检索结果-南通市图书馆

Prepulse inhibition (PPI) of tactile startle response in recombinant congenic strains of mice:QTL mapping and comparison with acoustic PPI

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2008年第3期35卷 139-151页

作者： Adam Torkamanzehi patricia Boksa Ridha Joober University of Sistan and Baluchestan Douglas Hospital Research Centre

Prepulse inhibition （PPI） of the startle response is a psychophysiological measure of sensorimotor gating believed to be cross-modal between different sensory systems. We analyzed the tactile startle response （TSR） and PPI of TSR （tPPI）, using light as a prepulse stimulus, in the mouse strains A/J and C57BL/6J and 36 recombinant congenic strains derived from them. Parental strains were significantly different for TSR, but were comparable for tPPI. Among the congenic strains, variation for TSR was significant in both genetic backgrounds, but that of tPPI was significant only for the C57BL/6J background. Provisional mapping for loci modulating TSR and tPPI was carried out. Using mapping data from our previous study on acoustic startle responses （ASR） and PPI of ASR （aPPI）, no common markers for aPPI and tPPI were identified. However, some markers were significantly associated with both ASR and TSR, at least in one genetic background. These results indicate cross-modal genetic regulation for the startle response but not for PPI, in these mouse strains.

关键词： tactile startle response prepulse inhibition (PPI) acoustic startle response recombinant congenic strains of mice QTL mapping microsatellite markers

Epididymosomes： transfer of fertility-modulating proteins to the sperm surface

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2015年第5期17卷 720-725,I0006页

作者： patricia A Martin-DeLeon Department of Biological Sciences University of Delaware Newark DE 19716 USA

A variety of glycosylphosphatidylinositol （GPI）-linked proteins are acquired on spermatozoa from epididymal luminal fluids （ELF） during sperm maturation. These proteins serve roles in immunoprotection and in key steps of fertilization such as capacitation, acrosomal exocytosis and sperm-egg interactions. Their acquisition on sperm cells is mediated both by membrane vesicles （epididymosomes, EP） which were first reported to dock on the sperm surface, and by lipid carriers which facilitate the transfer of proteins associated with the membrane-free fraction of ELF. While the nonvesicular fraction is more efficient, both pathways are dependent on hydrophobic interactions between the GPI-anchor and the external lipid layer of the sperm surface. More recently proteomic and hypothesis-driven studies have shown that EP from several mammals carry transmembrane （TM） proteins, including plasma membrane Ca^2＋-ATPase 4 （PMCA4）. Synthesized in the testis, PMCA4 is an essential protein and the major Ca^2＋ efflux pump in murine spermatozoa. Delivery of PMCA4 to spermatozoa from bovine and mouse EP during epididymal maturation and in vitro suggests that the docking of EP on the sperm surface precedes fusion, and experimental evidence supports a fusogenic mechanism for TM proteins. Fusion is facilitated by CD9, which generates fusion-competent sites on membranes. On the basis of knowledge of PMCA4＇s interacting partners a number of TM and membrane-associated proteins have been identified or are predicted to be present, in the epididymosomal cargo deliverable to spermatozoa. These Ca^2＋-dependent proteins, undetected in proteomic studies, play essential roles in sperm motility and fertility, and their detection highlights the usefulness of the hypothesis-driven approach.

关键词： epididymal maturation epididymal secretory proteins GPI-linked proteins lipid carrier membrane-associated proteins PMCA4 transmembrane proteins

The use of carbon nanomaterials in membrane distillation membranes:a review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2021年第4期15卷 755-774页

作者： Sebastian Leaper Ahmed Abdel-Karim patricia Gorgojo Department of Chemical Engineering and Analytical Science School of EngineeringThe University of ManchesterManchesterM139PLUK Water Pollution Research Department National Research CentreGiza 12622Egypt

