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Effect of gestational protein restriction on left ventricle hypertrophy and heart angiotensin II signaling pathway in adult offspring rats

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Health 2013年第4期5卷 78-84页

作者： Renan Brisolla da Silva Flavia Fernandes Mesquita Marilia Andreo Heloisa Balan Assalin Jose Antonio Rocha Gontijo patricia aline boer Fetal Programming Laboratory Department of MorphologyBotucatu Bioscience InstituteUNESP-Sao Paulo State UniversityBotucatuBrazil Hydro-Saline Metabolism Laboratory Internal Medicine DepartmentFaculty of Medical SciencesState University of CampinasCampinasBrazil

Maternal protein restriction may be a risk factor for cardiovascular disorders in adulthood. The RAS (renin-angiotensin-system) plays a pivotal role in cardiac remodeling. Components of the RAS, including angiotensin II (AngII) and its receptors type 1 (AT1R) and 2 (AT2R) are expressed in the heart. This study investigates whether gestational protein restriction alters the expression and localization of AT1R and AT2R and RAS signaling pathway proteins in parallel with left ventricle hypertrophy and systemic hypertension in male offspring. Dams were kept on normal (NP, 17% protein) or low (LP, 6% protein) protein diet during pregnancy. Systolic blood pressure (SBP) of male offspring was measured from the 8th to 16th week and left ventricles of 16-wk-old rats were processed for histology, morphometric, immunoblotting and immunohistochemistry. LP offspring showed a significant reduction in birth body weight and SBP increased significantly from the 8th week. Left ventricle mass and cardiomyocytes area were also significantly higher in LP animals. Widespread perivascular fibrosis was not detected in the heart tissue. Analysis by immunoblotting and immunohistochemistry demonstrated a significant enhance in cardiomyocyte expression of AT1R and ERK1 in LP offspring. Expression of PI3K in LP was significantly reduced in cardiomyocytes and in the intramural coronary wall, while AT2R expression was unchanged in the NP group. We also found reduced LP expression of JAK2 and STAT3. In conclusion, our data also suggest that changes in the RAS may play a role in the ventricular growth through upregulation of the AT1-mediated ERK1/2 response, despite unchanged AT2R expression.

关键词： Low Birth Weight Arterial Hypertension Fetal Programming Protein Restriction Angiotensin II Left Ventricle Hypertrophy Cardiovascular Disease

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A dahlia flower extract has antidiabetic properties by improving insulin function in the brain

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Life Metabolism 2023年第4期2卷 39-50页

作者： Dominik Pretz Philip M.Heyward Jeremy Krebs Joel Gruchot Charles Barter Pat Silcock Nerida Downes Mohammed Zubair Rizwan Alisa Boucsein Julia Bender Elaine J.Burgess Geke aline boer Pramuk Keerthisinghe Nigel B.Perry Alexander Tups Centre for Neuroendocrinology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Department of Physiology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Maurice Wilkins Centre for Molecular Biodiscovery University of AucklandAuckland 1010New Zealand Department of Medicine University of OtagoWellingtonWellington South 6242New Zealand Centre for Endocrine Diabetes and Obesity Research Wellington Regional HospitalNewtownWellington 6021New Zealand Product Development Research Centre University of OtagoDunedin 9054New Zealand Department of Chemistry The New Zealand Institute for Plant and Food ResearchUniversity of OtagoDunedin 9054New Zealand

Butein,a rare chalcone found in the toxic plant Toxicodendron vernicifluum,has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta(IKKβ)/nuclear factor kappa B(NF-κB)pathway in the ***,we investigated whether the nonpoisonous plant Dahlia pinnata could be a source of butein as a potential treatment for type 2 diabetes(T2D).In mice fed a high-fat diet(HFD)to induce glucose intolerance,an oral *** petal extract improved glucose tolerance at doses of 3.3 mg/kg body weight and 10 mg/kg body ***,this effect was not mediated by butein alone but by butein combined with the closely related flavonoids,sulfuretin and/or ***,the extract improved systemic insulin *** of phosphatidylinositol 3-kinase to block insulin signaling in the brain abrogated the glucoregulatory effect of the orally administered *** extract reinstated central insulin signaling and normalized astrogliosis in the hypothalamus of HFD-fed *** NF-κB reporter zebrafish to determine IKKβ/NF-κB activity,a potent anti-inflammatory action of the extract was found.A randomized controlled crossover clinical trial on participants with predia-betes or T2D confirmed the safety and efficacy of the extract in *** conclusion,we identified an extract from the flower petals of *** as a novel treatment option for T2D,potentially targeting the central regulation of glucose homeostasis as a root cause of the disease.

