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小鼠10号染色体上致聋突变基因hml的精确定位(英文)

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西安交通大学学报（医学版） 2004年第3期25卷 209-212,260页

作者： Belinda S Harris patricia f ward-bailey Heping Yu Roderick T Bronson Muriel T Davisson Kenneth R Johnson The Jackson Laboratory The Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson Laboratory Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA

目的　定位小鼠致聋基因 ,识别决定其性状的有关突变 ,为人类耳聋基因研究提供动物模型。方法　利用全基因组扫描来定位名为hml可致小鼠听力丧失突变基因。结果　①hml基因定位在小鼠 10号染色体上 ,距中心粒约4 3cM处。根据已知的鼠 ... 详细信息

目的　定位小鼠致聋基因 ,识别决定其性状的有关突变 ,为人类耳聋基因研究提供动物模型。方法　利用全基因组扫描来定位名为hml可致小鼠听力丧失突变基因。结果　①hml基因定位在小鼠 10号染色体上 ,距中心粒约4 3cM处。根据已知的鼠人同源同线性特点 ,提示人的同源基因位于 12 q2 2 -q2 4 ;②获得了 2 5个多态性微卫星标记 ,通过高分辨的小鼠图谱将 3个已知人类基因进行了正确排列 ,并将hml侯选基因限定在一个 5 0 0kb的区域内。

关键词：小鼠耳聋突变

food supply and the obesity scourge: Is there a relationship?

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Health 2012年第12期4卷 1457-1463页

作者： Lillian Mwanri Wendy foley John Coveney Robert Muller fiona Verity Paul R. ward patricia Carter Philip Mohr Anne Taylor Department of Social Work Flinders University Adelaide Australia Discipline of Public Health Flinders University Adelaide Australia Health Promotion Branch SA Health Adelaide Australia Inala Indigenous Health Service Queensland Health Inala Australia Population Research and Outcome Studies Unit SA Health Adelaide Australia School of Psychology University of Adelaide Adelaide Australia

This paper reviews literature on the relationship between food supply and obesity. The focus is on the supply, cost, and variety of food through various types of food outlets and the impact of these factors on obesity in developed countries. The article reveals complex relationships between food supply factors and obesity. A numer of factors related to lifestyles including the mobility of populations and the use of motor vehicles greatly reduce the impact of the local environment on family and individual eating patterns. However, obesity is also affected by factors such as the type and density of food outlets, the cost of food, the travel distance and means of transport to the food outlet. While the relationship between food supply and obesity in the literature reveals complex and mixed findings, this paper concludes obesity is complex and food supply is only part of this phenomenon’s predictors. Because the relationship between food supply and obesity is mediated by such multiple and complex factors including population behaviours, beliefs, lifestyles, knowledge and both food and physical environments;multiple strategies including policy development and other strategies aimed at manipulating food environments, physical environments, populations’ beliefs, behaviours and practices must be considered in searching for evidence to effectively combat obesity.

关键词： Obesity food Supply food Outlets Socio Economic Status Complex Relationships

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad f. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos f. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.f. Allen C.A. Allendes flores P.P. Allport A. Aloisio f. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli f. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-f. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu f. Backman A. Badea P. Bagnaia M. Bahmani A.J. bailey V.R. bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene f. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

Prophylactic Bactericidal Orthopedic Implants – Animal Testing Study

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Journal of Biomedical Science and Engineering 2010年第9期3卷 917-926页

作者： Richard A. Wysk Wayne J. Sebastianelli Rohan A. Shirwaiker Gregory M. bailey Charumani Charumani Mary Kennett Amy Kaucher Rachel Abrahams Thomas A. fuller patricia Royer Robert C. Voigt Paul H. Cohen 不详

