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Open Journal of Rheumatology and Autoimmune Diseases 2016年第1期6卷 13-21页

作者： Madeleine Singwe-Ngandeu Mickael Essouma Alain patrick Menanga Vicky Jocelyne Ama Moor caroline Ngoufack Sandrine Sa’a Lontsi Yolande Vanessa Ayi Efoua Thierry Ntandzi Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Rheumatology Unit Yaounde Central Hospital Yaounde Cameroon Cardiology Unit Yaounde General Hospital Yaounde Cameroon Biochemistry Laboratory Yaounde University Teaching Hospital Yaounde Cameroun

Introduction: Even though there is a huge burden of both chronic inflammatory rheumatic diseases (CIRD) and cardiovascular diseases in Sub-Saharan Africa, no published study from this region has yet addressed the issue of cardiovascular diseases in a group including different CIRD to the best of our knowledge. Objective: We conducted this research with the aim to explore the association between CIRD and cardiovascular risk in a Cameroonian population based on the World Health Organization (WHO) and International Society for Hypertension (ISH) risk charts. Methods: This cross-sectional study included CIRD patients, followed at the rheumatology unit of the Yaounde Central Hospital, and, who were matched to non-CIRD subjects for sex, age and race. Cardiovascular risk factors were studied and subsequently the cardiovascular risk was estimated using the WHO/ISH risk charts. Analyses were performed in Epi-info and SPSS software and results were considered statistically significant for a p-value less than 0.05. Results: In total, 109 CIRD patients and 111 non-CIRD subjects were included. Their respective mean ages were 44.4 ± 15.2 years and 44.2 ± 15.1 years. Odds ratio 2.09, 95% confidence interval (CI) (1.07 - 4.08);high BMI OR 1.89, 95% CI (1.1 - 3.24);diabetes mellitus (p = 0.03) and physical inactivity (p < 0.001) were all markedly found in CIRD patients compared with controls. Ten (9.2%) CIRD patients had a past history of atherosclerotic cardiovascular events compared with no control (p < 0.001). The cardiovascular risk estimated with the WHO/ISH risk charts was low in 43 (79.6%) patients with CIRD versus 52 (88.1%) non-CIRD subjects. Conclusions: CIRD were associated with hypertension, excess overall adiposity, diabetes mellitus, and physical inactivity. A substantially increased proportion of CIRD patients with a past history of atherosclerotic cardiovascular events were noted. But the WHO/ISH risk charts broadly found a similar and globally decremented cardiovasc

关键词： Chronic Inflammatory Rheumatic Diseases Cardiovascular Risk Cardiovascular Risk Factors Cardiovascular Disease WHO/ISH Risk Charts Sub-Saharan Africa

新型的持续配戴高DK值的角膜接触镜(英文)

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眼视光学杂志 2003年第4期5卷 204-208页

作者： Jennifer L. Smythe Peter Bergenske patrick J. caroline College of Optometry College of OptometryCollege of Optometry Pacific UniversityUSAPacific UniversityUSAPacific UniversityUSA

目的 :随着镜片材料和制作工艺的高速发展 ,更加安全地过夜配戴角膜接触镜已逐渐成为可能。方法 :对近年来涉及持续配戴高DK值角膜接触镜的一些研究论文进行综述。结果 :新型的高DK值的硅胶和硅氟化物水凝胶镜片与传统的HEMA镜片相比 ,... 详细信息

目的 :随着镜片材料和制作工艺的高速发展 ,更加安全地过夜配戴角膜接触镜已逐渐成为可能。方法 :对近年来涉及持续配戴高DK值角膜接触镜的一些研究论文进行综述。结果 :新型的高DK值的硅胶和硅氟化物水凝胶镜片与传统的HEMA镜片相比 ,氧传导性高出 6倍 ,这种新材料的镜片能够从根本上避免任何与组织缺氧有关的并发症。另一个明显的差异在于 :新一代的硅胶镜片有更高的系数。而且在生理反应、匹配以及易操作性方面 ,与传统的低DK值镜片也明显不同。另外 ,尽管与组织缺氧相关的并发症不再存在 ,但是由于镜片覆盖在角巩缘 36 0度范围 ,所以潜在的炎症反应以及机械性的损伤仍然不可避免。因此 ,制造者对涉及角膜生理反应的评估和对配适关系重要性的理解是这些新镜片获得成功过夜配戴的关键。结论 :作为眼保健的从业者 ,视光医师必须了解持续配戴镜片的新进展情况、新材料潜在的副反应和配适特性。

