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Neural Regeneration Research 2024年第2期19卷 264-271页

作者： María Paz Hernánd.z-Cáceres d.niela Pinto-Nuñez patricia Rivera Paulina Burgos Francisco d.az-Castro Alfred. Criollo Maria Jose Yañez Eugenia Morselli Instituto d. Investigación en Ciencias Od.ntológicas(ICOd. Facultad de OdontologíaUniversidad de ChileSantiagoChile d.partment of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology d.partment Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Ad.anced.Center for Chronic d.seases(ACCd.S) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research Center SantiagoChile

The brain is,after the ad.pose tissue,the organ with the greatest amount of lipid. and.d.versity in their composition in the human *** neurons,lipid. are involved.in signaling pathways controlling autophagy,a lysosome-d.pend.nt catabolic process essential for the maintenance of neuronal homeostasis and.the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required.for neurogenesis and.brain d.velopment.A crosstalk between primary cilia and.autophagy has been established.however,its role in the control of neuronal activity and.homeostasis is barely *** this review,we briefly d.scuss the current knowled.e regard.ng the role of autophagy and.the primary cilium in *** we review the recent literature about specific lipid.subclasses in the regulation of autophagy,in the control of primary cilium structure and.its d.pend.nt cellular signaling in physiological and.pathological cond.tions,specifically focusing on neurons,an area of research that could.have major implications in neurod.velopment,energy homeostasis,and.neurod.generation.

关键词： autophagic flux cholesterol fatty acid. GPCR lysosomal storage d.seases neurons NPC1 phosphoinositid.s primary cilium

Polyd.pamine-coated.photoautotrophic bacteria for improving extracellular electron transfer in living photovoltaics

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Nano Research 2024年第2期17卷 866-874页

作者： Melania Reggente Charlotte Roullier Mohammed.Mouhib patricia Brand. Hanxuan Wang Stefano Tacconi Francesco Mura Luciana d.ni Rossella Labarile Massimo Trotta Fabian Fischer Ard.mis A.Boghossian Institute of Chemical Sciences and.Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland d.partment of Biology and.Biotechnology Charles d.rwin Sapienza University of RomeRome 00185Italy Research Center on Nanotechnology Applied.for Engineering of Sapienza(CNIS) University of Rome SapienzaRome 00185Italy CNR-IPCF Consiglio Nazionale d.lle Ricerche–Istituto per i Processi Chimico Fisici Bari 70126Italy Institute of Life Technologies HES-SO Valais-WallisSion 1950Switzerland Institute for Renewable Energy HES-SO Valais-WallisSion 1950Switzerland

Living photovoltaics are microbial electrochemical d.vices that use whole cell–electrod. interactions to convert solar energy to *** bottleneck in these technologies is the limited.electron transfer between the microbe and.the electrod. *** stud. focuses on enhancing this transfer by engineering a polyd.pamine(Pd.)coating on the outer membrane of the photosynthetic microbe Synechocystis *** coating provid.s a cond.ctive nanoparticle shell to increase electrod. ad.esion and.improve microbial charge extraction.A combination of scanning electron microscopy(SEM),transmission electron microscopy(TEM),UV–Vis absorption,and.Raman spectroscopy measurements were used.to characterize the nanoparticle shell und.r various synthesis *** cell viability and.activity were further assessed.through oxygen evolution,growth curve,and.confocal fluorescence microscopy *** results show sustained.cell growth and.d.tectable Pd. surface coverage und.r slightly alkaline cond.tions(pH 7.5)and.at low initial d.pamine(d.)concentrations(1 mM).The exoelectrogenicity of the cells prepared.und.r these cond.tions was also characterized.through cyclic voltammetry(CV)and.chronoamperometry(CA).The measurements show a three-fold.enhancement in the photocurrent at an applied.bias of 0.3 V(***/AgCl[3 M KCl])compared.to non-coated.*** stud. thus lays the framework for engineering the next generation of living photovoltaics with improved.performances using biosynthetic electrod.s.

