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Cardiac diagnostics before oral propranolol therapy in infantile hemangioma: retrospective evaluation of 234 infants

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World Journal of Pediatrics 2018年第3期14卷 254-258页

作者： giovanni Frongia Ji-Oun Byeon Raoul Arnold Arianeb Mehrabi patrick günther Division of Pediatric Surgery Department of GeneralVisceral and Transplantation SurgeryUniversity Hospital of HeidelbergIm Neuenheimer Feld 11069120 HeidelbergGermany Department of Pediatric Cardiology Center for Pediatrics and Adolescent MedicineUniversity Hospital of HeidelbergHeidelbergGermany Department of general Visceral and Transplantation SurgeryUniversity Hospital of HeidelbergHeidelbergGermany

Background The indication and extent of cardiac screening before oral propranolol therapy (OPT) in patients with infantile hemangioma (IH) has been challenged. In this study, we evaluated pre-OPT cardiac diagnostics in a pediatric IH cohort in our department. Methods Retrospective chart review of infants ≤ 12 months old with IH undergoing OPT. The diagnostics prior to OPT, occurrence of complications, and outcome were recorded. Results A total of 234 patients were evaluated. The mean age at the onset of OPT was 4.2 ± 0.3 months, the average dura-tion of OPT was 6.1 ± 0.1 months, and the average follow-up was 12.3 ± 0.7 months. Echocardiograms and electrocardio-grams were performed prior to OPT in all patients. One hundred and three (44.0%) echocardiograms revealed pathological findings, 19 (8.1%) of which were minor (including atrial septal defects, pulmonary stenosis, and patent ductus arteriosus). Pathological findings were observed in 17 (7.3%) of electrocardiograms, only one (0.4%) of which was minor (suspected cardiac arrhythmia, subsequently excluded by long-term electrocardiogram analysis). These findings did not contraindicate OPT and no severe adverse events associated with OPT occurred during the follow-up period. Conclusions Routine cardiac screening by electrocardiogram and echocardiogram before OPT is debatable and not routinely indicated in children with IH. Further studies are necessary to draw definite conclusions on the reasonable indication and extent of this diagnostic approach.

关键词： Cardiac diagnostics Echocardiogram Electrocardiogram Hemangioma Propranolol

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel gruchot Laura Reiche Andrew Chan Robert Hoepner patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada patrick Heimel Markus Kerbl Lászlógál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). However, the use of tNgCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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A survey of the Szeg? equation Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1087-1100页

作者： patrick gérard Sandrine grellier Laboratoire de Mathématiques d'Orsay Université Paris-Sud CNRSUniversité Paris-Saclay Institut Denis Poisson-Université d'Orléans/Université de Tours CNRS UMR

We survey the main properties of the cubic Szeg? equation from the PDE viewpoint, emphasising global existence of smooth solutions, analytic regularity, growth of high Sobolev norms and the effects of weak damping.

关键词： cubic Szego equation integrable system Hankel operator spectral analysis analytic regularity wave turbulence

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Synthesis and characterization of Ce_(0.6)Sr_(0.4)Fe_(0.8)Co_(0.2)O_(3–δ) perovskite material:Potential cathode material for low temperature SOFCs

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Journal of Rare Earths 2017年第4期35卷 389-397页

作者： Mlungisi N.Sithole Bernard Omondi patrick g.Ndungu School of Chemistry and Physics University of KwaZulu-NatalWestville CampusPrivate Bag X54001Durban4000South Afrzca Department of Applied Chemistry Doornfontein Campus University of JohannesburgP.O.Box 1701 lDoornfontein 2028JohannesburgSouth.Africa

