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The best of both worlds:mastering nerve regeneration combining biological and nanotechnological tools

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Neural Regeneration Research 2023年第3期18卷 556-557页

作者： Paula A.Soto Marcela B.Fernández van Raap C.patricia Setton-Avruj Departamento de Química Biológica Cátedra de Química Biológica PatológicaUniversidad de Buenos AiresFacultad de Farmacia y BioquímicaInstituto de Química y Fisicoquímica Biológicas(IQUIFIB)Universidad de Buenos AiresBuenos AiresArgentina Departamento de Física Universidad Nacional de La Plata(UNLP)Facultad de Ciencias ExactasLa PlataArgentinaLaboratorio de BiotecnologíaUniversidad ORT UruguayMontevideoUruguay

Over the last decade,remarkable developments in nanotechnology have powered medical research,unveiling new approaches for the solution of public health issues such as the treatment of traumatic peripheral neuropathies.

关键词： traumatic technological treatment

Ultrastructural changes and asthenozoospermia in murine spermatozoa lacking the ribosomal protein L29/HIP gene

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Asian Journal of Andrology 2014年第6期16卷 925-926页

作者： Rolands G Aravindan Catherine B Kirn-Safran Michelle A Smith patricia A Martin-DeLeon Department of Biological Sciences University of Delaware NewarkDE 19716 USA.

Dear Editor, We present here the first report linking a specific gene, ribosomal protein L29 （Rp129）, also known as Hip （heparin/heparan sulfate interacting protein）, to the mammalian sperm flagellar morphological anomaly termed the ＂dag＂ defect. In addition, we show that loss of Rp/29 invariably results in low sperm motility with infertility accompanying this abnormality.

关键词： EXPRESSION HIP/RPL29 MICE

Detection of tumor stem cell markers in pancreatic carcinoma cell lines

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 92-97页

作者： Monika Olempska patricia Alice Eisenach Ole Ammerpohl Hendrik Ungefroren Fred Fandrich Holger Kalthoff Department of General and Thoracic Surgery University Hospital Schleswig-Holstein Campus Kiel Arnold Heller Str. 7 24 105 Kiel Germany

BACKGROUND: Cancer of the pancreas is the fourth leading cause of cancer death in industrialized countries. In malignancy, actively proliferating cells may be effectively targeted and killed by anti-cancer therapies, but stem cells may survive and support re-growth of the tumor. Thus, new strategies for the treatment of cancer clearly will also have to target cancer stem cells. The goal of the present study was to determine whether pancreatic carcinoma cell growth may be driven by a subpopulation of cancer stem cells. Because previous data implicated ABCG2 and CD133 as stem cell markers in hematopoietic and neural stem/progenitor cells, we analyzed the expression of these two proteins in pancreatic carcinoma cell lines. METHODS: Five established pancreatic adenocarcinoma cell lines were analyzed. Total RNA was isolated and real- time RT-PCR was performed to determine the expression of ABCG2 and CD133. Surface expression of ABCG2 and CD133 was analyzed by flow cytometric analysis. RESULTS: All pancreatic carcinoma cell lines tested expressed significantly higher levels of ABCG2 than non-malignant fibroblasts or two other malignant non- pancreatic cell lines, i.e., SaOS2 osteosarcoma and SKOV3 ovarian cancer. Elevated CD133 expression was found in two out of five pancreatic carcinoma cell lines tested. Using flow cytometric analysis we confirmed surface expression of ABCG2 in all five lines. Yet, CD133 surface expression was detectable in the two cell lines, A818-6 and PancTu1, which exhibited higher mRNA ***: Two stem cell markers, ABCG2 and CD133 are expressed in pancreatic carcinoma cell lines. ABCG2 and/or CD133 positive cells may represent subpopulation of putative cancer stem cells also in this malignancy. Because cancer stem cells are thought to be responsible for tumor initiation and its recurrence after an initial response to chemotherapy, they may be a very promising target for new drug developments.

关键词： pancreatic adenocarcinoma cancer stem cells stem cell markers ABCG2 CD133

Fluxes of water,sediments,and biogeochemical compounds in salt marshes

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Ecological Processes 2013年第1期2卷 26-41页

作者： Sergio Fagherazzi patricia L Wiberg Stijn Temmerman Eric Struyf Yong Zhao Peter A Raymond Department of Earth and environment Boston UniversityBostonMAUSA. Department of environmental Sciences University of VirginiaCharlottesvilleVAUSA. Department of Biology Ecosystem ManagementresearchgroupUniversity of AntwerpenAntwerpenBelgium School of Forestry&environmental Studies Yale UniversityNew HavenCTUSA.