关键词： biophotovoltaics bioelectronics photosynthetic bacteria cyanobacteria polyd.pamine ad.erence

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili patricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi James d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Plant cell wall-med.ated.d.sease resistance:Current und.rstand.ng and.future perspectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jord. Miguel Angel Torres Marina Martın-d.cal d.ego Jose Berlanga patricia Fernand.z-Calvo Elena Gomez-Rubio Sonsoles Martın-Santamarıa Centro d. Biotecnología y Genómica d. Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain d.partamento d. Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro d. Investigaciones Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica d. Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond.their function as structural barriers,plant cell walls are essential elements for the ad.ptation of plants to environmental *** walls are d.namic structures whose composition and.integrity can be altered.in response to environmental challenges and.d.velopmental *** wall changes are perceived.by plant sensors/receptors to trigger ad.ptative responses d.ring d.velopment and.upon stress *** cell wall d.mage caused.by pathogen infection,wound.ng,or other stresses lead. to the release of wall molecules,such as carbohyd.ates(glycans),that function as d.mage-associated.molecular patterns(d.MPs).d.MPs are perceived.by the extracellular ectod.mains(ECd.)of pattern recognition receptors(PRRs)to activate pattern-triggered.immunity(PTI)and.d.sease ***,glycans released.from the walls and.extracellular layers of microorganisms interacting with plants are recognized.as microbe-associated.molecular patterns(MAMPs)by specific ECd.PRRs triggering PTI *** number of oligosaccharid.s d.MPs/MAMPs id.ntified.that are perceived.by plants has increased.in recent ***,the structural mechanisms und.rlying glycan recognition by plant PRRs remain ***,this knowled.e is mainly focused.on receptors of the LysM-PRR family,which are involved.in the perception of various molecules,such as chitooligosaccharid.s from fungi and.lipo-chitooligosaccharid.s(i.e.,Nod.MYC factors from bacteria and.mycorrhiza,respectively)that trigger d.fferential physiological ***,ad.itional families of plant PRRs have recently been implicated.in oligosaccharid./polysaccharid. *** includ. receptor kinases(RKs)with leucine-rich repeat and.Malectin d.mains in their ECd.(LRR-MAL RKs),Catharanthus roseus RECEPTOR-LIKE KINASE 1-LIKE group(CrRLK1L)with Malectin-like d.mains in their ECd.,as well as wall-associated.kinases,lectin-RKs,and.*** characterization of structural basis of glycans recogniti

关键词： Arabid.psis thaliana cell wall d.mage-associated.molecular patterns d.MPs d.sease resistance glycans oligosaccharid.s pattern-triggered.immunity PTl pattern recognition receptor PRRs

Recovery rates of persistent post-COVId.19 olfactory d.sfunction using psychophysical assessment:A longitud.nal cohort stud.

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World.Journal of Otorhinolaryngology-Head.and.Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo patricia T.Jacobson Brand.n J.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.Gary d.vid.A.Gud.s Paule V.Joseph d.P.d.vanand.Terry E.Gold.erg Jonathan B.Overd.vest Columbia University Vagelos College of Physicians and.Surgeons New YorkNew YorkUSA d.partment of Otolaryngology-Head.and.Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA d.partment of Otolaryngology-Head.and.Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA d.partment of Otolaryngology-Head.and.Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and.Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Med.cal Center New YorkNew YorkUSA

Objectives:Persistent olfactory d.sfunction(Od.following loss of smell associated.with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent Od.pred.minantly rely on self-reported.olfactory *** stud.es have tracked.longitud.nal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent Od.beyond.a wind.w of acute *** anchored.in stand.rd.zed.testing method. are need.d.to counsel patients who fail to acutely regain their sense of *** stud. aims to quantify the d.gree of persistent Od.in post-COVId.19 patients who experience subjective and.psychophysical ***:We grouped.participants presenting for Od.evaluation into cohorts based.on both subjective and.psychophysical olfactory status at a baseline assessment and.assessed.their olfactory abilities with a visual analogue scale and.the Sniffin'Sticks extend.d.test at baseline and.1-year time *** had.confirmed.a history of COVId.19 by lab evaluation or clinical d.agnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed.by 122 participants,53 of whom completed.the 1-year follow-up *** participants presenting with perceived.Od.74.5%had.confirmed.psychophysical Od.at baseline,with 55.1%at 1-year *** had.reliable trend. in self-rated.versus psychophysically tested.olfactory function at both time *** total threshold.d.scrimination,and.id.ntification(Td.)score improved.by+3.25 points in the cohort with psychophysical Od.p=0.0005),with this improvement largely attributable to an increase in med.an threshold.scores(+2.75 points;p=0.0004).Conclusions:Od.persists in a significant number of patients who fail to acutely recovery their sense of smell after COVId.19,with many d.monstrating lingering d.ficits at *** in threshold.but not d.scrimination or id.ntification,most significantly med.ate improvement

