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Comparison of pediatric ventriculoperitoneal shunt infections arising in antibiotic-impregnated and standard catheters:a multicenter observational study

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World Journal of Pediatric Surgery 2023年第3期6卷 196-199页

作者： Joan Robinson Archana Balamohan Michelle Barton Marie-Astrid Lefebvre Ahmed Almadani Dolores Freire Alastair McAlpine Jocelyn Srigley patrick passarelli John Bradley Dele Davies Gwenn Skar Isabelle Viel-Theriault Sarah Khan Rupeena Purewal Nicole LeSaux Jennifer Bowes Michael Hawkes 无 Department of Pediatrics University of AlbertaEdmontonAlbertaCanada University of Arkansas for Medical Sciences Little RockArkansasUSA Arkansas Children's Hospital Little RockArkansasUSA Western University LondonOntarioCanada McGill University Faculty of Medicine MontrealQuebecCanada Umm Al-Qura University MakkahSaudi Arabia University of Alberta EdmontonAlbertaCanada The University of British Columbia VancouverBritish ColumbiaCanada Pediatrics Rady Children's Hospital San DiegoSan DiegoCaliforniaUSA Arnot Ogden Medical Center ElmiraNew YorkUSA Rady Children's Hospital San Diego San DiegoCaliforniaUSA Pediatrics University of Nebraska Medical CenterOmahaNebraskaUSA University of Nebraska Medical Center OmahaNebraskaUSA Laval University QuebecQuebecCanada McMaster University HamiltonOntarioCanada University of Saskatchewan SaskatoonSaskatchewanCanada CHEO OttawaOntarioCanada for the Pediatric Investigators Collaborative Network on Infections in Canada(PICNIC)

Antibiotic-impregnated ventricular shunt catheters(AIVSCs)with 0.15%clindamycin and 0.054%rifampin are commonly used to prevent ventriculo-peritoneal(VP)shunt *** approved by the United States Food and Drug Administration in 2003(https://***/file/general/***),they have antimicrobial activity documented for minimum 31 days(https://***/cdrh_docs/pdf11/***).These antibiotics were chosen as they cover the majority of Staphylococcus aureus and may provide some activity against coagulase negative staphylococci.1 These normal skin flora account for the majority of VP shunt *** the largest randomized controlled trial(RCT)to date,AIVSCs significantly reduced the risk of infection compared with standard shunts(cause-specific hazard ratio(HR)0.38).2 This effect was mainly due to a reduction in staphylococcal infections;the number of gram-negative infections was similar in both *** studies3–5 and a meta-analysis6 in children support the findings of this *** objective of this study was to examine the spectrum of pathogens,time to infection,and outcomes with AIVSCs vs standard shunts.

关键词： shunt infections peritoneal

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