Tidal oscillations systematically flood salt marshes,transporting water,sediments,organic matter,and biogeochemical elements such as *** we present a review of recent studies on these fluxes and their effects on both ecosystem functioning and morphological evolution of salt *** reexamine a simplified model for the computation of water fluxes in salt marshes that captures the asymmetry in discharge between flood and *** discuss the role of storm conditions on sediment fluxes both in tidal channels and on the marsh *** present recent methods and field instruments for the measurement of fluxes of organic *** methods will provide long-term data sets with fine temporal resolution that will help scientists to close the carbon budget in salt ***,the main processes controlling fluxes of biogenic and dissolved silica in salt marshes are explained,with particular emphasis on the uptake by marsh macrophytes and diatoms.

关键词： flood tidal storm

Prepulse inhibition (PPI) of tactile startle response in recombinant congenic strains of mice:QTL mapping and comparison with acoustic PPI

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Journal of Genetics and Genomics 2008年第3期35卷 139-151页

作者： Adam Torkamanzehi patricia Boksa Ridha Joober University of Sistan and Baluchestan Douglas Hospital Research Centre

Prepulse inhibition （PPI） of the startle response is a psychophysiological measure of sensorimotor gating believed to be cross-modal between different sensory systems. We analyzed the tactile startle response （TSR） and PPI of TSR （tPPI）, using light as a prepulse stimulus, in the mouse strains A/J and C57BL/6J and 36 recombinant congenic strains derived from them. Parental strains were significantly different for TSR, but were comparable for tPPI. Among the congenic strains, variation for TSR was significant in both genetic backgrounds, but that of tPPI was significant only for the C57BL/6J background. Provisional mapping for loci modulating TSR and tPPI was carried out. Using mapping data from our previous study on acoustic startle responses （ASR） and PPI of ASR （aPPI）, no common markers for aPPI and tPPI were identified. However, some markers were significantly associated with both ASR and TSR, at least in one genetic background. These results indicate cross-modal genetic regulation for the startle response but not for PPI, in these mouse strains.

关键词： tactile startle response prepulse inhibition (PPI) acoustic startle response recombinant congenic strains of mice QTL mapping microsatellite markers

“en bloc ” caudate lobe and inferior vena cava resection following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal and liver metastasis of colorectal cancer

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World Journal of Gastroenterology 2016年第46期22卷 10249-10253页

作者： patricia Sánchez-Velázquez Nicolas Moosmann Ingolf T?pel Pompiliu Piso Department of Surgery Barmherzige Brüder Krankenhaus Regensburg Department of Oncology and Hematology Barmherzige Brüder Krankenhaus Regensburg Department of Vascular Surgery Barmherzige Brüder Krankenhaus Regensburg

There are diverse protocols to manage patients with recurrent disease after primary cytoreductive surgery(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC) for peritoneal carcinomatosis. We describe a case of metachronous liver metastasis after CRS and HIPEC for colorectal cancer, successfully treated with a selective metastectomy and partial graft of the inferior vena cava. A 35-year-old female presented with a large tumour in the cecum and consequent colonic stenosis. After an emergency right colectomy, the patient received adjuvant chemotherapy. One year later she was diagnosed with peritoneal carcinomatosis, and it was decided to carry out a CRS/HIPEC. After 2 years of total remission, an isolated metachronous liver metastasis was detected by magnetic resonance imaging surveillance. The patient underwent a third procedure including a caudate lobe and partial inferior vena cava resection with a prosthetic graft interposition, achieving an R0 situation. The postoperative course was uneventful and the patient was discharged on postoperative day 17 after the liver resection. At 18-mo follow-up after the liver resection the patient remained free of recurrence. In selected patients, the option of re-operation due to recurrent disease should be discussed. Even liver resection of a metachronous metastasis and an extended vascular resection are acceptable after CRS/HIPEC and can be considered as a potential treatment option to remove all macroscopic lesions.