关键词： inflammation hypothalamus signal transduction neuroendocrine arcuate nucleus

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酶在皮革工业中的应用综述

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西部皮革 2013年第22期 40-47页

作者： aline DETTMER patricia SCHACKER DOS ANJOS MARILIZ GUTTERRES 杜卫宁

当今皮革行业面临着新的挑战,包括改善和优化生产过程来满足皮革制品对皮革质量的要求,以及遵循环保法规的相关规定。酶处理皮革是一项非常有前途的技术。酶是有机物质,通常是蛋白质,作为一种生物催化剂能催化复杂的化学反应。酶广泛应... 详细信息

当今皮革行业面临着新的挑战,包括改善和优化生产过程来满足皮革制品对皮革质量的要求,以及遵循环保法规的相关规定。酶处理皮革是一项非常有前途的技术。酶是有机物质,通常是蛋白质,作为一种生物催化剂能催化复杂的化学反应。酶广泛应用于洗涤剂、食品、医药、精细化工等行业。通常,理想的酶源是微生物。一些研究报导酶用于皮革生产的不同阶段,能够减少在脱毛和浸灰过程中化学品的使用,甚至有报导称酶可以完全替代化学品。一些学者将酶用于染浴过程中来提高染料吸收率和用于鞣制过程来提高鞣制效率。一种新酶的鉴定是一个漫长的过程,需要筛选和分离出符合特定条件的新细菌,并且掌握所选微生物生长所需的营养和其他必要条件。酶应用于制革生产过程中,相关参数如pH、温度和产物对酶的抑制作用等影响,应该做进一步的研究。

关键词：碱性蛋白酶化学品细菌皮革加工微生物变性(病理) 蛋白质变性顺式-4-羟基-L-脯氨酸羟脯氨酸营养物质非竞争性抑制剂浸灰

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社区75—85岁高危女性2年平衡训练项目预防跌倒引起受伤的效果研究：Ossébo随机对照试验

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英国医学杂志中文版 2015年第11期18卷 634-635页

作者： Fabiemle EL-Khoury Bernard Cassou Aurélien Latouche Philippe Aegerter Marie-aline Charles patricia Dargent-Molina 沈赟 Université Parls-Sud UMR-S1018 F-94807VillejuifFrance Université ParisDescartes UMR-S1153 F-75014 ParisFrance Inserm Centre de Recherche Epidémiologie et Statistique Sorbonne Paris Cité (CRESS)U1153 F-94807Villejuif France UVSQ UMR-S 1168Université VersaillesSt-Quentin-en-Yveli France Inserm VIMA :Vieillissement et Maladies ChroniquesU1168F-94807Villejuif France AP-HP H. pitalSainte PérineCentrede GérontologieF-75016 Paris France Conservatoire National des Arts et Metiers (Chain) Centre for Re.arch in Computer Science and Telecommtmications (Cédric) EA4629 Paris France Al AP-HP H. pital Ambroise Paré Unité de Recherche Clinique Département de Santé Publique Boulogne- Billancourt France 上海交通大学附属第六人民医院内分泌代谢科

目的在社区75～85岁跌倒及受伤高危风险的女性人群中，评价2年渐进式平衡训练项目对减少受伤性跌倒的效果。设计实用性、多中心、双臂、平行组、随机对照试验。背景法国16个中、大型城市中的20个研究点。参与者706名女性，年龄75—85岁... 详细信息

目的在社区75～85岁跌倒及受伤高危风险的女性人群中，评价2年渐进式平衡训练项目对减少受伤性跌倒的效果。设计实用性、多中心、双臂、平行组、随机对照试验。背景法国16个中、大型城市中的20个研究点。参与者706名女性，年龄75—85岁，居住在自己家中，维持平衡及步态的能力减退。这些女性被随机招募至试验干预组（锻炼项目，n=352）或对照组（非干预组，n=354）。

关键词：随机对照试验预防效果训练计划社区生活 OSS 平衡年龄妇女

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Factors Associated with Prolonged Poor Glycemic Control in Type 2 Diabetes Mellitus (T2DM) Patients Followed in the Department of Internal Medicine at the Yalgado Ouedraogo Teaching Hospital, Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2021年第1期11卷 1-26页

