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Achieving the best bowel preparation for colonoscopy

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World Journal of Gastroenterology 2014年第47期20卷 17709-17726页

作者： Adolfo Parra-Blanco Alex Ruiz Manuel Alvarez-Lobos Ana Amorós Juan Cristóbal Gana patricio Ibáez Akiko Ono Takahiro Fujii Department of Gastroenterology Escuela de MedicinaPontificia Universidad Católica de ChileSantiago 833-0024Chile Department of Gastroenterology Hospital Universitario de la Candelaria38916 Santa Cruz de TenerifeSpain Gastroenterology and Nutrition Unit Division of PediatricsEscuela de MedicinaPontificia Universidad Católica de ChileSantiago 833-0024Chile Department of Gastroenterology Hospital Universitario Virgen de la Arrixaca30001 MurciaSpain TF Clinic Tokyo 197-0804Japan

Bowel preparation is a core issue in colonoscopy,as it is closely related to the quality of the *** often find that bowel preparation is the most unpleasant part of the *** is widely accepted that the quality of cleansing must be excellent to facilitate detecting neoplastic *** spite of its importance and potential implications,until recently,bowel preparation has not been the subject of much *** most commonly used agents are high-volume polyethylene glycol(PEG)electrolyte solution and sodium *** has been some confusion,even in published meta-analyses,regarding which of the two agents provides better *** is clear now that both PEG and sodium phosphate are effectivewhen administered with proper ***,the timing of administration is recognized as one of the central factors to the quality of *** bowel preparation agent should be administered,at least in part,a few hours in advance of the *** low volume agents are available,and either new or modified schedules with PEG that usually improve *** adjuvants can also be used to reduce the volume of PEG,or to improve the efficacy of other *** factors apart from the choice of agent can improve the quality of bowel *** instance,the effect of diet before colonoscopy has not been completely clarified,but an exclusively liquid diet is probably not required,and a low-fiber diet may be preferable because it improves patient satisfaction and the quality of the *** patients,such as diabetics and persons with heart or kidney disease,require modified procedures and certain *** preparation for pediatric patients is also reviewed *** such cases,PEG remains the most commonly used *** detecting neoplasia is not the main objective with these patients,less intensive preparation may *** considerations must be made for patients with inflammatory bowel disease,including

关键词： Colonoscopy Optimal preparation Polyethylene glycol Sodium phosphate Special patients Timing

Distribution and origin of polycyclic aromatic hydrocarbons in surface sediments from an urban river basin at the Metropolitan Region of Curitiba,Brazil

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Journal of Environmental Sciences 2011年第6期23卷 904-911页

作者： Natalicio Ferreira Leite patricio Peralta-Zamora Marco Tadeu Grassi Instituto de Tecnologia do Paran(TECPAR) 81350-010 CuritibaBrazil Departamento de Química Universidade Federal do Parana'(UFPR)C.P.1908181531-990 CuritibaBrazil

The concentrations of 16 polycyclic aromatic hydrocarbons（PAHs） were determined in surface sediment samples from nine sites located at the Iguau River Basin in the Metropolitan Region of Curitiba,Brazil to evaluate their distribution and *** total concentration of the PAHs was greater for sediments from highly urbanized areas,while the sediments from the Iraí Environmental Protection Area（Iraí EPA） showed significantly low *** sediments from the Iguau and Barigui rivers were classified as highly contaminated,while those from the Cercado and Curralinho rivers were classified as moderately *** predominance of PAHs containing two to four aromatic rings in most of the samples suggested the direct input of raw sewage into the water resources ***[g,h,i]perylene,dibenzo[a,h]anthracene and indeno[1,2,3-cd]pyrene were predominant in sediments from the areas under the greatest urban and industrial *** correlation between thermodynamic stability and the kinetics of evolution presented by the isomeric pairs indicated that combustion is the predominant source of PAHs in the sediments because the combustion of fossil fuels affected most of the points evaluated,followed by combustion of biomass and eventually combustion of oil product *** general,the results showed that areas under strong urban influence,as well as the Iraí EPA,receive contributions of PAHs from similar sources.

关键词： PAHs trace level analysis fiver sediment isomeric ratio Igua^u River Basin

Endocytic Trafficking towards the Vacuole Plays a Key Role in the Auxin Receptor SCF^TIR-Independent Mechanism of Lateral Root Formation in A. thaliana

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Molecular Plant 2012年第6期5卷 1195-1209页

作者： patricio Perez-Henrique Natasha V. Raikhel Lorena Norambuena Plant Molecular Biology Laboratory Department of Biology Faculty of Sciences University of Chile Santiago Chile Millenium Nucleus in Plant Cell Biotechnology Chile Center for Plant Cell Biology and Department of Botany and Plant Sciences University of California Riverside CA 92521 USA

