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Busting the myth: more good than harm in transgenic cells

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Neural Regeneration Research 2019年第6期14卷 967-968页

作者： Gonzalo Pi?ero patricia Setton-Avruj Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicasy TécnicasInstituto de Químicay Fisicoquímica Biológicas (IQUIFIB)Facultad de Farmaciay Bioquímica

Peripheral neuropathy constitutes a highly incidental condition and a major public health concern worldwide(Hanewinckel et al.,2016).This pathology is triggered by peripheral nervous system damage as a consequence of systemic disease or ischemic-traumatic *** the latter case,nerve crush,partial or total transection and stretch injury interrupt nerve conduction and impair sensitivity and motility of the innervated area,which brings about partial or total functional loss in the affected limb and disabling neuropathic *** these reasons,digging into the molecular mechanisms underlying peripheral neuropathy becomes essential for the development of successful therapeutic strategies.

关键词： Busting the myth transgenic cells highly incidental

Place as Refuge： Exploring the Poetical Legacy of Matsuo Basho

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Frontiers of Philosophy in China 2017年第4期12卷 572-590页

作者： patricia Huntington SHArCS New College Arizona State University Glendale AZ 85306 USA

By drawing on phenomenological notions, this paper offers a ＂middle way＂ reading of Bash6＇s travelogues that accentuates their religious, rather than merely aesthetical purpose, which is to transmit the Buddha Dharma. Two distinctive poetic traditions of Bash6 interpretation exist： the Zen-inflected, monologic, and individualist tradition and the intertextual or dialogical interpretation. One way to reconcile these two strains in Bash6＇s poetics is to see his haikai through the lens of mind-to-mind transmission of light. This ＂middle way＂ interpretation traces a double movement of phenomenological reduction through two travelogues： first, by showing how home departure entails freeing the mind of fixity and, second, by suggesting that mind-to-mind transmission removes the ambition to find refuge in peak experiences, just as it resists being reduced to parodic subversion of reigning cultural values. In the Buddhist lineage, the heart of transmission rests neither upon conservation nor upon rejection of poetic essences but, rather, lies in transforming haikai into medicine, which is efficacious for the process of awakening.

关键词： Matsuo Basho haiku phenomenology religious versus aesthetictransmission mind-to-mind transmission Japanese poetics middle way place,Makoto Ueda Haruo Shirane

Learning to combine multiple string similarity metrics for effective toponym matching

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International Journal of Digital Earth 2018年第9期11卷 913-938页

作者： Rui Santos patricia Murrieta-Flores Bruno Martins Instituto Superior Técnico and INESC-ID University of LisbonLisbonPortugal Digital Humanities Research Center University of ChesterChesterUK

Several tasks related to geographical information retrieval and to the geographical information sciences involve toponym matching,that is,the problem of matching place names that share a common *** this article,we present the results of a wide-ranging evaluation on the performance of different string similarity metrics over the toponym matching *** also report on experiments involving the usage of supervised machine learning for combining multiple similarity metrics,which has the natural advantage of avoiding the manual tuning of similarity *** with a very large dataset show that the performance differences for the individual similarity metrics are relatively small,and that carefully tuning the similarity threshold is important for achieving good *** methods based on supervised machine learning,particularly when considering ensembles of decision trees,can achieve good results on this task,significantly outperforming the individual similarity metrics.

关键词： Toponym matching supervised learning string similarity metrics duplicate detection ensemble learning geographic information retrieval

Living on the edge： Effects of body size, group density and microhabitat selection on escape behaviour of southern leopard frogs Lithobates sphenocephalus

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Current Zoology 2014年第6期60卷 712-718页

作者： Philip W. BATEMAN patricia A. FLEMING Department of Environment and Agriculture Curtin University Perth Bentley WA 6845 Australial School of Veterinary and Life Sciences Murdoch University Perth Murdoch WA 6150 Australia