关键词：高DK 角膜接触镜配戴过夜副反应隐形眼镜

CETP as a Target in HDL-raising Therapy:lessons from APOE*3-Leiden. CETP Transgenic Mice

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中国动脉硬化杂志 2009年第7期17卷 574-575页

作者： Willeke de Haan Jitske de Vries-van der Weij caroline C. van der Hoogt José W.A. van der Hoorn Johannes A. Romijn J. Wouter Jukema Louis M. Havekes Hans M.G. Princen patrick C.N. Rensen Departments of General Internal Medicine Endocrinologyand Metabolic Diseases Departments of Human Genetics TNO-Biosciences Gaubius Laboratory Departments of Cardiology Leiden University Medical Center

Background Cardiovascular disease (CVD) is mainly caused by atherosclerosis,for which dyslipidemia (i.e. high (V)LDL-cholesterol (C),high triglycerides and low HDLC is a major risk factor. To reduce the risk to develo... 详细信息

关键词：心血管疾病动脉粥样硬化血脂胆固醇临床分析

Cardiovascular Risk Burden in Sub-Saharan Africans with Rheumatoid Arthritis: A Hospital-Based Study in Yaounde, Cameroon

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Open Journal of Rheumatology and Autoimmune Diseases 2016年第1期6卷 1-9页

作者： Madeleine Singwe-Ngandeu Mickael Essouma Vicky Jocelyne Ama Moor Ahmadou Jingi Musa Alain patrick Menanga caroline Ngoufack Sandrine Sa’a Lontsi Thierry Ntandzi Yolande Vanessa Ayi Efoua Mireille Cathy Melong Pianta Faculty of Medicine and Biomedical Sciences The University of Yaoundé I Yaounde Cameroon Rheumatology Unit Yaounde Central Hospital Yaounde Cameroon Biochemistry Laboratory Yaounde University Teaching Hospital Yaounde Cameroun Cardiology Unit Yaounde General Hospital Yaounde Cameroon

Introduction: Studies on RA (rheumatoid arthritis) and cardiovascular risk in African countries are scarce. Objective: To investigate the relationship between RA and cardiovascular risk in Cameroonian patients. Methodology: In 50 Black RA patients and 51 matched healthy individuals from the general population, we studied cardiovascular risk factors validated by the WHO. Cardiovascular risks estimates were carried out using WHO risk charts for the African region. Epi-info, R and SPPS were used for the statistical analysis. Results: Overall and abdominal adiposity as expressed by increased body mass index and abdominal obesity, were all markedly increased in RA patients compared to non-RA subjects [70% vs. 47%, OR (95% CI) = 2.62 (1.16 - 5.94), p = 0.026;and 54% vs. 33%, OR (95% CI) = 2.34 (1.05 - 5.25), p = 0.045 respectively]. RA patients were more physically inactive than their non-RA counterparts (20% vs. 0, p = 0.001). Whereas RA was associated with a reduced odds of alcoholism [OR (95% CI) = 0.19 (0.06 - 0.62), p = 0.005]. Increased BMI seemed to occur independently of methotrexate (p = 0.76), hydroxychloroquine (p = 0.59), corticosteroids (p = 0.79) treatments, and independently of sex (p = 0.15), age (p = 0.67), and sedentary lifestyle (p = 0.16) in RA patients;but their BMI was weakly correlated with disease duration (r = 0.26;p = 0.074). Meanwhile, male gender was associated with a reduced odds of abdominal obesity [OR (95% CI) = 0.02 (0 - 0.4), p = 0.011]. Cardiovascular risk, comparable by proportions between RA and non-RA subjects, was low in 26 patients (78.8%) and 30 non-RA subjects (83.3%) respectively. Conclusion: Despite the high adiposity burden and a sedentary lifestyle experienced by RA patients compared to their healthy counterparts, RA was not associated with cardiovascular risk as estimated by WHO risk charts.

