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CIMAvax^(█)EGF vaccine therapy for non-small cell lung cancer:A weighted log-rank tests-based evaluation

Modern Chemotherapy 2013年第3期2卷 51-56页

作者： Carmen Viada Gonzalez Jean-Francois Dupuy Martha Fors López patricia lorenzo luaces Gisela González Marinello Elia Neninger Vinagera Beatriz García Verdecia Tania Crombet-Ramos Clinical Trials Department Center of Molecular ImmunologyHavanaCuba National Institute of Applied Sciences of Rennes RennesFrance National Coordinator Center of Clinical Trial HavanaCuba Hermanos Ameijeiras Hospital HavanaCuba

Time-to-event has become one of the primary endpoints of many clinical trials. Comparing treatments and therapies using time-to-event (or “survival”) data requires some care, since survival differences may occur either early or late in the follow-up period, depending on various factors such as the initial potency or the duration of efficacy of the drugs. In this work, we investigate the effect of the CIMAvax?EGF vaccine therapy on the survival of patients with non-small cell lung cancer, using stratified and unstratified weighted log-rank tests. Weighted log-rank tests are designed to identify early and late survival differences between treatments. Using these tests, we conclude that the vaccine is more efficient than the standard therapy among patients less than 60 years of age.

关键词： Log-Rank Test Fleming-Harrington Test Stratified Tests

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Stratified Cox Regression Analysis of Survival under CIMAvax^(■)EGF Vaccine

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Journal of Cancer Therapy 2013年第8期4卷 8-14页

作者： Carmen Viada Gonzalez Jean-Francois Dupuy Martha Fors López patricia lorenzo luaces Camilo Rodríguez Rodríguez Gisela González Marinello Elia Neninger Vinagera Beatriz García Verdecia Bárbara Wilkinson Brito Liana Martínez Pérez Mayelin Troche de la Concepción Tania Crombet-Ramos Center of Molecular Immunology HavanaCuba Institut National des Sciences Appliquées de Rennes RennesFrance National Coordinator Center of Clinical Trial HavanaCuba Hermanos Ameijeiras Hospital HavanaCuba

Background: The Center of Molecular Immunology (CIM) is a center in Cuba devoted to the research, development and manufacturing of biotechnological products. CIMAvax?EGF is a vaccine for the treatment of non-small cell lung cancer patients (NSCL). Purpose: The aim of this work is to evaluate the effects of some potential prognostic factors on the overall survival of patients treated with CIMAvax?EGF vaccine, based on data collected in a phase II and a phase III clinical trials. Methods: The stratified Cox regression model is used to evaluate the effects of these prognostic factors, based on separate analysis for each trial, and on the combined data from both trials. Results: Patients with Performance status 0 or 1, with IV stage of tumor and male under 60 years obtain more benefit in terms of overall survival if they receive CIMAvax?EGF. Conclusions: Vaccinated group has a better performance if patients have a performance status 0 or 1, stage IV and age under 60 years. These prognostic factors influence overall survival in a positive way for those patients that received CIMAvax?EGF.

关键词： Stratified Cox Regression Model Risk Factor Non-Small Lung Cancer Censored Data

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Ten golden rules for individualized mechanical ventilation in acute respiratory distress syndrome

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Journal of Intensive Medicine 2021年第1期1卷 42-51页

作者： Denise Battaglini Marco Sottano lorenzo Ball Chiara Robba patricia R.M.Rocco Paolo Pelosi Anesthesia and Intensive Care San Martino Policlinico HospitalIRCCS for Oncology and NeuroscienceGenoa 16132Italy Department of Medicine University of BarcelonaBarcelona 08007Spain Department of Surgical Sciences and Integrated Diagnostics University of GenoaGenoa 16126Italy Laboratory of Pulmonary Investigation Carlos Chagas Filho Institute of BiophysicsFederal University of Rio de JaneiroRio de Janeiro 21941-901Brazil

Considerable progress has been made over the last decades in the management of acute respiratory distress syndrome(ARDS).Mechanical ventilation(MV)remains the cornerstone of supportive therapy for ***-protective MV minimizes the risk of ventilator-induced lung injury(VILI)and improves *** parame-ters contribute to the risk of VILI and require careful setting including tidal volume(V_(T)),plateau pressure(P_(plat)),driving pressure(ΔP),positive end-expiratory pressure(PEEP),and respiratory *** of energy and mechanical power allows quantification of the relative contributions of various parameters(V_(T),P_(plat),ΔP,PEEP,respiratory rate,and airflow)for the individualization of MV *** use of neuromuscular blocking agents mainly in cases of severe ARDS can improve oxygenation and reduce asynchrony,although they are not known to confer a survival *** respiratory therapies such as prone positioning,inhaled nitric oxide,and extracorporeal support techniques may be adopted in specific ***,respiratory weaning protocols should also be *** on a review of recent clinical trials,we present 10 golden rules for individualized MV in ARDS management.

关键词： Acute respiratory distress syndrome(ARDS) Protective mechanical ventilation Extracorporeal CO_(2)removal(ECCO_(2)R) Extracorporeal membrane oxygenation (ECMO)

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Giant and thrombosed left ventricular aneurysm

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World Journal of Cardiology 2015年第7期7卷 431-433页

作者： Jose Alberto de Agustin Jose Juan Gomez de Diego Pedro Marcos-Alberca Jose Luis Rodrigo Carlos Almeria patricia Mahia Maria luaces Miguel Angel Garcia-Fernandez Carlos Macaya Leopoldo Perez de Isla Instituto Cardiovascular Hospital Universitario San Carlos

Left ventricular aneurysms are a frequent complication of acute extensive myocardial infarction and are most commonly located at the ventricular apex. A timely diagnosis is vital due to the serious complications that can occur,including heart failure,thromboembolism,or tachyarrhythmias. We report the case of a 78-yearold male with history of previous anterior myocardial infarction and currently under evaluation by chronic heart failure. Transthoracic echocardiogram revealed a huge thrombosed and calcified anteroapical left ventricular aneurysm. Coronary angiography demonstrated that the left anterior descending artery was chronically occluded,and revealed a big and spherical mass with calcified borders in the left hemithorax. Left ventriculogram confirmed that this spherical mass was a giant calcified left ventricular aneurysm,causing very severe left ventricular systolic dysfunction. The patient underwent cardioverter-defibrillator implantation for primary prevention.

关键词： Myocardial infarction Echocardiography Coronary artery disease Left ventricular aneurysm Coronary angiography

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