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Food Science and Human Wellness 2024年第6期13卷 3083-3094页

作者： Guillermo Santos-Sánchez Ana IsabelÁlvarez-López Eduardo Ponce-España patricia judith lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro Instituto de Biomedicina de Sevilla Instituto de Biomedicina de Sevilla(IbiS)Hospital Universitario Virgen del RocíoConsejo Superior de Investigaciones Científi cas(CSIC)Universidad de SevillaSeville 41013Spain Departamento de Bioquímica Médica y Biología Molecular e Inmunología Facultad de MedicinaUniversidad de SevillaSeville 41009Spain

Cardiovascular diseases(CVDs)are the leading global cause of mortality and disease *** are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent *** biochemical mechanism of statins consists of competitive inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme(HMG-CoAR),the limiting enzyme in cholesterol *** to statin intolerance in some patient groups,the search for new inhibitors is a field of great *** review focusses on the studies reporting the inhibitory effect of protein hydrolysates and biopeptides on the HMG-CoAR enzyme *** analysis of the action mechanism and physicochemical characteristics of the HMG-CoAR inhibitory peptides revealed that the molecular weight,amino acid composition,charge,and polarity are key aspects of the interaction with the HMG-CoAR *** conclusion,this review reveals the potential of using food peptides as new cholesterol-lowering agents and opens a new interesting field of ***,clinical approaches are mandatory to confirm their therapeutic hypercholesterolemic effect.

关键词： Functional foods Cholesterol Cardiovascular diseases Statins 3-Hydroxy-3-methylglutaryl-coenzyme A

The Efficient Role of Dermestes in Damage of Fish in Bangui (Central African Republic)

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Advances in Entomology 2015年第3期3卷 111-117页

作者： Bolevane-Ouantinam Serge Florent Aba-Toumnou Lucie Gondi Armelle judith Wango Solange patricia Zinga Innocent Namkosséréna Salomon Lakouèténé Didier Ponel-Béranger Kongueret Ernest Semballa Silla Laboratory of Applied Animal Biology and Biodiversity University of Bangui Bangui Central African Republic Laboratory of Biological and Agronomical Sciences for Development Bangui Central African Republic Regional Pole of Applied Research to Development Farming Systems in Central Africa (PRASAC) Djamena Chad Central African Republic Institute of Agronomical researches (ICRA) Bangui Central African Republic

A bad conservation of food is recognized as being one of the critical constraints upon food security among resource poor population across Africa. We have evaluated the traditional management of pests in fish in Central African Republic. The data were analyzed by a factor analysis of correspondence. The Group I contained sensitive species of fish to the attacks of Dermetes frishii, Dermetes lardarius and Dermestes carnivorus. There were: Labeocoubie, Mormyrus deliciosus, Polydactylus quadrifilis, Auchenoglanis occidentalis, Synodontis nigrita, Hydrocynus forskalli, Districhodus rostratus, Hydrocynus goliath and Mormyrusrume. The group II contained sensitive species of fishes to the attacks of D. maculatus. There were: Cyprinus carpio, Malapterurus electricus, Oreochromis mossambicus, Barbus occidentalis and Oreochromis mossambicus. Clariasgariecilus is the mostsensitive of dried fish to the attacks of Dermestes. Oreochromis mossambicus, Mormyrusrume and Synodontis nigrita are the last sensitive of dried fish to the attacks of Dermestes. The results showed that the tradictional management of dried fish in Central African Republic couldn’t be efficient for reducing the development of Dermestes.