Models of optimal escape strategy predict that animals should move away when the costs of fleeing （metabolic and opportunity costs） are outweighed by the costs of remaining. These theoretical models predict that more vulnerable individuals should be more reactive, moving away when an approaching threat is further away. We tested whether escape behaviour （includ- ing ＇escape calling＇） ofLithobates sphenocephalus approached by a human was influenced by body size or the initial microhabi- tat that the individual was found in. Irrespective of their size, frogs in the open tended to remain immobile, enhancing their cryp- sis. Frogs in cover showed different responses according to their body size, but, contrary to our initial predictions, larger frogs showed greater responsiveness （longer flight initiation distance and distances fled） than small frogs. Small frogs tended to remain closer to water and escaped into water, while larger individuals were more likely to jump to terrestrial cover and call during escape. Density of frogs near the focal animal had no effect on escape behaviour. This study indicates a range of escape responses in this species and points to the importance of divergent escape choices for organisms which live on the edge of different environments .

关键词： Alarm call Flight initiation distance (FID) Distance fled Microhabitat selection Rana sphenocephala

Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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Food Science and Human Wellness 2024年

作者： Emily P.Laveriano-Santos Sara Castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón Estruch patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.Fernández-Alvira Rodrigo Fernández-Jiménez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute， Icahn School of Medicine at Mount Sinai Department de Nutrició， Ciències de l'Alimentació I Gastronomia， XIA， Facultat de Farmàcia i Ciències de l'alimentació， Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB)， Universitat de Barcelona Department of Internal Medicine， Hospital Clínic， Institutd'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)， University of Barcelona Consorcio CIBER， M.P.Fisiopatología de la Obesidad y Nutrición (CIBERObn)， Instituto de Salud Carlos III (ISCIII) Mediterranean Diet Foundation 5. Foundation for Science， Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend <0.001)， and the highest quintile of stilbene intake with lower BG (β=-1.83， 95%CI= -3.103;-0.64， P-for trend <0.001) and TG (β=-3.22， 95%CI= -4.95;-1.49， P-for trend=0.034)， and with higher HDL-c (β=2.328， 95%CI= 1.40;3.17， P-for trend=0.466) compared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， espe

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Smoke Alarms for Informal Settlements: Monitoring and Challenges from a Large‑Scale Community Rollout in Cape Town, South Africa

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International Journal of Disaster Risk Science 2022年第6期13卷 936-947页

作者： Robyn Pharoah patricia Zweig Richard Walls Rodney Eksteen Research Alliance for Disaster and Risk Reduction(RADAR) Stellenbosch UniversityStellenbosch 7602South Africa Fire Engineering Research Unit(FireSUN) Stellenbosch UniversityStellenbosch 7602South Africa College of Engineering Architecture and TechnologyOklahoma State UniversityStillwaterOK 74078USA

This article presents the findings of a pilot project to test the large-scale rollout of smoke alarms in an informal community in Cape Town, South Africa. The work provides novel insight into the effectiveness and challenges associated with using smoke detectors in low-income communities. Technical details and detector considerations are also provided that will assist in enhancing future *** project installed 1200 smoke detection devices in TRA informal settlement in the suburb of Wallacedene, in the City of Cape Town, and monitored their effectiveness for a period of 12 months. The monitoring showed that there were 11 real activations, where the presence of the devices likely saved lives and homes. The project also identified a series of challenges, especially in relation to nuisance alarms,where everyday household emissions, dust, and insect ingress caused false alarms, leading some participants to uninstall devices. The findings of the pilot study suggest that although smoke detectors could provide a valuable tool for reducing the frequency and impact of informal settlement fires in South Africa and elsewhere, they need to be adapted to meet the specific needs and conditions encountered in informal dwellings. Modifications, such as adjusting device sensitivity,preventing dust and insect ingress and tailoring devices to everyday conditions, will be essential to make smoke alarms more suitable and effective in the future. Smoke alarms could become an important component of low-income community fire safety if such challenges can be addressed.