Plants＇ developmental plasticity plays a pivotal role in responding to environmental conditions. One of the most plastic plant organs is the root system. Different environmental stimuli such as nutrients and water deficiency may induce lateral root formation to compensate for a low level of water and/or nutrients. It has been shown that the hor- mone auxin tunes lateral root development and components for its signaling pathway have been identified. Using chemi- cal biology, we discovered an Arabidopsis thaliana lateral root formation mechanism that is independent of the auxin receptor SCFTM. The bioactive compound Sortin2 increased lateral root occurrence by acting upstream from the morpho- logical marker of lateral root primordium formation, the mitotic activity. The compound did not display auxin activity. At the cellular level, Sortin2 accelerated endosomal trafficking, resulting in increased trafficking of plasma membrane recy- cling proteins to the vacuole. Sortin2 affected Late endosome/PVC/MVB trafficking and morphology. Combining Sortin2 with well-known drugs showed that endocytic trafficking of Late E/PVC/MVB towards the vacuole is pivotal for Sortin2- induced SCFTm-independent lateral root initiation. Our results revealed a distinctive role for endosomal trafficking in the promotion of lateral root formation via a process that does not rely on the auxin receptor complex SCFTM.

关键词： lateral root development endocytic trafficking Sortin2 endosomes Arabidopsis.

Phase-field modeling of fracture for quasi-brittle materials

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Underground Space 2019年第1期4卷 10-21页

作者： Jacinto Ulloa patricio Rodríguez Cristóbal Samaniego Esteban Samaniego Department of Civil Engineering Katholieke Universiteit LeuvenB-3001 LeuvenBelgium Departamento de Recursos Hídricos y Ciencias Ambientales Universidad de CuencaCuenca 010151Ecuador Universidad de Cuenca Cuenca 010151Ecuador Institut für Kontinuumsmechanik Leibniz Universität HannoverHannover 30167Germany Inria Bordeaux-Sud-Ouest Research Center 200 Avenue de la Vieille TourTalence 33405France Facultad de Ingeniería Universidad de CuencaEcuador

This paper addresses the modeling of fracture in quasi-brittle materials using a phase-field approach to the description of crack *** the computational mechanics community,several studies have treated the issue of modeling fracture using phase *** of these studies have used an approach that implies the lack of a damage *** herein explore an alternative model that includes a damage threshold and study how it compares with the most popular *** formulation is systematically explained within a rigorous variational ***,we present the corresponding three-dimensional finite element discretization that leads to a straightforward numerical *** simulations in two dimensions and three dimensions are then *** results show that while an elastic stage and a damage threshold are ensured by the present model,good agreement with the results reported in the literature can be obtained,where such features are generally absent.

关键词： Quasi-brittle materials Fracture Variational formulation Phase fields Gradient damage

Weighted binary relations involving core-EP inverse

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Frontiers of Mathematics in China 2020年第4期15卷 685-699页

作者： Yuefeng GAO Jianlong CHEN Pedro patricio College of Science University of Shanghai for Science and TechnologyShanghai 200093China School of Mathematics Southeast UniversityNanjing 210096China CMAT-Centro de Matematica Universidade do MinhoBraga 4710-057Portugal

We study a new binary relation defined on the set of rectangular complex matrices involving the weighted core-EP inverse and give its *** relation becomes a ***,one-sided preorders associated to the weighted core-EP i... 详细信息

关键词： Weighted core-EP inverse core-EP inverse pseudo core inverse pre-order

Effect of a single dose of malathion on spermatogenesisin mice

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Asian Journal of Andrology 2003年第2期5卷 105-107页

作者： Eduardo Bustos-Obregón patricio González-Hormazabal Biology of Reproduction Unit Program of Morphology ICBM Faculty of Medicine University of Chile Santiago ChileBiology of Reproduction Unit Program of Morphology ICBM Faculty of Medicine University of Chile Santiago Chile

Aim: To observe the acute effect of the organophosphorous insecticide malathion on testicular function in mice. Methods: The effects of a single dose of malathion [240 mg/kg (1/12 LD50)] on plasma acetylcholinesterase (ACE) activity, spermatozoa (epididymal cauda counts and teratozoospermia), testis and plasma testosterone concentration) were evaluated at day 1,8, 16, 35 and 40 after treatment. Results: The sperm count was decreased significantly 24 h after treatment and teratozoospermia was increased at day 35 and 40. The height of the seminiferous epithelium and the diameter of tubular lumen were decreased at day 8. The percentage of tubular blockade was increased between day 8 and 35. A decrease in testosterone plasma level was observed at day 16 after treatment. Conclusion: Malathion damages male reproduction. The depletion of seminiferous tubules and the increase in teratozoospermia may be a genotoxic damage to the renewing spermatogonia, but the possibility of spermatogenic/ spermiogenic disfunction due to a decrease in the plasma testosterone level can not be ruled out.

