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Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver

World Journal of Gastroenterology 2013年第19期19卷 2883-2893页

作者： Sumaiya Chowdhury Yiqian Chen Tsun-Wen Yao Katerina Ajami Xin M Wang Yury Popov Detlef Schuppan patrick bertolino Geoffrey W McCaughan Denise MT Yu Mark D Gorrell Centenary Institute and Sydney Medical School University of SydneySydneyNSW 2006Australia Division of Gastroenterology and Hepatology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States Molecular Hepatology Centenary InstituteNewtownSydneyNSW 2042Australia

AIM:To investigate the expression of dipeptidyl peptidase(DPP) 8 and DPP9 in lymphocytes and various models of liver ***:DPP8 and DPP9 expression were measured in mouse splenic CD4 + T-cells,CD8 + T-cells and B-cells(B220 +),human lymphoma cell lines and mouse splenocytes stimulated with pokeweed mitogen(PWM) or lipopolysaccharide(LPS),and in dithiothreitol(DTT) and mitomycin-C treated Raji ***8 and DPP9 expression were measured in epidermal growth factor(EGF) treated Huh7 hepatoma cells,in fibrotic liver samples from mice treated with carbon tetrachloride(CCl 4) and from multidrug resistance gene 2(Mdr2 /Abcb4) gene knockout(gko) mice with biliary fibrosis,and in human end stage primary biliary cirrhosis(PBC).RESULTS:All three lymphocyte subsets expressed DPP8 and DPP9 ***8 and DPP9 expression were upregulated in both PWM and LPS stimulated mouse splenocytes and in both Jurkat T-and Raji B-cell ***8 and DPP9 were downregulated in DTT treated and upregulated in mitomycin-C treated Raji ***9transfected Raji cells exhibited more annexin V + cells and associated ***8 and DPP9 mRNA were upregulated in CCl 4 induced fibrotic livers but not in the lymphocytes isolated from such livers,while DPP9 was upregulated in EGF stimulated Huh7 *** contrast,intrahepatic DPP8 and DPP9 mRNA expression levels were low in the Mdr2 gko mouse and in human PBC compared to non-diseased ***:These expression patterns point to biological roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis.

关键词： Dipeptidyl peptidase CD26 Lymphocytes Liver fibrosis Biliary fibrosis

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