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Assessing of the Therapeutic Efficacy of These 2 Treatment Regimens in the Management of Helicobacter pylori Infection at Kinshasa

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Open journal of Gastroenterology 2022年第3期12卷 71-87页

作者： Antoine Tshimpi patrick de jésus ngoma-Kisoko Aurore Beia Tressy Kalenga-Ngomba jacqueline Nkondi Fabrice Bokabanja Heritier Mawalala Trésor Monsere Pitshou Kengibe Mireille Nganga Nkanga Benjamin Longo-Mbenza department of Internal medicine Cliniques Universitaires de Kinshasa University of Kinshasa Kinshasa DR Congo Foundation Aurore Kinshasa DR Congo University Catholique of Bukavu Bukavu DR Congo department of Medical Biologie Cliniques Universitaires de Kinshasa University of Kinshasa Kinshasa DR Congo Lomo University of Research Kinshasa DR Congo

Introduction: Helicobacter pylori (Hp) infection is a worldwide public health problem. Unfortunately, its management poses a problem because of resistance to antibiotics. However, there are codified treatment protocols covering sequential and concomitant quadritherapy with regard to first-line probabilistic treatment. The objective of this study was to assess the therapeutic efficacy of these 2 treatment regimens in the management of Hp infection at Kinshasa. Methods: This was a mixed study, with documentary, descriptive and interventional approaches, carried out between September 1, 2018 and April 30, 2020. Results: Sixty-four patients were collected, including 36 men against 28 women with a sex ratio of 1H:1F;the mean age was 54 ± 16.5 years. There was an over-representation of senior patients (n = 29);an intermediate number of adult patients (n = 22) and a lower number of young patients (n = 13). 34 and 30 were respectively treated according to the concomitant and sequential regimens. Concomitant quadruple therapy offered an eradication rate of 91.2% compared to 56.7% for sequential quadruple therapy;concomitant treatment, advancing age and absence of risky behavior more quickly predicted the occurrence of eradication success. Conclusion: The present study showed superiority of concomitant quadruple therapy over sequential quadruple therapy in first-line treatment. Alcohol with active smoking had a negative influence, while concomitant quadruple therapy, advancement in age had a positive influence on the success of the eradication of Hp infection.

关键词： Helicobacter pylori Concomitant Quadruple Therapy Sequential Quadruple Therapy Eradication Kinshasa

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Clinical, Biological, Immunological and Therapeutic Profile of Patients Co-Infected with HIV-HBV and/or HCV in Kinshasa, in the democratic Republic of the Congo: Multicenter Cross-Sectional Study

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Open journal of Gastroenterology 2022年第4期12卷 107-118页

作者： jean-Paul Mayimona Kimpiatu Aliocha Natuhoyila Nkodila Antoine Wola Yaba Tshimpi Charles Nlombi Mbendi Thérèse Ndarabu jean jacques Matimbo Youyou Paka patrick de jésus ngoma Blaise Batumona Trésor Monsere Pitchou Kengibe jean Robert Rissassi Makulo Mireille Nganga Hippolyte Nani-Tuma Situakibanza Benjamin Longo Mbenza Garstroenterology department University of Kinshasa Kinshasa Democratic Republic of the Congo departement of Family Medicine and Primary Health Care Protestant University in Congo Kinshasa Democratic Republic of the Congo Unit of Gastroenterology Clinic Marie Yvette Kinshasa Democratic Republic of the Congo department of Nephrology University of Kinshasa Kinshasa Democratic Republic of the Congo department of Clinical Biology University of Kinshasa Kinshasa Democratic Republic of the Congo department of Infectious Diseases University of Kinshasa Kinshasa Democratic Republic of the Congo department of Cardiology University of Kinshasa Kinshasa Democratic Republic of the Congo

Background and Objective: HIV infection is often associated with HBV and HCV infection, together leading to high morbidity and mortality in developing countries. The objective of this study is to describe the clinical, biological, immunological and therapeutic profile of patients co-infected with HIV-HBV and/or HCV. Methods: A cross-sectional and descriptive study including 180 people living with HIV (PLWHIV) in the city of Kinshasa province was conducted. Socio-demographic, clinical, biological and serological characteristics were analyzed. Results: The frequency of HIV-HBV/HCV co-infection was 23.9%. The distribution of age and sex of patients did not differ significantly according to co-infection status. The notion of pedicure and manicure was significantly more observed in patients free from viral hepatitis (51.1% versus 32.6%, p = 0.034). The median duration of knowledge of the HIV status which was longer in the co-infected (4 years versus 2 years, p = 0.022). A lower median level of GPT was observed in co-infected compared to other patients (14 IU/L versus 20 IU/L, p = 0.041). Serum albumin (3.1 g/L versus 3.3 g/L, p = 0.034) and prothrombin (58.3% versus 65.6%, p = 0.045) were lower in HIV co-infected-VHB and/or VHC. The median INR was higher in co-infected than in other patients (1.6 versus 1.4;p = 0.009). Patients without therapy Antiretroviral (TARV) medication were more numerous in co-infected (20.9% versus 8.0%, p = 0.025). Conclusions: The profile of PLWHIV was dominated by the presence of pedicures and manicures with high transaminases and without anti-viral treatment.

关键词： HIV-HCV-HBV Co-Infection Clinical Profile Biology TARVs Kinshasa

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Assessing Malnutrition in Pregnant Women Using the Dietary Diversity Score and the Mid-Upper Arm Circumference: A Cross-Sectional Study, Zambia

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Food and Nutrition Sciences 2020年第7期11卷 712-725页

作者： Sebean Mayimbo Clara Maphosa Haruzivishe Concepta Kwaleyela Bwembya Phoebe Ellen Chirwa patrick Kaonga Catherine ngoma department of Midwifery Women and Child Health University of Zambia Lusaka Zambia department of Nursing Sciences University of Zimbabwe Harare Zimbabwe department of Research Monitoring and Evaluation University of Zambia Lusaka Zambia department of Community Health University of Zambia Lusaka Zambia department of Midwifery Kamuzu College of Nursing Blantyre Malawi department of Internal Medicine Tropical Gastroenterology and Nutrition Group University of Zambia Lusaka Zambia

The dietary diversity score (DDS) and the mid-upper arm circumference (MUAC) can be used to assess nutritional status. The DDS is a qualitative measure of food consumption reflecting an individual’s access to different food items and therefore a proxy indicator of the nutritional status. The aim of the study was to assess whether the dietary diversity score and MUAC can be used to assess the nutritional status of pregnant women attending antenatal. A cross-sectional survey was conducted at Chilenje level I Hospital in a township located in Lusaka city, Lusaka province. The study employed quantitative methods to collect and analyse data on the dietary patterns of individuals in the previous 24 hours before the survey. Health facilities were randomly selected and systematic sampling was used to select a sample of 299 pregnant women. An interview schedule was used to collect data. Median and interquartile range were used to compare demographic data. Spearman’s Correlation for two continuous variables was used to establish associations between DDS and the MUAC. The median age was 27 years. About 44% of the women were in the lowest dietary diversity category, indicating inadequate nutrient intake, 31% in the medium category and 24% in the high intake. Dietary diversity score was negatively correlated with mid-uppe

关键词： Dietary Diversity Score Malnutrition Mid-Upper Arm Circumference Pregnant Women Antenatal

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