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第18届国际真空大会

作者： Shunsuke Makimura Yasuo Kobayashi Yasuhiro Miyake Naritoshi Kawamura patrick strasser Akihiro Koda Kouichiro Shimomura Hiroshi Fujimori Kusuo Nishiyama Mineo Kato Kenji Kojima Ryosuke Kadono Muon Science Laboratory High Energy Accelerator Research Organization （KEK）

At the J-PARC muon science facility （J-PARC/MUSE）, a graphite target with 20-mm thickness has been used in vacuum to obtain an intense pulsed muon beam from the RCS 3-GeV proton beam [1]. In the current design, the target frame is constructed using copper with a stainless steel tube embedded for water cooling. The energy deposited by the proton beam at 1MW is evaluated to be 3.3 kW on the graphite target and 600 W on the copper frame by a Monte-Carlo simulation code, PHITS [2]. Graphite materials are known to lose their crystal structure and can be shrunk by the intense proton beam irradiation. Consequently, the lifetime of the muon target is essentially determined by the radiation damage in graphite, and is evaluated to be half a year [3]. Hence, we are planning to distribute the radiation damage by rotating a graphite wheel. Although the lifetime of graphite in this case will be more than 10 years, the design of the bearing must be carefully considered. Because the bearing in J-PARC/MUSE is utilized in vacuum, under high radiation, and in high temperature, an inorganic and solid lubricant must be applied on the bearing. Simultaneously, the temperature at the bearing must be also decreased to extend the lifetime. In 2009, a mock-up of the Muon Rotating Target, which could heat up and rotate a graphite wheel, was fabricated and then several tests were started to select the lubricant, and to decide the structure of the Muon Rotating Target, the control system and so on. In this presentation, the present status of the Muon Rotating Target for J-PARC/MUSE, especially the development of a rotation system in vacuum, will be described.

关键词： J-PARC Muon Target Bearing

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Electrocatalytic hydrogen peroxide formation on mesoporous non-metal nitrogen-doped carbon catalyst

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Journal of Energy Chemistry 2016年第2期25卷 249-255页

作者： Frédéric Hasché Mehtap Oezaslan Peter strasser Tim-patrick Fellinger Technische Universitat Berlin Department of Chemistry10623 BerlinGermany Max Planck Institut fur Kolloid-und Grenzfliichenforschung Department of Colloids14424 PoadamGermany Carl von Ossietzky University of Oldenburg Department of ChemistryElectrocatalysis26111 OldenburgGermany

Direct electrochemical formation of hydrogen peroxide（H2O2） from pure O2 and H2on cheap metal-free earth abundant catalysts has emerged as the highest atom-efficient and environmentally friendly reaction pathway and is therefore of great interest from an academic and industrial point of view. Very recently,novel metal-free mesoporous nitrogen-doped carbon catalysts have attracted large attention due to the unique reactivity and selectivity for the electrochemical hydrogen peroxide formation [1–3]. In this work,we provide deeper insights into the electrocatalytic activity, selectivity and durability of novel metal-free mesoporous nitrogen-doped carbon catalyst for the peroxide formation with a particular emphasis on the influence of experimental reaction parameters such as p H value and electrode potential for three different electrolytes. We used two independent approaches for the investigation of electrochemical hydrogen peroxide formation, namely rotating ring-disk electrode（RRDE） technique and photometric UV–VIS technique. Our electrochemical and photometric results clearly revealed a considerable peroxide formation activity as well as high catalyst durability for the metal-free nitrogen-doped carbon catalyst material in both acidic as well as neutral medium at the same electrode potential under ambient temperature and pressure. In addition, the obtained electrochemical reactivity and selectivity indicate that the mechanisms for the electrochemical formation and decomposition of peroxide are strongly dependent on the p H value and electrode potential.

关键词： Electrochemical hydrogen peroxide formation Selectivity Mesoporous nitrogen-doped carbon Green synthesis Electrocatalysis Metal-free catalysis

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Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

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Journal of Pharmaceutical Analysis 2021年第6期11卷 726-731页

作者： Lisa strasser Giorgio Oliviero Craig Jakes Izabela Zaborowska patrick Floris Meire Ribeiro da Silva Florian Füssl Sara Carillo Jonathan Bones Characterization and Comparability Laboratory NIBRT-National Institute for Bioprocessing Research and TrainingDublinA94 X099Ireland School of Chemical and Bioprocess Engineering University College DublinDublinD04 V1W8Ireland

Ensuring the removal of host cell proteins(HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies(m Abs) remains a *** residual HCPs might affect product stability or safety,constant monitoring is required to demonstrate their removal to be below the regulatory accepted level of 100 ng/*** current standard analytical approach for this procedure is based on ELISA;however,this approach only measures the overall HCP ***,the use of orthogonal methods,such as liquid chromatography-mass spectrometry(LC-MS),has been established,as it facilitates the quantitation of total HCPs as well as the identification and quantitation of the individual HCPs *** the present study,a workflow for HCP detection and quantitation using an automated magnetic bead-based sample preparation,in combination with a data-independent acquisition(DIA) LC-MS analysis,was *** the same instrumental setup commonly used for peptide mapping analysis of m Abs allows for its quick and easy implementation into pre-existing workflows,avoiding the need for dedicated instrumentation or ***,quantitation of HCPs over a broad dynamic range was enabled to allow monitoring of problematic HCPs or to track changes upon altered bioprocessing conditions.

关键词： Data-independent acquisition Host cell proteins Critical quality attributes Liquid chromatography-mass spectrometry Monoclonal antibody Chinese hamster ovary cells

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