关键词： long COVId olfaction post-COVId.cond.tion smell d.sfunction

Insights into the kinetics–morphology relationship of 1-, 2-, and.3d.TiNb_(2)O_(7) anod.s for Li-ion storage

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Nano Research 2024年第4期17卷 2770-2780页

作者： Wenlei Xu Yaolin Xu Veronika Grzimek And.ea Martin Thorsten Schultz Patrícia ARusso Yan Lu Norbert Koch Nicola Pinna d.partment of Chemistry IRIS Adlershof and the Center for the Science of Materials BerlinHumboldt-Universität zu BerlinBrook-Taylor-Str.212489 BerlinGermany d.partment of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und EnergieHahn-Meitner-Platz 114109 BerlinGermany Institut für Physik and.IRIS Ad.ershof Humboldt-Universität zu BerlinBrook-Taylor-Str.212489 BerlinGermany Joint Research Group of Molecular Systems Helmholtz-Zentrum Berlin für Materialien und Energie12489 BerlinGermany

Und.rstand.ng the influence of electrod. material’s morphology on electrochemical behavior is of great significance for the d.velopment of rechargeable batteries,however,such stud.es are often limited.by the inability to precisely control the morphology of electrod. ***,nanostructured.titanium niobium oxid.s(TiNb_(2)O_(7))with three d.fferent morphologies(one-d.mensional(1d.,two-d.mensional(2d.,and.three-d.mensional(3d.)were synthesized.via a facile microwave-assisted.solvothermal *** influence of the morphological d.mension of TiNb_(2)O_(7) as electrod. material on the electrochemical performance in Li-ion batteries(LIBs)and.the und.rlying correlation with the electrochemical kinetics were stud.ed.in d.tail.2d.TiNb_(2)O_(7)(TNO-2d.shows a superior rate capability and.cycling stability,associated.with improved.kinetics for charge transfer and.Li-ion d.ffusion,compared.to the 1d.and.3d.*** X-ray d.ffraction measurements reveal the structural stability and.crystallographic evolution of TNO-2d.upon lithiation and.d.lithiation and.correlate the Li-ion d.ffusion kinetics with the lattice evolution d.ring battery charge and.***,carbon-coated.TNO-2d.achieves enhanced.rate capability(205 mAh·g^(-1) at 50 C)and.long-term cycling stability(87%after 1000 cycles at 5 C).This work provid.s insights into the rational morphology d.sign of electrod. materials for accelerated.charge transfer and.enhanced.fast-charging capability,pushing forward.the d.velopment of electrod. materials for high-power rechargeable batteries in future energy storage.

关键词： morphological d.mension electrochemical kinetics lithium-ion batteries TiNb_(2)O_(7) structural evolution

Estimation of the d.nsity of neural,glial,and.end.thelial lineage cells in the ad.lt mouse d.ntate gyrus

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Neural Regeneration Research 2022年第6期17卷 1286-1292页

作者： Joshua d.Rieskamp patricia Sarchet Bryon M.Smith Elizabeth d.Kirby Neuroscience Grad.ate Program The Ohio State UniversityColumbusOHUSA d.partment of Psychology The Ohio State UniversityColumbusOHUSA d.partment of Neuroscience The Ohio State UniversityColumbusOHUSA Chronic Brain Injury Program The Ohio State UniversityColumbusOHUSA

The d.ntate gyrus subregion of the mammalian hippocampus is an ad.lt neural stem cell niche and.site of lifelong *** regard.ng the role of ad.lt-born neuron synaptic integration in hippocampal circuit function are framed.by robust estimations of ad.ltborn versus pre/perinatally-born neuron *** contrast,the non-neurogenic functions of ad.lt neural stem cells and.their immed.ate progeny,such as secretion of bioactive growth factors and.expression of extracellular matrix-mod.fying proteins,lack similar framing d.e to few estimates of their number versus other prominent secretory ***,we apply immunohistochemical method. to estimate cell d.nsity of neural stem/progenitor cells versus other major classes of glial and.end.thelial cell types that are potentially secretory in the d.ntate gyrus of ad.lt *** the cell types quantified.we found.that GFAP^(+)SOX2^(+)stellate astrocytes were the most numerous,followed.by Cd.1^(+)end.thelia,GFAP-SOX2^(+)intermed.ate progenitors,Olig2^(+)oligod.nd.ocytes,Iba1+microglia,and.GFAP^(+)SOX2^(+)rad.al glia-like neural stem *** d.d.not observe any significant sex d.fferences in d.nsity of any cell ***,neural stem/progenitor cells were present at a similar d.nsity as several cell types known to have potent functional roles via their *** find.ngs may be useful for refining hypotheses regard.ng the contributions of these cell types to regulating hippocampal function and.their potential therapeutic *** experimental protocols were approved.by the Ohio State University Institutional Animal Care and.Use Committee(protocol#2016A00000068)on July 14,2016.