Membrane distillation(MD)is a thermal-based separation technique with the potential to treat a wide range of water types for various applications and *** challenges remain however,which prevent it from becoming commercially widespread including moderate permeate flux,decline in separation performance over time due to pore wetting and high thermal energy ***,its attractive characteristics such as high rejection(ca.100%)of nonvolatile species,its ability to treat highly saline solutions under low operating pressures(typically atmospheric)as well as its ability to operate at low temperatures,enabling waste-heat integration,continue to drive research interests *** particular interest is the class of carbon-based nanomaterials which includes graphene and carbon nanotubes,whose wide range of properties have been exploited in an attempt to overcome the technical challenges that MD *** low dimensional materials exhibit properties such as high specific surface area,high strength,tuneable hydrophobicity,enhanced vapour transport,high thermal and electrical conductivity and *** use in MD has resulted in improved membrane performance characteristics like increased permeability and reduced fouling *** have also enabled novel membrane capabilities such as in-situ fouling detection and localised heat *** this review we provide a brief introduction to MD and describe key membrane characteristics and fabrication *** then give an account of the various uses of carbon nanomaterials for MD applications,focussing on polymeric membrane *** research directions based on the findings are also suggested.

关键词： carbon nanomaterials graphene membrane distillation desalination carbon nanotubes

Influence of individual tree characteristics,spatial structure and logging history on tree-related microhabitat occurrence in North American hardwood forests

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2021年第2期8卷 357-372页

作者： Maxence Martin patricia Raymond Yan Boucher Département des Sciences fondamentales Université du Québec à Chicoutimi555boul.de l’UniversitéChicoutimiQuébec G7H 2B1Canada Institut de la recherche sur les forêts Université du Québec en Abitibi-Témiscamingue445boul.de l’UniversitéRouyn-NorandaQuébec J9X 5E4Canada Centre d'étude de la forêt Université du Québec à MontréalP.O.Box 8888Centre-ville StationMontréalQuébec H3C 3P8Canada Direction de la recherche forestière Ministère des Forêtsde la Faune et des Parcs(MFFP)2700rue EinsteinQuébecQuébec G1P 3W8Canada

Background:Tree-related microhabitats(hereafter,"TreMs")are key components of forest biodiversity but they are still poorly known in North American hardwood *** spatial patterns of living trees bearing TreMs(hereafter,"TreM-trees")also remain to be *** logging practices can lead to a loss of TreM-trees and of their associated biodiversity,it is essential to identify the factors explaining TreM occurrence to better integrate them into forest *** therefore inventoried TreMs in 40.5-ha survey strips in northern hardwood forests in Quebec,Canada,while recording the spatial location of each *** strips were located in unmanaged oldgrowth forests,and 2 were in forests managed under selection *** 4 stands were dominated by sugar maple(Acer saccharum Marsh.)and American beech(Fagus grandifolia Ehrn.).Beech bark disease,an exotic pathology,was observed in all the ***:Large diameter at breast height and low tree vigor were the main characteristics explaining the presence of TreMs at the tree ***-trees presented slight spatial aggregation *** aggregates,however,were not well-defined and were generally constituted by a large number of trees bearing few different types of *** TreM classes(broken branch or top and woodpecker lodge)also presented a spatial *** practices had no significant effect on TreM *** bark disease increased the frequency of senescent *** impact of this pathology on TreMs was however mitigated by the small size of infected trees and probably by the short time elapsed since its ***:The factors explaining the presence and abundance of TreMs on trees has so far been little studied in North American hardwood *** results highlight that TreM-tree characteristics in the surveyed forests are consistent with those of previous studies conducted in other forest types and regions(e.g.,Europe or Northwestern America).To our knowledge,th

关键词： Habitat trees Wildlife habitat Northern hardwoods Old-growth forest Selection cutting Ecosystembased management Biodiversity indicators Conservation Forest management

