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World Journal of Emergency Medicine 2020年第1期11卷 60-63页

作者： Yan-jun Shi patrick mckiernan Kyle Soltys George Mazariegos Wei-lin Wang Department of Hepatobiliary&Pancreas Surgery the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Thomas E.Starzl Transplantation Institute Hillman Center for Pediatric TransplantationDepartment of Transplant SurgeryChildren's Hospital of Pittsburgh of the University of Pittsburgh Medical CenterPittsburghPAUSA

Dear editor,Hepatopulmonary syndrome(HPS)is not uncommon in the setting of liver disease,especially in liver cirrhosis *** prevalence of HPS in liver cirrhosis patients varies from 4%to 47%.[1-3]About the definition of HPS,it is a pulmonary vascular disorder with evidence of intrapulmonary arterial venous shunt.[4]Pulmonary dyspnea and polycythemia are common presentations of ***,cyanosis and clubbed fingers were present in most of all *** nevi is another common clinical feature of patients with HPS.

关键词： patients shunt liver

Expanding etiology of progressive familial intrahepatic cholestasis

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World Journal of Hepatology 2019年第5期11卷 450-463页

作者： Sarah AF Henkel Judy H Squires Mary Ayers Armando Ganoza patrick mckiernan James E Squires Division of Gastroenterology Hepatologyand NutritionEmory School of MedicineAtlantaGA 30322United States Department of Radiology UPMC Children’s Hospital of PittsburghPittsburghPA 15224United States Division of Gastroenterology Hepatologyand NutritionUPMC Children’s Hospital of PittsburghPittsburghPA 15224United States Division of Pediatric Transplantation Department of SurgeryUPMC Children’s Hospital of PittsburghPittsburghPA 15224United States

BACKGROUND Progressive familial intrahepatic cholestasis(PFIC)refers to a disparate group of autosomal recessive disorders that are linked by the inability to appropriately form and excrete bile from hepatocytes,resulting in a hepatocellular form of *** the diagnosis of such disorders had historically been based on pattern recognition of unremitting cholestasis without other identified molecular or anatomic cause,recent scientific advancements have uncovered multiple specific responsible *** variety of identified defects has resulted in an ever-broadening phenotypic spectrum,ranging from traditional benign recurrent jaundice to progressive cholestasis and end-stage liver *** To review current data on defects in bile acid homeostasis,explore the expanding knowledge base of genetic based diseases in this field,and report disease characteristics and *** We conducted a systemic review according to PRISMA *** performed a Medline/PubMed search in February-March 2019 for relevant articles relating to the understanding,diagnosis,and management of bile acid homeostasis with a focus on the family of diseases collectively known as *** only articles were accessed in *** manual search included references of retrieved *** extracted data on disease characteristics,associations with other diseases,and *** was summarized and presented in text,figure,and table *** Genetic-based liver disease resulting in the inability to properly form and secrete bile constitute an important cause of morbidity and mortality in children and increasingly in adults.A growing number of PFIC have been described based on an expanded understanding of biliary transport mechanism defects and the development of a common *** We present a summary of current advances made in a number of areas relevant to both the classically described FIC1(ATP8B1),BSEP(ABCB11),and MDR3(ABCB4)transporter deficiencie

关键词： Cholestasis Progressive familial intrahepatic cholestasis Benign recurrent intrahepatic cholestasis Intrahepatic cholestasis of pregnancy Drug induced cholestasis Bile acids Bile transport

On Isodual Double Toeplitz Codes

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Journal of Systems Science & Complexity 2024年第5期37卷 2196-2206页

作者： SHI Minjia XU Li SOLé patrick Key Laboratory of Intelligent Computing and Signal Processing Ministry of Education School of Mathematical Sciences Anhui University State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of Sciences CNRS University of Aix Marseille Centrale Marseille

Double Toeplitz（shortly DT） codes are introduced here as a generalization of double circulant codes. The authors show that such a code is isodual, hence formally self-dual（FSD）. FSD codes form a far-reaching generalization of self-dual codes, the most important class of codes of rate one-half. Self-dual DT codes are characterized as double circulant or double negacirculant. Likewise, even binary DT codes are characterized as double circulant. Numerical examples obtained by exhaustive search show that the codes constructed have best-known minimum distance, up to one unit, amongst formally self-dual codes, and sometimes improve on the known values. For q = 2, the authors find four improvements on the best-known values of the minimum distance of FSD codes. Over F4an explicit construction of DT codes, based on quadratic residues in a prime field, performs equally well. The authors show that DT codes are asymptotically good over Fq. Specifically, the authors construct DT codes arbitrarily close to the asymptotic Varshamov-Gilbert bound for codes of rate one half.