关键词： Traditonal Management Pests Dried Fish

Large Conventional Osteosarcoma of the Proximal Humerus in a 13-Year-Old Child: Case Report

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Open Journal of Pediatrics 2024年第2期14卷 297-304页

作者： Lucienne Irène patricia Ondima Rhodia Hélène Bosseba Missengue Cardinale Princilia Okiemy Niendet Nuptia Erica Akobande Jean Claude Mieret Caryne Mboutol-Mandavo Redy Atipo Galloye judith Nsondé Malanda Jennifer Mave Sirimé Ngandzo Fabien Mouamba Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Paediatric Surgery Department Brazzaville University Hospital Centre Brazzaville Congo Department of General Surgery Brazzaville University Hospital Centre Brazzaville Congo Carcinology Department Brazzaville University Hospital Centre Brazzaville Congo Anatomo-Pathology Laboratory Brazzaville University Hospital Centre Brazzaville Congo

Introduction: Osteosarcoma is the most common primary malignant bone tumor in children. It is highly aggressive and has a poor prognosis. A late presentation modifies and makes difficult the management affecting the survival of children. We report the case of a large conventional osteosarcoma in a 13-year-old girl. Case Presentation: Adolescent girl admitted for painful swelling of the left shoulder with absolute functional impotence of the thoracic limb and severe anemia. The painful swelling was thought to have been caused by a minor trauma that had occurred six months previously. The patient’s general condition was poor, and she presented with a large, shiny, painful mass over the shoulder and upper 2/3 of the left arm, measuring 28 cm long by 28 cm wide and 57 cm in circumference, and a large fistulous axillary adenopathy. CT scan showed a tumour lesion of the left humerus with liver and lung metastases, raising suspicion of osteogenic osteosarcoma. The tumor was classified according to TNM staging: T2N1M1(a + b). Management was modified when uncontrolled bleeding developed. It consisted of an extended amputation of the left thoracic limb. Pathological analysis showed a high-grade conventional osteosarcoma. Quality improvement was obtained for thirty days, followed by the onset of dyspnea. The evolution was towards death at forty days post-operatively. Conclusion: Osteosarcoma is a highly aggressive cancer. Delayed treatment leads to a fatal outcome. Early diagnosis is one of the challenges to be met in order to improve survival.

关键词： Osteosarcoma Child Conventional Case Report

Seroprevalence study of infection with influenza A(H1N1)pdm09 virus in San Felipe Town, Chile

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World Journal of Cardiovascular Diseases 2013年第7期3卷 476-482页

作者： Olea Andrea Fasce Rodrigo Aguilera Ximena Oliva Otavio Munoz Sergio Garcia Maritza Pedroni Elena Najera Manuel Guerrero Andrea Bustos patricia Mora judith Vega Jeanette Cerda Jaime Abarca Katia McCarron Meg Widdowson Marc-Alain Castillo Ernesto Alvarado Sergio Quijada Sandra Gallegos Doris Gonzalez Claudia Center of Epidemiology and Health Policies Department Faculty of MedicineUniversidad del DesarrolloConcepcionChile Section of Respiratory and Exanthematous viruses Sub-Department of Clinical VirologyInstitute of Public HealthMinistry of HealthSantiagoChile Center of Epidemiology and Health Policies of the Universidad del Desarrollo ConcepcionChile Panamerican Health Organization Washington DCUSA Public Health Department and Pediatrics Division Faculty of MedicinePontifical Catholic University of ChileSantiagoChile Centers for Diseases Control and Prevention AtlantaUSA Center for Micro Data Economics DepartmentUniversity of ChileSantiagoChile Epidemiology and Health Policies Department Universidad del DesarrolloConcepcionChile

Objective: To know the natural history of the first wave of pandemic influenza A(H1N1)pdm09 in the Southern hemisphere, through the detection of antibodies against influenza A(H1N1)pdm09 in a selected community, to estimate the population attack rate and its variations, the consultation rates, hospitallization and mortality rates. Methodology: A representative random sample of the population of a commune in Chile (San Felipe) was interviewed and taken blood samples between January and March 2010. A study against the antibodies of the influenza A(H1N1) pdm09 virus was conducted, by the technique of the Hemaglutination Inhibition (HAI) according to standardized methodology. Subjects with antibody titers ≥1:40 were considered positive. Results: 13.5% of the population of San Felipe had antibodies against influenza A(H1N1)pdm09;this percentage reached 30% of the population between 0 and 18 years and 6.1% among those over 19 years. The age variable was the only factor that evidenced significant differences in the prevalence of antibodies. There were no significant differences related to gender, vaccination history against seasonal inluenza, or comorbidity. 51% of people with positive serology showed IN-FLUENZA-LIKE SYMPTOMS. Conclusions: A relevant percentage of subclinical disease was detected in the first pandemic wave in Chile and the proportion of people with SARI and deaths was small. Data from epidemiological surveillance were useful to estimate the trend of TSI but not its magnitude.