Esophageal cancer management controversies: Radiation oncology point of view

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2014年第8期6卷 263-274页

作者： patricia Tai Edward Yu Department of Oncology Division of Radiation On-cology Allan Blair Cancer Center University of SaskatchewanRegina SK S4T 7T1 Canada Department of Oncology Division of Radiation On-cology Western University London ON N6A 4L6 Canada

Esophageal cancer treatment has evolved from single modality to trimodality *** are some controversies of the role,target volumes and dose of radiotherapy(RT)in the literature over *** present review focuses primarily on RT as part of the treatment modalities,and highlight on the RT volume and its dose in the management of esophageal *** randomized adjuvant chemoradiation(CRT)trial,intergroup trial(INT 0116)enrolled 559 patients with resected adenocarcinoma of the stomach or gastroesophageal *** were randomly assigned to surgery plus postoperative CRT or surgery *** show robust treatment benefit of adjuvant CRT in most subsets for postoperative *** Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study(CROSS)used a lower RT dose of41.4 Gray in 23 fractions with newer chemotherapeutic agents carboplatin and paclitaxel to achieve an excellent *** volume of external beam radiation therapy and its coverage have been in debate for years among radiation ***-operative and postoperative target volumes are designed to optimize for disease *** brachytherapy is effective in the palliation of dysphagia,but should not be given concomitantly with chemotherapy or external beam *** role of brachytherapy in multimodality management requires further ***-going studies of multidisciplinary treatment in locally advanced cancer include:ZTOG1201 trial(a phaseⅡtrial of neoadjuvant and adjuvant CRT)and QUINTETT(a phaseⅢtrial of neoadjuvant vs adjuvant therapy with quality of life analysis).These trials hopefully will shed more light on the future management of esophageal cancer.

关键词： Radiotherapy Chemotherapy Esophagus Cancer Treatment

A Survey on Type-3 Fuzzy Logic Systems and Their Control Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1744-1756页

作者： Oscar Castillo Fevrier Valdez patricia Melin Weiping Ding Tijuana Institute of Technology/Tecnologico Nacional de Mexico Division of Graduate StudiesCalzada Tecnologico S/NTijuana 22414Mexico School of Information Science and Technology Nantong UniversityJiangsu 226019China

In this paper,we offer a review of type-3 fuzzy logic systems and their applications in *** main objective of this work is to observe and analyze in detail the applications in the control area using type-3 fuzzy logic *** this case,we review their most important applications in control and other related topics with type-3 fuzzy *** algorithms have been receiving increasing attention in control and for this reason a review in this area is *** paper reviews the main applications that make use of Intelligent Computing ***,type-3 fuzzy logic *** aim of this research is to be able to appreciate,in detail,the applications in control systems and to point out the scientific trends in the use of Intelligent Computing *** is done with the construction and visualization of bibliometric networks,developed with VosViewer Software,which it is a free Java-based program,mainly intended to be used for analyzing and visualizing bibliometric *** this tool,we can create maps of publications,authors,or journals based on a co-citation network or construct maps of keywords,countries based on a co-occurrence networks,research groups,etc.

关键词： Applications control systems optimization review type-3 fuzzy logic.

Dissemination of Traditional Chinese Medicine in Latin America and the Caribbean: the Cases of Peru, Chile, and Cuba

在线全文

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2023年第4期6卷 330-338页

作者： patricia Palma Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáTarapacá1010069Chile

Traditional Chinese medicine(TCM) arrived from China to Latin America and the Caribbean in the 1840s due to the massive migration of Chinese people to the region. In a few years, the press noticed the presence of Chinese herbalists practicing in different cities and countries regardless of the demographic weight of the Chinese community. The fascination with Chinese doctors implicated not only the press but also the literature, a phenomenon particularly observed in Cuba. In the first decades of the 20th century, the reactivation of Chinese immigration to the region fostered an anti-Chinese climate that materialized in more significant migratory restrictions and control of their businesses, such as what happened with Chinese herbalists. These herbalists who practiced inside and outside the Chinese community started to object to criticism and persecution by the conservative press and professional doctors. Despite this, Chinese doctors will continue to maintain their support of a significant number of ill persons. This work seeks to illuminate the historical relevance of TCM in Latin America and the Caribbean, focusing on the cases of Peru, Chile, and Cuba. This last country was far from China culturally and geographically, but as in many other small towns in the region, Chinese medicine presented an alternative to the treatment of illnesses.