关键词： Cytoreductive surgery Liver resection Hyperthermic intraperitoneal chemotherapy Colorectal cancer Liver metastasis

Asymptomatic Hepadnaviral Persistence and Its Consequences in the Woodchuck Model of Occult Hepatitis B Virus Infection

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Journal of Clinical and Translational Hepatology 2015年第3期3卷 211-219页

作者： patricia M.Mulrooney-Cousins Tomasz I.Michalak Molecular Virology and Hepatology Research Group Faculty of Medicine Health Sciences Centre Memorial University St.John's NL Canada

Woodchuck hepatitis virus (WHV) is molecularly and pathogenically closely related to hepatitis B virus (HBV).Both viruses display tropism towards hepatocytes and cells of the immune system and cause similar liver pathology,where acute hepatitis can progress to chronic hepatitis and to hepatocellular carcinoma (HCC).Two forms of occult hepadnaviral persistence were identified in the woodchuck-WHV model:secondary occult infection (SOI) and primary occult infection (POI).SOI occurs after resolution of a serologically apparent infection with hepatitis or after subclinical serologically evident virus *** is caused by small amounts of virus and progresses without serological infection markers,but the virus genome and its replication are detectable in the immune system and with time in the *** can be accompanied by minimal hepatitis,while the hallmark of POI is normal liver ***,HCC develops in about 20% of animals with SOI or POI within 3 to 5 *** virus persists throughout the lifespan in both SOI and POI at serum levels rarely greater than 100 copies/mL,causes hepatitis and HCC when concentrated and administered to virus-na(i)ve *** is accompanied by virusspecific T and B cell immune responses,while only virusspecific T cells are detected in *** coincides with protection against reinfection,while POI does not and hepatitis develops after challenge with liver pathogenic doses >1000 *** SOI and POI are associated with virus DNA integration into the liver and the immune system ***,SOI and POI are two distinct forms of silent hepadnaviral persistence that share common ***,we review findings from the woodchuck model and discuss the relevant observations made in human occult HBV infection (OBI).

关键词： Hepatitis B Occult hepatitis B virus infection Woodchuck model of hepatitis B Woodchuck hepatitis virus Secondary occult infection Primary occult infection Consequences of occult hepadnaviral infection Hepatocellular carcinoma

Financial Accounting Robert Libby, patricia A. Libby & Daniel G. short 4th ed.

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Bacterial microbiome of Coptotermes curvignathus （Isoptera： Rhinotermitidae） reflects the coevolution of species and dietary pattern

2004年

作者： Robert Libby patricia A. Libby & Daniel G. short

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Insect Science 2014年第5期21卷 584-596页

作者： Jie Hung patricia King Nor Muhammad Mahadi Choon Fah Joseph Bong Kian Huat Ong Osman Hassan Faculty of Agriculture and Food Sciences Universiti Putra Malaysia Bintulu Sarawak Campus Sarawak Malaysia Genome Institute Jalan Bangi Lama 43000 Kajang Faculty of Science and Technology UniversiU Kebangsaan Malaysia 43600 UKM BangiSelangor Malaysia

Coptotermes curvignathus Holmgren is capable of feeding on living trees. This ability is attributed to their effective digestive system that is furnished by the termite＇s own cellulolytic enzymes and cooperative enzymes produced by their gut microbes. In this study, the identity of an array of diverse microbes residing in the gut of C. curvignathus was revealed by sequencing the near-full-length 16S rRNA genes. A total of 154 bacterial phylotypes were found. The Bacteroidetes was the most abundant phylum and accounted for about 65% of the gut microbial profile. This is followed by Firmicutes, Actinobacteria, Spirochetes, Proteobacteria, TM7, Deferribacteres, Planctomycetes, Ferrucomicrobia, and Termite Group 1. Based on the phylogenetic study, this symbiosis can be a result of long coevolution of gut enterotypes with the phylogenic distribution, strong selection pressure in the gut, and other speculative pressures that determine bacterial biome to follow. The phylogenetic distribution of cloned rRNA genes in the bacterial domain that was considerably different from other termite reflects the strong selection pressures in the gut where a proportional composition of gut microbiome of C. curvignathus has established. The selection pressures could be linked to the unique diet preference of C. curvignathus that profoundly feeds on living trees. The delicate gut microbiome composition may provide available nutrients to the host as well as potential protection against opportunistic pathogen.

关键词： Coptotermes curvignathus diet preference gut microbiome selection