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The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification

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Bone Research 2018年第3期6卷 217-225页

作者： patrick Aghajanian Subburaman Mohan Musculoskeletal Disease Center Veterans Affairs Loma Linda Healthcare System Department of Medicine Loma Linda University Department of Orthopedics Loma Linda University Department of Biochemistry Loma Linda University

There is a worldwide epidemic of skeletal diseases causing not only a public health issue but also accounting for a sizable portion of healthcare expenditures. The vertebrate skeleton is known to be formed by mesenchymal cells condensing into tissue elements(patterning phase) followed by their differentiation into cartilage(chondrocytes) or bone(osteoblasts) cells within the condensations. During the growth and remodeling phase, bone is formed directly via intramembranous ossification or through a cartilage to bone conversion via endochondral ossification routes. The canonical pathway of the endochondral bone formation process involves apoptosis of hypertrophic chondrocytes followed by vascular invasion that brings in osteoclast precursors to remove cartilage and osteoblast precursors to form bone. However, there is now an emerging role for chondrocyte-to-osteoblast transdifferentiation in the endochondral ossification process. Although the concept of "transdifferentiation" per se is not recent,new data using a variety of techniques to follow the fate of chondrocytes in different bones during embryonic and post-natal growth as well as during fracture repair in adults have identified three different models for chondrocyte-to-osteoblast transdifferentiation(direct transdifferentiation, dedifferentiation to redifferentiation, and chondrocyte to osteogenic precursor). This review focuses on the emerging models of chondrocyte-to-osteoblast transdifferentiation and their implications for the treatment of skeletal diseases as well as the possible signaling pathways that contribute to chondrocyte-to-osteoblast transdifferentiation processes.

关键词： cartilage(chondrocytes)or bone(osteoblasts) chondrocyte-to-osteoblast

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可用于风险管理的预训练语言模型提示

中国质量 2024年第1期 75-78页

作者：帕特里克·沃尔夫张睿

作为一名在私营、非营利和公共部门拥有超过25年国际风险管理和公司治理经验的特许会计师，帕特里克作为实践风险培训企业（***）及私人的培训师和教练，帮助个人和组织做出更好的决策，以取得更好的结果。编辑的介绍在2023年《质量经...

作为一名在私营、非营利和公共部门拥有超过25年国际风险管理和公司治理经验的特许会计师，帕特里克作为实践风险培训企业（***）及私人的培训师和教练，帮助个人和组织做出更好的决策，以取得更好的结果。编辑的介绍在2023年《质量经营》第2卷中，我们发表了多篇关于人工智能和质量管理的文章。成功使用人工智能技术的关键是对人工智能工具提出问题（“提示”），以生成我们寻求的输出。

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Guest Editorial:Special Section on Control Centers for the Evolving Power Grid:Architecture and Applications

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 I0001-I0002页

作者： Anjan Bose patrick Panciatici Xin Shan Washington State University PullmanUSA RTE ParisFrance NARI Group Corporation(State Grid Electric Power Research Institute) NanjingChina

THE world-wide drive to decrease greenhouse gases in the atmosphere is rapidly changing the mix of fuel resources that are used to generate *** percentage of fossil fuels,especially coal,is declining while the percentage of renewable resources,like wind and solar,is *** generation mix has always depended on the avail-ability of different fuels in different regions,like the availability of hydro or the acceptability of nuclear power,and the recent changes also depend on this geography,like the radiance of the sun or the intensity of the *** these changes will lead to different architectures in the evolving power grid,some trends are already being felt.

关键词： Power gases fuels

In situ Fourier Transform Infrared Spectroscopy Diagnostic for Characterization and Performance Test of Catalysts

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Chinese Journal of Chemical Physics 2017年第5期30卷 513-520,I0001页

作者： patrick Mountapmbeme Kouotou 田振玉中国科学院工程热物理研究所北京100190 中国科学院大学北京100049 马鲁阿大学萨赫拉高等研究院喀麦隆

The present work establishes a systematic approach based on the application of in-situ Fourier transform infrared spectroscopy （FTIR） for the investigation of the crystal structure, thermal stability, redox behavior （temperature-programmed reduction/temperatureprogrammed re-oxidation） as well as the catalytic properties of Co3O4 thin films. The syntheses of Co3O4 were achieved by chemical vapor deposition in the temperature range of 400-500℃. The structure analysis of the as-prepared material revealed the presence of two prominent IR bands peaking at 544 cm-1 （υ1） and 650 cm-1 （υ2） respectively, which originate from the stretching vibrations of the Co-O bond, characteristic of the Co3O4 spinel. The lattice stability limit of Co3O4 was estimated to be above 650℃. The redox properties of the spinel structure were determined by integrating the area under the emission bands υ1 and υ2 as a function of the temperature. Moreover, Co3O4 has been successfully tested as a catalyst towards complete oxidation of dimethyl ether below 340 ℃. The exhaust gas analysis during the catalytic process by in situ absorption FTIR revealed that only CO2 and H2O were detected as the final products in the catalytic reaction. The redox behavior suggests that the oxidation of dimethyl ether over Co3O4 follows a Mars-van Krevelen type mechanism. The comprehensive application of in situ FTIR provides a novel diagnostic tool in characterization and performance test of catalysts.

