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The Development of the Primitive iurisdictio episcopalis

History Research 2016年第4期6卷 212-222页

作者： Javier Belda Iniesta patricia blanco diez Universidad Catolica de Murcia (UCAM)

The irruption of Christianity in Roman society implied a necessary process of adaptation of both realities, which coexisted in a common political and cultural space. Outside of first incomprehension from both sides--crystallized in groups that, on the one hand, foresaw the imminent Parousia, and the periodic violent reactions against this weird group of followers of an executed Galileo, on the other hand--truth is that both parts must have little by little adapted to a cohabitation they saw themselves headed toward, since they shared a common space. In turn, Christians, no matter their diverse origin, social or geographical, had to become little by little aware of their own identity, building through the years an internal organization that should answer not only to the necessities of this primitive religious society inside the enormous flame of the Empire, but also to some circumstances presented in their own evolution, as they were a particular human group with a clear mission--Gospel preaching--and with very specific sources they could not separate from. Within these organization needs, one of them was the administration of Justice, needed in all societies, and clearly articulated in the Roman world, but completely distant from the evangelic principles that must guide every action of a Christian. There begins the difficult task of constructing an organization able to answer to the needs of the community and to the mission given by Jesus, doing this task, firstly, in parallel to the Empire, and later under its protection. However, this will not mean the abandonment of the authority due to the established political power, but a complicated combination between obedience toward the authorities and the application ad intra of a Law in accordance with the condition of being ＂saved＂ of the believers, whose starting point will be, no doubt, the Gospel. It is clear that when both visions collide, that born from the faith should be given priority, but both will be combined

关键词： Iufisdictio episcopalis Potestas directa Potestas indirecta auctoritas episcopalis relationsEmpire-Church

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Morphological Characterization and Hydrodynamic Behavior of Shortfin Mako Shark(Isurus oxyrinchus)Dorsal Fin Denticles

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Journal of Bionic Engineering 2019年第4期16卷 730-741页

作者： Fernandez-Waid patricia diez Guzman Bidaguren Inigo Izagirre Urtzi blanco Jesus Maria Soto Manu Department of Zoology and Animal Cell Biology Research Centre for Experimental Marine Biology and Biotechnology(PiE-UP V/EHU)University of the Basque CountryBilbao and Areatza z/gPlentzia 48620BizkaiaSpain Marine Research Division AZTITxatxarramendi s/n Sukarrieta 48395BizkaiaSpain Department of Nuclear Engineering and Fluid Mechanics School of Engineering(UP V/EHU)University of the Basque CountryPlaza lngeniero Torres Quevedo 148013 BilbaoBizkaiaSpain

The shortfin mako shark(Isurus oxyrinchus)is one of the fastest marine fishes,reaching speeds of up to 70 km·h^-*** speed is related to the skin surface design composed of dermal *** vary in size and shape according to placement on the body and minimize turbulence around the *** objective of this study is to analyze the interaction between seawater flow and denticles on the dorsal ***-resolution microscopy(scanning electron microscopy and confocal microscopy)were used to measure defined parts of the dermal *** measurements,along with ratios based on length-to-width define three morphologies(rounded,semi-rounded,long)that were 3D *** fluid dynamics simulated fluid passage over reconstructed denticles and describe hy-drodynamic efficiency under different *** increase in angle of inclination produced a relevant increase in the drag coefficient,especially for high velocity *** lowest drag coefficient values were found in long and semi-rounded,followed by rounded *** hydrodynamic behavior of shark skin demonstrates a relation to the morphological characteristics of dermal denticles on the dorsal *** is concluded that the best hydroefficiency relies on the rounded morphology and may serve to design hydrodynamically efficient surfaces or manmade assemblies.

关键词： denticles hydrodynamic mako shark computational fluid dynamics

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Erratum to: Morphological Characterization and Hydrodynamic Behavior of Shortfin Mako Shark (Isurus oxyrinchus) Dorsal Fin Denticles

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Journal of Bionic Engineering 2019年第5期16卷 965-965页

作者： patricia Fernandez-Waid Guzman diez Inigo Bidaguren Urtzi Izagirre Jesus Maria blanco Manu Soto Department of Zoology and Animal Cell Biology Research Centre for Experimental Marine Biology and Biotechnology(PiE-UPV/EHU)University of the Basque CountryBilbao and Areatza z/gPlentzia 48620BizkaiaSpain Marine Research Division AZT1Txatxarramendi s/n Sukarrieta 48395BizkaiaSpain Department of Nuclear Engineering and Fluid Mechanics School of Engineering (UPVIEHU)University of the Basque CountryPlaza Ingeniero Torres Quevedo 1.48013 BilbaoBizkaiaSpain

The names of the authors were incorrect in the published paper and should be revised as"patricia Feman-dez-Waid,Guzman diez,Inigo Bidaguren,Urtzi Izagirre,Jesus Maria blanco,Manu Soto".

关键词： Morphological revised names

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8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fabien Chantegreil Florian Nachon Xavier Brazzolotto Anna Skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia Binda Francisco López-Muoz Stanislav Gobec JoséMarco-Contelles University of Ljubljana Faculty of PharmacyLjubljana 1000Slovenia Laboratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of Biology and Biotechnology University of PaviaPavia 27100Italy Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal Anatomy and Preclinical Sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of Biochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of Translational Neurobiology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain Biotechnology and Vegetal Biology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hMAO-A/B)for the therapy of neurodegenerative *** identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available *** 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h MAO-B(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding,which was further studied by enzyme *** 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19.

关键词： Quinolylnitrone Butyrylcholinesterase Monoamine oxidase B Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task Novel object recognition

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