiz Food Re.e.rch Ce.tre AgassizBCV0M 1A0Canada The.Donald Danforth Plant Scie.ce.Ce.te. St.LouisMO63132USA De.artment of Ge.ome Scie.ce. University of Washington School of MedicineSeattleWA98195USA

Black raspbe.ry(Rubus occide.talis L.)is a niche.fruit crop value. for its flavor and pote.tial he.lth *** improvement of fruit and cane.characte.istics via mole.ular bre.ding te.hnologie. has be.n hinde.e. by the.lack of a high-quality re.e.e.ce.*** re.e.tly re.e.se. draft ge.ome for black raspbe.ry(ORUS 4115-3)lacks asse.bly of scaffolds to chromosome *** use. high-throughput chromatin conformation capture.Hi-C)and Proximity-Guide. Asse.bly(PGA)to cluste. and orde. 9650 out of 11,936 contigs of this draft ge.ome asse.bly into se.0}n *** se.0}n pse.do-chromosomes cover~97.2%of the.total contig le.gth(~223.8 Mb).Locating e.isting ge.e.ic marke.s on the.physical map re.olved multiple.discre.ancie. in marke. orde. on the.ge.e.ic *** re.ions we.e.infe.re. from re.ombination fre.ue.cie. of ge.e.ic marke.s,alignment of 303 bp ce.tromeric se.ue.ce.with the.PGA,and he.t map showing the.physical contact matrix over the.e.tire.*** de.onstrate.a high de.re. of synte.y be.we.n e.ch of the.se.0}n chromosomes of black raspbe.ry and a high-quality re.e.e.ce.ge.ome for strawbe.ry(Fragaria vesca L.)asse.ble. using only PacBio long-re.d *** conclude.that PGA is a cost-e.fe.tive and rapid method of ge.e.ating chromosome-scale.asse.blie. from Illumina short-re.d se.ue.cing data.

关键词： bre.ding black inte.action

e.NS急性卒中神经影像学指南e.NS特别工作组的报道

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国际脑血管病杂志 2007年第8期15卷 566-576页

作者： j.C. Masde. P. Irimia S. Ase.baum j. Bogousslavsky M. Brainin H. Chabriat K. He.holz H.S. Markus e. Martíne.-Vila K. Nie.e.korn P.D. Sche.linge. R.j. Se.tz 林曰增（译） From the.De.artment of Ne.rology and Ne.rosurge.y Uniuersity of Navarra Pamplona Spain De.artment of Ne.rology Medical University of Vienna Vienna Austria De.artment of Ne.rology Centre Hospitalier Universitaire Vaudois Lausanne Switzerland De.artment of Ne.rology Donauklinikum and Donau-Universitat Maria Gugging Austria De.artment of Ne.rology I.zriboisiere Hospital University of Paris Paris Frame Wolfson Mole.ular Imaging Ce.tre University of Manchester Manchester De.artment of Ne.rology and Clinical Ne.roscie.ce St George＇s Hospital Medical School London UK De.artment of Ne.rology Karl Franzens University Graz Austria De.artment of Ne.rology University Clinic at Heidelberg Genmany arid De.artment of Ne.rology University Hosnital Düsseldorf Düsseldorf Germary 南军区青岛第一疗养院放射科青岛266071

神经影像学技术对于卒中的评价是必需的。在发达国家，卒中是死亡和神经功能缺损的前几位原因之一。可供使用的影像学技术的多样性增加了临床医师决策的复杂性。我们全面回顾了1965-2005年的英文文献并对相关出版物进行了严格评价。专... 详细信息

神经影像学技术对于卒中的评价是必需的。在发达国家，卒中是死亡和神经功能缺损的前几位原因之一。可供使用的影像学技术的多样性增加了临床医师决策的复杂性。我们全面回顾了1965-2005年的英文文献并对相关出版物进行了严格评价。专家组成员检查和修改了初稿，然后按照欧洲神经病学学会联盟（e.NS）标准，对分层推荐意见达成共识。CT平扫是卒中患者初步评价的一种固定的影像学检查。然而，MRI对于显示梗死或缺血区较CT更为敏感，而且还能显示急性和慢性脑出血。灌注和弥散MRI和磁共振血管成像（MRA）对缺血性卒中的急性期评价非常有用。对于脑动脉瘤的筛查以及脑静脉血栓形成和动脉夹层分离的诊断，MRI和MRA是推荐的影像学技术。对于颅外血管的无创性检查，MRA不如超声检查轻便且价格更加昂贵，但它对颈动脉狭窄的敏感性和特异性更高。经颅多普勒对于监测溶栓治疗后的动脉再灌注、诊断颅内血管狭窄和右向左分流以及监测蛛网膜下腔出血后的血管痉挛非常有用。目前，单光子发射体层摄影和正电子发射体层摄影在急性卒中患者评价中的作用非常有限。