关键词： In situ Fourier transform infrared spectroscopy Diagnostic Thermal stability Redox property Catalytic mechanism

Construction of One-Lee Weight and Two-Lee Weight Codes over IF_p+vIF_p

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Journal of Systems Science & Complexity 2017年第2期30卷 484-493页

作者： SHI Minjia LUO Yong SOLE patrick Key Laboratory of Intelligent Computing&Signal Processing Ministry of EducationAnhui UniversityHefei 230039China School of Mathematical Sciences Anhui UniversityHefei 230601China National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China Telecom Paris Tech ParisFrance

This paper is devoted to the construction of one-Lee weight codes and two-Lee weight codes over IF_p+vIF_p(v^2=v) with type p^(2 k_1)p^(k2)p^(k3) based on two different distance-preserving Gray maps from((IF_p+vIF_p)~n, Lee weight) to(IF_p^(2 n), Hamming weight), where p is a prime. Moreover, the authors prove that the obtained two-Lee weight codes are projective only when p=2.

关键词： Generator matrix Gray map linear code one-Lee weight code two-Lee weight code

A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned

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Biosafety and Health 2024年第2期6卷 125-132页

作者： Reuben Kiggundu J.P.Waswa Niranjan Konduri Hassan Kasuja Marion Murungi patrick Vudriko Harriet Akello Eric Lugada Cecilia Muiva Esther Were Dinah Tjipura Henry Kajumbula Kate Kikule Emmanuel Nfor Mohan P.Joshi USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthArlingtonVA 22203USA College of Veterinary Medicine Animal Resources and BiosecurityMakerere UniversityKampala 256Uganda Ministry of Health Uganda Kampala 256Uganda USAID Strengthening Supply Chain Systems Activity Management Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthNairobi 254Kenya Department of Microbiology College of Health SciencesMakerere UniversityKampala 256Uganda

Uganda has been implementing the Global Health Security Agenda(GHSA)since 2015 to build its capacity according to World Health Organization(WHO)Benchmarks on International Health Regulations *** country remains prone to outbreaks,with more than 20 disease outbreaks reported in the past five years,including Ebola virus disease,Crimean-Congo haemorrhagic fever,Marburg haemorrhagic fever,measles,yellow fever,coronavirus disease 2019(COVID-19),and *** resistance(AMR)is an ongoing *** scored capacity level 3 on infection prevention and control(IPC)and antimicrobial stewardship(AMS)in the 2017 Joint External Evaluation(JEE)*** gaps were being addressed after a self-assessment in *** paper describes the technical assistance approaches provided to Uganda by the Medicines,Technologies,and Pharmaceutical Services Program,funded by the United States(U.S.)Agency for International Development,and implemented by Management Sciences for *** program,through a One Health approach,supported systematic capacity strengthening based on the JEE's capacity advancement framework for global health security,specifically relating to *** program's interventions impacted 32 WHO benchmark actions(7 for AMR multisectoral coordination,16 for IPC,and 9 for AMS),contributing to Uganda's strengthened GHSA *** success built on the AMR platform,the program trained 745 health workers in IPC for the Ebola virus and provided support for simulation exercises by eight district IPC *** program also worked with the Ministry of Health to coordinate IPC for the COVID-19 response in five health regions,covering 45 districts and reaching 5,452 health workers at 858 health facilities.

关键词： One health Antimicrobial resistance Antibiotic resistance Jointexternal evaluation Global health security Uganda Africa WHO Benchmarks for International Health Regulations Capacities

A Time to Remember:Neural Insights into Rapid Updating of Timed Behaviors

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Neuroscience Bulletin 2023年第4期39卷 699-702页

作者： Christopher Howard patrick Simen Neuroscience Department Oberlin CollegeOberlinOH44074USA

Processing temporal information is a critical brain function necessary for decision-making and *** timing,or processing of time intervals on the scale of seconds to minutes,is essential for associative learning,sensorimotor processing,and optimal foraging[1]and many neuropsychiatric illnesses including Parkinson's Disease,Huntington's Disease,and schizophrenia involve impaired interval timing.

关键词： Huntington impaired dating

Two-Weight Codes and Second Order Recurrences

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Chinese Journal of Electronics 2019年第6期28卷 1127-1130页

作者： SHI Minjia ZHANG Zhongyi SOLé patrick Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Mathematical Sciences Anhui University School of Wendian Anhui University Aix Marseille Univ CNRS Centrale Marseile

Cyclic codes of dimension 2 over a finite field are shown to have at most two nonzero weights. We compute their weight distribution, and give a condition on the roots of their check polynomials for them to be maximum ... 详细信息

关键词： Two-weight codes Irreducible Cyclic codes MDS codes Linear recurrences

The role of calcium sensor-interacting protein kinases in plant adaptation to potassium-deficiency: new answers to old questions

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Cell Research 2007年第6期17卷 483-485页

作者： Anna Amtmann patrick Armengaud Plant Sciences Group.Institute of Biomedical and Life Sciences University of GlasgowGlasgow G12 8QQUK.

Potassium （K-） is an essential macronutrient for all livingorganisms and large amounts are required for plant growthand development. In many regions of Asia K+-fertilizationhas been neglected and soils have become K+-depleted. K+-deficiency in the field diminishes not only crop productionbut also leads to environmental problems due to inefficientusage and leaching of nitrate. Consequences of K+-defi-ciency on crop production range from decreased biomass,nutritional quality and taste of the crops to inferior harvestand storage properties, as well as increased susceptibilityto disease. Effects of K+-deficiency on plant physiology in-clude decreased photosynthetic rate, impaired tissue alloca-tion of sugars and amino acids, decreased protein synthesis,and lack of control over turgor and gas exchange [1], K+-uptake and its re-distribution within the plant is facilitatedby a plethora of membrane transport proteins displayingan astonishing diversity with respect to their affinity andselectivity for K+, mode and direction of transport, tissuespecific expression, membrane localization and regulation[2]. Microarray experiments have shown that in contrastto transporters of other macronutrients - genes encodingK--transporters display surprisingly little responsiveness tothe external nutrient supply [3]. This observation probably

关键词： CIPK The role of calcium sensor-interacting protein kinases in plant adaptation to potassium-deficiency new answers to old questions