关键词： Rheumatoid Arthritis Excess Adiposity Physical Inactivity Cardiovascular Risk World Health Organization Risk Charts

Factors associated with DAA virological treatment failure and resistance-associated substitutions description in HIV/HCV coinfected patients

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World Journal of Hepatology 2018年第11期10卷 856-866页

作者： Dominique Salmon Pascale Trimoulet Camille Gilbert caroline Solas Eva Lafourcade Julie Chas Lionel Piroth Karine Lacombe Christine Katlama Gilles Peytavin Hugues Aumaitre Laurent Alric Franoois Boué Philippe Morlat Isabelle Poizot-Martin Eric Billaud Eric Rosenthal Alissa Naqvi patrick Miailhes Firouzé Bani-Sadr Laure Esterle Patrizia Carrieri Franoois Dabis Philippe Sogni Linda Wittkop 无 Assistance Publique des Hopitaux de Paris Hopitaux Universitaires Paris CentreHopital Hotel DieuUnitédes Maladies infectieuses et tropicalesParis 75004France Université Paris Descartes Sorbonne Paris CitéParis 75006France Trimoulet CHU de BordeauxHopital PellegrinLaboratoire de VirologieBordeaux 33000France Trimoulet CNRS-UMR 5234Microbiologie fondamentale et PathogénicitéUniversitéde BordeauxBordeaux 3000France Philippe Morlat Laure EsterleFrancois DabisLinda WittkopUniv.BordeauxISPEDInsermBordeaux Population Health Research Centerteam MORPH3EUSUMR 1219CIC-EC 1401Bordeaux F-33000France APHM Hopital La TimoneLaboratoire de Pharmacocinétique et ToxicologieMarseille 13005France Centre Hospitalier Universitaire de Dijon Département d'InfectiologieDijon cedex 21079France INSERM-CIC 1342 Universitéde Bourgogne Dijon 21000France Assistance Publique des Hopitaux de Paris GHUEP site Saint-AntoineServices Maladies infectieuses et tropicalesParis 75011France UniversitéPierre et Marie Curie UMR S1136Institut Pierre Louis d' Epidémiologie et de SantéPubliqueParis 75646France UniversitéParis-Sorbonne Paris 75005France Assistance Publique des Hopitaux de Paris Hopital PitiéSalpêtrière Services Maladies infectieuses et tropicalesParis 75013France Assistance Publique des Hopitaux de Paris Hopital Bichat-Claude BernardLaboratoire de PharmacologieParis 75877France IAME UMR 1137Sorbonne Paris CitéINSERMUniversitéParis DiderotParis 75890France Centre Hospitalier de Perpignan Service Maladies infectieuses et tropicalesPerpignan 66000Franc Centre Hospitalier Universitaire de Toulouse Hopital PurpanService Médecine interne-Pole DigestifToulouse 31300France UMR 152 IRD UniversitéToulouseⅢ Paul SabatierToulouse 31330France Hopital Antoine-Béclère Assistance Publique des Hopitaux de ParisUniversitéParis SudService Médecine interne et immunologieClamart 92140France Centre Hospitalier Universitaire de Bordeaux Service de médecine interneHopital Saint-AndréBordeaux 33000France Uni

AIMTo describe factors associated with treatment failure and frequency of resistance-associated substitutions （RAS）.METHODSHuman immunodefciency virus （HIV）/hepatitis C virus （HCV） coinfected patients starting a first direct-acting antiviral （DAA） regimen before February 2016 and included in the French ANRS CO13 HEPAVIH cohort were eligible. Failure was defned as：（1） non-response [HCV-RNA remained detectable during treatment, at end of treatment （EOT）]; and （2） relapse （HCV-RNA suppressed at EOT but detectable thereafter）. Sequencing analysis was performed to describe prevalence of drug class-specifc RAS. Factors associated with failure were determined using logistic regression *** 559 patients, 77% had suppressed plasmaHIV-RNA 〈 50 copies/mL at DAA treatment initiation41% were cirrhotic, and 68% were HCV treatmentexperienced. Virological treatment failures occurred in22 patients and were mainly relapses （17, 77%） thenundefined failures （3, 14%） and non-responses （29%）. Mean treatment duration was 16 wk overall. Posttreatment NS3, NS5A or NS5B RAS were detected in10/14 patients with samples available for sequencinganalysis. After adjustment for age, sex, ribavirin useHCV genotype and treatment duration, low platelecount was the only factor signifcantly associated with ahigher risk of failure （OR： 6.5; 95%CI： 1.8-22.6）. CONCLUSIONOnly 3.9% HIV-HCV coinfected patients failed DAAregimens and RAS were found in 70% of those failingLow platelet count was independently associated withvirological failure.