关键词： Double circulant codes double Toeplitz codes formally self-dual codes isodual codes

Inducing neuronal regeneration and differentiation via the BDNF/ TrkB signaling pathway: a key target against neurodegenerative diseases?

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Neural Regeneration Research 2024年第3期19卷 495-496页

作者： Mirjana Antonijevic patrick Dallemagne Christophe Rochais Normandie University UNICAENCERMNCaenFrance

Brain-derived neurotrophic factor(BDNF)is one of the neurotrophins,a specific polypeptide growth factor,which plays a crucial role in the proliferation,differentiation,survival,and death of neurons and non-neuronal *** is not only essential to maintain the balance between death on one side and survival of neurons on the other,but also it mediates additional higher-order activities such as learning,memory,and *** is initially synthesized as a precursor protein,proBDNF,that can be secreted as it is or it can be cleaved intracellularly by furin and proconvertases,or extracellularly by extracellular proteases such as matrix metalloprotease-9 and matrix metalloprotease-2,or plasmin to give mature BDNF.

关键词： death diseases degenerative

Trombe walls with porous medium insertion and their influence on thermal comfort in flats in Cusco,Peru

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Energy and Built Environment 2024年第2期5卷 194-210页

作者： patrick Facelli Sanchez Lisset Mercado Hancco Department of Civil Engineering Faculty of Architecture and Civil EngineeringUniversidad Nacional de San Antonio Abad del Cusco08003 CuscoPeru

The Trombe wall is a passive indirect heating system which should be used in Cusco,Peru to improve thermal conditions against the typical frosts and low temperatures during winter in the high Andean *** to this problem,the use of a modified Trombe wall with insertion of porous medium is proposed to improve thermal comfort in flat buildings in *** research aims to analyse and compare the performance of dwellings without Trombe wall,with traditional Trombe wall,and with Trombe wall with glass and plastic pellets insertion in thermal comfort ***■CFD was used to simulate and analyse the *** simulation was performed with three prototype flats(55 m^(2),75 m^(2) and 95 m^(2))for six months of the *** the results obtained,the level of thermal comfort in the traditional scenarios is low with an average PMV of-1.86,in the scenarios with Trombe wall is good and in the scenarios with Trombe wall with insertion of porous medium is slightly better than the previous one,reaching an average PMV of+0.10 and a temperature of 21.90℃.The study carried out is important because it represents an efficient eco-sustainable heating alternative that improves the thermal comfort sensation in houses during the coldest months of the year.

关键词： Trombe wall thermal comfort porous medium residential buildings computational fluid dynamics

Multiple sclerosis drug repurposing for neuroregeneration

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Neural Regeneration Research 2024年第3期19卷 507-508页

作者： Peter Göttle Michael Dietrich patrick Küry Department of Neurology Medical FacultyHeinrich-Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS)is an autoimmune disorder of the central nervous system(CNS)and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turning progressive over time with neurodegenerative processes taking over(Amin and Hersh,2023).Of note,beyond relapse-associated worsening early in disease progression independent of relapse activity may arise independently of relapse activity and can occur in all ***-mediated damage of myelin sheaths and the subsequent loss of mature oligodendrocytes are resulting in impaired axonal integrity,neurodegeneration and accounts for irreversible neuronal damage(Kuhlmann et al.,2023).The current landscape of available disease-modifying therapies comprises mainly immunomodulatory drugs that effectively diminish relapses and slow down progression at the onset form of the disease,namely relapsing MS(RMS).In this regard,a number of drugs have been approved as disease-modifying therapies for MS by US Food and Drug Administration and European Medicines Agencies(Box 1).

关键词： drugs impaired irreversible

What Knowledge is of Most Worth?Considering the Neo-Confucians in the Contemporary Debate Between Moral and Intellectual Learning

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ECNU Review of Education 2024年第1期7卷 155-163页

作者： John patrick Shekitka Manhattanville College

●The perennial debate regarding the relative usefulness of various forms of knowledge,especially between the theoretical and practical and the intellectual and moral,lies at the heart of education in both past and present times in both the West and China(de Bary,1988,2004,2005,2015).●Neo-Confucians remain relevant in the 21st century and can help us to understand and elucidate contemporary debates in education-specifically,to answer the question Spencer asked nearly a century and a half ago:"What knowledge is of most worth?".●Mencius,Zhu Xi,Wang Yangming,Xu Ai,and Kang Youwei advocated for a type of learning that would strongly resonate with John Dewey(1938)and Paulo Freire(1970,1978).Foundational philosophies of education,particularly in the United States,have drawn heavily on 20th century European-American thinkers;this article attempts to correct this myopia and broaden perspectives.