作者： Solo Traoré Oumar Guira Lassané Zoungrana Yempabou Sagna Réné Bognounou Constant B. Paré Désiré L. Dabourou Lassina Séré Daniel Zemba Laurette S. Dembélé patricia D. Somé Patrice P. C. Savadogo aline Tondé Tiéno Hervé Joseph Y. Drabo Training and Research Unit in Health Sciences Joseph Ki ZERBO University Ouagadougou Burkina Faso Department of Internal Medicine Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Higher Institute of Health Sciences/Nazi Boni University Bobo Dioulasso Burkina Faso Institute for Research in Health Sciences/National Center for Scientific and Technical Research Ouagadougou Burkina Faso Department of Internal Medicine Tengandogo Teaching Hospital Ouagadougou Burkina Faso Department of Internal Medicine Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: Achieving and maintaining glycemic targets are a challenge for health practitioners around the world. We aimed to study the factors associated with prolonged poor diabetes control in the cohort of T2DM patients monitored and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital in Ouagadougou in order to optimize therapeutic education in these patients. Methodology: This was a descriptive and analytical cross-sectional study combining retrospective data collection from the last year of patient follow-up and prospective collection of some information. The study included all diabetic patients, aged at least 18 years old, followed and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital between January 1, 2010 and December 31, 2018 following a systematic random sampling with a sampling step of 10. The variables collected were sociodemographic, anthropometric, lifestyle, cardiovascular risk factors and diabetes-related characteristics. To determine the risk factors associated with prolonged poor glycemic control, we performed modeling using logistic regression. All variables associated with prolonged poor glycemic control, in bivariate logistic regression with a p-value less than 0.20 were included in the full model. Later, we used a stepwise descending method to obtain the final model, which was then tested by a receiver operating characteristic (ROC) curve. The significance threshold was set at 5%. Raw and fitted Odds-Ratio (OR) and 95% confidence interval were presented. Results: 270 patients were included. Prolonged poor control of diabetes mellitus was observed in 73.70%. The mean age was 55.97 years (SD: ±11.52) and the sex ratio was 0.6 in favor of female. The mean time since diabetes mellitus diagnoses was 5.85 years (SD: ±5.15). A monthly ga

关键词： Type 2 Diabetes Mellitus Prolonged Poor Control Prevalence Associated Factors Burkina Faso

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Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

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Journal of Biomaterials and Nanobiotechnology 2011年第3期2卷 318-328页

作者： patricia C.Salgado Plinio C.Sathler Helena C.Castro Gutemberg G.Alves aline M.de Oliveira Rodrigo Cde Oliveira Monica D.C.Maia Carlos R.Rodrigues Paulo G.Coelho Andre Fuly Lúcio M.Cabral Jose M.Granjeiro Program of Post-Graduation in Medical Sciences Fluminense Federal UniversityNiteróiBrazil Post-Graduation in Biology of Interactions Institute of BiologyFluminense Federal UniversityNiteróiBrazil Program of Post-Graduation in Pathology Fluminense Federal UniversityNiteróiBrazil Clinical Research Unit Antonio Pedro HospitalNucleus of Cell TherapyFluminense Federal UniversityNiteróiBrazil School of Odontology Fluminense Federal UniversityNiteróiBrazil Department of Biological Sciences Dental School of BauruSão Paulo UniversitySão PauloBrazil School of Pharmacy Federal University of Rio de JaneiroRio de JaneiroBrazil Department of Biomaterials and Biomimetics New York UniversityNew YorkUSA

Presently, several different graft materials are employed in regenerative or corrective bone surgery. However current misconceptions about these biomaterials, their use and risks may compromise their correct application and development. To unveil these misconceptions, this work briefly reviewed concepts about bone remodeling, grafts classification and manufacturing processes, with a special focus on calcium phosphate materials as an example of a current employed biomaterial. Thus a search on the last decade was performed in Medline, LILACS, Scielo and other scientific electronic libraries using as keywords biomaterials, bone remodeling, regeneration, biocompatible materials, hydroxyapatite and therapeutic risks. Our search showed not only an accelerated biotechnological development that brought significant advances to biomaterials use on bone remodeling treatments but also several therapeutic risks that should not be ignored. The biomaterials specificity and limitations to clinical application point to the current need for developing safer products with better interactions with the biological microenvironments.