关键词： Human immunodeficiency virus Hepatitis C virus Direct-acting antiviral Treatment virological failure Resistant associated mutations

MALDI质谱成像技术用于皮肤T细胞淋巴瘤疾病标记物研究

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MALDI质谱成像技术用于皮肤T细胞淋巴瘤疾病标记物研究

Influence of Cleaning Time in Household Reservoirs on Trihalomethane Formation in Treated Water

中华医学会第十八次全国皮肤性病学术年会

作者： Liu Jie Marven El Osta caroline Truntzer Delphine Pecqueur Tony Petrella patrick Ducoroy Beijing Union Medical College Hospital Dermatology CLIPP(Clinical Innovation Proteomic Platform) IFR 100 Sante STICUniversite de Bourgogne1 rue Professeur Marion21079 Dijon.100730

目的原发性皮肤淋巴瘤是以皮肤损害为初发或首要表现的淋巴瘤,占结外非霍奇金淋巴瘤的第二位,仅次于胃肠道,估计年发病率为1:100,000。皮肤T细胞淋巴瘤是最常见的原发性皮肤淋巴瘤,蕈样肉芽肿(mycosis fungoides,MF)是其中最具代表性的...

目的原发性皮肤淋巴瘤是以皮肤损害为初发或首要表现的淋巴瘤,占结外非霍奇金淋巴瘤的第二位,仅次于胃肠道,估计年发病率为1:100,000。皮肤T细胞淋巴瘤是最常见的原发性皮肤淋巴瘤,蕈样肉芽肿(mycosis fungoides,MF)是其中最具代表性的疾病类型,占所有原发性皮肤淋巴瘤的50%。MF发病初期临床表现类似良性炎症性皮肤病,缺乏特异性,而MF晚期患者病情发展呈侵袭性,患者平均寿命明显缩短。目前尚无高度特异的MF早期肿瘤标记物,早期诊断仍有困难。近期基

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Journal of Water Resource and Protection 2019年第11期11卷 1389-1397页

作者： Ricardo Andreola Péricles Martim Reche Gervasio Tono Graciene de Souza Bido Daniele Fernanda Felipe Anny Rosi Mannigel André Ribeiro da Costa Gisele caroline Novakowski Letycia Lopes Ricardo Flavia Helena de Moura Liborio Stephane Raquel Almeida Velande da Fonseca Isabela Silva de Oliveira Giuliano patrick Rasera Thaise Moser Teixeira University Center of Maringá (UNICESUMAR) Master in Science Technology and Food Safety Maringá Brazil State University of Ponta Grossa Campus Uvaranas Ponta Grossa Brazil State University of Maringá Maringá Brazil Federal University of Paraná Palotina Brazil

Chlorination is an efficient and low-cost technique in disinfecting water for public water supply. However, during the process, the formation of undesirable by-products called halogen compounds, such as trihalome-thanes (THMs), occurs. Some of these compounds are proven to be carcinogenic to laboratory animals. The goal of this study was to investigate the occurrence of THMs in household reservoirs and the influence of cleaning time of these reservoirs on the formation of THMs. A total of 103 households were investigated in the city of Maringá, State of Paraná, Brazil. The residences were classified according to the cleaning time of the reservoir into: up to one year, one to two years and more than two years. Samples were taken from the reservoirs and total trihalomethanes (THMt) were analyzed by gas chromatography (GC-MS), total organic carbon (TOC) by means of a Hach kit for low concentrations and free residual chlorine (CLres) by means of a kit for in loco determination. According to the results, the highest concentrations of THMt were observed in the reservoirs with cleaning time of more than 2 years. However, no amount has exceeded the maximum limit allowed by law. In general, the longer the time for cleaning the reservoir, the greater the degradation of water quality in THMt.