关键词： testicular toxin malathion seminiferous tubule testosterone

Immediate bail-out Tap-stenting for the treatment of iatrogenic aortocoronary dissection involving left main bifurcation

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Journal of Geriatric Cardiology 2013年第2期10卷 202-204页

作者： Edmundo patricio Lopes Lao Shao-Ping Nie Chang-Sheng Ma Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Iatrogenic aortocoronary dissection is a rare but potentially disastrous complication of percutaneous coronary intervention. The left main dissection extending into distal bifurcation involving both the left anterior descending and left circumflex is a complex and vital complication, which is classified as Eshtehardi Type II dissection. We presented a case of iatrogenic left main coronary artery dissection with upcoming closure of both major branches, which was successfully managed by immediate bail-out Tap-stenting. The 77-year-old patient was discharged without any complication, and 1-year follow-up indicated stent patency and favorable clinical result. Immediate bail-out stenting is a feasible and reasonable initial management for this lethal complication.

关键词： Aorta Bail-out stenting Coronary artery Dissection Percutaneous coronary intervention

Role of Salmonella enterica exposure in Chilean Crohn's disease patients

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World Journal of Gastroenterology 2013年第35期19卷 5855-5862页

作者： Manuel Alvarez-Lobos Daniela P Pizarro Christian E Palavecino Abner Espinoza Valentina P Sebastián Juan C Alvarado patricio Ibaez Carlos Quintana Orlando Díaz Alexis M Kalergis Susan M Bueno CAREI Group (Active Cohort Registry of Inflammatory Bowel Disease) Department of Gastroenterology Facultad de MedicinaPontificia Universidad Católica de Chile Departamento de Genética Molecular y Microbiología Facultad de Ciencias Biológicas Pontificia Universidad Católica de Chile School of Medicine Facultad de MedicinaPontificia Universidad Católica de Chile Department of Respiratory Diseases Facultad de Medicina Pontificia Universidad Católica de Chile

AIM:To study the association between exposure toSalmonella enterica(SE)and Crohn’s disease(CD)and its clinical implications in Chilean ***:Ninety-four unrelated Chilean CD patients from CAREI(Active Cohort Registry of Inflammatory Bowel Disease)presenting to a single inflammatory bowel disease(IBD)unit of a University Hospital were prospectively included in this study.A complete clinical evaluation,including smoking history,was performed at the initial visit,and all the important data of clinical evolution of CD were *** samples from these CD patients and 88 healthy sex-and agematched control subjects were analyzed for exposure to SE and for their NOD2/CARD15 gene status using the presence of anti-Salmonella lipopolysaccharide antibodies[immunoglobulin-G type(IgG)]and polymerase chain reaction(PCR),*** also evaluated exposure to SE in 90 sex-and age-matched patients without CD,but with known smoking status(30 smokers,30 non-smokers,and 30 former smokers).RESULTS:CD patients comprised 54 females and 40males,aged 35.5±15.2 years at diagnosis with a mean follow-up of 9.0±6.8 *** was inflammatory in 59 patients(62.7%),stricturing in 24(25.5%)and penetrating in 15(15.5%).Thirty cases(31.9%)had lesions in the ileum,29(30.8%)had ileocolonic lesions,32(34.0%)had colonic lesions and 23(24.4%)had perianal *** CD patients(17%)were exposed to SE compared to 15(17%)of 88 healthy control subjects(P=0.8).Thirty-one CD patients(32.9%)were smokers,and 7(7.4%)were former smokers at *** the group exposed to SE,10 of 16 patients(62.5%)were active smokers compared to 21 of 78 patients(26.9%)in the unexposed group(P=0.01).On the other hand,10 of 31 smoking patients(32%)were exposed to SE compared to 5 of 56 nonsmoking patients(9%),and one of the seven former smokers(14%)(P=0.01).In the group of 90 patients without CD,but whose smoking status was known,there was no differ-ence in exposure to SE[3 of 30 smokers(10%),5 of30 non-s

关键词： Crohn’s disease Salmonella Infection Tobacco Smoking Environmental factors

Gamification in innovation teams

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International Journal of Innovation Studies 2022年第3期6卷 156-168页

作者： Rui patricio Antonio Carrizo Moreira Francesco Zurlo UNIDCOM/IADE Unidade de Investigacao em Design e ComunicacaoAv.D.Carlos I41200-649LisboaPortugal GovcoPP and DEGEIT Department of EconomicsManagementIndustrial Engineering and TourismUniversity of AveiroAveiroPortugal INESCTEC-Institute for Systems and Computer Engineering Technology and SciencePorto4099-002Portugal Department of Design Politecnico di MilanoMilano20133Italy

The paper examines the relationship between gamification-the use of game elements in non-gaming contexts-and innovation teams *** builds on psychological and teamwork theories,arguing that gamification overcomes collaboration issues and generates multiple positive outcomes,particularly in coordination,alignment,engagement,and teams'*** research follows a qualitative theory-driven using a case study of an innovation *** conceptual model built through the findings offers valuable insights about applying gamification in innovation teams,namely:i)surprising teams with such a new and playful approach reduces stress among team members;i)rules and time constraints play a crucial role in teams'coordination by avoiding dispersion and enhancing focused *** paper provides a set of testable theoretical propositions derived from the conceptualization of gamification in the context of innovation *** supports innovation managers interested in measuring gamification outcomes in teams.

关键词： Gamification Innovation teams Outcomes Innovation management