关键词： Biocompatible materials Bone remodeling Hydroxyapatite Therapeutic risks

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Concentrations of Silver Nitrate in the In Vitro Development and Conservation of Passiflora gibertii ***

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American Journal of Plant Sciences 2017年第12期8卷 2944-2955页

作者： Gláucia Amorim Faria Lucas Menezes Felizardo Antonio Flávio Arruda Ferreira Paula Suares Rocha aline Namie Suzuki Antonio da Silva Souza Tatiana Góes Junghans Maria Angélica Pereira de Carvalho Costa Ana patricia Bastos Peixoto Augusto Ramalho de Morais Beatriz Garcia Lopes Tiago Almeida de Oliveira Departmentof Mathematics School of EngineeringSao Paulo State University(Unesp)Ilha SolteiraBrazil Department of Civil Engineering School of EngineeringSao Paulo State University(Unesp)Ilha SolteiraBrazil Laboratory of Environmental Mutagenesis Institute of BiosciencesSao Paulo State University(Unesp)Rio ClaroBrazil Embrapa Cassava and Fruticulture Cruz das AlmasBrazil Center for Agrarian Biological and Environmental SciencesFederal University of the Recôncavo of Bahia(UFRB)Cruz das AlmasBrazil Department of Statistics State University of Paraíba(UEPB)Campina GrandeBrazil Department of Exact Sciences Federal University of Lavras(UFLA)LavrasBrazil

The aim of this study was to evaluate the effects of silver nitrate in the in vitro development and conservation of passion fruit plants. Experiments were carried out at the Laboratory of Culture and Tissues, in the National Cassava and Fruits Research Center (EMBRAPA), using microcuttings of Passiflora gibertii N. E. Br., previously cultivated in vitro. The microcuttings were placed in MS media supplemented with silver nitrate at concentrations of 0, 1, 2, 4 and 8 mg·L-1, and, during 30, 60 and 90 days, the following variables were identified: Shooting length (cm), number of roots, number and coloration of leaves. A completely randomized design with 30 replications in a split-plot scheme was employed. Polynomial regression equations were adjusted in analysis of variance to compare averages of treatments. The obtained results support the assumption of high sensitivity of passion fruit tissues to ethylene, which reflects in the lost of vigor and in the induction of culture senescence by its accumulation. Based on obtained results, and in order to mitigate this problem, it is possible to indicate an addition of 2 mg·L-1?of silver nitrate in culture media, for the micropropagation of passion fruit plant, allowing the controlling of the atmosphere inside the culture test tubes, during the establishment of explants and other steps of the process.

关键词： Passion Fruits Tropical Fruits Plant Propagation Reduced Growth Ethylene

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音乐屋——奥尔堡创意中心

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城市环境设计 2020年第4期126卷 174-185页

作者：沃尔夫·狄·普瑞克斯 Marcelo Bernardi Jesper Bork Bo Stjerne Hansen Roberta Jiraschek Daniel Krüger Carsten Laursen Martin Oberascher Florian Pfeifer Robert Pippan Marita Schnepper Sigrid Svensson Eva Wolf Carola B?ker Moa Carlson Isak Foged Annina G?hwiler patricia Gola Robin Heather Per Kruse Win Man Ruth Mandl aline Müller Tenna Olsen Anke Pasolt Annemarie Pedersen Eva Ravnborg Carolin Schmitz-Remberg Tim Seidl Guro Sollid Michele Zanella Jan-Ruben Fischer Markus Pillhofer Markus Baumann Robin Heather Anja Sorger Bo Stjerne Thomsen Anna Wasserthal Philip Wilck Blaine Lepp Talya Kozminsky Hannes Walzl Morten Grau Jensen Stephanie Neufeld Tyler Bornstein Laura Githa Julia G?rtner Jenny Draxlbauer Duccio Malagamba Martin Schubert

项目大事记/CHRONOLOGY竞赛（第一名）/Competition （1st Place）:2003一期规划设计/Layout Planning Ho M I:2003—2005项目延期/Postponement of the Project:2006—2007二期规划设计/Start of Layout Planning Ho M II:2008二期动工/Start of Construction Ho M II:2010二期竣工/Completion Ho M II:2014项目参数/PROJECT DATA建筑净面积/Net Floor Area:17 637m2建筑毛面积/Gross Floor Area:20 257m2音乐厅/Concert Hall:1 298座/1 289 Seats

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