关键词： Freire John Dewey Neo-Confucian

Small activating RNA delivery in vivo:Challenges,prospects,and lessons learned from siRNA delivery

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Nano Research 2024年第10期17卷 8990-9002页

作者： Shalini Pandey patrick T.Bednarz Matthias A.Oberli Omid Veiseh Department of Bioengineering William Marsh Rice UniversityHouston 77030USA Xibus Systems 199 Dexter AveWatertown 02472USA

Over the last two decades,small activating RNAs(saRNAs)have quickly moved from discovery to clinical *** as 20 nucleotide long,double stranded RNA,saRNAs have the unique ability to increase gene transcription at the chromatin *** therapeutic modality has great potential as a safe and redosable alternative to gene therapy by increasing target protein expression without changing the genetic *** describe the successful in vivo saRNA delivery vectors and found that similar to small interfering RNA(siRNA)and mRNA targeting tissues outside the liver works best at the end of a *** highlight nanoparticle vectors and RNA-conjugates,where some success has been reported for non-hepatic delivery of saRNAaptamers.

关键词： small activating RNA hepatic bias lipid nanoparticles RNA-conjugates

Impact of multifocal gas-permeable lens designs on short-term choroidal response, axial length, and retinal defocus profile

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 247-256页

作者： Muteb Alanazi patrick Caroline Amane Alshamrani Maria Liu Optometry Department College of Applied Medical SciencesKing Saud UniversityRiyadh 14813Saudi Arabia College of Optometry Pacific UniversityForest GroveOregon 97116-1756United States Optometry School University of California at BerkeleyCalifornia 94720United States

AIM:To investigate the impact of multifocal gas permeable contact lens(MFGPCL)in various add power and distance/near area allocation on short-term changes of choroidal thickness(ChT),axial length(AL),and retinal defocus profile in young ***:Seventeen young adults(2 males and 15 females;age 23.17±4.48y)were randomly assigned to wear two designs binocularly with a one-week washout period in *** of four MFGPCL designs were *** designs were distance-center that varied in two add power(+1.50 and 3.00 D)and/or two distance zone(DZ)diameters(1.50 and 3.00 mm;design A:DZ 1.5/add 3.0,B:DZ 1.5/add 1.5,C:DZ 3.0/add 3.0,D:DZ 3.0/add 1.5).ChT,AL,and peripheral refraction data were collected on each subject at baseline,on days 1 and 7 of MFGPCL daily *** was assessed in four quadrants using a spectraldomain optical coherence ***:AL was shortened by-26±44μm with lens C,-18±27μm with lens D,-13±29μm with lens A,and-8±30μm with lens B(all P<0.05).A significant overall increase in ChT was observed with all 4 designs(lens A:+6±6μm,B:+3±7μm,C:+8±7μm,and D:+8±7μm).Temporal and superior choroid exhibited more choroidal thickening associated with *** designs induced significant relative peripheral myopia(RPM)beyond the central 20o across the horizontal meridian in both nasal and temporal fields(P<0.05).CONCLUSION:MFGPCLs show a significant influence on ChT and AL,which are associated with significant increase in RPM after short-term *** reliability and feasibility of quantifying short-term changes in ChT support its use as a promising marker for the long-term efficacy of myopia-controlling treatments.

关键词： choroid gas-permeable contact lens retinal defocus axial length myopia

A new species of Discostella guiyangensis ***.(Bacillariophyta,Stephanodiscales)from Guiyang,China:morphology and phylogeny

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Journal of Oceanology and Limnology 2024年第4期42卷 1312-1324页

作者： Yandan XIANG Fangru NAN Xudong LIU Shulian XIE John patrick KOCIOLEK Qi LIU School of Life Science Shanxi UniversityTaiyuan 030006China Department of Ecology and Evolutionary Biology and Museum of Natural History University of ColoradoBoulder CO 80309USA

We describe a new species of Discostella from Guiyang based on light and scanning electron microscopic observations,as well as molecular *** species is morphologically distinguished from other species by a relatively smooth and slightly recessed central area with marginal striae of unequal lengths forked near the *** fultoportulae and a single rimoportula are situated between every two costae or on the *** morphological characters and the concatenated data of rbc L and SSU rDNA indicate that Discostella guiyangensis is a unique and new *** to divergence time estimation analysis,Discostella guiyangensis is the oldest species among the Discostella species sequenced *** addition,we complement molecular data of Discostella asterocostata and Discostella stelligera.

关键词： Discostella morphology molecular analysis divergence time estimation new species