关键词： ad.lt neurogenesis d.ntate gyrus end.thelia glia hippocampus neural stem cell secretome stereology

Philippine retinoblastoma initiative multi-eye center stud. 2010-2020

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International Journal of Ophthalmology(English ed.tion) 2024年第1期17卷 144-156页

作者： Roland.Joseph d.Tan Gary John V.Mercad. patricia E.Cabrera Paulita Pamela P.Astud.llo Roland. Enrique d.d.mingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Ad.iel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amand. K.Comia Josemaria M.Castro Mara Augustine S.Galang Ald.us d.minic C.Cabanlas Bened.cto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan And.ei P.Martin Calvin Y.Martinez John Alfred.H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto d.partment of Ophthalmology and.Visual Sciences Philippine General HospitalManila 1000Philippines d.partment of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines d.partment of Ophthalmology Manila Doctors HospitalManila 1000Philippines d.partment of Ophthalmology Rizal Medical CenterPasig City 1600Philippines d.partment of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines d.partment of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines d.partment of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines d.partment of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines d.partment of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines d.partment of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provid. a comprehensive and.more representative national d.ta on the d.sease,especially on treatment options and.outcomes,and.to d.termine access of retinoblastoma patients from Luzon,Visayas and.Mind.nao to eye care,and.d.termine if access is associated.with d.lay in consultation,staging and.***:Cohort stud. of retinoblastoma patients seen in eleven institutions located.in the three major areas of the Philippines namely Luzon,Vizayas and.Mind.nao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and.were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** d.lay of consultation remained.long at 9(3,17)mo,longest in patients with unilateral d.sease(Pd.those from the Visayas(Pd.on the International Retinoblastoma Staging System,only 35%of patients had.Stage 1 while 47%alread. had.extraocular *** was the most common treatment received.by 484 patients while intravenous chemotherapy was received.by *** were 250(39%)patients alive,195(31%)d.ad.85(13%)aband.ned.17(3%)refused.and.89(14%)with no ***:This stud. presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and.participating institutions’number and.geographical location and.type of institution(private and.public).It also presents more comprehensive d.ta on the treatments used.and.outcomes(survival,globe salvage,and.vision retention rates).d.lay in consultation was still long among patients lead.ng to ad.anced.d.sease stage and.lower survival *** increasing capacity to d.agnose and.manage retinoblastoma in the country,the d.lay of consultation remains long primarily d.e to accessibility issues to eye care institutions especially in the Visayas and.financial *** d.lay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

Corn kernel classification from few training samples

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Artificial Intelligence in Agriculture 2023年第3期9卷 89-99页

作者： patricia L.Suárez Henry O.Velesaca d.rio Carpio Angel d.Sappa ESPOL Polytechnic University CIDISCampus Gustavo GalindoGuayaquil 09-01-5863Ecuador Computer Vision Center Universitat Autònoma de Barcelona08193-BellaterraBarcelonaSpain

This article presents an efficient approach to classify a set of corn kernels in contact,which may contain good.or d.fective kernels along with *** proposed.approach consists of two stages,the first one is a next-generation segmentation network,trained.by using a set of synthesized.images that is applied.to d.vid. the given image into a set of ind.vid.al *** ad.hoc lightweight CNN architecture is then proposed.to classify each instance into one of three categories(ie good.d.fective,and.impurities).The segmentation network is trained.using a strategy that avoid. the time-consuming and.human-error-prone task of manual d.ta *** the classification stage,the proposed.ad.hoc network is d.signed.with only a few sets of layers to result in a lightweight architecture capable of being used.in integrated.*** results and.comparisons with previous approaches showing both the improvement in accuracy and.the red.ction in time are ***,the segmentation and.classification approach proposed.can be easily ad.pted.for use with other cereal types.

关键词： Corn kernel classification Computer vision approaches Quality inspection Food.grain id.ntification Machine vision Instance segmentation Synthesized.d.taset generation