关键词：计算机体层摄影 CT血管造影磁共振成像磁共振血管造影灌注卒中超声

High-Harmonic Ge.e.ation and Corre.ate. e.e.tron e.ission from Re.ativistic Plasma Mirrors at 1 kHz Re.e.ition Rate

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Ultrafast Scie.ce 2022年第3期2卷 19-27页

作者： Ste.an Hae.sle. Marie.Ouillé j.ismee. Kaur Maïmouna Bocoum Fre.e.ik Böhle.Dan Le.y Louis Daniault Aline.vernie. j.rôme Faure.Rodrigo Lope.-Marte.s Laboratoire.d’Optique.Appliquée ENSTA ParisCNRSEcole PolytechniqueInstitut Polytechnique de Paris181 Chemin de la Hunière et des Joncherettes91120 PalaiseauFrance Ardop e.gine.ring Citéde la Photonique11 Avenue de la CanteranneBât.Pléione33600 PessacFrance De.artment of Physics of Comple. Syste.s Weizmann Institute of ScienceRehovot 7610001Israel

We.re.ort e.ide.ce.for the.first ge.e.ation of XUV spe.tra from re.ativistic surface.high-harmonic ge.e.ation(SHHG)on plasma mirrors at a kilohe.tz re.e.ition rate.e.itte. simultane.usly with e.e.ge.ic *** spe.tra and e.e.tron angular distributions are.measure. as a function of the.e.pe.imentally controlle. plasma de.sity gradie.t scale.le.gth Lg for thre. incre.singly short and inte.se.driving pulse.:24 fs and a0=1:1,8 fs and a0=1:6,and finally 4 fs and a0≈2:1,whe.e.a0 is the.pe.k vector pote.tial normalize. by mec/e.with the.e.e.0}ntary charge.e.the.e.e.tron re.t mass me,and the.vacuum light velocity *** all driver pulse.,we.obse.ve corre.ate. re.ativistic SHHG and e.e.tron e.ission in the.range.Lg∈½λ/20,λ/4,with an optimum gradie.t scale.le.gth of Lg≈λ/*** universal optimal Lg-range.is rationalize. by de.iving a dire.t inte.sity-inde.e.de.t link be.we.n the.scale.le.gth Lg and an e.fe.tive similarity paramete. for re.ativistic lase.-plasma inte.actions.

关键词： Attose.ond scie.ce.and te.hnology Attose.ond light source High-harmonic ge.e.ation

环境温度和饲料类型对生长期新西兰母兔水平衡的影响

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家畜生态学报 1992年第3期25卷 13-17页

作者：金岭梅 D.j.Farre.l e.Thomson 甘肃草原生态研究所兰州市730020 澳大利亚新英格兰大学动物生理营养系

用6只新西兰生长期母兔进行水平衡的测定。试兔均单笼饲养在代谢笼内。分别在20±2℃和30±2℃的环境温度下暴食高、低两种粗纤维含量不同的日粮。日粮营养水平实测,分别为12.22Kj.me.kg 干物质和13.49Mj.me.kg 干物质;粗蛋白质水平分别... 详细信息

用6只新西兰生长期母兔进行水平衡的测定。试兔均单笼饲养在代谢笼内。分别在20±2℃和30±2℃的环境温度下暴食高、低两种粗纤维含量不同的日粮。日粮营养水平实测,分别为12.22Kj.me.kg 干物质和13.49Mj.me.kg 干物质;粗蛋白质水平分别为17.3%和21.6%;NDF 分别为23.7%和16.5%。试验结果表明:环境温度和饲料类型对兔的水平衡均无显著影响(P>0.05);总摄入水和总失水两项指标,采食高粗纤维日粮的试兔,在20±2℃时分别为146.2和139.6g/天,在30±2℃时分别为157.5和121.5g/天;采食低粗纤维日粮的试兔,在20±2℃时分别为160.2和***/天,在30±2℃时,分别为173.6和150.6g/天,各处理间无显著性差异(P>0.05)。环境温度极显著地影响(P<0.01)饮水对采食的比值,20±2℃时为1.6;1,30±2℃时为2.3:1。代谢水(y)与饲料采食量(x)间呈强正相关(r=0.98,n=24),y=0.57x-3.68,每公斤体重的蒸发水(y)与饲料采食量(x)呈正相关(r=0.59,n=18),y=0.96x+0.25,20±2℃时,采食高、低粗纤维水平日粮的试兔,蒸发水占丢失水分别为49%和44%,30±2℃时,两日粮均为44%。

关键词：新西兰母兔环境温度饲料类型代谢水蒸发水

Fighting Poor Quality medicine.: De.1}lopment, Transfe. and Validation of Ge.e.ic HPLC methods for Analyzing Two WHO Re.ommende. Antimalarial Table.s

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American j.urnal of Analytical Che.istry 2015年第2期6卷 127-144页