This paper summarizes preliminary rat studies aimed at identifying the effectiveness of using electrically stimulated silver as a bactericidal agent for indwelling residual hardware devices (RHD). A variety of bactericidal indwelling devices were designed, fabricated and surgically inserted into the medullary cavity of live rats. The rats were inoculated with Staphylococcus aureus to try and induce osteomyelitis. A total of 37 surgeries were performed by implanting the rats with both control and potentially bactericidal devices. As surgical procedures and devices were improved, it appeared that the implants produced antibiotic effects in the animals. All of the control animals and all of the animals where the device failed tested positive for Staphylococcus aureus growth. Of the rats with operational bactericidal devices (those that survived the surgery and incubation period), half tested negative for Staphylococcus aureus. The device designs are discussed in this paper along with the test procedures, operating practices and results. A statistical analysis of the results, which shows a very high confidence level in the effectiveness of electrically stimulated silver as a bactericidal agent/antibiotic, is also presented.

关键词： Antibacterial Antimicrobial Bactericidal Silver Ionic Silver Residual Hardware Devices (RHD) Animal Testing

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七个天才团队的故事

Tako-Tsubo Cardiomyopathy—The Role of Physical and Emotional Stressors:Two Case Report

作者： (美)沃伦·本尼斯(Warren Bennis) (美)帕特里夏·沃德·比德曼(patricia ward Biederman)

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International Journal of Clinical Medicine 2012年第2期3卷 145-150页

作者： Patrícia Margarida Serra Carvalho Jandira Helena Lima Joao Bernardo Cunha patricia Gloria Dinis Dias Jose Goncalo Diniz Vieira Jose Manuel Nascimento Costa Internal Medicine ward Coimbra University HospitalCoimbraPortugal

Introduction: Tako-Tsubo cardiomyopathy describes a form of acute and reversible left ventricular dysfunction with a clinical presentation, ECG and cardiac biomarkers that makes it indistinguishable from acute coronary syndrome. Case Presentation: The authors present two cases of tako-tsubo cardiomyopathy in postmenopausal women, the first case following an emotional stressful event and a second case following a blood transfusion and probably associated with intravenous catecholamine perfusion. Both had unobstructed coronary arteries and regional wall-motion abnormalities typical of this syndrome. Conclusions: Tako-tsubo cardiomyopathy is a condition often misdiagnosed. A clinical presentation suggestive of acute coronary syndrome in a postmenopausal woman without history of coronary disease and in whom a precipitating stressful event can be found should lead the physician to suspect the diagnosis of tako-tsubo cardiomyopathy. This syndrome associated with blood transfusion has rarely been described.

关键词： Tako-Tsubo Left Ventricle Postmenopausal Stress

叶绿酸对肝癌高发区黄曲霉毒素暴露人群的干预研究

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中国肿瘤 2004年第5期13卷 270-272页

作者：王金兵 patricia A.Egner 朱源荣张宝初吴燕张启南钱耕荪旷双远 Stephen J.Gange Lisa P.Jacobson Kathy J.Helzlsoure George S.bailey John D.Groopman Thomas W.Kensler 江苏省启东肝癌防治研究所江苏启东226200 Bloomberg School of Public Health Johns Hopkins University 上海市肿瘤研究所上海200032

[目的]评估叶绿酸能否降低肝癌高危人群尿中黄曲霉毒素(AfT)鄄N7鄄鸟嘌呤的水平。[方法]采用随机双盲、以安慰剂为对照的预防干预试验。将180名健康成人随机分成叶绿酸干预组(服用100mg叶绿酸)和安慰剂对照组。采用顺序免疫亲和色谱法... 详细信息

[目的]评估叶绿酸能否降低肝癌高危人群尿中黄曲霉毒素(AfT)鄄N7鄄鸟嘌呤的水平。[方法]采用随机双盲、以安慰剂为对照的预防干预试验。将180名健康成人随机分成叶绿酸干预组(服用100mg叶绿酸)和安慰剂对照组。采用顺序免疫亲和色谱法和液相色谱法结合电子喷射质谱法测定尿中AfT鄄N7鄄鸟嘌呤的变化。[结果]在169份尿样中,105份检出AfT鄄N7鄄鸟嘌呤。叶绿酸组尿中AfT鄄N7鄄鸟嘌呤比安慰剂组下降了55%(P=0.036)。未见副作用。[结论]应用叶绿酸或富含叶绿素的食物进行预防干预是可能阻断肝癌的有效手段。