关键词： Trihalomethanes Distribution Network Chlorination Cancer

Sustainable strategies for Ebola virus disease outbreak preparedness in Africa:a case study on lessons learnt in countries neighbouring the Democratic Republic of the Congo

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Infectious Diseases of Poverty 2022年第6期11卷 60-69页

作者： caroline S.Ryan Marie‑Roseline D.Belizaire Miriam Nanyunja Olushayo Oluseun Olu Yahaya Ali Ahmed Anderson Latt Matthew Tut Kol Bertrand Bamuleke Jayne Tusiime Nadia Nsabimbona Ishata Conteh Shamiso Nyashanu patrick Otim Ramadan Solomon Fisseha Woldetsadik Jean‑Pierre Mulunda Nkata Jim T.Ntwari Senya D.Nzeyimana Leopold Ouedraogo Georges Batona Vedaste Ndahindwa Elizabeth A.Mgamb Magdalene Armah Joseph Francis Wamala Argata Guracha Guyo Alex Yao Sokemawu Freeman Alexander Chimbaru Innocent Komakech Muhau Kuku Walter M.Firmino Grace E.Saguti Faraja Msemwa Shikanga O‑Tipo Precious C.Kalubula Ngoy Nsenga Ambrose Otau Talisuna WHO Sub-Regional Ofce for Africa NairobiKenya WHO Country Ofce BanguiCentral African Republic WHO Country Ofce JubaSouth Sudan WHO Regional Ofce for Africa BrazzavilleCongo WHO Sub-Regional Ofce for Africa DakarSenegal Africa Centres for Disease Control and Prevention Addis AbabaEthiopia WHO Country Ofce BrazzavilleCongo WHO Coun‑try Ofce BujumburaBurundi WHO Country Ofce AsmaraEritrea WHO Country Ofce KigaliRwanda WHO Country Ofce KampalaUganda WHO Country Ofce LuandaAngola WHO Country Ofce Dar Es SalaamTanzania WHO Country Ofce LusakaZambia

Background: From May 2018 to September 2022, the Democratic Republic of Congo (DRC) experienced seven Ebola virus disease (EVD) outbreaks within its borders. During the 10th EVD outbreak (2018–2020), the largest experienced in the DRC and the second largest and most prolonged EVD outbreak recorded globally, a WHO risk assessment identified nine countries bordering the DRC as moderate to high risk from cross border importation. These countries implemented varying levels of Ebola virus disease preparedness interventions. This case study highlights the gains and shortfalls with the Ebola virus disease preparedness interventions within the various contexts of these countries against the background of a renewed and growing commitment for global epidemic preparedness highlighted during recent World Health Assembly *** text: Several positive impacts from preparedness support to countries bordering the affected provinces in the DRC were identified, including development of sustained capacities which were leveraged upon to respond to the subsequent coronavirus disease 2019 (COVID-19) pandemic. Shortfalls such as lost opportunities for operationalizing cross-border regional preparedness collaboration and better integration of multidisciplinary perspectives, vertical approaches to response pillars such as surveillance, over dependence on external support and duplication of efforts especially in areas of capacity building were also identified. A recurrent theme that emerged from this case study is the propensity towards implementing short-term interventions during active Ebola virus disease outbreaks for preparedness rather than sustainable investment into strengthening systems for improved health security in alignment with IHR obligations, the Sustainable Development Goals and advocating global policy for addressing the larger structural determinants underscoring these ***: Despite several international frameworks established at the global level for e

关键词： Ebola virus disease Emergency preparedness and response Lessons learned Case study International Health Regulations Democratic Republic of the Congo

Fluctuating temperature modifies heat-mortality association around the globe

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical Methodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Climate Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s Medical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the Ministry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atmospheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environmental Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidemiology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environmental Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive Medicine University of BernBern 3012Switzerland Oeschger Center for Climate Change Research University of BernBern 3012Switzerland Department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Department of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environment Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environmental Assessment and

Studies have investigated the effects of heat and temperature variability(TV)on ***,few assessed whether TV modifies the heat-mortality *** on daily temperature and mortality in the warm season were collected from 717 locations across 36 *** was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.

关键词： deviation modif heat