关键词： Influenza A(H1N1)pdm09 Influenza Seroprevalence

Mexican Guidelines for the Diagnosis and Treatment of Chronic Myeloid Leukaemia

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Journal of Cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo Cervera Federico Godínez Rosa Sosa Ramón Rivas Carlos Best Juan Hernández Adrián Morales Hugo Zurita Ivette Carrasco Jorge Cruz álvaro Aguayo José Espinoza Juan Labardini Luis Valero judith Cruz Diana Arcos Diego Limón Omar López-Navarro Daniela Gordillo-Bastidas Myrna Candelaria Francisco Torres Juan Kassack Oscar de Jesús Pérez Ramírez Jorge Aquino Guillermo Díaz Mariela Cardiel Margarita Rodríguez patricia Montoya Juan Contreras María Chávez Sandra Chávez David Gómez Olga Cantú Jorge Duque Luis Pita Eduardo Lobato Julio López Antonio López Pedro González Jorge Cortés Haematology and Oncology Department National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haematology Deparment from Hospital Juárez Mexico City Mexico Haematology Department Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haematology Department Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico 2Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Haematology Department Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haematology Department General Hospital of Sonora State Sonora Mexico Haematology Department Hospital Universitario UANL Monterrey Mexico Haematology Haematology Service Hospital General Regional SSG León Mexico Haematology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haematology Hospital “Aranda de la Parra” León Mexico Haematology Hospital General de Especialidades Campeche Mexico Haematology Hospital General de México Mexico City Mexico Haematology Hospital General de Occidente SSA Guadalajara Mexico Haematology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haematology Mérida Clinic Yucatán Mexico Haematology Oncology Unit SSEP Puebla Mexico Hospital Betania Puebla Mexico Hospital of the Poblano Child Puebla Mexico Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Leukaemias Clinic at ISSEMyM Toluca Mexico Leukemia Department MD Anderson Cancer Center Houston Mexico Los Mochis General Hospital Sinaloa Mexico Renaissance Clinic Morelia Mexico State Council for AIDS Prevention and Control Chihuahua Mexico Universidad Autónoma de Yucatán Mérida Mexico

Background: This document includes recommendations and guidelines issued by a group of Mexican researchers and specialists gathered in the First National Colloquium for the Diagnosis and Management of Chronic Myeloid Leukaemia (CML) by initiative of Instituto Nacional de Cancerología and with the support of the Leukaemia Department of the MD Anderson Cancer Center. Mexico lacks of updated information taken from its own reality on the diagnosis and treatment of CML and other haematological disorders;besides, there are no national guidelines. Aim: To publish a consensus document with guidelines for the management of CML adjusted to the national environment and overall characteristics. Method: The participants answered a DELPHI questionnaire about the overall aspects of the disease, aiming to target controversial topics, discuss them in the colloquium, and to agree on the best ones. After those meetings, a final document was drawn up. Results: The group presents recommendations for definition, diagnosis, prognosis, monitoring, and treatment of CML in Mexico. Conclusions: Having consensus guidelines for the clinical management of CML in our country will enable the consensual practice of Mexican specialists regarding the clinical approach to CML, as well as optimize the resources which allow the rational planning of the medical care strategies.

关键词： Chronic Myeloid Leukaemia Management Guidelines Diagnosis Treatment.