关键词：肝细胞肿瘤黄曲霉毒素叶绿酸黄曲霉毒素-N^7-鸟嘌呤干预

Paediatric Mortality: Aetiologies and Predictors among Children Aged 1 Month to 15 Years in a Tertiary Hospital in Douala, Cameroon

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Open Journal of Pediatrics 2021年第3期11卷 360-378页

作者： Daniele Kedy Koum Calixte Ida Penda Laurent Mireille Endale Henri Essome Christiana Mpongo Moukongo Loick Pradel Kojom foko Cecile Okalla Ebongue Diomede Noukeu Dominique Enyama Charlotte Eposse Mbono Rhita patricia Epée Eboumbou Emile Telesphore Mboudou Paul Koki Ndombo Department of Clinical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Pediatrics Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Deido District Hospital Douala Cameroon Department of Internal Medicine Faculty of Health Sciences University of Buea Buea Cameroon Department of Internal Medicine Laquintinie Hospital Douala Cameroon Department of Surgery Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Department of Gynecology Laquintinie Hospital Douala Cameroon Department of Animal Organism Biology Faculty of Science The University of Douala Douala Cameroon Department of Biology Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Department of Gynecology Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaoundé Cameroon Chantal Biya foundation Mother-Child Centre Yaoundé Cameroon

Background: Children and adolescent mortality remains a public health concern in developing countries. This study aimed to describe risk factors and aetiologies of mortality among children and young adolescents at a tertiary hospital in the town of Douala, Cameroon. Methods: We carried out a retrospective cohort study from January 1st to May 31st, 2019 among deceased patients aged 1 month to 15 years admitted to the paediatric ward of the Gynaeco-Obstetric and Paediatric Hospital. Data of interest were collected and analysed. Results: Out of 3088 children admitted, 123 death cases were recorded. The overall hospital mortality rate was 3.98%. Females accounted for 51% of the deceased patients. Fever was the main reason for consultation. Severe malaria was the most common diagnosis. In univariate logistic regression analysis, factors associated with mortality included hyperthermia (OR = 0.24;95% CI 0.80 - 1.33;p = 0.012), coma/impaired consciousness (OR = 0.30;95% CI 0.10 font-fa

关键词： Children Young Adolescents Mortality Aetiologies Risk factors Cameroon

Mobility after Heart Surgery： What Are Influential factors？

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 429-435页

作者： Gabriela Lago Rosier Gleide Gllcia Gama Lordello Marcela Araujo de Moura Larissa Santana Correia Luana Lais Silva Polte Giulliano Gardenghi Luis Claudio Correia patricia Alcantara Doval de Carvalho Viana Escola Bahiana de Medicina e Saude Publica Salvador 40290-000 Brasil Hospital ENCORE Goias 74930-390 Brasil

Objective: To analyze postoperative mobility after cardiac surgery. Methods: Observational study in patients, aged ≥ 18 years, undergoing myocardial revascularization and/or valvular heart surgery, hospitalized in a Brazil hospital. The data collection took place between April 2016 and March 2017. On admission to the ward, patients received a calibrated pedometer. They were asked to use the device during five consecutive days, yet only three days of full use were analyzed. Results: Analyzed were data of 87 individuals with mean age of 58.70 ± 12.59 years, 52 (59.8%) of them were males. Regarding surgery, 53 (60.9%) underwent myocardial revascularization. The median number of steps was 738 (185-1,557), which showed a weak and inverse correlation with the length of stay in the intensive care unit (r = -0.3 / p = 0.02), however, it was not statistically significant when related to clinical and surgical data. Male patients had a better mobility when compared to patients of the female sex (p = 0.04). Conclusions: Individuals who had a longer stay in the intensive care unit, as well as females, had a lower mobility in the ward. The mobility did not show a relation with intra- and postoperative factors.

关键词：活动性外科数据收集使用设备计步器手术心肌病房