A sol-gel method and a modified chemical vapour deposition technique were used to produce nanostructured Ce0.6Sr0.4Fe0.8Co0.2O3-δ materials at temperatures as low as 400 ℃. Powders were characterized using Fourier transform infrared spectroscopy （FTIR）, Raman spectroscopy, thermo gravimetric analysis, powder X-ray diffraction （XRD）, scanning electron microscopy （SEM） with energy dispersive X-ray spectroscopy, high resolution transmission electron microscopy （HRTEM）, and nitrogen sorption at 77 K. FTIR spectra showed that the sol-gel method resulted in residual carbon groups on the materials after calcination, while the Raman and XRD analysis confirmed that both synthesis methods resulted in cubic perovskite structure. However, the chemical va- pour deposition （CVD） method resulted in materials with a smaller crystallite size when compared to those prepared via the sol-gel route. The overall morphology of the powders was irregularly shaped aggregated particles as observed by SEM and HRTEM. In addition, HRTEM analysis showed that the materials were highly crystalline. Textural analysis revealed the powders had some mesoporosity, and the surface areas were 76.69 and 65.90 m2/g for materials synthesized using the CVD and sol-gel methods, respectively. The synthesized perovskite powders were used to fabricate button cells employing samarium doped ceria （SDC） as the electrolyte and NiO/SDC as the anode materials. As cathode materials, the maximum power density observed was 308.4 mW/cm2 at 500℃.

关键词： nanostructured materials low temperature SOFCs perovskites ceria rare earths

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Multiple sclerosis drug repurposing for neuroregeneration

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Neural Regeneration Research 2024年第3期19卷 507-508页

作者： Peter göttle Michael Dietrich patrick Küry Department of Neurology Medical FacultyHeinrich-Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS)is an autoimmune disorder of the central nervous system(CNS)and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turning progressive over time with neurodegenerative processes taking over(Amin and Hersh,2023).Of note,beyond relapse-associated worsening early in disease progression independent of relapse activity may arise independently of relapse activity and can occur in all ***-mediated damage of myelin sheaths and the subsequent loss of mature oligodendrocytes are resulting in impaired axonal integrity,neurodegeneration and accounts for irreversible neuronal damage(Kuhlmann et al.,2023).The current landscape of available disease-modifying therapies comprises mainly immunomodulatory drugs that effectively diminish relapses and slow down progression at the onset form of the disease,namely relapsing MS(RMS).In this regard,a number of drugs have been approved as disease-modifying therapies for MS by US Food and Drug Administration and European Medicines Agencies(Box 1).

关键词： drugs impaired irreversible

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Biliary leaks after laparoscopic cholecystectomy:time to stent or time to drain

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Hepatobiliary & Pancreatic Diseases International 2008年第6期7卷 628-632页

作者： Haim Pinkas patrick g.Brady Division of Digestive Diseases and Nutrition University of South Florida

BACKgROUND:Endoscopic retrograde cholangiopan- creatography(ERCP)with placement of a biliary stent or nasobiliary(NB)drain is the procedure of choice for treatment of post-cholecystectomy bile duct *** aim of this study was to compare the effect of NB drainage versus internal biliary stenting on rates of leak closure, time elapsed until drain or stent removal,length of hospital stay and number of required endoscopic procedures. METHODS:Charts were reviewed on 20 patients who underwent laparoscopic cholecystectomy complicated by Luschka or cystic duct *** patients were treated with NB drains connected to low intermittent suction and repeat NB cholangiograms were performed until leak closure was *** patients were treated with internal biliary *** sphincterotomies were performed for stone extraction or a presumed papillary *** bilomas were drained percutaneously prior to stenting. RESULTS:In all 20 patients,a cholangiogram and successful placement of a NB drain or internal stent was *** patients(20%)were found to have bile duct stones,which were extracted following a sphincterotomy. Sixteen patients required percutaneous drains to evacuate large bilomas prior to biliary *** cystic duct leaks and 5 Luschka duct leaks were reviewed. There were no complications related to *** of the leak was documented within 2 to 11 days(mean 4.7±0.9 days)in patients receiving a NB *** drains were removed non-endoscopically following leak closure. The internal stent group required stenting for 14 to 53 days(mean 29.1±4.4 days).The stent was then removed endoscopically after documentation of leak *** leaks following laparoscopic cholecystectomy closed rapidly after NB drainage and did not require repeat endoscopy for removal of the NB drain,resulting in fewer ERCPs required for treatment of biliary *** biliary stents were in place longer owing to the nature of this intermittent endos