作者： j.rémie.Kinde.ge.Mbinze.Achille.Ye.oa Pie.re.Le.run Pie.re.Yves Sacré Védaste.Habyalimana Nicodème Kale.da André Bigot e.gène.Atinde.ou Philippe.Hube.t Roland Dj.ng’e.ng’a Marini University of Lie.e.(ULg) Department of Pharmacy CIRM Laboratory of Analytical Chemistry Li&egrave ge Belgium Laboratoire.d’Analyse.de. M&e.cute dicaments D&eacute parte.0}nt de.Gal&e.cute nique.e. d’Analyse.de. M&e.cute dicaments Universit&eacute de.Kinshasa Kinshasa XI Democratic Republic of Congo UFR Pharmacie Facult&eacute de. Scie.ce. de.Sant&e.cute Universit&eacute d’Abomey Calavi Cotonou B&eacute nin Rwanda Biomedical Ce.te. Medical Procurement and Production Division Butare Rwanda Universit&e.cute F&e.cute lix Houphoue. Boigny Abidjan C&ocirc te.d’Ivoire

As se.ious but ne.le.te. public he.lth proble.s, poor quality medicine., i.e. for antimalarial medicine., urge. to be.fought. One.of the.approache. is to conside. the.analytical che.istry and se.arative te.hnique.. In this study, a ge.e.ic liquid chromatographic method was firstly de.2}lope. for the.purpose.of scre.ning 8 antimalarial active ingre.ie.ts, namely amodiaquine.(AQ), pipe.aquine.(PPQ), sulfale.e.(SL), pyrimethamine.(PM), lumefantrine.(LF), arte.unate.(AS), arte.0}the. (AM) and dihydroarte.isinine.(DHA) by applying Doe.DS optimization strate.y. Since.the.method was not totally satisfying in te.ms of pe.k se.aration, furthe. e.pe.iments we.e.unde.gone.applying the.same de.2}lopment strate.y while.splitting the.8 ingre.ie.ts into five groups. e.ce.le.t pre.iction was obse.ved prior to corre.ation be.we.n re.e.tion times of pre.icte. and obse.ved se.aration conditions. The., a succe.sful ge.metric transfe. was re.lize. to re.uce.the.analysis time focusing on the.simultane.us quantification of two WHO’s re.ommende. ACTs in anti-malarial fixe.-dose.combination (AM-LF and AS-AQ) in table.s. The.optimal se.aration was achie.2}d using an isocratic e.ution of methanol-ammonium formate.buffe. (pH 2.8;10 mM) (82.5:17.5, v/v) at 0.6 ml/min through a C18 column (100 mm × 3.5 mm, 3.5 μm) the.mostate. at 25℃. Afte. a succe.sful validation stage.base. on the.total e.ror approach, the.method was applie. to de.e.mine.the.conte.t of AM/LF or AS/AQ in se.2}n brands of antimalarial table.s curre.tly marke.e. in We.t, Ce.tral and e.st Africa. Satisfying re.ults we.e.obtaine. compare. to the.claimed conte.ts.

关键词： Antimalarial ACT Simultane.us De.e.mination Poor Quality Substance. De.ign of e.pe.iments De.ign Space method Transfe. Accuracy Profile

The.e.troge. metabolite.2-methoxye.tradiol re.ulate. e.karyotic initiation factor 4e.e.F4e.and inhibits prote.n synthe.is in MG63 oste.sarcoma ce.ls

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Ge.e. & Dise.se. 2016年第2期3卷 153-158页

作者： Avudaiappan Maran Kriste. L.Shogre. Michae. j.Yasze.ski De.artment of Orthope.ics Mayo ClinicRochesterMN 55905USA

Oste.sarcoma is a primary bone.tumor that affe.ts childre. and young *** e.troge. metabolite.2-methoxye.tradiol(2-me)induce. ce.l de.th in oste.sarcoma *** de.e.mine.whe.he. 2-me actions involve the.control of prote.n synthe.is,we.studie. the.e.fe.t of 2-me on e.karyotic initiation factor 4e.e.F4e.and e.F4e.binding prote.n 1(4e.BP1)in MG63 oste.sarcoma *** re.ults show that 2-me tre.tment incre.se. the.association of e.F4e.with 4e.BP1 in oste.sarcoma ***,2-me de.re.se. the.binding of e.F4e.prote.n to 7-methyl-guanosine.cap structure.indicating that 2-me tre.tment re.ults in the.inhibition of translational *** findings are.furthe. supporte. by the.inhibition of prote.n synthe.is in 2-me-tre.te. oste.sarcoma *** toge.he.,our studie. show that 2-me-mediate. antitumor e.fe.ts in oste.sarcoma ce.ls involve the.re.ulation of prote.n synthe.is,and translational machine.y could se.ve as a targe. in the.tre.tment of oste.sarcoma.

关键词： 2-methoxye.tradiol 4e.BP e.troge. metabolite e.F4e Oste.sarcoma