关键词： Fire safety Informal dwellings Smoke alarms South Africa

Opioid growth factor and the treatment of human pancreatic cancer:A review

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World Journal of Gastroenterology 2014年第9期20卷 2218-2223页

作者： Ian S Zagon patricia J McLaughlin Department of Neural and Behavioral Sciences Pennsylvania State University College of Medicine Hershey PA 17033 United States

Opioid growth factor (OGF), chemically termed [Met5]-enkephalin, and its receptor, OGF receptor (OGFr), form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia. Modulation of the OGF-OGFr pathway mediates the course of pancreatic cancer, with exogenous OGF or upregulation of OGFr repressing growth of human pancreatic cancer cells in culture and in nude mice. OGF therapy alone or in combination with standard chemotherapies such as gemcitabine and 5-fluorouracil results in enhanced inhibition of DNA synthesis and tumor growth. Molecular manipulation of OGFr confirms that the receptor is specific for OGF’s inhibitory action. Preclinical studies have warranted Phase I and Phase II clinical trials using OGF infusions as a treatment for patients with advanced, unresectable pancreatic cancers. OGF, an endogenous neuropeptide, is a safe, non-toxic, and effective biotherapy that utilizes the OGF-OGFr axis to mediate pancreatic tumor progression.

关键词： Enkephalins DNA synthesis Pancreatic adenocarcinoma Opioids Nude mice Receptor transfection

The role of the teaching practice in undergraduate education-A British perspective

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Family Medicine and Community Health 2018年第2期6卷 85-88页

作者： patricia Houlston Deputy Head of Academy Com-munity Based MedicineCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamB152TTUnited Kingdom

This article describes and reflects on the role of the teaching practice in undergraduate education on the basis of the author’s experience in the United *** that China is addressing the huge task of developing a general practice workforce in an unprecedented short time,I hope that sharing these ideas will be *** practitioners are well able to teach the basics of ***,their real strengths come when they are focusing on key consulting skills needed for general practice,developing reflective lifelong learners,and cultivating good *** practice is also able to demonstrate preventive medicine,chronic disease management,and multidisciplinary *** providing exposure to general practice at this early stage in a medical career,the teaching practice will hopefully inspire and attract the general practice workforce of the future.

关键词： General practice teaching consulting skills reflection

Effects of ambient DIN:DIP ratio on the nitrogen uptake of harmful dinoflagellate Prorocentrum minimum and Prorocentrum donghaiense in turbidistat

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Chinese Journal of Oceanology and Limnology 2011年第4期29卷 746-761页

作者：李纪 patricia M. GLIBERT Jeffrey A. ALEXANDER University of Maryland Center for Environmental Science Horn Point Laboratory PO Box 775 Cambridge MD 21613 USA

The effects of varying nitrogen （N）： phosphorus （P） ratios on the growth and N-uptake and assimilation of the harmful dinoflagellates Prorocentrum minimum and Prorocentrum donghaiense were examined in turbidistat culture experiments. Algal cultures were supplied with media containing PO4^3- in various concentrations to obtain a wide range of N：P ratios. Experiments to determine rates of N uptake and assimilation of different N sources （NO^3-, NH4^＋, urea and glycine by P. minimum and NO3^-, NH4^＋ by P. donghaiense） were conducted using ^15-N tracer techniques at each N：P ratio. The growth rates suggested nutrient limitation at both high and low N：P ratios relative to the Redfield ratio. On a diel basis, the growth of both species was regulated by the light-dark cycle, which may be a result of regulation of both lightdependent growth and light-independent nutrient uptake. Maximum growth rates of both species always occurred at the beginning of light phase. In P-rich medium （low N：P ratio）, both species had higher N assimilation rates, suggesting N limitation. Low assimilation coefficients at high N：P ratios suggested P limitation of N uptake and assimilation. NO3 ^-and NH4^＋ contributed more than 90% of the total N uptake of P. minimum. Reduced N sources were more quickly assimilated than NO3^-. Highest average daily growth rates were recorded near an N：P ratio of 12 for both species. The N uptake rates of cultures at N：P ratios near Redfield ratio were more balanced with growth rates. The linkage between growth rates and N uptake/assimilation rates were conceptually described by the variation of cell N quota. The N：P ratios affect the N uptake and growth of Prorocentrum spp., and may regulate their bloom progression in eutrophic ecosystems.

关键词： harmful dinoflagellate N:P ratio nitrogen uptake continuous culture Prorocentrum spp