关键词： biliary leak cholecystectomy,laparoscopic endoscopic retrograde cholangiopancreatography nasobiliary drain biliary stent

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HOXB13 and other high penetrant genes for prostate cancer

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Asian Journal of Andrology 2016年第4期18卷 530-532页

作者： patrick g Pilie Veda N giri Kathleen A Cooney Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston TX USA Department of Medical Oncology Sidney Kimmel Cancer Center Thomas Jefferson University Philadelphia PA USA Division of Hematology/ Oncology Department of Internal Medicine University of Michigan Medical School and The University of Michigan Comprehensive Cancer Center Ann Arbor MI USA

Cancer initiation and progression is the result of an accumulation of mutations inkey tumor suppressor genes, mismatch repair genes, or oncogenes, which impact cancer cell growth, death, and differentiation. Mutations occurring in cancer tissue are termed somatic; whereas, heritable mutatons that may be passed onto subsequent generations occur in germline DNA. It is these germline mutations that can lead to cancer family syndromeswhereby family members carrying a deleterious germline mutation have an increased susceptibility to certain cancer phenotypes. Common features of hereditary cancer syndromes include early age-of-onset, multiple affected generations, rare tumor types, and/or multiple primary malignancies.

关键词： @@

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Reinforcement learning and A^(*)search for the unit commitment problem patrick de Mars^(∗),Aidan O’Sullivan

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Energy and AI 2022年第3期9卷 172-181页

作者： patrick de Mars Aidan O’Sullivan UCL Energy Institute United Kingdom

Previous research has combined model-free reinforcement learning with model-based tree search methodsto solve the unit commitment problem with stochastic demand and renewables generation. This approachwas limited to shallow search depths and suffered from significant variability in run time across probleminstances with varying complexity. To mitigate these issues, we extend this methodology to more advancedsearch algorithms based on A^(*) search. First, we develop a problem-specific heuristic based on priority list unitcommitment methods and apply this in guided A^(*) search, reducing run time by up to 94% with negligibleimpact on operating costs. In addition, we address the run time variability issue by employing a novel anytimealgorithm, guided IDA^(*), replacing the fixed search depth parameter with a time budget constraint. We showthat guided IDA^(*) mitigates the run time variability of previous guided tree search algorithms and enablesfurther operating cost reductions of up to 1%.

关键词： Unit commitment Reinforcement learning Tree search Power systems

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Targeting mitoNEET with pioglitazone for therapeutic neuroprotection after spinal cord injury

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Neural Regeneration Research 2017年第11期12卷 1807-1808页

作者： Alexander g.Rabchevsky Samir P.Patel patrick g.Sullivan Spinal Cord and Brain Injury Research Center University of KentuckyLexingtonKYUSA Departments of Physiology University of KentuckyLexingtonKYUSA Departments of Neuroscience University of KentuckyLexingtonKYUSA Veterans Administration Medical Center University of KentuckyLexingtonK.YUSA

There is mounting evidence that targeting mitochondrial dysfunction following neurotrauma could be key in developing effective therapeutic strategies since mitochondria are known to play a major role in cellular bioenergetics, function, and survival following traumatic spinal cord injury （SCI）（Rabchevsky et al., 2011）. Our research group is one of the pioneers in targeting mitochondrial dysfunction to foster functional neuroprotection, having documented that phar- macological maintenance of mitochondrial function acutely results in long-term neuroprotection and improved function- al recover. We have recently reported that treatment with the pleiotropic drug, pioglitazone, maintains acute mitochondrial integrity correlated with chronic tissue sparing and functional recovery after contusion SCI, but that this was not correlated with altered neuroinflammation （Patel et al., 2017）. We herein propose that the mechanism（s） by which pioglitazone confers neuroprotection may not be entirely dependent upon its activation of peroxisome proliferator activated receptor （PPAR）,

关键词： Targeting mitoNEET therapeutic neuroprotection

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