关键词： Caribbean Chile Chinese migration Cuba History of medicine Latin America Peru Traditional Chinese medicine

Seasonal dynamics of cyanobacteria and eukaryotic phytoplankton in a multiplereservoir recycling irrigation system

在线全文

学校读者我要写书评

暂无评论

Ecological Processes 2019年第1期8卷 465-475页

作者： Ping Kong patricia Richardson Chuanxue Hong Hampton Roads Agricultural Research and Extension Center Virginia Tech1444 Diamond Springs RoadVirginia BeachVA 23455USA

Background:Agricultural runoff recycling systems are manmade aquatic ecosystems of growing significance to global water sustainability,crop health,and *** study investigated the seasonal dynamics of microbial community in a three-reservoir recycling irrigation system with a stepwise water flow and compared with that of an adjacent runoff-free *** water from all production areas was captured in a sedimentation reservoir which overflowed to a transition reservoir then retention reservoir through a *** water was pumped to replenish the reservoirs as needed during growing ***:16S rDNA PCR clone libraries of quarterly water samples from three reservoirs and one stream were sequenced,and 575 operational taxonomic units(OTUs)were identified and assigned to cyanobacteria,eukaryotic phytoplankton,and other *** compared to the stream,three reservoirs consistently had low microbial diversity.A distinct seasonal pattern of microbial community structure was observed for each reservoir and the *** was consistently dominated by other *** reservoir was dominated by cyanobacteria during the summer and fall and eukaryotic phytoplankton during the winter and *** reservoir was dominated by cyanobacteria beginning in the spring but that dominance was altered when water was pumped from the stream from early spring to fall *** reservoir had the greatest shift of microbial community structure,being dominated by other bacteria in the summer,cyanobacteria in the fall,and eukaryotic phytoplankton in the winter and *** temperature and ammonium level were the two most important contributing factors to the seasonality of microbial community in these ***:The three recycling irrigation reservoirs consistently had lower microbial diversity and distinct community structure when compared to the *** reservoirs were typically dominated by cyanobacteria dur

关键词： Bacteria Cyanobacteria Phytoplankton Seasonal dynamics Water recycling Water quality

Treatment of inflammatory bowel disease:A review of medical therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第3期14卷 354-377页

作者： patricia L Kozuch Stephen B Hanauer Division of Gastroenterology and Hepatology Department of Medicine Thomas Jefferson University Hospital Philadelphia PA United States University of Chicago Hospitals Department of Medicine Section of Gastroenterology and Nutrition Chicago IL 60637 United States

Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract. While a cure remains elusive, both can be treated with medications that induce and maintain remission. With the recent advent of therapies that inhibit tumor necrosis factor (TNF) alpha the overlap in medical therapies for UC and CD has become greater. Although 5-ASA agents have been a mainstay in the treatment of both CD and UC, the data for their efficacy in patients with CD, particularly as maintenance therapy, are equivocal. Antibiotics may have a limited role in the treatment of colonic CD. Steroids continue to be the first choice to treat active disease not responsive to other more conservative therapy; non- systemic steroids such as oral and rectal budesonide for ileal and right-sided CD and distal UC respectively are also effective in mild-moderate disease. 6-mercaptopurine (6-MP) and its prodrug azathioprine are steroid-sparing immunomodulators effective in the maintenance of remission of both CD and UC, while methotrexate may be used in both induction and maintenance of CD. Infliximab and adalimumab are anti-TNF agents approved in the US and Europe for the treatment of Crohn's disease, and infliximab is also approved for the treatment of UC.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Medical therapy