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Treatment of colonic varices and gastrointestinal bleeding by recanalization and stenting of splenic-vein-thrombosis:A case report and literature review

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World Journal of Gastroenterology 2023年第24期29卷 3922-3931页

作者： Lisa-michaela Füssel Rene müller-Wille patrick Dinkhauser Walter Schauer Harald Hofer Department of Internal medicine Ⅰ Gastroenterology and HepatologyKlinikum Wels-GrieskirchenWels 4600Austria Department of Radiology Klinikum Wels-GrieskirchenWels 4600Austria Department of Abdominal Surgery Klinikum Wels-GrieskirchenWels 4600Austria

BACKGROUND Splenic vein thrombosis is a known complication of *** can lead to increased blood flow through mesenteric *** segmental hypertension may result in the development of colonic varices(CV)with a high risk of severe gastrointestinal *** clear guidelines for treatment are lacking,splenectomy or splenic artery embolization are often used to treat *** vein stenting has been shown to be a safe *** SUmmARY A 45-year-old female patient was admitted due to recurrent gastrointestinal *** was anemic with a hemoglobin of 8.0 g/*** a source of bleeding,CV were *** tomography scans revealed thrombotic occlusion of the splenic vein,presumably as a result of a severe acute pancreatitis 8 years *** a selective angiography,a dilated mesenterial collateral leading from the spleen to enlarged vessels in the right colonic flexure and draining into the superior mesenteric vein could be *** hepatic venous pressure gradient was within normal *** an interdisciplinary board,transhepatic recanalization of the splenic vein via balloon dilatation and consecutive stenting,as well as coiling of the aberrant veins was discussed and successfully *** evaluation revealed complete regression of CV and splenomegaly as well as normalization of the red blood cell count during *** Recanalization and stenting of splenic vein thrombosis might be considered in patients with gastrointestinal bleeding due to ***,a multidisciplinary approach with a thorough workup and discussion of individualized therapeutic strategies is crucial in these difficult to treat patients.

关键词： Pancreatitis-induced splenic vein thrombosis Gastrointestinal hemorrhage Colonic varices Splenic vein stenting Segmental/sinistral hypertension Case report

Cosmogenic ^(10)Be dating of Guxiang and Baiyu Glaciations

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Chinese Science Bulletin 2007年第10期52卷 1387-1393页

作者： ZHOU ShangZhe XU LiuBing patrick m. Colgan DAVID m. mickelson WANG XiaoLi WANG Jie ZHONG Wei Department of Geography South China Normal University Guangzhou 510631 China Department of Geology Grand Valley State University Allendale Michigan 49401 USA Department of Geology and Geophysics University of Wisconsin-Madison Madison Wisconsin 53706 USA Department of Geography Lanzhou University Lanzhou 730000 China

Guxiang and Baiyu Glaciations are two previously recognized local glaciations of the Tibetan Plateau. They have been widely used as the reference standard for classifying Late Quaternary glaciations on the Tibetan Plateau and its surrounding mountains. However, the numerical chronologies of both glaciations have been lacking. In this study, cosmogenic 10Be dating was undertaken to define the timing of these two glaciations. The surface boulders deposited by the glaciers of the Guxiang and Baiyu Glaciations have exposure ages of 112.9±16.7―136.5±15.8 ka BP and 11.1±1.9―18.5±2.2 ka BP, respectively. It is likely that the Guxiang and Baiyu Glaciations correspond to marine isotope stages 6 and 2, respectively.

关键词：宇宙核素铍10 测年冰川作用青藏高原

Patterns of reptile and amphibian species richness along elevational gradients in mt. Kenya

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Zoological Research 2015年第6期36卷 342-347页

作者： patrick Kinyatta mALONZA National museums of Kenya Herpetology Section

Faunal species richness is traditionally assumed to decrease with increasing elevation and decreasing prmary productivity. Species richness is reported to peak at mid-elevation. This survey examines the herpetofaunal diversity and distribution in mt. Kenya （central Kenya） by testing the hypothesis that changes in species richness with elevation relate to elevation-dependent changes in climate. Sampling along transects from an elevation of approximately 1 700 m in Chogoda forest block （wind-ward side） and approximately 2 600 m in Sirimon block （rain shadow zone） upwards in march 2009. This starts from the forest to montane alpine zones. Sampling of reptiles and amphibians uses pitfall traps associated with ddfl fences, time-limited searches and visual encounter surveys. The results show that herpetofaunal richness differs among three vegetation zones along the elevation gradient. Chogoria has higher biodiversity than Sirimon. more species occur at low and middle elevations and few exist at high elevations. The trends are consistent with expected optimum water and energy variables. The lower alpine montane zone has high species richness but low diversity due to domi- nance of some high elevations species. Unambiguous data do not support a mid-domain effect （mid-elevation peak） because the observed trend better fits a model in which climatic variables （rainfall and temperature） control species richness, which indirectly measures productivity. It is important to continue protection of all indigenous forests, especially at low to mid elevations. These areas are vulnerable to human destruction yet are home to some endemic species. Firebreaks can limit the spread of the perennial wildfires, especially on the moor- lands.

关键词： Herpetofauna Elevation Rainfall Temperature Species diversity

Architecting Fault Tolerance with Exception Handling: Verification and Validation

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Journal of Computer Science & Technology 2009年第2期24卷 212-237页

作者： patrick H. S. Brito Rogério de Lemos Cecília m. F. Rubira Eliane martins Institute of Computing State University of Campinas Brazil Computing Laboratory University of Kent U.K.

When building dependable systems by integrating untrusted software components that were not originally designed to interact with each other, it is likely the occurrence of architectural mismatches related to assumptions in their failure behaviour. These mismatches, if not prevented during system design, have to be tolerated during runtime. This paper presents an architectural abstraction based on exception handling for structuring fault-tolerant software systems. This abstraction comprises several components and connectors that promote an existing untrusted software element into an idealised fault-tolerant architectural element. moreover, it is considered in the context of a rigorous software development approach based on formal methods for representing the structure and behaviour of the software architecture. The proposed approach relies on a formal specification and verification for analysing exception propagation, and verifying important dependability properties, such as deadlock freedom, and scenarios of architectural reconfiguration. The formal models are automatically generated using model transformation from UmL diagrams： component diagram representing the system structure, and sequence diagrams representing the system behaviour. Finally, the formal models are also used for generating unit and integration test cases that are used for assessing the correctness of the source code. The feasibility of the proposed architectural approach was evaluated on an embedded critical case study.

关键词： exception handling fault-tolerant software architecture model-based test model checking software verification and validation

Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis

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Cellular & molecular Immunology 2018年第8期15卷 756-767页

作者： Weici Zhang Ren Zhang Jun Zhang Ying Sun patrick SC Leung Guo-Xiang Yang Zongwen Shuai William m Ridgway m Eric Gershwin Division of Rheumatology Allergy and Clinical ImmunologyUniversity of CaliforniaDavisCaliforniaUSA Department of Pathogenic Biology and Immunology Guangzhou University of Chinese MedicineGuangzhou 510006China Center for non-infectious liver diseases Beijing 302 HospitalBeijing 100039China Department of Rheumatology and Immunology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Division of Immunology Allergy and RheumatologyUniversity of CincinnatiCincinnatiOH 45267

Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this ***,little is known about the regulation of their functional behavior during disease *** previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC ***,we used SOmAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different *** addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)*** use of the unique SOmAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary *** total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) *** contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways.

关键词： autoimmune cholangitis CD8 dnTGFβRII mice proteomic analysis

The role of stem cells in airway repair:implications for the origins of lung cancer

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Chinese Journal of Cancer 2013年第2期32卷 71-74页

作者： michael S.mulvihill Johannes R.Kratz patrick Pham David m.Jablons Biao He Thoracic Oncology Program Department of SurgeryHelen Diller Family Comprehensive Cancer CenterUniversity of California San Francisco

Lung cancer is the leading cause of cancer-related deaths ***,advancements in our ability to identify and study stem cell populations in the lung have helped researchers to elucidate the central role that cells with stem cell-like properties may have in lung *** of this research has focused on the use of the airway repair model to study response to *** this review,we discuss the primary evidence of the role that cancer stem cells play in lung cancer *** implications of a stem cell origin of lung cancer are reviewed,and the importance of ongoing research to identify novel therapeutic and prognostic targets is reiterated.

关键词：细胞起源干细胞肺癌修复气道研究人员识别能力癌症

Forgotten node:A case report

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World Journal of Gastroenterology 2009年第39期15卷 4974-4975页

作者： patrick m Fratellone melissa A Holowecki Fratellone medical Associates

Sister mary Joseph nodule or node refers to a palpable nodule bulging into the umbilicus and is usually a result of a malignant cancer in the pelvis or *** it has been considered a sign of ominous *** malignancies,most commonly gastric,colon and pancreatic cancer account for about 52% of the underlying *** cancers,most commonly ovarian and uterine cancers account for about 28% of the sources.

关键词： Umbilical node Sister mary Joseph node Gastroenterology Gastric malignancies Endometriosis

The Adjacency Codes of the First Yellow Graphs

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Journal of Systems Science & Complexity 2023年第4期36卷 1757-1768页

作者： SHI minjia LI Shitao KIm Jon-Lark SOLE patrick Key Laboratory of Intelligent Computing and Signal Processing Ministry of EducationSchool of Mathematical SciencesAnhui UniversityHefei 230601China State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of SciencesBeijing 100093China School of mathematical Sciences Anhui UniversityHefei 230026China Department of math Sogang UniversitySeoulSouth Korea Aix marseille Univ CNRSCentrale MarseilleI2MMarseilleFrance

The authors study the binary codes spanned by the adjacency matrices of the strongly regular graphs(SRGs)on at most two hundred vertices whose existence is *** authors show that in length less than one hundred they cannot be cyclic,except for the exceptions of the SRGs of parameters(85,42,20,21)and(96,60,38,36).In particular,the adjacency code of a(85,42,20,21)is the zero-sum *** the range[100,200]the authors find 29 SRGs that could possibly have a cyclic adjacency code.

关键词： Cyclic codes strongly regular graphs adjacency codes self-orthogonal codes

Nanogels:A novel approach in antimicrobial delivery systems and antimicrobial coatings

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Bioactive materials 2021年第10期6卷 3634-3657页

作者： Damla Keskin Guangyue Zu Abigail m.Forson Lisa Tromp Jelmer Sjollema patrick van Rijn University of Groningen University Medical Center GroningenDepartment of Biomedical EngineeringW.J.Kolff InstituteAntonius Deusinglaan 19713 AVGroningenthe Netherlands

The implementation of nanotechnology to develop efficient antimicrobial systems has a significant impact on the prospects of the biomedical *** are soft polymeric particles with an internally cross-linked structure,which behave as hydrogels and can be reversibly hydrated/dehydrated(swollen/shrunken)by the dispersing solvent and external *** excellent properties,such as biocompatibility,colloidal stability,high water content,desirable mechanical properties,tunable chemical functionalities,and interior gel-like network for the incorporation of biomolecules,make them fascinating in the field of biological/biomedical *** this review,various approaches will be discussed and compared to the newly developed nanogel technology in terms of efficiency and applicability for determining their potential role in combating infections in the biomedical area including implant-associated infections.

关键词： Nanogels Coatings Antibacterial activity Antifouling Biocompatibility